Bio

BIOGRAPHY

Dr Nyongesa Albert Wafula is a holder of PhD in Animal Physiology of the University of Nairobi. He is a lecturer at the Department of Veterinary Anatomy and Physiology, University of Nairobi, specializing in reproductive physiology and behavioral sciences. He is a registered Veterinary Surgeon (No. 1799) and member of Kenya Veterinary Association (No. 0964). His area of research is on impact of khat (Catha edulis) on reproductive and mental health of users as well as assessment of socioeconomic dimensions to the larger economy.

Publications


2015

2014

Nyongesa, AW, Oduma JA, Nakajima M, Odongo HO, Adoyo A, al'Absi M.  2014.  Dose-response inhibitory effects of purified cathinone from khat (Catha edulis) on cortisol and prolactin release in vervet monkeys (Chlorocebus aethiops). Metabolic Brain Disease. 29(2):451-458.nyongesa_hormone_paper.pdf
Nyongesa, AW, Oduma JA, Nakajima M, Odongo HO, Adoyo A, al'Absi M.  2014.  Acute and sub-chronic effects of purified cathinone from khat (Catha edulis) on behavioural profiles in vervet monkeys (Chlorocebus aethiops). Metabolic Brain Disease. 29(2):441-449.abstract_behavior_paper.pdf

2013

2010

Nyongesa, AW, Onyango DW.  2010.  Khat (Catha edulis Forsk): A boon or bane to humanity. Recent Progress in Medicinal Plants. , Texas: Studium Press, LLCkhat_chapter.pdf

2008

Nyongesa, AW, Patel NB, Onyango DW, Odongo HO, Wango EO.  2008.  Khat (Catha edulis) lowers plasma luteinizing hormone (LH) and testosterone secretion, but increases cortisol levels in male rabbits. Journal of Ethnopharmacology. 116:245-250.
Kimania, ST, Nyongesa AW.  2008.  Effects of single daily khat (Catha edulis) extract on spatial learning and memory. Abstract

This study investigated the effects of fresh khat extract on learning and memory in CBA mice. A total of 20 male CBA mice, weighing 20–30 g, 5–6 weeks old were administered intraperitoneally with a single daily dose of khat extract for 5 days. The animals were divided into four groups, each comprising five animals. The first three groups were administered three doses (40, 120 and 360 mg/kg body weight) of khat extract, respectively. The last group served as controls and was administered with 0.5 ml normal saline intraperitoneally. The animals were then subjected to Morris water maze (MWM) task performance. Moderate and high doses (120 and 360 mg/kg body weight) of khat extract significantly impaired (P < 0.05) while low dose (40 mg/kg body weight) of khat extract did not have a significant effect on CBA mice acquisition learning. The high dose of khat extract significantly (P < 0.05) improved while moderate and low doses impaired accuracy for spatial memory of the platform location. This study has shown that khat extract has selective effect on spatial learning and memory, with low dose having no effect on learning but impairing memory, whereas high dose impairs learning but improves memory.

2007

Nyongesa, AW, Patel NB, Onyango DW, Wango EO, Odongo HO.  2007.  In vitro study of the effects of khat (Catha edulis Forsk) extract on isolated mouse interstitial cells. Journal of Ethnopharmacology. 110:401-405.

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