Simonsen PE, Meyrowitsch DW, Jaoko WG, Malecela MN, Michael E.Immunoepidemiology of Wuchereria bancrofti infection in two East African communities: Antibodies to the microfilarial sheath and their role in regulating host microfilaraemia.Acta Trop. 2008 Ju

Citation:
W. PROFJAOKOGODFREY. "Simonsen PE, Meyrowitsch DW, Jaoko WG, Malecela MN, Michael E.Immunoepidemiology of Wuchereria bancrofti infection in two East African communities: Antibodies to the microfilarial sheath and their role in regulating host microfilaraemia.Acta Trop. 2008 Ju.". In: Acta Trop. 2008 Jun;106(3):200-6. Epub 2008 Mar 27. AIDS 24(6):891-7; 2008.

Abstract:

The response pattern of specific antibodies to the microfilarial sheath (sheath-Ab) of the mosquito-borne filarial parasite Wuchereria bancrofti was investigated in individuals from two East African communities with different levels of endemicity. Individuals from both communities presented a strong inverse relationship between positivity for sheath-Ab and being positive for microfilariae (mf) and circulating filarial antigens (CFA). The prevalence of sheath-Ab positivity was highest in young individuals, but peaked at a younger age in the high (1-14 years) than the low (15-19 years) endemicity community. IgG1, IgG2, IgG3 and IgE intensities to a crude adult filarial worm antigen were higher, and IgG4 intensities were lower, in sheath-Ab positive than in sheath-Ab negative individuals, probably reflecting the infection status of individuals. From the study it appears that individuals become sheath-Ab positive before mf and/or CFA can be detected in the peripheral blood, and only after later disappearance of sheath-Ab from the circulation can CFA and mf be diagnosed. In light of the findings, possible roles of the distinct sheath-Ab in the host-parasite relationship are discussed, and a hypothesis is proposed which suggests that sheath-Ab play an important role in the regulation of host microfilaraemia.

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