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DR. GICHUHI JOSEPH WANYOIKE CV

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Publications


2009

Wanyoike, G, Rukaria RK, Gachuno OW.  2009.  Risk factors associated with tubal infertility.

2006

WANYOIKE, DRGICHUHIJOSEPH, WANYOIKE DRGICHUHIJOSEPH.  2006.  Mugo NR, Kiehlbauch JA, Nguti R, Meier A, Gichuhi JW, Stamm WE, Cohen CR. Department of Obstetrics and Gynecology, Kenyatta National Hospital, Nairobi, Kenya. Effect of human immunodeficiency virus-1 infection on treatment outcome of acute salpingitis.Obs. PMID: 16582116 [PubMed - indexed for MEDLINE]. : Starmat Designers & Allied, Nairobi Abstract
{ OBJECTIVE: To examine the effect of human immunodeficiency virus (HIV)-1 infection on treatment outcome of laparoscopically verified acute salpingitis. METHODS: Women aged 18-40 years with laparoscopically verified acute salpingitis received antibiotic therapy that included cefotetan 2 g intravenously and doxycycline 100 mg orally every 12 hours and laparoscopically guided drainage of tuboovarian abscesses of 4 cm or more. Clinical investigators blinded to HIV-1 serostatus used predetermined clinical criteria, including calculation of a clinical severity score and a standard treatment protocol to assess response to therapy. RESULTS: Of the 140 women with laparoscopically confirmed acute salpingitis, 61 (44%) women had mild, 38 (27%) had moderate, and 41 (29%) had severe disease (ie, pyosalpinx, tuboovarian abscesses, or both). Fifty-three (38%) were HIV-1-infected. Severe disease was more common in HIV-1-infected in comparison with HIV-1-uninfected women (20 [38%] compared with 21 [24%]
WANYOIKE, DRGICHUHIJOSEPH.  2006.  Biophysical profile scores and resistance indices of the umbilical artery as seen in patients with pregnancy induced hypertension. East Afr Med J. 2006 Mar;83(3):96-101.. East Afr Med J. 2006 Mar;83(3):96-101.. : Starmat Designers & Allied, Nairobi Abstract
OBJECTIVE: The role of Biophysical Profile Score and resistive index of the umbilical artery for monitoring pre-eclampsia patients. DESIGN: Descriptive prospective study. SETTING: Kenyatta National Hospital and Mater Hospital, Nairobi, Kenya. SUBJECTS: One hundred and ten cases during a three month period. RESULTS: Normal biophysical profile scores were found in 93 (84.5%), and 17 (17.5%) cases had abnormal scores ranging from mild to severe foetal distress. Resistive index of umbilical artery (RI-UA) were normal in 72 (66.1%) and high resistive index accounted for 33.9%. Intra-Uterine Growth Restriction (IUGR) was a prominent finding accounting for 30.5%. A positive relationship was shown to exist between IUGR and RI-UA and also with severity of hypertension with P-values < 0.05. Resistive index of umbilical artery was positively related to the duration of illness confirming its dependence on chronicity (P = 0.004). Resistive index of umbilical artery proved to be an earlier indicator of foetal compromise before any foetal distress becomes obvious. CONCLUSION: Regular obstetrical ultra sound foetal surveillance in pre-eclampsia patients is important for foetal wellbeing. Doppler evaluation of high risk patients is more sensitive test than the biophysical profile score.

2005

WANYOIKE, DRGICHUHIJOSEPH, OTIENO DRODAWAFRANCISXAVIER.  2005.  Reproductive Health: Abortion, Pregnancy, Fertility, Contraception A chapter in: Forensic medicine, Medical Law and Ethics in East Africa (2005). Contribution from: J. Wanyoike Gichuhi, Peter Kimani, Editors: Mahomed A. Dada, Kirasi A. Olumbe, David J. Mc. Journal of Obstetrics and Gynaecology of East Africa. Vol. 18 No. 1:1-66 May 2005.. : Starmat Designers & Allied, Nairobi Abstract
{ OBJECTIVE: To examine the effect of human immunodeficiency virus (HIV)-1 infection on treatment outcome of laparoscopically verified acute salpingitis. METHODS: Women aged 18-40 years with laparoscopically verified acute salpingitis received antibiotic therapy that included cefotetan 2 g intravenously and doxycycline 100 mg orally every 12 hours and laparoscopically guided drainage of tuboovarian abscesses of 4 cm or more. Clinical investigators blinded to HIV-1 serostatus used predetermined clinical criteria, including calculation of a clinical severity score and a standard treatment protocol to assess response to therapy. RESULTS: Of the 140 women with laparoscopically confirmed acute salpingitis, 61 (44%) women had mild, 38 (27%) had moderate, and 41 (29%) had severe disease (ie, pyosalpinx, tuboovarian abscesses, or both). Fifty-three (38%) were HIV-1-infected. Severe disease was more common in HIV-1-infected in comparison with HIV-1-uninfected women (20 [38%] compared with 21 [24%]
WANYOIKE, DRGICHUHIJOSEPH.  2005.  Incidence of wound infection after caesarean delivery in a district hospital in central Kenya. East Afr Med J. 2005 Jul;82(7):357-61.. East Afr Med J. 2005 Jul;82(7):357-61.. : Starmat Designers & Allied, Nairobi Abstract
OBJECTIVE: To determine the incidence of post-caesarean wound infection. DESIGN: Prospective descriptive study. SETTING: Maternity unit of Kiambu District Hospital in Central Province of Kenya. SUBJECTS: All women undergoing caesarean delivery during the study period. MAIN OUTCOME MEASURES: Overall incidence of post-caesarean wound infection, relationship between incidence and socio-demographic characteristics, pre-operative labour events, intrapartum events as well as HIV status. RESULTS: The caesarean delivery rate was 7.8%. The overall post-caesarean wound infection rate was 19%. The incidence was 32% among single women as compared to 16% among married women, but this difference is not statistically significant. Among the 35% of women who laboured for more than 12 hours, the incidence of wound infection was 33% compared to 15% among those who laboured for 12 hours or less (p < 0.01). Rupture of membranes (ROM) for more than 12 hours was associated with high incidence of wound infection than among women in whom ROM was 12 hours or less (38% and 14% respectively, p < 0.001). Also duration of operation exceeding 60 minutes was associated with much higher incidence of wound infection (71%) compared to when the operation lasted 60 minutes or less (16%, p < 0.001). The incidence of post-caesarean wound infection does not appear to be significantly affected by HIV status or whether caesarean delivery was emergency or elective. CONCLUSION: The overall post-caesarean wound infection rate is quite high. Prolonged pre-operative duration of labour, prolonged ROM and long duration of operation are associated with significantly higher incidence of wound infection. This should be seen against a background of a relatively low caesarean delivery rate and high incidence of prolonged labour. Strict labour management policies need to be inculcated in labour wards in District Hospitals in order to ensure timely caesarean delivery interventions, and hence, reduce post-caesarean wound infection rates.
WANYOIKE, DRGICHUHIJOSEPH, OTIENO DRODAWAFRANCISXAVIER.  2005.  Amniotic fluid embolism: case report and review. Wanyoike J G Journal of Obstetrics and Gynaecology of Eastern and central Africa. Vol 18 NO 1:1-66 May 2005. Journal of Obstetrics and Gynaecology of Eastern and central Africa. Vol 18 NO 1:1-66 May 2005. : Starmat Designers & Allied, Nairobi Abstract
{ OBJECTIVE: To examine the effect of human immunodeficiency virus (HIV)-1 infection on treatment outcome of laparoscopically verified acute salpingitis. METHODS: Women aged 18-40 years with laparoscopically verified acute salpingitis received antibiotic therapy that included cefotetan 2 g intravenously and doxycycline 100 mg orally every 12 hours and laparoscopically guided drainage of tuboovarian abscesses of 4 cm or more. Clinical investigators blinded to HIV-1 serostatus used predetermined clinical criteria, including calculation of a clinical severity score and a standard treatment protocol to assess response to therapy. RESULTS: Of the 140 women with laparoscopically confirmed acute salpingitis, 61 (44%) women had mild, 38 (27%) had moderate, and 41 (29%) had severe disease (ie, pyosalpinx, tuboovarian abscesses, or both). Fifty-three (38%) were HIV-1-infected. Severe disease was more common in HIV-1-infected in comparison with HIV-1-uninfected women (20 [38%] compared with 21 [24%]
WANYOIKE, DRGICHUHIJOSEPH, OTIENO DRODAWAFRANCISXAVIER.  2005.  Gachuno O W, Wanyoike Gichuhi J, Rukaria R M K Effects of calcium supplementation in patients at risk of pregnancy induced hypertension Journal of Obstetrics and Gynaecology of East Africa. Vol. 18 No. 1:1-66 May 2005. Gachuno O W, Wanyoike Gichuhi J, Ruk. Journal of Obstetrics and Gynaecology of East Africa. Vol. 18 No. 1:1-66 May 2005.. : Starmat Designers & Allied, Nairobi Abstract
{ OBJECTIVE: To examine the effect of human immunodeficiency virus (HIV)-1 infection on treatment outcome of laparoscopically verified acute salpingitis. METHODS: Women aged 18-40 years with laparoscopically verified acute salpingitis received antibiotic therapy that included cefotetan 2 g intravenously and doxycycline 100 mg orally every 12 hours and laparoscopically guided drainage of tuboovarian abscesses of 4 cm or more. Clinical investigators blinded to HIV-1 serostatus used predetermined clinical criteria, including calculation of a clinical severity score and a standard treatment protocol to assess response to therapy. RESULTS: Of the 140 women with laparoscopically confirmed acute salpingitis, 61 (44%) women had mild, 38 (27%) had moderate, and 41 (29%) had severe disease (ie, pyosalpinx, tuboovarian abscesses, or both). Fifty-three (38%) were HIV-1-infected. Severe disease was more common in HIV-1-infected in comparison with HIV-1-uninfected women (20 [38%] compared with 21 [24%]

2004

WANYOIKE, DRGICHUHIJOSEPH, OTIENO DRODAWAFRANCISXAVIER.  2004.  Wanyoike J G. A case of reproductive technology in Africa: Wanyoike J G. Journal of Obstetrics and Gynaecology of Eastern and central Africa. Volume 17 No 1:1-80 February 2004. Journal of Obstetrics and Gynaecology of Eastern and central Africa. Volume 17 No 1:1-80 February 2004. : Starmat Designers & Allied, Nairobi Abstract
OBJECTIVE: To determine the incidence of post-caesarean wound infection. DESIGN: Prospective descriptive study. SETTING: Maternity unit of Kiambu District Hospital in Central Province of Kenya. SUBJECTS: All women undergoing caesarean delivery during the study period. MAIN OUTCOME MEASURES: Overall incidence of post-caesarean wound infection, relationship between incidence and socio-demographic characteristics, pre-operative labour events, intrapartum events as well as HIV status. RESULTS: The caesarean delivery rate was 7.8%. The overall post-caesarean wound infection rate was 19%. The incidence was 32% among single women as compared to 16% among married women, but this difference is not statistically significant. Among the 35% of women who laboured for more than 12 hours, the incidence of wound infection was 33% compared to 15% among those who laboured for 12 hours or less (p < 0.01). Rupture of membranes (ROM) for more than 12 hours was associated with high incidence of wound infection than among women in whom ROM was 12 hours or less (38% and 14% respectively, p < 0.001). Also duration of operation exceeding 60 minutes was associated with much higher incidence of wound infection (71%) compared to when the operation lasted 60 minutes or less (16%, p < 0.001). The incidence of post-caesarean wound infection does not appear to be significantly affected by HIV status or whether caesarean delivery was emergency or elective. CONCLUSION: The overall post-caesarean wound infection rate is quite high. Prolonged pre-operative duration of labour, prolonged ROM and long duration of operation are associated with significantly higher incidence of wound infection. This should be seen against a background of a relatively low caesarean delivery rate and high incidence of prolonged labour. Strict labour management policies need to be inculcated in labour wards in District Hospitals in order to ensure timely caesarean delivery interventions, and hence, reduce post-caesarean wound infection rates.

2003

WANYOIKE, DRGICHUHIJOSEPH, K. PROFSINEISAMUEL, OTIENO DRODAWAFRANCISXAVIER.  2003.  Cohen R, Joseph Gichuhi, Rukaria R, Sinei SK, Gultai S.Investigation of immunogenetic correlates for Chlamydia trachomatis associated tubal infertility. American Journal of Obstetric and Gynaecology Vol 101 . American Journal of Obstetric and Gynaecology Vol 101 . : Starmat Designers & Allied, Nairobi Abstract
Cohen CR, Gichui J, Rukaria R, Sinei SS, Gaur LK, Brunham RC. Departments of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195, USA. crcohen@u.washington.edu OBJECTIVE: To understand immunogenetic mechanisms of Chlamydia trachomatis infection and tubal scarring. METHODS: We measured and compared previously significant human leukocyte antigen (HLA) class II DQ alleles, their linked DRB genes, and polymorphisms in selected cytokine genes (tumor necrosis factor alpha-308 promoter; transforming growth factor beta1-10 and -25 codons; interleukin 10-1082, -819, and -592 promoters; interleukin 6-174 promoter; and interferon gamma+874 codon 1) among Kenyan women with confirmed tubal infertility with and without C trachomatis microimmunofluorescence antibody. RESULTS: Two class II alleles, HLA-DR1*1503 and DRB5*0101, were detected less commonly in C trachomatis microimmunofluorescence seropositive women than in C trachomatis microimmunofluorescence seronegative women with infertility (0% versus 20%; odds ratio [OR] 0.05; 95% confidence interval [CI] 0, 0.7, and 6% versus 26%; OR 0.2; 95% CI 0.02, 1.0, respectively). These alleles are commonly linked as a haplotype at the DRB locus. This finding could not be explained through linkage disequilibrium with the other studied HLA or cytokine genes. CONCLUSION: These alleles may lead to an immunologically mediated mechanism of protection against C trachomatis infection and associated tubal damage, or alternatively increase risk for tubal scarring due to another cause. PMID: 12636945 [PubMed - indexed for MEDLINE]

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