Epidemiology of 2009 Pandemic Influenza A Virus Subtype H1N1 Among Kenyans Aged 2 Months to 18 Years, 2009–2010

Citation:
Wong KK, Bulimo WD, Magana J, Achilla RA, Schwarcz SK, Simwa M, Majanja JM, Wadegu MO, Osuna FA, Mukunzi SO, Mwangi JK, Wangui JM, Muthoni JN, Njiri JO, Obura BD, Opot BH, Mitei KK, Barani J, Lifumo S, Schnabel DC. "Epidemiology of 2009 Pandemic Influenza A Virus Subtype H1N1 Among Kenyans Aged 2 Months to 18 Years, 2009–2010." Journal of Infectious Diseases. 2012;206:S68-S73.

Abstract:

Background.The US Army Medical Research Unit–Kenya (USAMRU-K) conducts surveillance for influenza-like illness (ILI) in Kenya. We describe the temporal and geographic progression of A(H1N1)pdm09 as it emerged in Kenya and characterize the outpatient population with A(H1N1)pdm09 infection.Methods.We included patients with ILI aged 2 months to 18 years enrolled during June 2009–August 2010. Respiratory specimens were tested by real-time reverse-transcription polymerase chain reaction for influenza virus. Patients with A(H1N1)pdm09 infection were compared to those with seasonal influenza A virus infection and those with ILI who had no virus or a virus other than influenza virus identified (hereafter, “noninfluenza ILI”).Results.Of 4251 patients with ILI, 193 had laboratory-confirmed A(H1N1)pdm09 infection. The first pandemic influenza case detected by USAMRU-K surveillance was in August 2009; peak activity nationwide occurred during October–November 2009. Patients with A(H1N1)pdm09 infection were more likely to be school-aged, compared with patients with seasonal influenza A virus infection (prevalence ratio [PR], 2.0; 95% confidence interval [CI], 1.3–3.1) or noninfluenza ILI (PR, 3.2; 95% CI, 2.4–4.3).Conclusions.USAMRU-K ILI surveillance detected the geographic and temporal distribution of pandemic influenza in Kenya. The age distribution of A(H1N1)pdm09 infections included more school-aged children, compared with seasonal influenza A virus infection and noninfluenza ILI.

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