Structure of the 40S ribosomal subunit of Plasmodium falciparum by homology and de novo modeling

Citation:
Mwangi HN'u, Wagacha P, Mathenge P, Sijenyi F, Mulaa F. "Structure of the 40S ribosomal subunit of Plasmodium falciparum by homology and de novo modeling." 7. 2017;1:97-105.

Abstract:

Generation of three dimensional structures of macromolecules using in silico
structural modeling technologies such as homology and de novo modeling has improved
dramatically and increased the speed by which tertiary structures of organisms can be
generated. This is especially the case if a homologous crystal structure is already available.
High-resolution structures can be rapidly created using only their sequence information as
input, a process that has the potential to increase the speed of scientific discovery.

Full Text

Generation of three dimensional structures of macromolecules using in silico
structural modeling technologies such as homology and de novo modeling has improved
dramatically and increased the speed by which tertiary structures of organisms can be
generated. This is especially the case if a homologous crystal structure is already available.
High-resolution structures can be rapidly created using only their sequence information as
input, a process that has the potential to increase the speed of scientific discovery.

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