Publications


1998

B, PROFMBAYAVERTISTINE.  1998.  Mbaya, V.B., Hypertension in East Africans and Others of African Descent: A Review, E. Afr. Med. J. 75(5): 300 1998. E. Afr. Med. J. 75(5): 300. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.

1976

Mbaya, VB.  1976.  Hepatic changes induced by Schrebera alata (Hochst): a preliminary report on the toxicology of II kau kawa.. Abstract

Schrebera alata is a deciduous fuel tree from which the Samburu people in Northern Kenya obtain bark for medicinal purposes. A pharmacologically active principle that produces analgesic effects can be extracted from the bark with hot water. When administered to rats daily for a period of 6 weeks, the extract of bark (referred to as II kau kawa by the Samburu) caused reduced activities of succinic dehydrogenase, an enzyme that is involved in oxidative processes, and cholinesterase in heart and liver tissues. Histological sections from the liver revealed extensive cellular degeneration and small areas with necrotic lesions. Only that fraction of the bark extracts which contained components less soluble in alcohol produced such lesions within a 2 weeks period. The same fraction is associated with pharmacological activity. Since hepatic injuries occur frequently and the incidence of primary hepatic carcinoma is high in tropical areas, the role of natural toxins as aetiologic factors for cirrhotic conditions must be adequately clarified. It is apparent that bark from S.alata possesses some toxicity and its effects on the liver indicate it can contribute significantly to prevalent hepatocellular damages.

1975

B, PROFMBAYAVERTISTINE.  1975.  Mbaya, V. B., Hepatic Changes Induced by Schrebera alata: A Preliminary Report on The Toxicology of Il Kau Kawa, Afr.J. Med. Sci. 5:131 1975. Afr.J. Med. Sci. 5:131. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.

1967

B, PROFMBAYAVERTISTINE.  1967.  Foy, H., A. Kondi and V.B. Mbaya, Erythroid Aplasia in Riboflavin Deficient Baboons And it. Brit. J. Haematology 13:967. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.

1966

B, PROFMBAYAVERTISTINE.  1966.  Foy H, Kondi A, Mbaya V.Serum vitamin B12 and folate levels in normal and riboflavin-deficient baboons (Papio anubis). Br J Haematol. 1966 Mar;12(2):239-45. Br J Haematol. 1966 Mar;12(2):239-45. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.
B, PROFMBAYAVERTISTINE.  1966.  Foy, H., A. Kondi and V.B. Mbaya, Serum B-12 and Folate Levels in Normal and Riboflavin Deficient Baboons. Brit. J. Haematology 12:234 1966. Brit. J. Haematology 12:234. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.

1965

B, PROFMBAYAVERTISTINE.  1965.  Foy H, Kondi A, Mbaya V.Hematologic and biochemical indices in the East African baboon.Blood. 1965 Nov;26(5):682-6. Blood. 1965 Nov;26(5):682-6. : Wangari Veronica Wanjiru Abstract

Hematologic values for peripheral blood and marrow, serum proteins, B12 and folic acid levels are given for recently caught and captive baboons (P. anubis and P.sinocephalus) in Nairobi. The hemaglobin levels were higher in captive than in wild animals. There was no change in the serum proteins unless the animals were on a riboflavindeficient diet. Marrow activity as estimated by counting red cell precursors as a percentage of the total nucleated red cell population agreed with that of red cell uptake of Fe59 ferric chloride. Hemosiderin was present in the marrow in all the animals. Protein turnover studies using I131-labeled albumin with ion exchange resins indicated that the protein catabolic rate and turnover was high. This may have been due to the selective destruction of the human albumin in the baboon.

1964

B, PROFMBAYAVERTISTINE.  1964.  Foy, H., A. Kondi and V.B. Mbaya, Riboflavin Deficiency and Bone Marrow Function in Baboons, Brit. J. Nutr. 18:307 1964. Brit. J. Nutr. 18:307. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.
B, PROFMBAYAVERTISTINE.  1964.  FOY H, KONDI A, MBAYA V.EFFECT OF RIBOFLAVINE DEFICIENCY ON BONE MARROW FUNCTION AND PROTEIN METABOLISM IN BABOONS. PRELIMINARY REPORT.Br J Nutr. 1964;18:307-18. Br J Nutr. 1964;18:307-18. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.

1963

B, PROFMBAYAVERTISTINE.  1963.  KONDI A, MACDOUGALL L, FOY H, MEHTA S, MBAYA V.Anaemias of marasmus and kwashiorkor in Kenya.Arch Dis Child. 1963 Jun;38:267-75. Arch Dis Child. 1963 Jun;38:267-75. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.

1962

B, PROFMBAYAVERTISTINE.  1962.  Kondi, A., H. Foy and V.B. Mbaya, Erythroid Aplasia in Kwashiorkor, Brit. Med. J. 1:725 1962. Med. J. 1:725. : Wangari Veronica Wanjiru Abstract
As the number of fatalities from cardiovascular diseases declines in western industrial nations, an opposite trend is observed in the East African region. Inter-regional variations in the prevalence of vascular disorders have been attributed to socioeconomic, psychosocial and heritable physiological parameters. Although faulty mineralocorticoid metabolism and the dysfunctional kidney are prominent features of circulatory problems, many current studies are focused on membrane receptors, transmembrane ion transport mechanisms, ion channels and the possible genetic polymorphisms that determine the characteristics of those molecular structures in the vascular system of normal or hypertensive persons. In this review, a composite of the data available on each of the above parameters and its significance in the pathogenesis of hypertension in the industrial West and transforming economies of East Africa is presented.

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