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2020
Lutta HO, Odongo D, Mather A, Perez-Casal J, Potter A, Gerdts V, Berberov EM, Prysliak T, Martina Kyallo, Kipronoh A, Olum M, Pelle R, Naessens J. "Baseline analysis of Mycoplasma mycoides subsp. mycoides antigens as targets for a DIVA assay for use with a subunit vaccine for contagious bovine pleuropneumonia." BMC Vet Res. 2020;16(1):236. Abstract

Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia in cattle. A prototype subunit vaccine is being developed, however, there is currently no diagnostic test that can differentiate between infected cattle and those vaccinated with the prototype subunit vaccine. This study characterized Mmm proteins to identify potential antigens for use in differentiating infected from vaccinated animals.

Obara I, Githaka N, Nijhof A, Krücken J, Nanteza A, Odongo D, Lubembe D, Atimnedi P, Mijele D, Njeri A, Mwaura S, Owido G, Ahmed J, Clausen PH, Bishop RP. "The Rhipicephalus appendiculatus tick vector of Theileria parva is absent from cape buffalo (Syncerus caffer) populations and associated ecosystems in northern Uganda." Parasitol Res. 2020;119(7):2363-2367. Abstract

Rhipicephalus appendiculatus is the major tick vector of Theileria parva, an apicomplexan protozoan parasite that causes the most economically important and lethal disease of cattle in East and central Africa. The African cape buffalo (Syncerus caffer) is the major wildlife host of T. parva from southern Uganda and Kenya to southern Africa. We show herein that R. appendiculatus appears to be absent from the two largest national parks in northern Uganda. Syncerus caffer is common in both of these national parks, specifically Murchison falls (MFNP) and Kidepo Valley (KVNP). We re-confirmed the previously reported absence of T. parva in buffalo sampled in the two northern parks based on RLB data using a nested PCR based on the T. parva p104 gene. By contrast, T. parva-infected R. appendiculatus ticks and parasite-infected buffalo were present in Lake Mburo (LMNP) in South central Uganda. This suggests that the distribution of R. appendiculatus, which is predicted to include the higher rainfall regions of northern Uganda, may be limited by additional, as yet unknown factors.

Mwamuye MM, Obara I, Elati K, Odongo D, Bakheit MA, Jongejan F, Nijhof AM. "Unique Mitochondrial Single Nucleotide Polymorphisms Demonstrate Resolution Potential to Discriminate Vaccine and Buffalo-Derived Strains." Life (Basel). 2020;10(12). Abstract

Distinct pathogenic and epidemiological features underlie different strains resulting in different clinical manifestations of East Coast Fever and Corridor Disease in susceptible cattle. Unclear delineation of these strains limits the control of these diseases in endemic areas. Hence, an accurate characterization of strains can improve the treatment and prevention approaches as well as investigate their origin. Here, we describe a set of single nucleotide polymorphisms (SNPs) based on 13 near-complete mitogenomes of strains originating from East and Southern Africa, including the live vaccine stock strains. We identified 11 SNPs that are non-preferentially distributed within the coding and non-coding regions, all of which are synonymous except for two within the gene of buffalo-derived strains. Our analysis ascertains haplotype-specific mutations that segregate the different vaccine and the buffalo-derived strains except Muguga and Serengeti-transformed strains suggesting a shared lineage between the latter two vaccine strains. Phylogenetic analyses including the mitogenomes of other species: , , and , with the latter two sequenced in this study for the first time, were congruent with nuclear-encoded genes. Importantly, we describe seven haplotypes characterized by synonymous SNPs and parsimony-informative characters with the other three transforming species mitogenomes. We anticipate that tracking mitochondrial haplotypes from this study will provide insight into the parasite's epidemiological dynamics and underpin current control efforts.

Ngugi SK, Muiruri P, Odero T, Gachuno O. "Factors affecting uptake and completion of isoniazid preventive therapy among HIV-infected children at a national referral hospital, Kenya: a mixed quantitative and qualitative study." BMC Infect Dis. 2020;20(1):294. AbstractWebsite

Tuberculosis (TB) is the most common opportunistic infection and the leading cause of death in people living with HIV (PLHIV). HIV-infected children are at a higher risk of TB infection and disease compared to those without HIV. Isoniazid preventive therapy (IPT) is an effective intervention in preventing progression of latent TB infection to active TB. The World Health Organization (WHO) currently recommends that all children aged > 12 months and adults living with HIV in whom active TB has been excluded should receive a 6-months course of IPT as part of a comprehensive package of HIV care. Despite this recommendation, the uptake of IPT among PLHIV has been suboptimal globally. This study sought to determine the factors affecting IPT uptake and completion among HIV-infected children in a large HIV care centre in Nairobi, Kenya.

Oladapo OT, Vogel JP, Piaggio G, et al. "Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries." N Engl J Med. 2020;383(26):2514-2525. Abstract

The safety and efficacy of antenatal glucocorticoids in women in low-resource countries who are at risk for preterm birth are uncertain.

Oladapo OT, Vogel JP, Piaggio G, et al. "Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries." N Engl J Med. 2020;383(26):2514-2525. Abstract

The safety and efficacy of antenatal glucocorticoids in women in low-resource countries who are at risk for preterm birth are uncertain.

Brizuela V, Bonet M, Romero CLT, Abalos E, Baguiya A, Fawole B, Knight M, Lumbiganon P, Minkauskienė M, Nabhan A, Osman NB, Qureshi ZP, Souza JP. "Early evaluation of the 'STOP SEPSIS!' WHO Global Maternal Sepsis Awareness Campaign implemented for healthcare providers in 46 low, middle and high-income countries." BMJ Open. 2020;10(5):e036338. Abstract

To evaluate changes in awareness of maternal sepsis among healthcare providers resulting from the WHO Global Maternal Sepsis Study (GLOSS) awareness campaign.

Arunga S, Kintoki GM, Mwesigye J, Ayebazibwe B, Onyango J, Bazira J, Newton R, Gichuhi S, Leck A, Macleod D, Hu VH, Burton MJ. "Epidemiology of Microbial Keratitis in Uganda: A Cohort Study." Ophthalmic Epidemiol. 2020;27(2):121-131. AbstractWebsite

: To describe the epidemiology of Microbial Keratitis (MK) in Uganda.: We prospectively recruited patients presenting with MK at two main eye units in Southern Uganda between December 2016 and March 2018. We collected information on clinical history and presentation, microbiology and 3-month outcomes. Poor vision was defined as vision < 6/60).: 313 individuals were enrolled. Median age was 47 years (range 18-96) and 174 (56%) were male. Median presentation time was 17 days from onset (IQR 8-32). Trauma was reported by 29% and use of Traditional Eye Medicine by 60%. Majority presented with severe infections (median infiltrate size 5.2 mm); 47% were blind in the affected eye (vision < 3/60). Microbiology was available from 270 cases: 62% were fungal, 7% mixed (bacterial and fungal), 7% bacterial and 24% no organism detected. At 3 months, 30% of the participants were blind in the affected eye, while 9% had lost their eye from the infection. Delayed presentation (overall = .007) and prior use of Traditional Eye Medicine (aOR 1.58 [95% CI 1.04-2.42], = .033) were responsible for poor presentation. Predictors of poor vision at 3 months were: baseline vision (aOR 2.98 [95%CI 2.12-4.19], < .0001), infiltrate size (aOR 1.19 [95%CI 1.03-1.36], < .020) and perforation at presentation (aOR 9.93 [95% CI 3.70-26.6], < .0001).: The most important outcome predictor was the state of the eye at presentation, facilitated by prior use of Traditional Eye Medicine and delayed presentation. In order to improve outcomes, we need effective early interventions.

Birech Z, Mwangi PW, Sehmi PK, Nyaga NM. "Application of Raman spectroscopy in comparative study of antiobesity influence of oxytocin and freeze-dried extracts of Uvariodendron anisatum Verdeck (Annonaceae) in Sprague Dawley rats." Journal of Raman SpectroscopyJournal of Raman Spectroscopy. 2020;51(3):398-405. AbstractWebsite

Abstract Obesity is a condition affecting a substantial number of people in the world. Obese people have increased risks of developing chronic metabolic diseases such as type II diabetes, hypertension, and cancer, among others. Predicting potential development together with rapid diagnosis of the condition followed by early interventions is therefore necessary. This work investigated, first, utility of Raman spectroscopy in performing comparative antiobesity influence studies of oxytocin and a freeze-dried extract of a local herbal plant exhibiting oxytocin-like properties called Uvariodendron anisatum Verdeck (Annonaceae) (UAV) on diet induced obesity in Sprague Dawley rat models. Second, we looked for obesity biomarker Raman spectral bands. The blood extracted from the rats were applied onto conductive silver paste smeared glass slides and excited using a 785-nm laser. Raman spectra of blood from oxytocin- and UAV-treated rats displayed similar profiles with low doses of UAV (100 mg/kg of body weight) being more similar to oxytocin than high doses (200 mg/kg of body weight) as revealed by cosine similarity value of 0.997. Their profiles were also different from blood of obese and nonobese (normal controls) animals. A prominent peak in spectra of treated rats centred at 401 cm?1 can be oxytocin's biomarker band in blood. Comparison of average intensity trend of fructose bands at around 638 and 812 cm?1 between prepared fructose solution and blood of treated rats revealed elevated levels of fructose in blood of rats intraperitoneally injected oxytocin and UAV extracts. The result implied upregulation of fructose in oxytocin- and UAV-treated animals. Principal component analysis confirmed that Raman spectral profiles from blood of obese rats were different from those of nonobese rats with bands ascribed to fructose (638, 812, and 1,217 cm?1) and branched chain amino acids (BCAAs; 478, 1,318, and 1,443 cm?1), being utilized in the segregation of the spectral data sets. It also showed that spectra from oxytocin-treated and UAV-treated rat's blood were similar implying identical influence of the drugs on the animals. The study showed potential of Raman spectroscopy as tool for quick obesity (or metabolic syndrome) screening with intensity of Raman bands associated with fructose and BCAAs as biomarkers. Besides, the same bands may be used in comparative efficacy studies of antiobesity drugs. The results reported here are rare in literature.

Mwangi N, Bascaran C, Ng'ang'a M, Ramke J, Kipturgo M, Gichuhi S, Kim M, Macleod D, Moorman C, Muraguri D, Gakuo E, Muthami L, Foster A. "Feasibility of a cluster randomized controlled trial on the effectiveness of peer-led health education interventions to increase uptake of retinal examination for diabetic retinopathy in Kirinyaga, Kenya: a pilot trial." Pilot Feasibility Stud. 2020;6:102. AbstractWebsite

Background: People living with diabetes can reduce their risk of vision loss from diabetic retinopathy by attending screening, which enables early detection and timely treatment. The aim of this pilot trial was to assess the feasibility of a full-scale cluster randomized controlled trial of an intervention to increase uptake of retinal examination in this population, as delivered within existing community-based diabetes support groups (DSGs).

Methods: All 16 DSGs in Kirinyaga county were invited to participate in the study. The first two groups recruited took part in the pilot trial. DSG members who met the eligibility criteria were recruited before the groups that were randomized to the two arms. In the intervention group, two peer educators were trained to deliver monthly DSG-based eye health education and individual telephone reminders to attend screening. The control group continued with usual DSG practice which is monthly meetings without eye health education. The recruitment team and outcome assessors were masked to the allocation. We documented the study processes to ascertain the feasibility, acceptability, and potential effectiveness of the intervention. Feasibility was assessed in terms of clarity of study procedures, recruitment and retention rates, level of acceptability, and rates of uptake of eye examination. We set the target feasibility criteria for continuation to the main study to be recruitment of 50 participants in the trial, 80% monthly follow-up rates for individuals, and no attrition of clusters.

Results: Of the 122 DSG members who were assessed for eligibility, 104 were recruited and followed up: 51 (intervention) and 53 (control) arm. The study procedures were well understood and easy to apply. We learnt the DSG meeting days were the best opportunities for recruitment. The study had a high acceptance rate (100% for clusters, 95% for participants) and high follow-up and retention rate (100% of those recruited). All clusters and participants were analysed. We observed that the rate of incidence of eye exam was about 6 times higher in the intervention arm as compared to the control arm. No adverse unexpected events were reported in either arm.

Conclusions: The study is feasible and acceptable in the study population. The results support the development of a full-scale cluster RCT, as the success criteria for the pilot were met.

Mwangi N, Bascaran C, Ramke J, Kipturgo M, Kim M, Ng'ang'a M, Gichuhi S, Mutie D, Moorman C, Muthami L, Foster A. "Peer-support to increase uptake of screening for diabetic retinopathy: process evaluation of the DURE cluster randomized trial." Trop Med Health. 2020;48:1. AbstractWebsite

Background: There is limited evidence on how implementation of peer support interventions influences effectiveness, particularly for individuals with diabetes. We conducted a cluster randomized controlled trial to compare the effectiveness of a peer-led health education package versus usual care to increase uptake of screening for diabetic retinopathy (DR).

Methods: Our process evaluation used a mixed-method design to investigate the recruitment and retention, reach, dose, fidelity, acceptability, and context of implementation, and was guided by the Consolidated Framework for Implementation Research (CFIR). We reviewed trial documents, conducted semi-structured interviews with key informants (n = 10) and conducted four focus group discussions with participants in both arms of the trial. Three analysts undertook CFIR theory-driven content analysis of the qualitative data. Quantitative data was analyzed to provide descriptive statistics relevant to the objectives of the process evaluation.

Results: The trial had positive implementation outcomes, 100% retention of clusters and 96% retention for participants, 83% adherence to delivery of content of group talks (fidelity), and 78% attendance (reach) to at least 50% (3/6) of the group talks (dose). The data revealed that intervention characteristics, outer setting, inner setting, individual characteristics, and process (all the constructs of CFIR) influenced the implementation. There were more facilitators than barriers to the implementation. Facilitators included the relative advantage of the intervention compared with current practice (intervention characteristics); awareness of the growing prioritization of diabetes in the national health policy framework (outer setting); tension for change due to the realization of the vulnerability to vision loss from DR (inner setting); a strong collective sense of accountability of peer supporters to implement the intervention (individual characteristics); and regular feedback on the progress with implementation (process). Potential barriers included the need to queue at the eye clinic (intervention characteristic), travel inconveniences (inner setting), and socio-political disruption (outer setting).

Conclusions: The intervention was implemented with high retention, reach, fidelity, and dose. The CFIR provided a valuable framework for evaluating contextual factors that influenced implementation and helped to understand what adaptations may be needed during scale up.

Sorensen JPR, Carr AF, Nayebare J, Diongue DML, Pouye A, Roffo R, Gwengweya G, Ward JST, Kanoti J, Okotto-Okotto J, van der Marel L, Ciric L, Faye SC, Gaye CB, Goodall T, Kulabako R, Lapworth DJ, MacDonald AM, Monjerezi M, Olago D, Owor M, Read DS, Taylor RG. "Tryptophan-like and humic-like fluorophores are extracellular in groundwater: implications as real-time faecal indicators.". 2020;10(1):15379. AbstractWebsite

Fluorescent natural organic matter at tryptophan-like (TLF) and humic-like fluorescence (HLF) peaks is associated with the presence and enumeration of faecal indicator bacteria in groundwater. We hypothesise, however, that it is predominantly extracellular material that fluoresces at these wavelengths, not bacterial cells. We quantified total (unfiltered) and extracellular (filtered at < 0.22 µm) TLF and HLF in 140 groundwater sources across a range of urban population densities in Kenya, Malawi, Senegal, and Uganda. Where changes in fluorescence occurred following filtration they were correlated with potential controlling variables. A significant reduction in TLF following filtration (ΔTLF) was observed across the entire dataset, although the majority of the signal remained and thus considered extracellular (median 96.9%). ΔTLF was only significant in more urbanised study areas where TLF was greatest. Beneath Dakar, Senegal, ΔTLF was significantly correlated to total bacterial cells (ρs 0.51). No significant change in HLF following filtration across all data indicates these fluorophores are extracellular. Our results suggest that TLF and HLF are more mobile than faecal indicator bacteria and larger pathogens in groundwater, as the predominantly extracellular fluorophores are less prone to straining. Consequently, TLF/HLF are more precautionary indicators of microbial risks than faecal indicator bacteria in groundwater-derived drinking water.

Munyua M M, W MS, N MJ. "Effect of Carbon Fiber Reinforced Polymer Strengthening on the Axial Capacity and Ductility of Non-Slender Square Concrete Columns.". In: UoN Architecture & Engineering Conference. Nairobi Kenya; 2020.
Njiru FM, Siriba DN, Karanja FN. "Review of GIS System Audit Parameters in an Organization.". In: Architecture and Engineering Conference. University of Nairobi; 2020.
Njiru FM, Siriba DN, Karanja FN. "Review of GIS System Audit Parameters in an Organization.". In: Architecture and Engineering Conference. University of Nairobi; 2020.
Obiero K, Lawrence T, Ives J, Smith S, Njaya F, Kayanda R, Waidbacher H, Olago D, Miriti E, Hecky RE. "Advancing Africa’s great lakes research and academic potential: Answering the call for harmonized, long-term, collaborative networks and partnerships." Journal of Great Lakes Research. 2020. Abstractdio.org

Abstract
The African Great Lakes (AGL) have rich fisheries and are renowned “biodiversity hotspots”. Consequently the AGLand the ecosystem services they provide, underpin the welfare and livelihoods of over 50 million people across 10 countries. Despite the recognized importance of the AGL, these vital ecosystems and their livelihood support systems are threatened by numerous anthropogenic stressors at local, regional, and global scales. Past and continued efforts to address critical challenges on these lakes are often short-term, parochial, disparate, and uncoordinated resulting in a lack of comprehensive and comparable scientific data and inadequate resources to influence evidence-based policy. Over the past two decades, several international workshops, conferences and scientific publications have identified the need for collaboration, knowledge sharing, and harmonization of research and management as key elements to enhance conservation efforts in the AGL. In this commentary, we introduce the African Center for Aquatic Research and Education (ACARE), which aims to strengthen research and provide the scientific evidence needed to make informed decisions related to sustainable fisheries and aquatic resource management in the AGL. To do this, ACARE will administer a highly collaborative network of experts with three long-term goals: (1) strengthen global and regional research partnerships; (2) establish transboundary and inter-jurisdictional lake advisory groups; and (3) build capacity of freshwater scientists through experiential education and public engagement.

Keywords
African Great Lakes Collaborative networks Transboundary lake advisory groups, educationResearch partnerships

Nunow A, Nzioka JM, Kinama JM. "Analysis of gender parity in climate change adaptation actions within Kajiado and Kiambu counties, Kenya." East African Journal of Science, Technology and Innovation. 2020;1(2).
JessicaOsanya, I.Adam R, Otieno DJ, Nyikal R, Jaleta M. "An analysis of the respective contributions of husband and wife in farming households in Kenya to decisions regarding the use of income: A multinomial logit approach." Women's Studies International Forum. 2020;83. AbstractWebsite

This paper analyzes the socio-economic characteristics of households that affect husbands and wives' contributions to decisions regarding the use of income from crop and livestock sales in Kenya. Using a sample of 276 households, we apply a multinomial logit model to assess factors affecting decision-making. Results show that husbands make most decisions concerning agriculture, while wives mainly decide on daily household expenditure. Higher education levels were found to increase women's involvement in decision-making on income use. Group membership had a positive effect on joint decision-making on income use. The study recommends improving women's access to education, which will improve their access to productive resources, hence their decision-making power. Providing incentives for members of agricultural groups can provide avenues for learning. Gender-transformative approaches that empower women and sensitize men to allow space for women to engage in decision-making, can have an impact in improving the decision-making capacity of women in households.

Kimondo J, Mutai P, Njogu P, Kimwele C. "Anti-inflammatory activity of selected plants used by the Ilkisonko Maasai, Kenya." Afr. J. Therapeut. Pharmacol. 2020;9(2):39-43.
Owor RO, Bedane KG, Zühlke S, Derese S, Ong’amo GO, Ndakala A, Spiteller M. "Anti-inflammatory Flavanones and Flavones from Tephrosia linearis." Journal of Natural Products. 2020;83(4):996-1004. AbstractJournal of Natural Products

Description
Phytochemical analysis of a methanol–dichloromethane (1:1) extract of the aerial parts of Tephrosialinearis led to the isolation of 18 compounds. Seven of these, namely, lineaflavones A–D (1–4), 6-methoxygeraldone (5), 8″-acetylobovatin (6), and 5-hydroxy-7-methoxysaniculamin A (7) are new compounds. The compounds were characterized based on their NMR and HRMSn data. The anti-inflammatory effects of the crude extract and isolated compounds were evaluated by measuring the levels of interleukins (IL-1β, IL-2, and IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). The crude extract inhibited the release of all cytokines except IL-1β, which slightly increased in comparison to the LPS control. All the tested compounds suppressed the production of IL-2, GM-CSF, and …

Mukavi J, Omosa LK, Nchiozem-Ngnitedem V-A, Nyaga J, Omole R, Bitchagno GTM, Spiteller M. "Anti-inflammatory norhopanes from the root bark of Fagaropsis angolensis (Engl.) H. M. Gardner." Fitoterapia. 2020;146:104690.mukavi_et_al_2020_fitoterapia.pdf
Nchiozem-Ngnitedem V-A, Omosa LK, Bedane KG, Derese S, Brieger L, Strohmann C, Spiteller M. "Anti-inflammatory Steroidal Sapogenins and a Conjugated Chalcone-stilbene from Dracaena usambarensis Engl." Fitoterapia. 2020;146:104717.alexe_et_al_2020_fitoterapia.pdf
Wanja DW, Mbuthia PG, Waruiru RM, Bebora LC, Nyaga PN, Ngowi, H. "Antibiotic and disinfectants susceptibility patterns of bacterial pathogens recovered from farmed fish in Kirinyaga County, Kenya." Hindawi International Journal of Microbiology. 2020;2020(Article ID 8897338. https://doi.org/10.1155/2020/8897338).
Babiaka SB, Nia R, Abuga KO, Mbah JA, Nziko VN, Paper DH, Ntie-Kang F. "Antioxidant potential of flavonoid glycosides from Manniophyton fulvum Müll. (Euphorbiaceae): Identification and molecular modeling." Scientic African. 2020;8(e00423):1-7. Abstract

Chemical investigation of the leaves of Manniophyton fulvum led to the isolation of seven flavonoid glycosides: myricetin-3-O-β-Dd-rhamnoside (1), kaempferol-3-O-β-d-rhamnoside (2), quercetin-3-O-β-d-glucoside (3), quercetin-3-O-β-d-rhamnoside (4), quercetin-3-O-β-d-galactoside (5), rutin (6) and quercetin (7). The structures of the compounds were established by spectroscopic analyses as well as by comparison with published data. Some of the compounds showed strong antioxidant activity which validates the traditional use of the plant. An attempted correlation between the computed HOMO-LUMO energies and the measured antioxidant activities was established. We have also estimated the cardiotoxicity of the compounds by calculating the predicted logarithm of the human Ether-`a-go-go Related Gene (loghERG) using the QikProp program. These purified flavonoids are new potential lead compounds for the development of antioxidant drugs.

Chepkirui C, Ochieng PJ, Sarkar B, Hussain A, Pal C, Yang LJ, Coghi P, Akala HM, Derese S, Ndakala A, Heydenreich M, Wong VKW, Erdélyi Máté, Yenesew A. "Antiplasmodial and antileishmanial flavonoids from Mundulea sericea." Fitoterapia. 2020;149:104796. AbstractFitoterapia

Abstract
Five known compounds (1–5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6–8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 μM against chloroquine-resistant W2, and 6.6 μM against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 μM, respectively. In a cytotoxicity assay, lupinifolin (3) showed significant activity on BEAS-2B (IC50 4.9 μM) and HePG2 (IC50 10.8 μM) human cell lines. All the other compounds showed low cytotoxicity (IC50 > 30 μM) against human lung adenocarcinoma cells (A549), human liver cancer cells (HepG2), lung/bronchus cells (epithelial virus transformed) (BEAS-2B) and immortal human hepatocytes (LO2)

Graphical abstract
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Chepkirui C, Ochieng PJ, Sarkar B, Hussain A, Pal C, Yang LJ, Coghi P, Akala HM, Derese S, Ndakala A, Heydenreich M, Wong VKW, Erdélyi Máté, Yenesew A. "Antiplasmodial and antileishmanial flavonoids from Mundulea sericea." Fitoterapia. 2020;149:104796. AbstractFitoterapia

Description
A new flavanonol, 3-hydroxyerythrisenegalone (1), and four known compounds (2–5) were isolated from the extract of Mundulea sericea leaves. Investigation of the roots of this plant afforded an additional three known compounds (6–8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 μM against chloroquine-resistant W2, and 6.6 μM against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 μM, respectively. In a cytotoxicity assay, erythrisenegalone (3) showed significant …

Andima M, Coghi P, Yang LJ, Wong VKW, Ngule CM, Heydenreich M, Ndakala AJ, Yenesew A, Derese S. "Antiproliferative Activity of Secondary Metabolites from Zanthoxylum zanthoxyloides Lam: In vitro and in silico Studies." Pharmacognosy Communications. 2020;10(1). AbstractPharmacognosy Communications

Description
Background: Plant derived compounds have provided proming leads in search for safer anticancer chemotherapies. Zanthoxylum zanthoxyloides is a common medicinal plant in Uganda whose bioactive composition has not been fully elucidated. The aim of this study was to evaluate the in vitro antiproliferative potential of compounds isolated from Zanthoxylum zanthoxyloides and their probable in silico anticancer mechanisms of action. Methods: Column chromatography was used to isolate compounds from MeOH: CH2Cl2 (1: 1) extract of the stem bark extract of Zanthoxylum zanthoxyloides. The structures of the isolated compounds were elucidated by NMR and MS analyses. MTT assay was used to measure cell viability. Using in silico docking, the interaction of the compounds with key target proteins in the p53 pathway was determined. Results: From the root bark of this plant five compounds were isolated, namely; dihydrochelerythrine (1), skimmianine (2), tridecan-2-one (3), sesamin (4) and hesperidin (5). Dihydrochelerythrine (1) inhibited proliferation of liver cancer (HCC) cells (IC50 21.2), breast cancer (BT549) cells,(IC50 21.2 μM). Similarly, sesamin (4) exhibited moderate inhibitory activity against BT549 cancer cells (IC50 47.6 μM). Hesperidin (5) showed low inhibitory activity against A549 and HEp2 (Larynx) cells but was significantly toxic to normal liver and lung cells.
In silico docking studies showed that all the compounds strongly bind to cyclin-dependent kinases (CDK2 and CDK6) and weakly bind to caspases 3 and 8 suggesting that they inhibit cancer cells by inducing cell cycle arrest and apoptosis. Conclusion: This study indicates …

Andima M, Coghi P, Yang LJ, Wong VKW, Ngule CM, Heydenreich M, Ndakala AJ, Yenesew A, Derese S. "Antiproliferative Activity of Secondary Metabolites from Zanthoxylum zanthoxyloides Lam: In vitro and in silico Studies." Pharmacognosy Communications. 2020;10(1). AbstractPharmacognosy Communications

Description
Background: Plant derived compounds have provided proming leads in search for safer anticancer chemotherapies. Zanthoxylum zanthoxyloides is a common medicinal plant in Uganda whose bioactive composition has not been fully elucidated. The aim of this study was to evaluate the in vitro antiproliferative potential of compounds isolated from Zanthoxylum zanthoxyloides and their probable in silico anticancer mechanisms of action. Methods: Column chromatography was used to isolate compounds from MeOH: CH2Cl2 (1: 1) extract of the stem bark extract of Zanthoxylum zanthoxyloides. The structures of the isolated compounds were elucidated by NMR and MS analyses. MTT assay was used to measure cell viability. Using in silico docking, the interaction of the compounds with key target proteins in the p53 pathway was determined. Results: From the root bark of this plant five compounds were isolated, namely; dihydrochelerythrine (1), skimmianine (2), tridecan-2-one (3), sesamin (4) and hesperidin (5). Dihydrochelerythrine (1) inhibited proliferation of liver cancer (HCC) cells (IC50 21.2), breast cancer (BT549) cells,(IC50 21.2 μM). Similarly, sesamin (4) exhibited moderate inhibitory activity against BT549 cancer cells (IC50 47.6 μM). Hesperidin (5) showed low inhibitory activity against A549 and HEp2 (Larynx) cells but was significantly toxic to normal liver and lung cells.
In silico docking studies showed that all the compounds strongly bind to cyclin-dependent kinases (CDK2 and CDK6) and weakly bind to caspases 3 and 8 suggesting that they inhibit cancer cells by inducing cell cycle arrest and apoptosis. Conclusion: This study indicates …

Simiyu MT, Nyongesa FW, Aduda BO, Birech Z, Mwebaze G. "Application of An Organic Plant-Derived Binder in the Fabrication of Diatomaceous Earth Waste-Based Membranes for Water Purification Systems." MRS Advances. 2020;5(26):1339-1348.
Ng’ang’a JW, Odero D, Buigutt KSA. "Application of Library Service Charter in Quality Service Delivery in University Libraries." Library Philosophy and Practice (e-journal). . 2020;4007(4007).Website
Cheserek JJ, Ngugi K, Muthomi JW, Omondi CO. "Assessment of Arabusta coffee hybrids [Coffea arabica L. X Tetraploid Robusta (Coffea canephora )] for green bean physical properties and cup quality." African Journal of Food Science. 2020;14(5):119-127.
Mugo JN, Karanja NN, Gachene CK, Klaus Dittert, Nyawade SO, Schulte-Geldermann E. "Assessment of soil fertility and potato crop nutrient status in central and eastern highlands of Kenya.". 2020.
James. N. Mugo, Nancy N. Karanja, Gachene CS, Klaus Dittert, Nyawade SO, Schulte-Geldermann E. "Assessment of soil fertility and potato crop nutrient status in Central and Eastern Highlands of Kenya." Nature research. 2020.
Makori AO, Nyongesa AW, Odongo HO, Masai RJ. "Assessment of stress on serum estradiol and cortisol levels in female subordinate naked mole rats following isolation from natal colony." Journal of Biosciences and Medicines. 2020;8:9-17.
MO F, M ET, NM A, OB A-B, RJ S, JL C, JI V, BO G, R A, A K, A V, CA F. "Association between early childhood caries and poverty in low and middle-income countries." BMC Oral health. 2020;2020; 20:8(2020; 20:8):2020; 20:8.
N A, NM A, MO F, Y K, JI V, OB A-B, SZ M, S A, H H, S B, DA M, A R, I K, M M, M R, V P, S C, Y C, E J, JL C, K N, A S, G G, A P, P P, D M, J K, MM A, A A, MA D, M N, I H, MM A, AP V, A I, AM K, ME T. "Behavior change due to COVID-19 among dental academics - The theory of planned behavior: stresses, worries, training, and pandemic severity." PLoS ONE. 2020;15(9): e0239961(15(9): e0239961):15(9): e0239961.
Ng'asike O'aoP, Hagmann T, Wasonga OV. "Brokerage in the borderlands: the political economy of livestock intermediaries in northern Kenya." Journal of Eastern African Studies. 2020.
Ndung’u CW, Ogutu M, Yabs J, Muranga NJ, Kinoti M. "Business Environment, Corporate Image, Competitive Strategies And Performance Of Large Manufacturing Firms In Kenya." African Journal of Business and Management (AJBUMA). 2020;6(1):215-233. Abstractbusiness_environment_corporate_image_competitive_strategies_and_performance_of_large_manufacturing_firms_in_kenya.pdf

Firms’ performance differs from firm to firm in the same industry with some firms achieving higher
levels of performance than others which can be connected to the type of competitive strategies a
firm adopts. The never-ending changes today calls for firms to continuously monitor their business
environment with a view to creating strategies that will make them different from their competitors
and improve their corporate image in the eyes of their customers. The study sought to determine
how business environment and corporate image affect the relationship between competitive
strategies and the performance of large manufacturing firms in Kenya. It was guided by positivist
philosophy and a cross-sectional descriptive survey. The target population was large
manufacturing firms in Kenya where a structured questionnaire was utilized to collect data.
Regression analysis was used to test the hypotheses. The study found that the joint influence of
competitive strategies, business environment and corporate image on performance of large
manufacturing firms in Kenya was statistically significant. Manufacturing firms should adopt
competitive strategies in response to business environment and craft strategies to enable them
position themselves better than competitor. The firms can indirectly improve performance by
maintaining a good corporate image also.

Rogito DO, Maitho T, Nderitu A. "Capacity Building in Participatory Monitoring and Evaluation on Sustainability of Food Security Irrigation Projects. Journal of Engineering, Project, and Production Management 2020, 10(2), 94-102.". 2020. Abstract

Project, and Production Management 2020, 10(2), 94-102
Abstract: health-related problems and even death among animals and human beings. Agriculture is the main food source; thus, many interventions are made such as that of irrigation by the local county and national government initiated through the National Irrigation Board (NIB). Despite the irrigation projects food insufficiency still persists, therefore their sustainability is questionable. One such approach to improving the sustainability of irrigation projects is participatory monitoring and evaluation which leads to ownership and then higher sustainability. In the study, the objective was to asses if taking corrective action after participatory monitoring and evaluation (PME) influence project sustainability. The study used a descriptive survey and correlation designs to collect data from 316 respondents selected using stratification sand purposeful with strict randomization. Questionnaires were administered and interviews were conducted on selected sample respondents on appointed dates. Data were analyzed using SPSS version 25.0 to get descriptive statistics, correlations coefficients were obtained to test association and degree of strength. Testing of the hypothesis was done using linear regression. The study findings were that a large number of respondents were between ages 31 to 40 years and most were female with their highest level of education being primary school. The influence of PME capacity building on the dependent variable and irrigation projects sustainability found that the farmers were not taken for exposure visits and project officers were not accountable for money use. Age, gender, and education level have very minimal influence on PME capacity building. PME capacity building had a weak positive influence of r = 0.290 and it explained only 8.4% of irrigation projects sustainability in Kitui County. The study recommends that to improve project capacity building: project revenue must be controlled on use, farmers must be taken for exposure visits to learn from successors, project officers should be accountable for funds use, and project guidelines should be improved to increase sustainability. Implementation of these recommendations will reduce the loss of Arid and Semi-Srid Lands (ASALs) and attain higher and longer sustainability in food projects, thus, reducing the recurrence rate of food shortage, improve and hasten the implementation of irrigation projects, show the need to involve primary stakeholders in project monitoring and appraisal for sustainability, better and efficient decisions by policymakers to increase chances of project's success. Keywords: Food security, Participatory monitoring and evaluation, irrigation, taking corrective action, capacity building, sustainability, funds management, projects

Njogu REN, Njenga LW, Kariuki DK, Amir O. Yusuf, Wendt OF. "Catalytic Properties of Luminescent Tris-Homoleptic Cyclometalated Iridium(III) Complexes in the Oxidation of Morin in Visible Light. ." Journal of Physical Sciences. 2020;5. AbstractJournal of Physical Sciences

The photo-oxidation of Morin, 2′,3,4′,5,7-pentahydroxyflavone by six luminescent homoleptic tris-cyclometalated iridium(III) complexes was investigated with the aim of evaluating the catalytic properties of the complexes. The Iridium complexes were synthesized using 2-(1-naphthyl)-pyridine (npy) ligand and its derivatives such as npy-OMe, npy-CF3 and npy-Me to form Tris-homoleptic cyclometalated complexes; Ir(npy)3, Ir(npy-OMe)3, Ir(npy-CF3)3, Ir(npy-Me)3, Ir(Me-npy-Me)3, and Ir(Me-npy)3 with substitution at para position relative to nitrogen. The ligand substitution positions were found to influence the excited state lifetimes, where the complexes exhibited long lifetimes, τ, 1.4 – 3.6 μs, ensuring time for substrates to react before relaxation to ground state. All the six complexes displayed reversible or pseudo reversible redox processes with ground state oxidation potential range of 0.57 to 0.93V compared to Standard Calomel Electrode in CH2Cl2. The complexes degraded morin with rate constants kobs between 0.023-0.036 s -1 within a timescale of 12 minutes. The Ir(npy-Me)3 complex was found to have a high degradation with a rate constant of kobs = 0.036 s -1. Degradation reactions using all the six Iridium (III) complexes photoredox catalysts were found to follow first order kinetics and ca. 10-fold faster compared to similar oxidative reaction

Achollah AM, Karanja DN, Ng’ang’a CJ, Bebora LC. "Causes of organ condemnations in cattle at slaughter and associated financial losses in Siaya County, Kenya." Journal of Veterinary Medicine and Animal Health . 2020;12(2):27-35.
Achollah AM, Karanja DN, Ng’ang’a CJ, Bebora LC. "Causes of organ condemnations in cattle at slaughter and associated financial losses in Siaya County, Kenya." Journal of Veterinary Medicine and Animal Health. 2020;12:27-35.
Rop K, Mbui D, Karuku GN, Michira I, Njomo N. "Characterization of water hyacinth cellulose-g-poly (ammonium acrylate-co-acrylic acid)/nano-hydroxyapatite polymer hydrogel composite for potential agricultural application." Results in Chemistry. 2020;2:100020. AbstractResults in Chemistry

Description
Polymer nano-composite was prepared by grafting partially neutralized acrylic acid onto swollen cellulose isolated from water hyacinth in the presence of nano-hydroxyapatite (nano-HA) using N,N-methylene-bis-acrylamide (MBA) as the cross-linker and ammonium persulphate (APS) as the free radical initiator. Water absorption tests showed an increase in swelling ratio of the copolymer with increased nano-HA content to value of 120 g/g at 2.5% w/v above which it declined. FTIR spectrum of nano-composite revealed grafting of the monomer (acrylic acid/ammonium acrylate) onto cellulose and nano-HA. Transmission electron microscopy (TEM) images of nano-HA synthesized in the presence of Triton X-100 (non-ionic surfactant) displayed rod-shaped agglomerates and nano-particle dispersion within the copolymer matrix. Energy dispersive X-ray (EDX) spectra revealed the constituents of nano-composite to be …

Rop K, Mbui D, Karuku GN, Michira I, Njomo N. "Characterization of water hyacinth cellulose-g-poly (ammonium acrylate-co-acrylic acid)/nano-hydroxyapatite polymer hydrogel composite for potential agricultural application." Results in Chemistry. 2020;2:100020. AbstractResults in Chemistry

Description
Polymer nano-composite was prepared by grafting partially neutralized acrylic acid onto swollen cellulose isolated from water hyacinth in the presence of nano-hydroxyapatite (nano-HA) using N,N-methylene-bis-acrylamide (MBA) as the cross-linker and ammonium persulphate (APS) as the free radical initiator. Water absorption tests showed an increase in swelling ratio of the copolymer with increased nano-HA content to value of 120 g/g at 2.5% w/v above which it declined. FTIR spectrum of nano-composite revealed grafting of the monomer (acrylic acid/ammonium acrylate) onto cellulose and nano-HA. Transmission electron microscopy (TEM) images of nano-HA synthesized in the presence of Triton X-100 (non-ionic surfactant) displayed rod-shaped agglomerates and nano-particle dispersion within the copolymer matrix. Energy dispersive X-ray (EDX) spectra revealed the constituents of nano-composite to be …

Rop K, Mbui D, Karuku GN, Michira I, Njomo N. "Characterization of water hyacinth cellulose-g-poly (ammonium acrylate-co-acrylic acid)/nano-hydroxyapatite polymer hydrogel composite for potential agricultural application." Results in Chemistry. 2020;2:100020. AbstractResults in Chemistry

Description
Polymer nano-composite was prepared by grafting partially neutralized acrylic acid onto swollen cellulose isolated from water hyacinth in the presence of nano-hydroxyapatite (nano-HA) using N,N-methylene-bis-acrylamide (MBA) as the cross-linker and ammonium persulphate (APS) as the free radical initiator. Water absorption tests showed an increase in swelling ratio of the copolymer with increased nano-HA content to value of 120 g/g at 2.5% w/v above which it declined. FTIR spectrum of nano-composite revealed grafting of the monomer (acrylic acid/ammonium acrylate) onto cellulose and nano-HA. Transmission electron microscopy (TEM) images of nano-HA synthesized in the presence of Triton X-100 (non-ionic surfactant) displayed rod-shaped agglomerates and nano-particle dispersion within the copolymer matrix. Energy dispersive X-ray (EDX) spectra revealed the constituents of nano-composite to be …

Rop K, Mbui D, Karuku GN, Michira I, Njomo N. "Characterization of water hyacinth cellulose-g-poly (ammonium acrylate-co-acrylic acid)/nano-hydroxyapatite polymer hydrogel composite for potential agricultural application." Results in Chemistry. 2020;2:100020. AbstractResults in Chemistry

Description
Polymer nano-composite was prepared by grafting partially neutralized acrylic acid onto swollen cellulose isolated from water hyacinth in the presence of nano-hydroxyapatite (nano-HA) using N,N-methylene-bis-acrylamide (MBA) as the cross-linker and ammonium persulphate (APS) as the free radical initiator. Water absorption tests showed an increase in swelling ratio of the copolymer with increased nano-HA content to value of 120 g/g at 2.5% w/v above which it declined. FTIR spectrum of nano-composite revealed grafting of the monomer (acrylic acid/ammonium acrylate) onto cellulose and nano-HA. Transmission electron microscopy (TEM) images of nano-HA synthesized in the presence of Triton X-100 (non-ionic surfactant) displayed rod-shaped agglomerates and nano-particle dispersion within the copolymer matrix. Energy dispersive X-ray (EDX) spectra revealed the constituents of nano-composite to be …

Chalo DM, Kakudidi E, Origa-Oryem H, Namukobe J, Franke K, Yenesew A, Wessjohann LA. "Chemical constituents of the roots of Ormocarpum sennoides subsp. zanzibaricum." Biochemical Systematics and Ecology. 2020;93:104142. AbstractBiochemical Systematics and Ecology

Description
Phytochemical investigation of the roots of O. sennoides subsp. zanzibaricum Brenan & J.B. Gillett resulted in the isolation of three biflavonoids (trime-chamaejasmin, (+)- chamaejasmin, (+)-liquiritigeninyl-(I-3,II-3)-naringenin), one bi-4-phenyldihydrocoumarin (diphysin), one isoflavan (glabridin), one triterpenoid (3-O-acetyloleanoic acid) and a phytosterol (β-sitosterol). Compounds were identified by detailed MS, 1D and 2D NMR spectroscopic analyses. Their absolute configurations were elucidated based on ECD spectra. The previously undescribed trime-chamaejasmin represents a bis-epi-chamaejasmenin C diastereomer. The chemophenetic significance is discussed in detail. The results contribute to the phytochemical characterization of the genus Ormocarpum and suggest a close chemophenetic relationship with other genera within the subfamily Papilionoideae. Furthermore, this report provides baseline …

Nyamweya NN, Kimani SN, Abuga KO. "Chewable Antacid Tablets: Are Disintegration Tests Relevant?" AAPS PharmSciTech . 2020;21:139. Abstract

A recently published FDA guidance on chewable tablets has addressed the quality attributes of this class of dosage forms. This study evaluated disintegration as a quality attribute for a number of commercially available chewable antacid tablets. Additionally, acid-neutralizing-capacity values were evaluated. A number of the products exhibited prolonged disintegration times—which were far longer than those of conventional immediate-release tablets. The mean disintegration times ranged from 6 to more than 60 min in distilled water and from 9 to over 60 min in 0.1 N HCl. The products with longer disintegration times had higher breaking force and tensile strength values. Despite the range in disintegration times, all products met the criteria for acid-neutralizing capacity. These results indicate a need for patients to be aware of the need to thoroughly chew antacid tablets upon administration. Given these considerations, disintegration testing would be a useful quality control test in evaluating these dosage forms as the implicit assumption by the manufacturer that patients will chew the product sufficiently may not be met in every case.

Owino JO, Olago D, Wandiga SO, Ndambi A. "A cluster analysis of variables essential for climate change adaptation of smallholder dairy farmers of Nandi County, Kenya." African Journal of Agricultural Research. 2020;16(7):1007-1014. AbstractA cluster analysis of variables essential for climate change adaptation of smallholder dairy farmers of Nandi County, Kenyadoi.org

Smallholder dairy farmers occupy high potential areas of Kenya and are a source of manure, crops and milk. There is need to use other means of characterising smallholder dairy farmers as they mostly practice mixed farming. The objective of this paper is to use cluster analysis method to characterize the smallholder dairy farmers with added farmer and activity data variables. Clusters of 336 farmers in this study were derived using 28 key variables. This paper demonstrates how to conduct farmer assessments for climate change adaptation activities, climate smart technologies implementation using knowledge of key farmer variables and their distribution in the smallholder dairy farmers of Nandi County, Kenya. This paper demonstrates the importance of integrating agricultural information for smallholder dairy farmers to machine models to characterize the groups and observe the natural groupings. This allows for policy managers to know the key characteristics and how to use them in policy implementation especially in designing climate change adaptation programs factoring education and training of farmers as demonstrated in this paper that they are practicing many activities on their farms.

Key words: Cluster analysis, smallholder dairy farmers, farm utilisation, climate change adaptation.

Owino JO, Olago D, Wandiga SO, Ndambi A. "Constraints limiting the improvement of manure management as climate smart technology for smallholder dairy farmers." African Journal of Agricultural Research. 2020;16(8):1155-1168. Abstractacademicjournals.org

The global quest for a sustainable bio-economy has brought to the fore importance of engaging agricultural systems in the production and in practice change. There have been issues limiting farmers from improving the practice of manure management as smart climate technology. The objective of this paper was to highlight the constraints, type, and valuation of manure types and information sources that smallholder dairy farmers find it useful to change Practices regarding manure management. In this present study, 336 smallholder dairy farmers were surveyed on various constraints the farmers faced and, on the type, and value of different manure types and information on manure management received by the farmers. The study used descriptive statistics for the variables and compared them using frequency tables. The key findings from this study would support information to stakeholders in inducing climate-smart manure management practices as a climate adaptation practice. The study highlights the type of information systems that determine areas for further investigation as drivers of practice change for smallholder dairy farmers. The paper focuses on these constraints and synthesizes them into factors that determine practice change on manure management by smallholder dairy farmers in order to improve manure management.

Key words: Manure management, agricultural information, smallholder dairy farmers, practice change,
information value.

Ntwiga DB, Wanyonyi AW. "Consumer Perceptions and Behaviour toward Credit Usage in Kenya." Open Access Library Journal. 2020;7(6):1-16. AbstractWebsite

Consumer behaviour and perceptions evolve over time and affect credit usage from the financial service providers. We use the 2016 FinAccess Household survey data of 2015 from 8665 households to examine how perceptions and behaviour of un(der) banked consumers can shape their dynamics towards credit usage. The perceptions and behaviour are based on source of financial advice, trust of the institutions, characteristics of the financial instrument and cost of credit. The multinomial logistic regression model predicts the odds of credit usage based on perceptions and behaviour of the consumers. The categories for the credit usage are: have credit, used to have credit and never had credit. Consumer perceptions and behaviour based on cost of credit and trust increase credit usage, while source of financial advice had minimal influence on credit usage. The characteristics of the financial instrument are catering to emergencies and being safe to use increased credit usage. The Savings and Credit Cooperative Organizations and microfinance are the most trusted financial institutions by the consumers, while shylock has the highest cost of credit. Radio as a source of financial advice reduced credit usage. The dynamics of credit usage are shaped by the perceptions and behaviour of the consumers.

Mundo L, Porro LD, Granai M, Siciliano MC, Mancini V, Santi R, Marcar L, Vrzalikova K, Vergoni F, Stefano GD, Schivoni G, Segreto G, Noel Onyango, Nyagol JA, Amato T, Bellan C, Anagnostopoulos I, Falini B, Leoncini L, Lazzi S. "Correction: Frequent traces of EBV infection in Hodgkin and non-Hodgkin lymphomas classified as EBV-negative by routine methods: expanding the landscape of EBV-related lymphomas." Modern Pathology. 2020:10.1038/s41379-020-0608-y.
M G, L M, AU A, MC S, H R, V M, N O, J N, OA A, I M, S M, W W, M B, PP P, L Q-M, F F, S L, Leoncini L, T M. "Correction: Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program. ." Infect Agent & Cancer . 2020;15(39):doi:10.1186/s13027-020-00304-9.
P M, N MJ, O AS, Mang'uriu GN. "A Corrosion Model for Prediction of Service Life of Reinforced Concrete Water Structures." International Journal of Scientific and Research Publications. 2020;Vol 10(2).
P M, O AS, N MJ, Mang'uriu GN. "A Corrosion Model for Prediction of the Service Life of Reinforced Concrete Water Conveyancing Structures." British Journal of Civil and Architecture Engineering. 2020;Vol 02(6):153-181.
Ntwiga DB. "Credit usage among the un (der) banked: consumer socio-economic characteristics and influence of financial technology." International Journal of Financial Services Management. 2020;10(1):38-54. AbstractWebsite

We use the 2016 FinAccess Household survey data of 2015 from 8665 households to analyse how the socio-economic characteristics and financial literacy of un(der) banked consumers can shape their dynamics towards credit usage. A qualitative analysis is presented on the influence of financial technology on consumer credit usage. The access to financial services is influenced by the socio-economic characteristics and financial literacy of the consumers. Gender, financial literacy, age, income, marital status, education level and geographical cluster are statistically significant in influencing credit usage, both current and past usage relative to never had credit. As financial technology continues to expand and offer credit, there is need to understand the user experience to match their social and economic status as a means to increase credit usage in Kenya.

Lutta AI, Wasonga OV, Robinson LW, Nyangito MM, Jason Sircely. "Determinants of livestock market participation among pastoral communities of Tana River County, Kenya." Environment, Development and Sustainability. 2020.
Ndungu JM, Moturi CA. "Determinants of Mobile Fintech Uptake in Kenyan Microfinance Sector." Current Journal of Applied Science and Technology. 2020;39(28):102-114. AbstractWebsite

The Kenyan microfinance sector faces many challenges such as high operation costs, increased credit risk, low visibility and poor understanding of emerging technology opportunities and risks among others. These problems are persistent due to low levels of innovation and limited uptake of digital financial technologies. This research aimed to identify the determinants that influence uptake of mobile fintech and propose an appropriate model for uptake of mobile fintech within the sector. A descriptive survey of all 30 Microfinance institutions registered with Association of Microfinance Institutions (AMFI) 2018 in Kenya was carried out. Data was collected using questionnaires from 120 respondents. Data was analyzed using descriptive and inferential statistics. Based on correlation model, this study established that technology factors (r=0.862, P<.05), environmental characteristics (r=0.387, P<.05) and organizational factors (r=0.256, P<.05) have a strong influence on the uptake of mobile fintech. Using regression model, technology factors (β=.563, P<.05), organizational factors (β=.281, P<.05) and environmental characteristics (β=.562, P<.05) all have positive and significant influence on uptake of mobile fintech. These factors include technology availability, perceived technology benefits, organization size, resources availability, and competition, regulatory and legal environment among others. Uptake of mobile fintech was found to reduce operation costs and improve business operations efficiency. Understanding of the factors derived in this study will help microfinance institutions, software developers and policy makers as they develop strategies directed at promoting successful implementation of mobile fintech.

Sala, M.S., Otieno JD, Nzuma, M.J., Mureithi, S.M. "Determinants of Pastoralists’ Participation in Commercial Fodder Markets for Livelihood Resilience in Drylands of Northern Kenya: Case of Isiolo." Pastoralism: Research, Policy and Practice . 2020;10(1):DOI: 10.1186/s13570-020-00166-1.
Murage JK, Amugune BK, Njogu P, Ndwigah SN. "Development and application of a spectrophotometric method in quality evaluation of benzimidazole anthelminthics in Nairobi City County." Future Journal of Pharmaceutical Sciences . 2020;6:74.
Murage JK, Amugune BK, Njogu PM, S.N.Ndwigah. "Development and application of aspectrophotometric method in qualityevaluation of benzimidazole anthelminthicsin Nairobi city county." Future Journal of Pharmaceutical Sciences . 2020;6:74.
OLALE P, Ngau P. "Dialogues on Informality: Land Sharing as a Sustainable approach to Tenure Security in Kiandutu Informal Settlement Thika, Kenya.". In: Reframing the Urban Challenge in Africa. New York: Routledge; 2020.
Langat MK, Ndunda B, Salter C, Odusina BO, Isyaka SM, Mas-Claret E, Onocha PA, Midiwo JO, Nuzillard J-M, Mulholland DA. "Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert." Phytochemistry Letters. 2020;39:1-7.
Langat MK, Ndunda BM, Salter C, Odusina BO, Isyaka SM, Mas-Claret E, Onocha PA, Midiwo JO, Nuzillard J-M, Mulholland DA. "Diterpenoids from the stem bark of Croton megalocarpoides Friis & MG Gilbert." Phytochemistry Letters. 2020;39:1-7. AbstractPhytochemistry Letters

Description
Five previously undescribed compounds, megalocarpoidolide I (1), megalocarpoidolide J (3), 12-epi-crotonzambefuran A (4), megalocarpoidolide K (5), 1-trans-p-hydroxycoumaroyl–geranylgerani-1-ol (6) were isolated from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. The known ent-trachyloban-18-ol, megalocarpoidolide B, megalocarpoidolide C (2), megalocarpoidolide H, crotocorylifuran, 7,8-dehydrocrotocorylifuran, 1,2-dehydrocrotocorylifuran-2-one, acetyl aleuritolic acid, lupeol, N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine, dodecyl trans-ferulate and lignoceryl trans-ferulate were also isolated. The structures of the compounds were determined using NMR, IR spectroscopy and HRMS. The structure of compound 1 was determined using Logic for Structural Determination (LSD). Compounds 1, 2 and 3 that were selected for screening based on their ability to add diversity to the …

Brizuela V, Bonet M, Romero CLT, Abalos E, Baguiya A, Fawole B, Knight M, Lumbiganon P, Minkauskienė M, Nabhan A, Osman NB, Qureshi ZP, Souza JP. "Early evaluation of the ‘STOP SEPSIS!’ WHO Global Maternal Sepsis Awareness Campaign implemented for healthcare providers in 46 low, middle and high-income countries." British Medical Journal . 2020;10(5). AbstractWebsite

Objective To evaluate changes in awareness of maternal sepsis among healthcare providers resulting from the WHO Global Maternal Sepsis Study (GLOSS) awareness campaign.

Design Independent sample precampaign/postcampaign through online and paper-based surveys available for over 30 days before campaign roll-out (pre) and after study data collection (post). Descriptive statistics were used for campaign recognition and exposure, and odds ratio (OR) and percentage change were calculated for differences in awareness, adjusting for confounders using multivariate logistic regression.

Setting and participants Healthcare providers from 398 participating facilities in 46 low, middle and high-income countries.

Intervention An awareness campaign to accompany GLOSS launched 3 weeks prior to data collection and lasting the entire study period (28 November 2017 to 15 January 2018) and beyond.

Main outcome measures Campaign recognition and exposure, and changes in awareness.

Results A total of 2188 surveys were analysed: 1155 at baseline and 1033 at postcampaign. Most survey respondents found the campaign materials helpful (94%), that they helped increase awareness (90%) and that they helped motivate to act differently (88%). There were significant changes with regard to: not having heard of maternal sepsis (−63.4% change, pre-OR/post-OR 0.35, 95% CI 0.18 to 0.68) and perception of confidence in making the right decisions with regard to maternal sepsis identification and management (7.3% change, pre-OR/post-OR 1.44, 95% CI 1.01 to 2.06).

Conclusions Awareness raising campaigns can contribute to an increase in having heard of maternal sepsis and an increase in provider perception of confidence in making correct decisions. Offering the information to make accurate and timely decisions while promoting environments that enable self-confidence and support could improve maternal sepsis identification and management.

Alphayo I. Lutta, Lance W. Robinson, Oliver V. Wasonga, Ruto E, Jason Sircely, Nyangito MM. "Economic valuation of grazing management practices: discrete choice modeling in pastoral systems of Kenya." Environmental Planning and Management. 2020;63(2).
O OD, N MJ, K KC. "The Effect of Cassava Starch on the Durability Characteristic of Concrete." The Open Civil Engineering Journal. 2020;Vol 14:289-301.
Njenga KG, Kariuki MI. "Effect of macroeconomic variables on financial performance of microfinance banks in Kenya." Scholarly Research Journal For Humanity Science & English Language. 2020;3(8).
P M, O AS, N MJ, Mang'uriu GN. "Effect of Selected Commercially Available Corrosion Inhibitors in Kenya on Bond Strength of Reinforced Concrete." British Journal of Civil and Architecture Engineering. 2020;Vol 02(1):133-152.
Nkunu Z, M GP, J.G. K. "Electrocatalytic reduction and characterization of Tetrachlorvinphos in acetonitrile-water (1:1) media in presence of cyanocobalamin." Africa Journal of Physical Sciences. 2020;4:xxxx. Abstractabstract.pdfAfrica Journal of Physical Sciences

Abstract

This work investigates a possible electrocatalytic degradation of tetrachlorvinphos pesticide in acetonitrile-water media using cyanocobalamin as the catalyst. The catalyst and its derivatives are employed in some organic synthesis due to their ability to form and selectively cleave Co-C bonds. There is inadequate data from previous related works. This study explores possible electrocatalytic route for degradation of tetrachlorvinphos using the catalyst at temperature of 24 ± 1° by cyclic voltammetry method. Tetrachlorvinphos exhibited two consecutive reduction peaks at ~-0.710 ± 0.004 V and ~ -1.096 ± 0.029 V Versus Ag/AgCl. The second reduction peak registered a diffusion coefficient value of 3.68 x 10-5 cm2s-1 and current density of be 5.83 x 10-5 A/cm2. The reduction potential for tetrachlorvinphos in presence of cyanocobalamin was observed to be -0.923 ± 0.03 V versus Ag/AgCl. The diffusion coefficient and current density value was reported at 3.37 x 10-5 cm2s-1 and 2.56 X 10-5 A/cm2 respectively for an electro-reduction process. This implies that, catalytic reduction of the pesticide occurred at a significantly lower potential compared to direct reduction. The over potential saving of about 0.168 V is an indication of the catalyst efficiency on the pesticide degradation.

Nkunu ZN, Guto PM, Kithure JG. "Electrocatalytic Reduction and Characterization of Tetrachlorvinphos in Acetonitrile-Water (1:1) Media in Presence of Cyanocobalamin." African Journal of Physical Sciences (AJPS). 2020;4:60-67.
Mwangi P, Muvengei O, MBUYA TO, Ndeto M. "Energy Optimisation of a Single Toggle Jaw Crusher using Discrete Element Method." Journal of Sustainable Research in Engineering. 2020;5(4):180-193. Abstracthttps://jsre.jkuat.ac.ke/index.php/jsre/article/view/98

Comminution process has always been associated with very low energy efficiencies. Most of the energy during
comminution is lost through noise, heat and vibrations. Therefore, it is necessary to obtain the optimal operating parameters of a comminution machine. In this research, the efficiency of a jaw crusher has been optimised using Genetic Algorithms (GA) and Discrete Element Method (DEM) techniques. DEM, even though a powerful tool, demands high computational capabilities hence a scaled down jaw crusher was used for simulation purposes. The GA codes were used in determining the critical velocity and also in developing the equation for up-scaling the jaw crusher. Critical parameters which affect the power consumption of a jaw crusher are toggle speed, throw and reduction ratio. These parameters were varied during the simulation as guided by the design of experiment technique. In addition, a Bonded Particle Model (BPM), was used in modelling the rock used in the simulation. A BPM model gives more realistic results than Particle Replacement Model (PRM) and Fast Breakage Model (FBM). To create the BPM of an irregularly shaped rock, custom API factory was coded in C++ and loaded to EDEM software. At the end of this research, the optimal energy efficiency was obtained as 59.7758% at a toggle speed of 157.7965 rpm, a throw of 33.445 mm and a reduction ratio of 4. A mathematical model showing the relationship between energy efficiency and process parameters was also developed.

Nyawade S, Gitari HI, Karanja NN, Gachene CKK, Schulte-Geldermann E, Sharma K, Parker ML. "Enhancing Climate Resilience of Rain-Fed Potato Through Legume Intercropping and Silicon Application.". 2020.
Bauza V, Madadi V, Ocharo R, Nguyen TH, Guest JS. "Enteric pathogens from water, hands, surface, soil, drainage ditch, and stream exposure points in a low-income neighborhood of Nairobi, Kenya." Science of The Total Environment. 2020;709:135344. AbstractScience of The Total Environment

Description
Child exposure to fecal-oral pathogens occurs through several transmission pathways. However, the relative importance of different exposure points for pathogen transmission both inside and outside households is not well understood. We conducted a cross-sectional study in the urban slum of Kibera in Nairobi, Kenya, collecting 237 environmental samples from 40 households from source water, stored drinking water, caregiver hands, child hands, household surfaces, soil, standing water, open drainage ditches, and streams. We quantified the fecal indicator Escherichia coli and the enteric pathogens of adenovirus, Campylobacter jejuni, Shigella spp./enteroinvasive E. coli (EIEC), and Vibrio cholerae. At least one enteric pathogens was detected in 13% of household stored water, 47% of hand, 46% of table surface, 26% of plate surface, 75% of floor surface, 96% of soil, 56% of standing water, 77% of drainage ditch …

Bauza V, Madadi V, Ocharo R, Nguyen TH, Guest JS. "Enteric pathogens from water, hands, surface, soil, drainage ditch, and stream exposure points in a low-income neighborhood of Nairobi, Kenya." Science of The Total Environment. 2020;709(March 2020):135344.
O OT, O. KD, N. MJ. "Evaluating Superplasticizer Compatibility in the Production of High Performance Concrete using Portland Pozzolana Cement CEM II/B-P." SSRG International Journal of Civil Engineering. 2020;Vol. 7(6):92-100.
Nyakundi JO, Ombui JN, Wanyonyi WC. "Evaluation of Bacillus cereus Strain 1-p Protease for the Unhairing of Goatskins during Leather Production." Textile & Leather Review., https://doi.org/10.31881/TLR.2020.18 ,. 2020:1-17.
N. MJ. "Evaluation of Stiffnesss of Concrete Beams Reinforced with Dry and Green Bamboo." International Journal of Scientific and Research Publications. 2020;Vol 10(4):676-687.
Magutu PO, Inyega JO, Nyaanga RO. Evidence-based training assessment approaches and methodologies in procurement planning and supply chain managemen. Knowledge Empowerment Foundation. ISBN: 978-81-942015-4-0; 2020.
N MJ, N OV. "Experimental Study on Behavoir of Lightweight Concrete with Partial Replacement of Coarse Aggregates with Expanded Polystyrene." The Open Journal of Scientific and Research Publication. 2020;Vol 10(2):351-362.
Kabue KG, Njogu PM, Mwangi AN. "Exploring different approaches to improve the success of drug discovery and development projects." Futur. J. Pharm. Sci. 2020;6:27.
Muthini D, Nzuma J, Nyikal R. "Farm production diversity and its association with dietary diversity in Kenya." Food Security. 2020;https://doi.org/10.1007/s12571-020-01030-1.
Muthini D, Nzuma J, Nyikal R. "Farm production diversity and its association with dietary diversity in Kenya." Food Security volume . 2020;12:1107-1120 . AbstractWebsite

Agriculture has the potential to improve dietary diversity through farm production diversity if farming households consume what they produce. However, the linkages between a household’s own agricultural production and dietary diversity are not well understood. This study uses a count of crop species, animal species, production diversity score, and the Simpson’s index as measures of farm production diversity to assess the effect of production diversity on the dietary diversity of households, women and children. A Poison model was employed on a sample of 779 farming households selected using a multistage sampling technique in a household survey representative at the County level in Kisii and Nyamira Counties, Kenya. The findings of the study indicate that farm production diversity is significantly associated with the dietary diversity of women and that of the entire household, but is not associated with the dietary diversity of children. The count of the animal species has the highest magnitude of association with dietery diversity in this study. Every additional animal species kept leads to a 0.33 and 0.13 increase in household dietery diversity and the dietery diversity of women respectively. Children’s dietary diversity is significantly associated with the education of the mother, household size and age of the child. The study highlights the need to consider individual dietary requirements when developing nutrition interventions and policy, as opposed to general dietary interventions targeting the entire household.

Kasule F, Wasswa P, Mukasa SB, Okiror A, Nghituwamhata SN, Rono EC, Mukuze C, Mwang’ombe AW. "Farmer Preference of Cassava Cultivars in Eastern Uganda: A Choice Beyond Disease Resistance." Agricultural Science. 2020;2(2):169-177.
Ndegwa R, Simiyu J, E Ayieta, Odero N. "A Fast and Accurate Analytical Method for Parameter Determination of a Photovoltaic System Based on Manufacturer’s Data." Journal of Renewable Energy. 2020;(2020):1-18.
Chitedze I, Nwedeh CC, Ang’u C. "Financial Modelling of Feed-In Tariff for Increasing Solar Photovoltaic Energy Portfolio in Malawi." Journal of Energy and Natural Resources. 2020;9(1):14-27.
Waruiru RM, Mbuthia PG, Bebora LC, Nyaga PN, Wanja DW, Mwadime JM, Ngowi HA. "Fish husbandry practices and water quality in central Kenya: potential risk factors for fish mortality and infectious Diseases." Hindawi Veterinary Medicine International . 2020;2020.
Wanja DW, Mbuthia PG, Waruiru RM, Mwandime JM, Bebora LC, Nyaga PN, Ngowi, H. "Fish husbandry practices and water quality in central Kenya: Potential risk factors for fish mortality and infectious diseases." Veterinary Medicine International. 2020;2020.
Bebora LC, Mbuthia PG, Nyaga PN, Waruiru RM, Wanja DW, H.A N. "Fish Husbandry Practices and Water Quality in Central Kenya: Potential Risk Factors for Fish Mortality and Infectious Diseases." Hindawi Veterinary Medicine International . 2020;2020.abstract.pdf
Buyinza D, Chalo DM, Derese S, Ndakala A, Yenesew A. "Flavonoids and Isoflavonoids of Millettia dura and Millettia ferruginea: Phytochemical review and chemotaxonomic values." Biochemical Systematics and Ecology. 2020;91:104053. AbstractBiochemical Systematics and Ecology

Description
The phytochemical information on Millettia dura Dunn, M. ferruginea (Hochst.) Baker and M. ferruginea subsp. darassana (Cufod.) J.B. Gillett was reviewed. All the three taxa elaborate mainly isoflavones (33 reported), occurring in the flowers, seeds/seed pods, stem bark and root bark. Out of the 33 isoflavones reported, some 19 (ca. 58%) contain prenyl at C-8 or its modification as 2,2-dimethylchromene ring at C-7/C-8, occurring in all the three taxa. Except for three isoflavones isolated from M. ferruginea subsp. darassana, all the isoflavones of these taxa are 5-deoxygenated. In these taxa, oxygenation at C-6 is a common feature, while isoflavones with C-8 oxygenation are rare, only three reported, and all of these from M. dura. There are 7 rotenoids reported from these taxa, and occur almost entirely in the seeds/seedpods of these plants. The major rotenoid with methylenedioxy group at C-2/C-3, millettone and its …

Buyinza D, Chalo DM, Derese S, Ndakala A, Yenesew A. "Flavonoids and Isoflavonoids of Millettia dura and Millettia ferruginea: Phytochemical review and chemotaxonomic values." Biochemical Systematics and Ecology. 2020;91:104053. AbstractBiochemical Systematics and Ecology

Description
The phytochemical information on Millettia dura Dunn, M. ferruginea (Hochst.) Baker and M. ferruginea subsp. darassana (Cufod.) J.B. Gillett was reviewed. All the three taxa elaborate mainly isoflavones (33 reported), occurring in the flowers, seeds/seed pods, stem bark and root bark. Out of the 33 isoflavones reported, some 19 (ca. 58%) contain prenyl at C-8 or its modification as 2,2-dimethylchromene ring at C-7/C-8, occurring in all the three taxa. Except for three isoflavones isolated from M. ferruginea subsp. darassana, all the isoflavones of these taxa are 5-deoxygenated. In these taxa, oxygenation at C-6 is a common feature, while isoflavones with C-8 oxygenation are rare, only three reported, and all of these from M. dura. There are 7 rotenoids reported from these taxa, and occur almost entirely in the seeds/seedpods of these plants. The major rotenoid with methylenedioxy group at C-2/C-3, millettone and its …

Mwangi M, Tirop L, Njogu P, Bururia J, Mwaura N, Mbae E. "Formulation of dispersible isoniazid/pyridoxine fixed-dose combination tablets for isoniazid-preventive therapy in paediatrics." Cogent Med. 2020;7(1):1787684.
Mundo L, Porro LD, Granai M, Siciliano MC, Mancini V, Santi R, Marcar L, Vrzalikova K, Vergoni F, Stefano GD, Schivoni G, Segreto G, Noel Onyango, Nyagol JA, Amato T, Bellan C, Anagnostopoulos I, Falini B, Leoncini L, Lazzi S. "Frequent traces of EBV infection in Hodgkin and non-Hodgkin lymphomas classified as EBV-negative by routine methods: expanding the landscape of EBV-related lymphomas." Modern Pathology . 2020.
Masila VM, Ndakala AJ, Midiwo JO, Byamukama R, Kamau RW, Kumarihamy M, Muhammad I. "Full View Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties." Natural Product Research. 2020:1-8. AbstractNatural Product Research

Abstract
Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzyloxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2), 2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (4), cis-3-hydroxypiperitone (6) and carvacrol (7). Structure of 2 was determined based on NMR and HRMS spectral data. Compound 4 exhibited activity against fungi Cryptococcus neoformans with an IC50 value of < 0.8 µg/mL. In addition, this compound 4 had an IC50 value of 14.97 µg/mL against methicillin resistant Staphylococcus aureus bacteria. Previous to the current study, both compound 6 and 7 had been reported to have anti-microbial and anti-fungal activities.

Graphical abstract
Keywords: MonoterpenesCarvacrolCis-3-hydroxypiperitoneAnti-MRSAAnti-cryptococcal

Kamunyu R, Ndungo C. "Gender Preference of Counsellors among University Students Seeking Counselling Services." IOSR Journal Of Humanities And Social Science (IOSR-JHSS). 2020;25(2):20-28.
Nyang'au EM, Bulimo WD, Mobegi V, Opanda S, Magiri E. "Genetic Analysis of HA1 Domain of Influenza A/H3N2 Viruses Isolated in Kenya During the 2007 to 2013 Seasons Reveal Significant Divergence from WHO-Recommended Vaccine Strains." Int J Infect Dis. 2020. Abstractnyagau_et_al_2020.pdf

BACKGROUND: Influenza viruses evolve rapidly and cause regular seasonal epidemics in humans challenging effective vaccination. The virus surface HA glycoprotein is the primary target for the host immune response. Here, we investigated the vaccine efficacy and evolution patterns of human influenza A/H3N2 viruses that circulated in Kenyan in the period before and after the 2009 A/H1N1 pandemic, targeting the HA1 domain. MATERIALS AND METHODS: A hundred and fifteen HA sequences of Kenyan virus viruses were analyzed relative to the corresponding WHO vaccine reference strains using bioinformatics approaches. RESULTS: Our analyses revealed varied amino acid substitutions at all the five antigenic sites (A-E) of the HA1 domain, with a majority the changes occurring at sites A and B. The Kenyan A/H3N2 viruses isolated during 2007/2008 seasons belonged to A/Brisbane/10/2007- like viruses lineage, while those circulating in 2009 to 2012 belonged to the lineage of A/Victoria/361/2011-like viruses. The 2013 viruses clustered in clade 3C.3 of the A/Samara/73/2013-like viruses. The mean evolutionary rate of the A/H3N2 viruses analyzed in the study was at 4.17×10(-3) (95% HPD=3.09×10(-3) to 5.31×10(-3)) nucleotide substitutions per site per year, whereas the TMRCA was estimated at 11.18 (95% HPD=9.00-14.12) years ago from 2013. The Prediction of vaccine efficacy revealed modest vaccine efficaciousness during 2008, and 2010 influenza seasons, whilst sub-optimal effectiveness was registered in 2007,2009, 2012 and 2013. Further, the overall selective pressure acting on the HA1 domain was estimated at 0.56 (ω<1), suggesting that a majority of codon sites in the HA1 epitopes were evolving under purifying selection. CONCLUSIONS: Generally, our results highlight the genetic plasticity of A/H3N2 viruses and reveal considerable disparity in vaccine efficaciousness against the A/H3N2 viruses that circulated in Kenya, specifically during 2007,2009, 2012, and 2013 influenza seasons. Our findings underscore the importance and need for consistent surveillance and molecular characterization of influenza viruses, to inform decision making and enhance early of detection of strains with epidemic/pandemic potential as well as benefit in guiding decisions regarding the appropriate annual influenza vaccine formulations.

Cheserek JJ, Ngugi K, Muthomi JW, Omondi CO. "Genetic variability, heritability and correlation of quantitative traits for Arabusta coffee (C. arabica L. X Tetraploid C. canephora Pierre)." Journal of Plant Breeding and Crop Science. 2020;12(1):50-57.
Elsayed HM, Wadee S, Zaki MS, Were AJO, Ashuntantang GE, Bamgboye EL, Davids MR, Hafez MH, Mahamat M, Naicker S, Niang A, Seck SM, Swanepoel CR, Tannor EK, Twahir A, Yao HK. "Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa." African Journal of Nephrology. 2020;98(5):S117-S134.Website
Waruiru RM, Mbuthia PG, Bebora LC, Nguhiu JM, Wamboi P. "Haemato- biochemical changes and prevalence of parasitic infections of indigenous chicken sold in markets of Kiambu County, Kenya." International Journal of Veterinary Science and Medicine. 2020;8(1):18-25.
Wamboi P, Waruiru RM, Mbuthia PG, Nguhiu-Mwangi J, Bebora LC. "Haemato-biochemical changes and prevalence of parasitic infections of indigenous chicken sold in markets of Kiambu County, Kenya, ." International Journal of Veterinary Science and Medicine. 2020;8(1):18-25.
Wamboi P, Waruiru RM, Mbuthia PG, Nguhiu JM, Bebora LC. "Haemato-biochemical changes and prevalence of parasitic infections of indigenous chicken sold in markets of Kiambu County, Kenya." International Journal of Veterinary Science and Medicine. 2020;8(1):18-25.abstract1.pdf
Susan Gachau, Matteo Quartagno, NJAGI EDMUNDNJERU, Nelson Owuor, English M, Ayieko P. "Handling missing data in modelling quality of clinician-prescribed routine care: sensitivity analysis of departure from missing at random assumption." Statistical methods in medical research. 2020;29(10):3076-3092. AbstractWebsite

Missing information is a major drawback in analyzing data collected in many routine health care settings. Multiple imputation assuming a missing at random mechanism is a popular method to handle missing data. The missing at random assumption cannot be confirmed from the observed data alone, hence the need for sensitivity analysis to assess robustness of inference. However, sensitivity analysis is rarely conducted and reported in practice. We analyzed routine paediatric data collected during a cluster randomized trial conducted in Kenyan hospitals. We imputed missing patient and clinician-level variables assuming the missing at random mechanism. We also imputed missing clinician-level variables assuming a missing not at random mechanism. We incorporated opinions from 15 clinical experts in the form of prior distributions and shift parameters in the delta adjustment method. An interaction between trial intervention arm and follow-up time, hospital, clinician and patient-level factors were included in a proportional odds random-effects analysis model. We performed these analyses using R functions derived from the jomo package. Parameter estimates from multiple imputation under the missing at random mechanism were similar to multiple imputation estimates assuming the missing not at random mechanism. Our inferences were insensitive to departures from the missing at random assumption using either the prior distributions or shift parameters sensitivity analysis approach

M G, L M, AU A, MC S, H R, V M, N O, J N, OA A, I M, S M, W W, M B, PP P, L Q-M, F F, S L, Leoncini L, T M. "Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program. ." Infectious Agents & Cancer . 2020;15(28).
Nyang'au P, Muriithi B, Nzuma J, Irungu P, Gichungi H, Diiro G. "Impact of Integrated Fruit Fly Management Strategy on Food Security among Smallholder Mango Farmers in Kenya." African Journal of Food, Agriculture, Nutrition and Development. 2020;20(2):15431-15454.
Njeru N, Charles Midega, Muthomi J, Wagacha J, Zeyaur Khan. "Impact of push–pull cropping system on pest management and occurrence of ear rots and mycotoxin contamination of maize in western Kenya." Plant Pathology . 2020;69(9):1644-1654.
Nyamai DK;, Imonje R;, Mugambi M. "The implicit curriculum and teenagers’ emotional and spiritual stability amid COVID-19." ?. European Journal of Education Studies. 2020;7(11):384-497.
Njeru NK, Midega CAO, Muthomi JW, WAGACHA JOHNMAINA, Khan ZR. "In vitro antifungal activity of Desmodium intortum and D. uncinatum root extracts against growth of toxigenic Fusarium verticillioides and Aspergillus flavus." Australian Journal of Crop Science . 2020;14(12):1942-1948.
BO O, EN K, N MB. "Infection Control Practices Among Private Practicing Dentists in Nairobi During the Pre-coronavirus Disease 2019 Period." Front. Oral. Health. 2020;(doi: 10.3389/froh.2020.587603 ).
Nyakundi, Kalai, J.M., Nyagah, G., Munayi SP. "Influence of Head Teachers’ Support Strategies for Slow Learners on Children’s learning Outcomes at the Early Childhood Centres in Nairobi City County, Kenya." Journal of Research and Innovation in Social Science (IJRISS). 2020;4(6):697-703.
Karingithi M.G., Aosa E., K. O, Njihia J. M., and Mose J. M. "Influence of Strategy Typology on the Performance of Freight Forwarding Companies in Kenya." BA Africa Management Review. 2020;10(1):28-36.
McCormick D, Manga E, Upadhyaya R, Kamau P, Wamalwa H, Ngigi S. "Informality and development in Africa.". In: Research Handbook on Development and the Informal Economy. London: Edward Elgar Publishing; 2020.
Ndiritu, M. M, Gatotoh A. "Information and Communication Technology skills for Effective Competence Based Curriculum Implementation in Kenya. Advances in Social Sciences Research Journal, 7(6), 712-721. https://doi.org/10.14738/assrj.76.8544.". 2020. Abstract

The vision of education service delivery in Kenya is to have an internationally competitive quality education, training and research for sustainable development. More developed countries are associated with their great investment in human capital. They are also associated with development of ICT which has led to improved standards of living and good governance. This study was carried out on 395 pre-school teachers who were undertaking their in-service training in Kiambu County. The study sort to establish ICT whether the teachers engaged in ECD centers had any skills in ICT. This study further sort to establish whether there was integration of ICT in teaching and learning in selected preschools in Kenya. A researcher designed questionnaire was used in the study. A total of 60.83 % of the total population had no knowledge of ICT and therefore did not integrate ICT in their teaching and learning in the selected preschools. All the teachers expressed that the government had not sponsored them for ICT training and the little they had they had sponsored themselves. Grounded on these findings the study recommended that the government should be on the forefront to not only invest in ICT infrastructure but also in education of teachers in ICT. With the paradigm shift in the Kenya’s education curriculum this concern should be immediate. The government should take up the responsibility of ensuring that all teachers are exposed to ICT skills since these will change their interaction with the students who are quite ahead of their teachers in technology.

Nchiozem-Ngnitedem V-A, Omosa LK, Bedane KG, Derese S, Spiteller M. "Inhibition of ProInflammatory Cytokine Release by Flavones and Flavanones from the Leaves of Dracaena steudneri Engl." Planta Medica. 2020:DOI: 10.1055/a-1306-1368.alexe_et_al_2020_planta_medica.pdf
K SG, Abuodha SO, N MJ. "Investigating The Potential Use of Tuff Aggregates to Produce Lightweight Concrete." International Journal of Scientific and Research Publications. 2020;Vol 10(9):458-478.
Owor RO, Derese S, Bedane KG, Zühlke S, Ndakala A, Spiteller M. "Isoflavones from the seedpods of Tephrosia vogelii and pyrazoisopongaflavone with anti-inflammatory effects." Fitoterapia. 2020;146:104695. AbstractFitoterapia

Description
Phytochemical investigation of Tephrosia vogelii seedpods led to the isolation of twelve compounds: vogelisoflavone A (1), vogelisoflavone B (2), isopongaflavone (3), onogenin, luteolin, 4′,7-dihydroxy-3′-methoxyflavanone, trans-p-hydroxycinnamic acid, tephrosin, 2-methoxygliricidol, dehydrorotenone, 6a,12a-dehydro-α-toxicarol and pinoresinol. Compounds 1 and 2 are reported as new natural products. Isopongaflavone (3) was structurally modified using hydrazine to pyrazoisopongaflavone (4). These compounds were characterized based on their NMR and HRESIMS data. Further, four compounds (1–4) were evaluated for their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the compounds at a concentration of 100 μM suppressed the secretion of interleukin IL-1β interferon-gamma (IFN-γ …

Owor RO, Derese S, Bedane KG, Zühlke S, Ndakala A, Spiteller M. "Isoflavones from the seedpods of Tephrosia vogelii and pyrazoisopongaflavone with anti-inflammatory effects." Fitoterapia. 2020;146:104695.
Okeyo MP, Rambo CM, NYONJE RO. "Judicial Evaluation Model and Resolution of Contractual Disputes in Construction Projects: the Case of Road Construction Projects in Kenya." Strategic Journal of Business and Change Management. 2020:527-540.
N A, Aly NM, Folayan MO, Mohebbi SZ, P H-H, S B, Y K, DA M, A R, I K, M M, AA S, OB A-B, M R, V P, S C, G G, A P, D M, A A, MA D, M N, P P, J K, Y C, JL C, E J, MM A, MM A, I H, AP V, A I, AM K, ME T. "Knowledge of Dental Academics About the COVID-19 Pandemic: A Multi-Country – Online Survey." BMC Medical Education. 2020;2020; 20:399.(2020; 20:399.):2020; 20:399.
N MJ. "Mechanical Properties, Column Buckling Behavior, and Concrete Beam and Slab Reinforcement Behavior of Bamboo." International Journal of Scientific and Research Publications. 2020;Vol 10(3):836-848.
Weboko FI, Nyongesa BS, Makhanu MN, Santos MS, Luna KDG, Dey GES, Viloria IL. "Mineral Trioxide Aggregate Pulpotomy for Apexogenesis of an Immature Permanent Molar. A Case Report." Endodontic Society of the Philippines journal . 2020;32(1):16-21.
Nyambura M, Anne N. "Mobilization of Domestic Savings in Formal Financial Institutions: The Missing Link to Economic Growth. International Journal of Business and Social Science, Vol. 11 • No. 3 • March 2020.". 2020. Abstract

The purpose of the study was to examine factors that affect a Kenyan household’s decision to save in formal financial
institutions. This is because domestic saving finances investment and therefore economic growth. A non-experimental
research design was utilized using secondary data collected from a national-wide household survey in Kenya in 2009.
Cluster stratified probability sampling was used in selecting regions and households that were included in the survey.
A total of 6,598 households were used in the survey, using a questionnaire to gather information on financial access.
Descriptive and inferential statistics were used for data analysis. The results indicated the factors that influence
household’s decision to save in formal financial institutions were availability of loans, level of financial information,
location of household, sector of employment, expectations about future economic conditions, level of income, number
of banks in district of residence, transaction cost and time to nearest bank branch.
Keywords: household savings, formal financial institutions, economic growth,

Joab Odhiambo, Weke P, Ngare P. "Modeling Kenyan economic impact of corona virus in Kenya using discrete-time Markov chains." Journal of Finance and Economics. 2020;8(2):, 80-85. AbstractWebsite

Since the outbreak of pandemic COVID-19 (Corona virus), many countries have continued to suffer
economically leading to massive losses in terms of trillions of dollars globally in terms of trade loses. In reaction to
this effect, many countries in the world have taken emergency measures to ensure that the impact does not lead to
huge economic and financial implications in terms of rapid recession. In Africa, where many countries have taken
measures to deal with global recession to the citizens especially through fiscal and monetary policies, which includes
Kenya. In addition, the social economic statues have continued to change instantaneously and stochastically
more so after huge number of populations losing their daily informal jobs with new measures to stop the spread of
COVID-19 virus. This paper seeks to model the effect of COVID-19 pandemic on Kenyan Gross Domestic Product
(GDP) contributors using a Discrete-time Markov Chain Analysis. In addition, the paper seeks to find the ultimate
effect of the Covid-19 to the top five key sectors of the Kenyan economy that contributes massively to GDP growth
by looking at the proportion of the contributors at steady state. Moreover, the results from this paper should help the
government of Kenya as well as global investors to understand different economic stimulus planning packages to
launch in the “hard-hit” sectors of the economy to reduce the impact of the potential economic recession. Ultimately,
the information should be help in formulating a post COVID-19 economic recovery plan for the Kenyan economy
but also act as a benchmark strategy for many other countries in Africa that has economic and financial dynamics
similar to that of Kenya

Joab O Odhiambo, Ngare P, Weke P, Otieno RO. "Modelling of covid-19 transmission in kenya using compound poisson regression model." Journal of Advances in Mathematics and Computer Science. 2020; 35(2):101-111. AbstractWebsite

Since the inception of the novel Corona Virus Disease-19 in December in China, the spread has been massive leading World Health Organization to declare it a world pandemic. While epicenter of COVID-19 was Wuhan city in China mainland, Italy has been affected most due to the high number of recorded deaths as at 21st April, 2020 at the same time USA recording the highest number of virus reported cases. In addition, the spread has been experienced in many developing African countries including Kenya. The Kenyan government need to make necessary plans for those who have tested positive through self-quarantine beds at Mbagathi Hospital as a way of containing the spread of the virus. In addition, lack of a proper mathematical model that can be used to model and predict the spread of COVID-19 for adequate response security has been one of the main concerns for the government. Many mathematical models have been proposed for proper modeling and forecasting, but this paper will focus on using a generalized linear regression that can detect linear relationship between the risk factors. The paper intents to model and forecast the confirmed COVID-19 cases in Kenya as a Compound Poisson regression process where the parameter follows a generalized linear regression that is influenced by the number of daily contact persons and daily flights with the already confirmed cases of the virus. Ultimately, this paper would assist the government in proper resource allocation to deal with pandemic in terms of available of bed capacities, public awareness campaigns and virus testing kits not only in the virus hotbed within Nairobi capital city but also in the other 47 Kenyan counties.

Peter SG, Gabriel A, Hellen WK, Esther K, Daniel WG, Ndichu M, Charles MM, Alfred OM. "Molecular prevalence of emerging Anaplasma and Ehrlichia pathogens in apparently healthy dairy cattle in peri- urban Nairobi, Kenya." BMC Veterinary Research. 2020;16(1).
Makanya A, Mills-Thompson AN, Nguhiu-Mwangi J, Oduma J, Ojoo R. "Morphometric and stereological methods for quantifying the coarse structural parameters of the ruminal tissues in sheep." International Journal of Veterinary Science and Medicine. 2020;8(1):59-70.
Makanya A, Mills-Thompson AN, Nguhiu-Mwangi J, Oduma J, Ojoo R. "Morphometric and stereological methods for quantifying the coarse structural parameters of the ruminal tissues in sheep." International Journal of Veterinary Science and Medicine. 2020;8(1):59-70.
Makanya A, Mills-Thompson AN, Nguhiu-Mwangi J, Oduma J, Ojoo R. "Morphometric and stereological methods for quantifying the coarse structural parameters of the ruminal tissues in sheep." International Journal of Veterinary Science and Medicine. 2020;8(1):59-70.
Cynthia Ikamari, Ngare P, Weke P. "Multi-asset option pricing using an information-based model." Scientific African. 2020;10:00564. AbstractWebsite

Diversification of assets by an investor offers reduced exposure to risk compared to investing in a single asset. A multi-asset option gives an investor this advantage as its payout depends on the overall performance of several underlying assets. This study uses an information-based model to derive an approximate price for European call multi-asset options. The single asset price is derived using the risk-neutral pricing approach, and the multi-asset case uses the notion of comonotonicity. A numerical illustration is looked at to validate the theoretical results and to show the accuracy of the information-based model. The results show that prices from the information-based model provide a close fit to the empirical prices using a suitable information flow rate parameter. Hence, by making use of the information available in the market, an investor can price multi-asset European call options.

Nambati EA, Njoka M, Eyase F, Majanja J, Njuguna N, Gitonga SM, Mwikwabe N, Lelo E, Mwangi M, kingoro A, Kimani F, Lubano K, Bulimo W. "Multidisciplinary approach towards training of the next generation of forensic DNA analysts in Africa; a Kenyan perspective." Forensic Science International: Synergy. 2020;2:123-125. Abstract1-s2.0-s2589871x20300267-main.pdfWebsite

The uptake of forensic DNA testing technologies in Africa has been slow despite the revolutionary technology being discovered and adopted 3 decades ago. African governments and partners have invested in construction and equipping of forensic laboratories in Africa but the benefits are yet to be realised as the laboratories are still faced with the challenge of shortage of adequately trained personnel. This paper describes an innovative multidisciplinary training approach that was developed and used to train officers from the Directorate of Criminal Investigations Kenya. We report on the structure, implementation and effectiveness of the training. It is expected that with the increased number of trained forensic DNA analysts, there will be an improvement in quality of forensic DNA evidence presented in courts and a reduction in backlog in the forensic biology laboratories in Kenya.

Nanji, "Gichuhi", Nyenze, Kherani, damji, Kiage. "The muranga teleophthalmology study: A comparison of virtual (teleretina) assessment with in-person clinical examination to diagnose diabetic retinopathy and age-related macular degeneration in kenya." MEAJO. 2020;27(2):91-99. AbstractWebsite

PURPOSE: This study compares a web-based teleophthalmology assessment with a clinical slit lamp examination to screen for diabetic retinopathy (DR) and age-related macular degeneration (AMD) among diabetic patients in a rural East African district.
METHODS: Six hundred and twelve eyes from 306 diabetic patients underwent both a clinical slit lamp examination and a teleretina (TR) assessment by an experienced ophthalmologist. Both assessments were compared for any DR and AMD using the early treatment diabetic retinopathy study and age-related eye disease study grading scales, respectively.
RESULTS: Of the 612 TR assessment photos, 74 (12%) were deemed ungradable due to media opacities, poor patient cooperation, or unsatisfactory photographs. The ability to detect DR and AMD showed a fair agreement (kappa statistic 0.27 and 0.23, respectively) between the TR and clinical slit lamp examination. Relative to a clinical slit lamp evaluation, a positive TR diagnosis carried a 75.0% positive predictive value when diagnosing DR and a 27.3% positive predictive value when diagnosing AMD. A negative TR diagnosis carried a 97.2% negative predictive value for the diagnosis of DR and a 98.1% negative predictive value for the diagnosis of AMD.
CONCLUSION: When comparing TR assessments to clinical slit lamp examinations to diagnose DR and AMD, there was a fair agreement. Although further validation is needed, the TR approach provides a promising method to diagnose DR and AMD, two major causes of ocular impairment worldwide.

Keywords: Age-related macular degeneration, diabetic retinopathy, slit lamp examination, teleretina, teleophthalmology

Rop PBK, Nyamai PCM, Namwiba WH. Narrative Glossary of Fundamentals for Applied Geology. Scholars' Press; 2020.Website
Wanja DW, Mbuthia PG, Waruiru RM, Bebora LC, Nyaga PN. "Natural concurrent infections with black spot disease and multiple bacteriosis in farmed Nile tilapia in central Kenya." Natural concurrent infections with black spot disease and multiple bacteriosis in farmed Nile tilapia in central Kenya. 2020;2020(Article ID 8821324. https://doi.org/10.1155/2020/8821324).
Mbugua SN, Sibuyi NRS, Njenga LW, Odhiambo RA, Wandiga SO, Meyer M, Lalancette RA, Onani MO. "New Palladium(II) and Platinum(II) Complexes Based on Pyrrole Schiff Bases: Synthesis, Characterization, X ray Structure, and Anticancer Activity." ACS Omega . 2020;5(25):14942−14954 . AbstractACS OMEGA

New palladium (Pd)II and platinum (Pt)II complexes (C1−C5) from the Schiff base ligands, R-(phenyl)methanamine (L1), R-(pyridin-2-yl)methanamine (L2), and R-(furan2-yl)methanamine (L3) (R-(E)-N-((1H-pyrrol-2-yl) methylene)) are herein reported. The complexes (C1−C5) were characterized by FTIR, 1 H and 13C NMR, UV−vis, and microanalyses. Single-crystal X-ray crystallographic analysis was performed for the two ligands (L1−L2) and a Pt complex. Both L1 and L2 belong to P21/n monoclinic and P-1 triclinic space systems, respectively. The complex C5 belongs to the P21/c monoclinic space group. The investigated molar conductivity of the complexes in DMSO gave the range 4.0−8.8 μS/cm, suggesting neutrality, with log P values ≥ 1.2692 ± 0.004, suggesting lipophilicity. The anticancer activity and mechanism of the complexes were investigated against various human cancerous (Caco-2, HeLa, HepG2, MCF-7, and PC-3) and noncancerous (MCF-12A) cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Apopercentage assays, respectively. C5 demonstrated strong DNA-binding affinity for calf thymus DNA (CTDNA) with a binding constant of 8.049 × 104 M−1 . C3 reduced cell viability of all the six cell lines, which included five cancerous cell lines, by more than 80%. The C5 complex also demonstrated remarkably high selectivity with no cytotoxic activity toward the noncancerous breast cell line but reduced the viability of the five cancerous cell lines, which included one breast cancer cell line, by more than 60%. Further studies are required to evaluate the selective toxicity of these two complexes and to fully understand their mechanism of action

Mbugua SN, Sibuyi NRS, Njenga LW, Odhiambo RA, Wandiga SO, Meyer M, Lalancette RA, Onani MO. "New Palladium(II) and Platinum(II) Complexes Based on Pyrrole Schiff Bases: Synthesis, Characterization, X‑ray Structure, and Anticancer Activity." ACS Omega. 2020. Abstractdx.doi.org

New palladium (Pd)II and platinum (Pt)II complexes (C1–C5) from the Schiff base ligands, R-(phenyl)methanamine (L1), R-(pyridin-2-yl)methanamine (L2), and R-(furan-2-yl)methanamine (L3) (R-(E)-N-((1H-pyrrol-2-yl) methylene)) are herein reported. The complexes (C1–C5) were characterized by FTIR, 1H and 13C NMR, UV–vis, and microanalyses. Single-crystal X-ray crystallographic analysis was performed for the two ligands (L1–L2) and a Pt complex. Both L1 and L2 belong to P21/n monoclinic and P-1 triclinic space systems, respectively. The complex C5 belongs to the P21/c monoclinic space group. The investigated molar conductivity of the complexes in DMSO gave the range 4.0–8.8 μS/cm, suggesting neutrality, with log P values ≥ 1.2692 ± 0.004, suggesting lipophilicity. The anticancer activity and mechanism of the complexes were investigated against various human cancerous (Caco-2, HeLa, HepG2 …

Rotich J, Nyamota W, J. K. "Nutrition knowledge and practices in management of stage 5 chronic kidney disease by adult Patients at Kenyatta National hospital, Kenya." International Journal of Scientific and Research Publication . 2020;10(3):613-625. Abstract

This study sought to determine nutrition knowledge and its association with practices in management of stage 5 chronic
kidney disease (CKD) among renal adult patients in Kenyatta National Hospital. A cross-sectional analytical design was used to
facilitate collection of qualitative and quantitative data and enable identification of associations between variables. Cochran formula
was used to calculate a sample of 110 respondents. A research administered questionnaire with closed ended questions was used to
collect information. Descriptive statistics such as frequency and percentage were used to describe demographic and socio-economic
characteristics of the population. Inferential statistics were done using chi square with an alpha of 0.05 to test association between
independent and dependent variables. Most participants had moderate knowledge levels whereas more than half of the participants
(66%) indicated poor nutrition management practices of their condition. There was significant association between period on dialysis
in months and practices in management of stage 5 chronic kidney disease. Knowledge on importance of diet in management of stage 5
CKD (<0.001), moderation of fluid intake (<0.001), reduction in salt/ sodium intake (<0.001), and moderation in protein intake
(<0.004) were significantly associated with nutritional management practices of stage 5 CKD. The study concluded that Knowledge
levels were low in identifying foods rich in phosphorus, calcium and fat soluble vitamins. Practice scores were also poor despite
moderate nutrition knowledge levels. Patients’ knowledge on nutrition management of their condition may be achieved through
frequent and consistent nutrition education and counseling including follow ups.
Key Terms: Knowledge, Practice, chronic kidney disease, nutrition management

Nzimbi BM, Luketero SW. "On Unitary Quasi-Equivalence of Operators." International Journal of Mathematics And its Applications. 2020;8(1):207-215. Abstractfull text link

In this paper we investigate unitary quasi-equivalence of operators in Hilbert spaces. We characterize operators that are unitarily quasi-equivalent. We also investigate equivalence relations closely related to unitary quasi-equivalence. We give and prove conditions under which unitary quasi-equivalence coincides with other operator equivalence relations.

F EA, N MJ, K KC. "Openings Effects on the Performance of Reinforced Concrete Beams Loaded in Bending and Shear." Engineering, Technology & Applied Science Research. 2020;Vol 10(2):5352-5360.
Nyawade SO, Karanja NN, Gachene CKK, Gitari HI, Schulte-Geldermann E, Parker M. "Optimizing soil nitrogen balance in a potato cropping system through legume intercropping.". 2020.
Langat SK, Eyase FL, Berry IM, Nyunja A, Bulimo W, Owaka S, Ofula V, Limbaso S, Lutomiah J, Jarman R, Distelhorst J, Sang RC. "Origin and evolution of dengue virus type 2 causing outbreaks in Kenya: Evidence of circulation of two cosmopolitan genotype ." Virus Evol. 2020;6(1):veaa026. Abstractveaa026.pdfWebsite

Dengue fever (DF) is an arboviral disease caused by dengue virus serotypes 1-4 (DENV 1-4). Globally, DF incidence and disease burden have increased in the recent past. Initially implicated in a 1982 outbreak, DENV-2 recently reemerged in Kenya causing outbreaks between 2011 and 2014 and more recently 2017-8. The origin and the evolutionary patterns that may explain the epidemiological expansion and increasing impact of DENV-2 in Kenya remain poorly understood. Using whole-genome sequencing, samples collected during the 2011-4 and 2017-8 dengue outbreaks were analyzed. Additional DENV-2 genomes were downloaded and pooled together with the fourteen genomes generated in this study. Bioinformatic methods were used to analyze phylogenetic relationships and evolutionary patterns of DENV-2 causing outbreaks in Kenya. The findings from this study have shown the first evidence of circulation of two different Cosmopolitan genotype lineages of DENV-2; Cosmopolitan-I (C-I) and Cosmopolitan-II (C-II), in Kenya. Our results put the origin location of C-I lineage in India in 2011, and C-II lineage in Burkina Faso between 1979 and 2013. C-I lineage was the most isolated during recent outbreaks, thus showing the contribution of this newly emerged strain to the increased DENV epidemics in the region. Our findings, backed by evidence of recent local epidemics that have been associated with C-I in Kenya and C-II in Burkina Faso, add to the growing evidence of expanding circulation and the impact of multiple strains of DENV in the region as well as globally. Thus, continued surveillance efforts on DENV activity and its evolutionary trends in the region, would contribute toward effective control and the current vaccine development efforts.

Mungai GN, Njenga HN, MATHU ELIUDM, Madadi VO. "Origin of Carbon dioxide in Selected Mofette Springs in the Eastern Mt. Kenya Region and Associated Characteristics." Africa Journal of Physical Sciences. 2020;5:48-62.
Segera D, Mbuthia M, Nyete A. "Particle Swarm Optimized Hybrid Kernel-Based Multiclass Support Vector Machine for Microarray Cancer Data Analysis.". In: Prime Archives in Medicine. Hyderabad (India): Vide Leaf; 2020.
Buyana K, Lwasa S, Tugume D, Mukwaya P, Walubwa J, Owuor S, Kasaija P, Sseviiri H, Nsangi G, Byarugaba D. "Pathways for resilience to climate change in African cities. Environ. Res. Lett. 15 (2020) 073002.". 2020.2020_environmental_research_letters_journal.pdf
Opiyo R, Were A, Nabakwe E, Mbogo A, Olenja J, Bukania Z. "Patients with Chronic Kidney Disease: How Can They Make Informed Nutritional Decisions?" Office of DVC Research, Innovation and Enterprise, University of Nairobi. 2020:39-40. AbstractWebsite

The Ministry of Health and partners should develop national standard operating procedures and IEC materials in renal nutrition counsellingfor harmonized messages. All patients with chronic kidney disease should get takeaway information leaflets with patient-specific simple nutrition messages to ensure the accuracy of nutrition information; All nutritionists and healthcare workers in renal units should participate in regular continuing nutrition education on most recent evidence-based nutrition information.

Wabwire EO, Mukhovi SM, Nyandega IA. "The Perception of Rural Households on Climate Change Effect on Rural Livelihoods in Lake Victoria Basin." Ghana Journal of Geography . 2020;13(2):62-83.
Langat MK, Djuidje EFK, Ndunda BM, Isyaka SM, Dolan NS, Ettridge GD, Whitmore H, Lopez I, Alqahtani AM, Atiku I, Lobe JS, Mas-Claret E, Crouch NR, Midiwo JO, Mulholland DA, Kamdem AFW. "The phytochemical investigation of five African Croton species: Croton oligandrus, Croton megalocarpus, Croton menyharthii, Croton rivularis and Croton megalobotrys." Phytochemistry Letters. 2020;40:148-155. AbstractPhytochemistry Letters

Description
The chemistry of five African Croton taxa, Croton oligandrus Pierre ex Hutch., Croton megalocarpus Hutch., Croton menyharthii Pax, Croton rivularis Mull.Arg. and Croton megalobotrys Mull.Arg. is described. The undescribed ent-19-hydroxyisopimara-8(9),15-dien-7-one and ent-isopimara-7(8),15-dien-16,19-diol were isolated from the fruits of C. oligandrus, ent-isopimara-7(8),15-dien-19-yl octadecanoate was obtained from both the fruits and leaves, and ent-19-hydroxyisopimara-8(9),15-dien-7-one was isolated from the leaves of this species. The undescribed 3,4,15,16-diepoxy-8α-hydroxycleroda-13(16),14-dien-12S,17-olide and (5S,9R,10S)-7,13-ent-abietadien-2-one were isolated from the leaves and roots of C. megalocarpus respectively. Compounds isolated from C. menyharthii, C. rivularis and C. megalobotrys have been reported from other sources. The structures of the compounds were determined using …

Langat MK, Djuidje EFK, Ndunda BM, Isyaka SM, Dolan NS, Ettridge GD, Whitmore H, Lopez I, Alqahtani AM, Atiku I, Lobe JS, Mas-Claret E, Crouch NR, Midiwo JO, Mulholland DA, Kamdem AFW. "The phytochemical investigation of five African Croton species: Croton oligandrus, Croton megalocarpus, Croton menyharthii, Croton rivularis and Croton megalobotrys." Phytochemistry Letters. 2020;40(2020):148-155.chemistry_of_five_croton_species_phytolletters_2020.pdf
N A, N A, S M, S A, H H, S B, D M, A R, I K, O A-B, Y K, M R, V P, S C, K N, G G, A P, M F, A S, M M, A AA, D M, P P, J K, Y C, M D, J V, M A, J C, M N, I H, A V, A I, A K, E J, ME T. "Preparedness of dental academic institutions to manage the COVID-19 pandemic: a global survey." Int. J Environ Res Public Health. 2020;2021; 18:1445(2021; 18:1445):2021; 18:1445.
Kimenju JW, Ngugi RK, Chimoita EL, Muiruri EW, Amwoka E. "Preparing Agriculture Graduates for the Job Market: A Case Study of On-farm Experiential Learning by Students." RUFORUM Working Document Series (ISSN 1607-9345) 2018. 2020;17(3)(httpp://repository.ruforum.org):700-705.preparing_agriculture_graduates_for_the_job_market.pdf
Kimenju JW, Ngugi RK, Chimoita EL, Muiruri EW, Amwoka E. "Preparing Agriculture Graduates for the Job Market: A Case Study of On-farm Experiential Learning by Students." RUFORUM Working Document Series (ISSN 1607-9345) 2018. 2020;17(3)(httpp://repository.ruforum.org):700-705.preparing_agriculture_graduates_for_the_job_market.pdf
Kimenju JW, Ngugi RK, Chimoita EL, Muiruri E, Waitugi S, Amwoka E. "Preparing Agriculture Graduates for the Job Market: A Case Study of On-farm Experiential Learning by Students." RUFORUM Working Document Series (ISSN 1607-9345) 2018. 2020;17(3)(httpp://repository.ruforum.org):700-705.preparing_agriculture_graduates_for_the_job_market.pdf
Nancy M, Githigia S, Karanja D, Mbae C, Zeyhle E, Mulinge E, Magambo J, ogolla K. "Prevalence and intensity of gastrointestinal parasites in donkeys in selected abattoirs in Kenya. ." Hindawi Scientifica . 2020;Article ID 5672140(https://doi.org/10.1155/2020/5672140).
Njoroge EN, Mutembei HM, Kipyegon AN, Kimeli P, Olum2 MO. "Prevalence of Repeat Breeding Syndrome in Dairy Cattle in Selected Regions of Kenya." International Journal of Veterinary Science. 2020;10(2):144-118.
Edouard Singirankabo, Ngare P, Ogutu C. "Pricing Lookback Option Using Multinomial Lattices." Communications of Mathematical Finance, . 2020;9(1, ):1-12,.
Kiuri J, MARU S, Ndwigah SN. "Product Evaluation of Carbamazepine 200mg Controlled Release Tablets using an in vitro-in vivo Correlation Simulation Model. ." The East and Central African Journal of Pharmaceutical Sciences. 2020;23(2):60-66.
Okello JJ, Shiundu FM, Mwende J, Lagerkvist CJ, Nyikal RA, Muoki P, Mburu J, Low JW. "Quality and psychosocial factors influencing purchase of orange‐fleshed sweet potato bread." International Journal of Food Science and Technology. 2020. AbstractWebsite

This 2018 study, conducted in six Tusky's supermarkets in Nairobi, Kenya, combined the Just-About-Right, Penalty and Mean-End-Chain analyses to examine the quality and psychosocial factors influencing the purchase of a novel bread made from orange-fleshed sweet potato (OFSP), a biofortified crop, focusing on sixty-one male and eighty female urban OFSP bread buyers recruited at point of purchase. It finds that sensory and psychosocial factors drive purchasing decisions and that some of the bread's sensory characteristics are misaligned with consumers' expectations. It also finds that women and men's evaluations of the bread's characteristics are different, as are their motivations for purchase. However, good sensory attributes and the knowledge of the bread's nutritional value were key drivers. Some misaligned characteristics reveal levers for the reformulation of the bread and present opportunities for segmenting the market. Several other implications of the findings for policy and future improvement of the bread are discussed.

Abuga KO, Ndwigah SN, Amugune BK, Ongarora DB, Njogu PM, Okaru AO, Kibwage IO. "Quality Control Report of Drugs Analyzed in the Drug Analysis and Research Unit during the Period 2011-2015." East Cent. Afr. J. Pharm. Sci.. 2020;23(3):79-86. Abstract

During the period 2011-2015, the Drug Analysis and Research Unit (DARU) analyzed 1972 drug samples. The samples consisted of 21.5% locally manufactured and 78.2% imported products while the origin of 0.3% of products was indeterminate. Samples were subjected to compendial and/or in-house analytical specifications. The overall non-compliance rate was 4.5% comprising 2.5% local products and 2.0% imports. High failure rates were recorded for uterotonics (37.5%), hemostatics (33%), anthelmintics (17%) and anticancers (10.5%) while ophthalmic, immunomodulatory, musculoskeletal and endocrine drugs all complied with the quality acceptance criteria. Erectile dysfunction drugs, received by the laboratory for the first time, all complied with specifications. The results obtained demonstrate an improvement in the quality of samples submitted to DARU when compared to previous performance.

Abuga KO, Ndwigah SN, Amugune BK, Ongarora DB, Njogu PM, Okaru AO, Kibwage IO. "Quality control report of drugs analyzed in the Drug Analysis and Research Unit during the period 2011-2015." East Cent. Afr. J. Pharm. Sci. 2020;23(3):79-86.
Mugo JW, Opijah F, Ngaina J, Karanja F, Mburu M. "Rainfall variability under present and future climate scenarios using the Rossby Center Bias-corrected Regional Climate Model." American Journal of Climate Change. 2020;9(1):243-265.
Gitari HI, Nyawade SO, Kamau S, Karanja NN, Gachene CKK, Raza MA, Maitra S, Schulte-Geldermann E. "Revisiting intercropping indices with respect to potato-legume intercropping systems.". 2020.
C O, K KC, N MJ. "Rice Straw and Egg Shell as Partial Replacements of Cement in Concrete." Engineering, Technology & Applied Science Research. 2020;Vol 10(6):6481-6487.
J.O'Connell P, Brown M, Chan TM, Granado RC-D, J.Davies S, Eiam-Ong S, H.Hassan M, Kalantar-Zadeh K, Levin A, E.Martin D, Muller E, Ossareh S, Tchokhonelidze I, Trask M, Twahir A, J.O.Were A, Yang C-W, Zemchenkov A, N.Harden P. "The role of kidney transplantation as a component of integrated care for chronic kidney disease." Science Direct. 2020.Website
Nyapela MA. "The Role of Knowledge Management in Life-Saving Initiatives: Case of COVID-19 Pandemic." The Role of Knowledge Management in Life-Saving Initiatives: Case of COVID-19 Pandemic . 2020.
Kanoti, Olago, D. O., Akech, Nyamai, C.M., Dulo, Ayah, Taylor, D. "Sanitation challenges, groundwater perspectives and their intertwined relationships in Kisumu." Kenya Policy Briefs . 2020;1(1).
Kanoti J, Olago D, Nyamaoi C, Dulo SI, Ayah R, Taylor R. "Sanitation challenges, groundwater perspectives and their intertwined relationships in Kisumu, Kenya." Kenya Policy Briefs. 2020;1(1):15-16. AbstractSanitation challenges, groundwater perspectives and their intertwined relationships in Kisumu, Kenyauonresearch.org

Groundwater is the preferred alternative water source during times of shortages and in areas not served by piped water supplies. Pit latrines are the main sanitation facilities in Kisumu where sewerage extends over less than 20 per cent of the city. Pit latrines contribute to microbial contamination of shallow groundwater in Kisumu.

N. MJ. "A Simple Computer Model for the Prediction of Chemical Shrinkage and Heat of Hydration of Sugarcane Waste Fiber Ash (SWFA)-Cement Paste." International Journal of Scientific and Research Publications. 2020;Vol 10(4):597-615.
Ndegwa R, E Ayieta, Simiyu J, Odero N. "A Simplified Method for Parameter Determination of a Photovoltaic Module using Manufacturer’s data." Africa Journal of Physical Science. 2020;5:1-9.

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