Intraocular pressure changes in eyes receiving intravitreal acetonide in Kikuyu Eye Unit.

Mingaine M, K G, Gichuhi S, J K. "Intraocular pressure changes in eyes receiving intravitreal acetonide in Kikuyu Eye Unit. .". In: East African Journal of Ophthalmology. Elsevier; 2009.


Objective: To determine the magnitude and pattern of intraocular pressure (IOP) changes in eyes that received intravitreal triamcinolone acetonide (IVTA) in Kikuyu Eye Unit.
Study Design: Retrospective interventional case series.
Setting: Kikuyu Eye Unit.
Subjects: Seventy-two eyes (of 61 patients) injected between January 2007 and August 2008.
Methods: Data on intraocular pressure (IOP), diagnosis, additional procedures and treatment was collected using questionnaires and analysed using SPSS version 11.5. 
Results: The mean pre-injection IOP was 16.0 (SD 5.2) mmHg, which increased to 23.8 (SD 11.5) mmHg after IVTA injection (p<0.001). IOP started increasing significantly within 2 weeks (p=0.006). The median post-injection time before IOP peak was 4.6 weeks, and IOP remained high for 24 weeks after injection. Intraocular pressure increase of 5 mmHg or more was found in 39 (54.2%) eyes, while that of 10 mmHg or more was found in 22 (30.1%). Thirty-three eyes (45.8%) had maximum post-injection IOP beyond 21 mmHg. Twenty-two eyes (30.6%) received treatment for IOP elevation. Eyes with pre-injection IOP of more than 21 mmHg were associated with significantly higher IOP increases (p<0.001) and all received pressure-lowering medication. No associations were noticed between age, sex, other procedures, diagnosis and pattern of IOP change.
Conclusions: Intraocular increase was found to be a common complication of IVTA, and the increase occurred in the first six months.




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