Pterocarpans and Isoflavones from the Root Bark of Millettia micans and of Millettia dura

Citation:
Marco M, Deyou T, Gruhonjic A, Holleran JP, Duffy S, Heydenreich M, Fitzpatric PA, Landberg G, Koch A, Derese S, Pelletier J, Avery VM, Erdélyi Máté, Yenesew A. "Pterocarpans and Isoflavones from the Root Bark of Millettia micans and of Millettia dura." Advances in Drug Discovery and Development. 2016: 1-8.

Abstract:

Pterocarpans and Isoflavones from the Root Bark of Millettia micans and of
Millettia dura
Makungu Marco1, Tsegaye Deyou1,2, Amra Gruhonjic2,5, John P. Holleran3, Sandra Duffy3,
Matthias Heydenreich4, Paul A. Fitzpatrick5, Göran Landberg5, Andreas Koch4, Solomon
Derese1, Jerry Pelletier6, Vicky M. Avery3, Máté Erdélyi2,7,* and Abiy Yenesew1,*
1Department of Chemistry, University of Nairobi, P. O. Box 30197-00100, Nairobi, Kenya; 2Department of
Chemistry and Molecular Biology, University of Gothenburg, SE-40530, Gothenburg, Sweden; 3Discovery
Biology, Eskitis Institute for drug discovery, Griffith University, Nathan Qld 4111 Australia; 4Institut für Chemie,
Universität Potsdam, Karl-Liebknecht-Str. 24-25, D-14476 Potsdam, Germany; 5Sahlgrenska Cancer
Centre, University of Gothenburg, SE-405 30 Gothenburg, Sweden; 6Department of Biochemistry, McGill
University, Montreal, QC, H3G 1Y6, Canada and 7Swedish NMR Center, University of Gothenburg, P.O. Box
465, SE-40530, Gothenburg, Sweden
Abstract: From the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia micans, a new pterocarpan,
(6aR,11aR)-7,8,9-trimethoxy-3-hydroxypterocarpan (1), named micanspterocarpan, was isolated. Similar
investigation of the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia dura gave a further new pterocarpan,
3-O-prenylmaackiain (2) along with six known isoflavones (3-8) and a chalcone (9). All purified
compounds were identified by NMR and MS, and the absolute configuration of 1 was established by quantum
chemical CD calculation. The isolated constituents, calopogonium isoflavone B (3) and isoerythrin A-4'-
(3-methylbut-2-enyl) ether (4) showed marginal activities against the 3D7 and the Dd2 strains of Plasmodium
falciparum (70-90% inhibition at 40

UoN Websites Search