Antiplasmodial Quinones from Pentas longiflora and Pentas lanceolata

SOLOMON DRDERESE. "Antiplasmodial Quinones from Pentas longiflora and Pentas lanceolata." Planta Medica. 2012; 78:31-35.


Milkyas Endale, John Patrick Alao, Hoseah M. Akala, Nelson K. Rono, Fredrick L. Eyase, Solomon Derese,
Albert Ndakala, Martin Mbugua, Douglas S.Walsh, Per Sunnerhagen, Mate Erdelyi, Abiy Yenesew

Planta Med 2012; 78: 31–35

The dichloromethane/methanol (1 :1) extracts of the roots of Pentas longiflora and Pentas lanceolata showed low micromolar (IC50 = 0.9–3 μg/mL) in vitro antiplasmodial activity against chloroquineresistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum. Chromatographic separation of the extract of Pentas longiflora led to the isolation of the pyranonaphthoquinones pentalongin (1) and psychorubrin (2) with IC50 values below 1 μg/mL and the naphthalene derivative mollugin (3), which showed marginal activity. Similar treatment of Pentas lanceolata led to the isolation of eight anthraquinones (4–11, IC50 = 5–31 μg/mL) of which one is new (5,6-dihydroxydamnacanthol, 11), while three – nordamnacanthal (7), lucidin-ω-methyl ether (9), and damnacanthol (10) – are reported here for the first time from the genus Pentas. The compounds were identified by NMR and mass spectroscopic techniques.




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