Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus

Citation:
Derese S. "Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus." Natural product communications. 2013;8(2):175-6.

Abstract:

Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus.

Leonidah Omosa Kerubo, Jacob Ogweno Midiwo, Solomon Derese, Moses K Langat, Hosea M Akala, Norman C Waters, Martin Peter, Matthias
Natural Products Communications: 2013; 8(2):175-6.

From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 microg/mL respectively.

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