Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica.

Citation:
SOLOMON DRDERESE. "Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica." Phytochemistry. 2004;65(22):3029-32.

Abstract:

Phytochemistry. 2004 Nov;65(22):3029-32.

Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica.

Yenesew A, Induli M, Derese S, Midiwo JO, Heydenreich M, Peter MG, Akala H, Wangui J, Liyala P, Waters NC.

The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC(50) values of 7.9+/-1.1 and 5.3+/-0.7 microg/ml, respectively. From this extract, a new chalcone, 2',3,4,4'-tetrahydroxy-5-prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'-prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti-plasmodial principles. The structures were determined on the basis of spectroscopic evidence.

Notes:

n/a

Website

UoN Websites Search