PROF. DOSSAJI SAIFUDDIN FIDAHUSSEIN
B.Sc.(Univ of Poona, India), M.Sc.(UoN, Kenya), Ph.D. (Univ of Texas at Austin)
254-20-4449004, ext 2477, +254 733721165, School of Biological Sciences, room BS 209, Chiromo Campus, saifuddin.dossaji@uonbi.ac.ke
254-20-4449004, ext 2477, +254 733721165, School of Biological Sciences, room BS 209, Chiromo Campus, saifuddin.dossaji@uonbi.ac.ke
From roots of Peddiea volkensii (Thymelaeaceae) the irritant factors and and from roots of P. africana
the irritant factor Aj were isolated. Their structures are the 9,13,14-ort/io-(2,4,6-decatrienoates) of 5/8-
hydroxyresiniferonol-6a,7a-oxide (Vi) and of 5^,12iS-dihydroxyresiniferonol-6a,7a-oxide (Aj) and the 12-0-acetate of the latter (Vj). Factors V i and do not exhibit tumour-promoting activity in the standard initiation-promotion protocol on mouse skin, although is a moderate irritant.
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