Skin irritant deterpene orthoesters of the daphanane type fropm Peddiea africana and P. Volkensii,

Citation:
Adolf W, Dossaji SF, Seip EH, Hecker E. "Skin irritant deterpene orthoesters of the daphanane type fropm Peddiea africana and P. Volkensii,." Phytochemistry. 1985;24:2047-2049.

Abstract:

From roots of Peddiea volkensii (Thymelaeaceae) the irritant factors and and from roots of P. africana
the irritant factor Aj were isolated. Their structures are the 9,13,14-ort/io-(2,4,6-decatrienoates) of 5/8-
hydroxyresiniferonol-6a,7a-oxide (Vi) and of 5^,12iS-dihydroxyresiniferonol-6a,7a-oxide (Aj) and the 12-0-acetate of the latter (Vj). Factors V i and do not exhibit tumour-promoting activity in the standard initiation-promotion protocol on mouse skin, although is a moderate irritant.

Notes:

n/a

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