Antimalarial Activity of the Alkaloid Nitidine, isolated from a Kenyan Herbal remedy

Citation:
Gakunju DM, Mberu E, Dossaji SF, Gray I, Waigh RD, Waterman PG, Watkins WM. "Antimalarial Activity of the Alkaloid Nitidine, isolated from a Kenyan Herbal remedy." Antimicrobial Agents & Chemotherapy, (39), 2606.. 1995;39:2606.-2609.

Abstract:

Bioassay guided fractionations of extracts of Toddalia asiatica, a plant used by Pokot tribe in Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for range of chloroquine-susceptible and resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine

Notes:

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