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Morris Ogero, Rachel Sarguta, Malla L, Aluvaala J, Agweyu A, Akech S. "Methodological rigor of prognostic models for predicting in-hospital paediatric mortality in low-and middle-income countries: a systematic review protocol." Wellcome Open Research. 2020;5:106. AbstractWebsite

Introduction: In low-and middle-income countries (LMICs) where healthcare resources are often limited, making decisions on appropriate treatment choices is critical in ensuring reduction of paediatric deaths as well as instilling proper utilisation of the already constrained healthcare resources. Well-developed and validated prognostic models can aid in early recognition of potential risks thus contributing to the reduction of mortality rates. The aim of the planned systematic review is to identify and appraise the methodological rigor of multivariable prognostic models predicting in-hospital paediatric mortality in LMIC in order to identify statistical and methodological shortcomings deserving special attention and to identify models for external validation.
Methods and analysis: This protocol has followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols. A search of …

Morris Ogero, Rachel Jelagat Sarguta, Malla L, Aluvaala J, Agweyu A, English M, Onyango NO, Akech S. "Prognostic models for predicting in-hospital paediatric mortality in resource-limited countries: a systematic review." BMJ open. 2020;10(10):035045. AbstractWebsite

Objectives
To identify and appraise the methodological rigour of multivariable prognostic models predicting in-hospital paediatric mortality in low-income and middle-income countries (LMICs).
Design
Systematic review of peer-reviewed journals.
Data sources
MEDLINE, CINAHL, Google Scholar and Web of Science electronic databases since inception to August 2019.
Eligibility criteria
We included model development studies predicting in-hospital paediatric mortality in LMIC.
Data extraction and synthesis
This systematic review followed the Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies framework. The risk of bias assessment was conducted using Prediction model Risk of Bias Assessment Tool (PROBAST). No quantitative summary was conducted due to substantial heterogeneity that was observed after assessing the studies included.

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