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Forthcoming
Jayne M. "Adult Literacy and the Place of Kiswahili.". In: proceedings on Language Curriculum Development. Kenyatta University; Forthcoming.
Adha ya Ndoa. . Nairobi: Focus publishers; Forthcoming.
Amani Mtoto wa Imani. ( Reader-children ) . Kenya Literature Bureau; Forthcoming.
O. KG. "Advance Geomorphology.". Forthcoming. Abstract
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Submitted
MWANGI MUREITHISTEPHEN. "Aboveground net primary productivity in grazed and ungrazed pastures: Grazing optimisation hypothesis or local extinction of vegetation species. Otieno, S.G., T.J. Njoka, T.P. Young, S.M. Mureithi and Ngugi, R.K. .". In: Nature Proceedings. Afr. J. Range For. Sci.; Submitted. Abstract

The controversy that has surrounded herbivory studies in the last few decades prompted our investigation to establish the extent to which herbivore optimisation hypothesis or compensatory growth evidence is real. We used the traditional movable cage method to collect primary productivity data on herbage, functional groups and key individual grass species in various controlled large herbivore treatments in an east African savanna. The herbivore treatments in triplicate blocks included cattle, wild herbivores with and without mega herbivores and combinations of cattle and wild herbivores also with and without mega herbivores. The findings revealed that at herbage level, most grazed treatments (four out of five) had higher productivity than the ungrazed control and three showed grazing optimisation curve at sixth polynomial degree between monthly productivity and grazing intensity (1-g/ng). At functional group level forbs productivity was higher in the ungrazed control than in any of the grazed treatments while at individual grass species level Themeda triandra productivity was higher in all grazed treatments than in ungrazed control. We conclude against presence of herbivore optimisation hypothesis at herbage, functional group and species level because of lack of attributable grazing effect in grazed treatments that matches complex ecological effects in the ungrazed treatment.

Kariuki S, Mirza N, Mitema ES, Olsvik O. "Acquired tetracycline resistance genes in nosocomial Salmonella typhimurium infection in a Kenyan hospital.". Submitted. AbstractWebsite

Tetracyclines have been among the most widely used antibiotics worldwide. Plasmid-mediated tetracycline resistance among hospital strains of bacteria has continued to rise and of major concern has been the transfer of resistance to pathogenic organisms. Bacteraemia due to hospital acquired S. typhimurium has been a major cause of morbidity at Kenyatta National Hospital (KNH), hence the need to study drug susceptibility pattern of this organism. This study also characterized the tetracycline resistance genes using oligonucleotide probes. Ninety seven S. typhimurium strains isolated from patients at KNH were used. Agar dilution method was used to determine minimum inhibitory concentration (MIC). Plasmids were isolated from each strain and the different plasmid profiles were grouped by their molecular weights into 6 patterns. Out of 97, 87 (88%) strains were resistant. MIC ranged from 1 microgram/ml to 128 micrograms/ml. Genes encoding for tetracycline resistance were located on plasmids of molecular weights 65 MDa, 5.2 or both. Plasmid-encoded antimicrobial resistance is likely to spread to other pathogenic organisms, reduce our ability to treat the infection and increase the cost and duration of treatment.

Olsvik O, Mitema ES, Gathuma J, Mirza N. "Acquired tetracycline resistance genes in nosocomial Salmonella typhimurium infection in a Kenyan hospital.". Submitted. AbstractWebsite

Tetracyclines have been among the most widely used antibiotics worldwide. Plasmid-mediated tetracycline resistance among hospital strains of bacteria has continued to rise and of major concern has been the transfer of resistance to pathogenic organisms. Bacteraemia due to hospital acquired S. typhimurium has been a major cause of morbidity at Kenyatta National Hospital (KNH), hence the need to study drug susceptibility pattern of this organism. This study also characterized the tetracycline resistance genes using oligonucleotide probes. Ninety seven S. typhimurium strains isolated from patients at KNH were used. Agar dilution method was used to determine minimum inhibitory concentration (MIC). Plasmids were isolated from each strain and the different plasmid profiles were grouped by their molecular weights into 6 patterns. Out of 97, 87 (88%) strains were resistant. MIC ranged from 1 microgram/ml to 128 micrograms/ml. Genes encoding for tetracycline resistance were located on plasmids of molecular weights 65 MDa, 5.2 or both. Plasmid-encoded antimicrobial resistance is likely to spread to other pathogenic organisms, reduce our ability to treat the infection and increase the cost and duration of treatment.

MUTONGA PENINAH. "Adaptation of Swahili architecture and identity, a case of Lamu and Shela." Africa Habitat Review Journal. Submitted;1(1/2019):50.
African Capacity Enhancement Programme (ACEP) leading to Post Graduate Certificate in Material Development in Open, Distance and e-Learning. African Virtual University (AVU) and Association of Colleges and Universities of Canada; Submitted.
Owakah F, Aswani DR. "African Ontology: It’s Implications on Socio-Political Development.". In: Reflections of African Societies and Development: Perspectives from African Philosophers.; Submitted.
IRIBEMWANGI PI, Kabwana I. Alfa na Omega (Play). Nairobi: Oxford University Press; Submitted. Abstract

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Odhiambo MA. Antimicrobial and phytochemical properties of some medicinal plants used by the Luo community of Kenya.; Submitted. Abstract

The Luo community of Kenya have traditionally used plants for treatment of various disease conditions,
some of which we now know to be caused by microbial infections. Some of these plants, namely Lannea
stuhlmanii, Carissa edulis, Combretum fragrans, Conyza sumatrensis, Ormocarpum trichocarpum, Sida
cuneifolia, Plumbago zeylanica, and Rhoicissus revoilii, were studied. Their ethanol extracts were
screened for their antimicrobial activity against Candida albicans, Escherichia coli, Staphylococcus aureus
and Bacillus pumulus.
Ethanolic root extract of C sumatrensis had good antibacterial activity against E. coli, while extracts of
C fragrans root bark, C edulis root, S. cuneifolia whole plant, R. revoilii tubers and leaf extract of C
sumatrensis in the same solvent had good activity against it. Activity against B. pumulus was observed in
all extracts except those of L. stuhlmanii bark and R. revoilii tubers. Good activity against S. aureus was
observed for C fragrans, S. cuneifolia and L. stuhlmanii.
R. revoihi, L. stuhlmanii, C fragrans and C edulis exhibited good antifungal activity against Candida
albicans.
Combretum fragrans bark extract had the highest overall antimicrobial activity of all the different plant
extracts examined and was subsequently chosen for further studies. All its ethanol, methanol, ethyl
acetate and chloroform extracts were found to have significant antimicrobial activity.
Combretum fragrans bark powder was found to contain saponins, cardiac glycosides, free anthraquinones
(anthracene glycosides), tannins and flavonoids. However, it had no starch nor alkaloids.
The chloroform extract of C fragrans was subjected to column chromatographic separation and
sitosterol (with stigmasterol as a minor compound) was isolated and identified. Sitosterol was shown to
have antifungal activity against C albicans and antibacterial activity against Escherichia coli.
The results of this work would therefore appear to lend support to the traditional use of Lannea
stuhlmanii, Combretum fragrans, Conyza sumatrensis (tineasis), Plumbago zeylanica, and Rhoicissus
revoilii in disease conditions where microbial infections may be a factor. Use of growth enhancers like
Carissa edulis in combination therapy may be justified on the basis of their immune boosting activity.

Omolo MJ. Assessment Of Knowledge And Attitude On Antiretroviral Therapy Among Nursing Students.; Submitted. Abstract

Title: Assessment of knowledge and attitude on antiretroviral therapy among nursing students. Objective: To assess the knowledge and attitude of final year nursing students at Kenyatta National Hospital. Specific Objectives were to establish the knowledge of nursing students on Anti-retroviral therapy and to determine the attitude of students towards patients who are on Anti-retroviral therapy Method: The study done at Kenyatta National hospital administered questionnaires to 150 students and 138 were found eligible. Data collected was analyzed using STATA. Results: The findings of the study showed that 39.8% of the nursing students had knowledge about Anti-Retroviral drugs; 42% of the students had some ideas while 18% of the students did not have adequate knowledge. Married and older students seemed to have better knowledge on ART compared to young and single Nurses significant at a P-value of 0.033. Attitude towards ART was positive from 34.8% of the students while 65.2% of the nursing students had not expressed their feeling. There was significant association between attitude and sex. Conclusion: This study confirmed lack of adequate knowledge on Antiretroviral therapy among newly qualified nursing students. The study recommended inclusion of HIV/AIDS based units in the basic training of nurses

Njoroge PK. Assessment of parental sex education to own adolescents among parents in a Peri urban community.; Submitted. Abstract

This was a Survey of Parents' Knowledge, Attitude and Practice of sex education to their own adolescents. The study was conducted between January and March in three divisions of Kiambaa Division of Kiambu District, Central Province of Kenya. This study area is located about 20 km from the city of Nairobi. The study population were parents with at least one child in adolescence. Depending on availability either one or both parents were included in the study. The study instrument was structured, mainly pre-coded questionnaire. The data was obtained through personal interviews conducted from house La ho u sc . The sample population was made up of 729 parents, 70.4% of whom were females. The survey found that 46.3% of parents gave sex education to their own adolescents, majority of them giving it to those of their sex only. Parents gave their adolescents sex education from a mean age (of the adolescent) of 10.33 years (SD=3.51) and the practice was associated with Parents Social, Economic and Demographic factors. 'Of these factors, knowledge that own adolescents received sex education from sources other than the parent had highest odds ratio 10R=4.l8). Age of the parent was the only other factor with odds for the practice (OR=.l.03 ). The level of sex education given to adolescents was higher for girls than for boys. The level of practice to boys was associated with age and socio-economic status (SES) inde~ of the parent. Knowledge of sex education among parents was high and associated with a parents' sex and SES index. Males scored signi ficantly higher than females and parents of Jow SES scored significantly higher than those of high SES index. The attitude to sex education was positive, with nearly all parents feeling that sex education for adolescents was appropriate and that it should be given by own parents, starting from a mean age of 10.61 years (SD=2. 84) and that it should include contraceptive education. The study recommended further studies on parents to understand why the level of practice is unmatched with the high levels of knowledge and attitude and to determine why those parents who know that their adolescents receive sex education from other sources are more likely to give sex education to their adolescents than those who did not. 'Other recommendations were: a study to assess the feasibility of using PTA' s to impart sex education to adolescents in schools, beginning Family Life education in primary schools at standard four (corresponding to age .10-11 years),and establishing of community based centres for sex education counselling for parents with adolescents and adolescents out of school.

K PROFNDELEJOHNSON. "Academia .". In: The Nairobi Journal of Medicine Vo. 19 No. 2 pp 30-34. University of Nairobi Press; Submitted. Abstract
The present studies were designed and carried out to determine if hydrogen peroxide (H2O2) is involved in the regulation of erythropoietin (Epo) gene expression and stimulation of Epo production in the hepatocellular (Hep 3B) cells. Hep 3B cells were incubated with varying concentrations of H2O2 for periods of 6 hours or 24 hours. In other experiments Hep 3B cells were incubated for 24 hours with or without increasing concentrations of catalase and in the presence of H2O2. Culture medium levels of Epo were determined and quantitation of Epo mRNA was also made. The results indicate that H2O2 increases the levels of Epo mRNA and Epo hormone production in Hep 3B cells, and that catalase, the specific scavenger of hydrogen peroxide, inhibits Epo production in these cells. Based on these findings, it is concluded that H2O2 takes part in the signal transduction mechanisms in Epo production. It is recommended that further studies be undertaken to find out the source of the hydrogen peroxide in the hepatocellular carcinoma cells.
N PROFNZOMODAUDI. ""Accountancy - The Making of Professional Accountants." Part II, by J.D. Newtron ad N.D. Nzomo. This article continues the analysis and discussions started in Part 1 above.It presents data on citizenship, age, education and projects into the future of the.". In: Journal of the Kenya Institute of Management, (pages 24-25). RIVERBRROKS COMMUNICATIONS; Submitted. Abstract
Journal of the Institute of Certified Public Accountants of Kenya. (pages 13-15)
N PROFNZOMODAUDI. ""Accountancy - The Making of Professional Accountants." Part II, by J.D. Newtron ad N.D. Nzomo. This article continues the analysis and discussions started in Part 1 above.It presents data on citizenship, age, education and projects into the future of the.". In: Journal of the Kenya Institute of Management, (pages 24-25).; Submitted. Abstract

Journal of the Institute of Certified Public Accountants of Kenya. (pages 13-15)

N PROFNZOMODAUDI. ""Accounting for Harambee" This article presents the rationale for auditing harambee funds, discusses practical procedures for doing so and then calls for legislation to regulate authorization, safe custody, management and reporting as aspects of national .". In: Journal of the Accounting Students Association, Faculty of Commerce, University of Nairobi, pages 3 & 4. RIVERBRROKS COMMUNICATIONS; Submitted. Abstract
Journal of the Institute of Certified Public Accountants of Kenya. (pages 13-15)
N PROFNZOMODAUDI. ""Accounting for Harambee" This article presents the rationale for auditing harambee funds, discusses practical procedures for doing so and then calls for legislation to regulate authorization, safe custody, management and reporting as aspects of national .". In: Journal of the Accounting Students Association, Faculty of Commerce, University of Nairobi, pages 3 & 4.; Submitted. Abstract

Journal of the Institute of Certified Public Accountants of Kenya. (pages 13-15)

N PROFNZOMODAUDI. ""Accounting for Stock-Devidends" . This article discusses the theoretical inconsistencies in the Accounting treatment of stock dividends and the commensurate capitalization of Retained Earnings.". In: National Association of Black Accountants, USA Spectrum, Vol. 7, , New York, (pages 8-10). RIVERBRROKS COMMUNICATIONS; Submitted. Abstract
No abstract available
N PROFNZOMODAUDI. ""Accounting Versus Accountability." This article highlights the need for financial accountability in our economy. It cites the collapsing financial institutions and the costly mismanagement exposed by the likes of "the multi-billion Bura Irrigation Scheme.". In: Journal for the Institute of Certified Public Accountants of Kenya. (pages 4-6). RIVERBRROKS COMMUNICATIONS; Submitted. Abstract
Journal of the Institute of Certified Public Accountants of Kenya. (pages 13-15)
N PROFNZOMODAUDI. ""Accounting Versus Accountability." This article highlights the need for financial accountability in our economy. It cites the collapsing financial institutions and the costly mismanagement exposed by the likes of "the multi-billion Bura Irrigation Scheme.". In: Journal for the Institute of Certified Public Accountants of Kenya. (pages 4-6).; Submitted. Abstract

Journal of the Institute of Certified Public Accountants of Kenya. (pages 13-15)

N PROFKAMAUGEOFREY. "Accumulation of DDT residues in aquarium fish, sediment, plant and water," Accepted, J. Environment International.". In: Submitted to Journal of Electrochimica Acta. Survey Review; Submitted. Abstract
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Mwangi W.E., Mogoa E.M N-MJ, C.M. M. "Addition of xylazine in epidural ketamine anaesthesia causes cardiopulmonary depression but minimizes hematological changes in dogs." International journal of veterinary sciences. Submitted;5. Abstract
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KICHAMU MRAKIVAGASYMONDS. "Adult Education and political culture, S.K. Akivaga.". In: East Afr. Medi. Journal. Elsevier; Submitted. Abstract
Analysis of 355 cases with fractures of the mandible indicated that 74.9% of the cases were due to interpersonal violence and 13.8% were caused by road traffic accidents. The men to women ratio was 8.4:1 and 75.5% of the fracture cases had single fractures while 24.5% had multiple fractures. In cases with a single fracture, the most commonly involved mandibular site was the body (42.2%). The angle of mandible was most frequently fractured (50.5%) in cases with multiple fractures.
CLAUDIO MRACHOLA. "Algebra 1 and 11 (O.D.L Lecture Notes).". In: E.A.E.P. Journal of British Ceramic Transactions, 99 [5], 206-211.; Submitted.
N PROFNZOMODAUDI. ""All Expenditures must be properly authorized." Continuing on the theme of planning and management control, this article delineates and discusses some of the most effective financial control mechanisms. Management:.". In: Journal of the Kenya Institute of Management. (pages 9-10). RIVERBRROKS COMMUNICATIONS; Submitted. Abstract
Journal of the Institute of Certified Public Accountants of Kenya. (pages 13-15)
N PROFNZOMODAUDI. ""All Expenditures must be properly authorized." Continuing on the theme of planning and management control, this article delineates and discusses some of the most effective financial control mechanisms. Management:.". In: Journal of the Kenya Institute of Management. (pages 9-10).; Submitted. Abstract

Journal of the Institute of Certified Public Accountants of Kenya. (pages 13-15)

Aduda BOC, Egbe PDDDAM, Musembi RJ, WAITA SEBASTIAN, Kaduki KA, Simiyu J, Agacho A, Nyongesa F. "ANSOLE Mini-Symposium in Kenya (AMSK 2013).". Submitted. Abstract
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B. PROFESTAMBALEBENSON. "Antibodies in the serum of golden hamsters experimentally infected with the intestinal trematode Echinostoma caproni. J Helminthol. 1991 Dec;65(4):239-47. Erratum in: J Helminthol 1992 Mar;66(1):78.". In: J Helminthol. 1991 Dec;65(4):239-47. Erratum in: J Helminthol 1992 Mar;66(1):78. Taylor & Francis; Submitted. Abstract
The serum antibody response in golden hamsters (Mesocricetus auratus) infected with the intestinal trematode Echinostoma caproni was examined with ELISA, SDS-PAGE and Western blot, and IFAT techniques. All methods showed that the hamsters responded slowly but developed a clear positive humoral response to the infection. In most hamsters, an antibody response to infection could not be detected earlier than 11-13 weeks after infection with 6 or 25 metacercariae, and responses were weak when compared to previous results from mice infected with the same parasite. IFAT with positive hamster sera on live juvenile E. caproni showed only fluorescence at the posterior tip, which is a different pattern from that seen using from infected mice, indicating a different response to antigens on the juvenile parasites by these two hosts. The results are discussed in relation to the limited selfcure and development of resistance which is observed in golden hamsters infected with E. caproni.
N PROFKAMAUGEOFREY. "The antihypertensive Effect of an extract from the Bark of Podocarpus Sp",.". In: Submitted, East Africa Medical Journal. Survey Review; Submitted. Abstract
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O DROGARAWILLIAM. "Antimicrobial susceptibility of non-sorbitol fermenting Escherichia coli isolated from cattle feaces and milk samples.". In: Journal. African Journal of Microbiology Research; Submitted.
O DROGARAWILLIAM. "Antimicrobial susceptibility of non-sorbitol fermenting Escherichia coli isolated from cattle feaces and milk samples.". In: Journal. African Journal of Microbiology Research; Submitted.
O DROGARAWILLIAM. "Antimicrobial susceptibility of non-sorbitol fermenting Escherichia coli isolated from cattle feaces and milk samples.". In: Journal. African Journal of Microbiology Research; Submitted.
AKUMU PROFODIRAPATTSM, K. MRNGARISAMUEL. ""Application of Ground Charcoal as a Coarse Medium in Dual Media Filtration of Water". East African Journal of Engineering.". In: Jadini Beach Hotel, Mombasa. IBIMA Publishing; Submitted. Abstract
Joint exhibition of paintings and sculptures
AKUMU PROFODIRAPATTSM, K. MRNGARISAMUEL. ""Application of Ground Charcoal as a Coarse Medium in Dual Media Filtration of Water". East African Journal of Engineering.". In: Canadian and International Education Journal. VOL: 19, No:1'1990. Prof. James Otieno-Odek; Submitted. Abstract

This paper reports the detailed results of a study of the impact of the Health Workers for Change (HWFC) workshop series on clients' perceptions of health services, relationships within the health centre and relations between the health facility and the district health system. The study was carried out in three stages: baseline, intervention and evaluation over a period of 20 months. Data, both qualitative and quantitative, were collected at three levels: client, facility and system. Results indicate that relations between health workers and clients improved a great deal after the intervention while those between the facility and the system remained to a large extent unchanged. The paper concludes that, with external support and help, especially from the health system level, health workers can work towards improving health services and their job satisfaction, which can lead to better health worker-client relations.

AKUMU PROFODIRAPATTSM, K. MRNGARISAMUEL. ""Application of Ground Charcoal in the Removal of Organic Matter in Water Treatment". East African Journal of Engineering.". In: East African Journal of Engineering. IBIMA Publishing; Submitted. Abstract
Joint exhibition of paintings and sculptures
AKUMU PROFODIRAPATTSM, K. MRNGARISAMUEL. ""Application of Ground Charcoal in the Removal of Organic Matter in Water Treatment". East African Journal of Engineering.". In: East African Journal of Engineering. Prof. James Otieno-Odek; Submitted. Abstract

This paper reports the detailed results of a study of the impact of the Health Workers for Change (HWFC) workshop series on clients' perceptions of health services, relationships within the health centre and relations between the health facility and the district health system. The study was carried out in three stages: baseline, intervention and evaluation over a period of 20 months. Data, both qualitative and quantitative, were collected at three levels: client, facility and system. Results indicate that relations between health workers and clients improved a great deal after the intervention while those between the facility and the system remained to a large extent unchanged. The paper concludes that, with external support and help, especially from the health system level, health workers can work towards improving health services and their job satisfaction, which can lead to better health worker-client relations.

ARAP MRKENDUIWOJOHNK. "An Application of The Transportation Model: The case of Inter-factory Transfer of Bulk Whole Milk at The Kenya co-operative Creameries (KCC) Limited (MBA Research project paper of the University of Nairobi).". In: E.A.J.P.Sc. 1 (1998) 1-27. Folio Morphol; Submitted. Abstract
Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica. In the present study, the mechanism of anticancer effect of AA on skin cancer was investigated. AA decreased viability and induced apoptosis in human melanoma SK-MEL-2 cells in a time- and dose-dependent manner. AA also markedly increased intracellular reactive oxygen species (ROS) level and enhanced the expression of Bax but not Bcl-2 protein in the cells. In addition, AA-induced activation of caspase-3 activity in a dose-dependent manner. Pretreatment with Trolox, an antioxidant, significantly blocked the induction of Bax and activation of caspase-3 in AA-treated cells. Furthermore, Ac-DEVD-CHO, a specific caspase-3 inhibitor, and Trolox prevented the AA-induced apoptosis. AA did not elevate p53 nuclear protein levels that are present in a mutant form in SK-MEL-2 cells. These results suggest that AA-induced apoptosis may be mediated through generation of ROS, alteration of Bax/Bcl-2 ratio and activation of caspase-3, but p53-independent. These results further suggest that AA may be a good candidate for the therapeutic intervention of human skin cancer.
PAUL PROFBAKI. "Astrophysics In The Quest for Renewable Source of Energy, Proceedings of The Third TWAS .". In: The Third TWAS . Heinrich Boll Foundation.; Submitted.
In Press
S. Z, G. C, I. V, G. B, D.M. H, K.M. M, J.R. B. "Adaptive radiation of the endemic Alcolapia cichlids of the East African soda lakes: genetic and morphological perspectives." Journal of Evolutionary Biology. In Press.
Wamalwa P, Okoti M MHMKMBB. "Adoption of Improved Biomass Cook Stoves: Case Study of Baringo and West Pokot Counties in Kenya." Journal of Sustainable Bioenergy Systems. In Press.
Oloo CM, Onyari JM, Wanyonyi WC, Wabomba JN, Muinde VM. "Adsorptive removal of hazardous crystal violet dye form aqueous solution using Rhizophora mucronata stem-barks: Equilibrium and kinetics studies." Environmental Chemistry and Ecotoxicology. In Press. AbstractEnvironmental Chemistry and Ecotoxicology

Description
Adsorption of crystal violet (CV) dye from aqueous solution using dried bark powder of mangrove species Rhizophora mucronata was studied. Characterization of adsorbent was done using FTIR and SEM. Batch experiment was carried out to examine the viability of using mangrove bark for adsorption of CV dye from aqueous solutions under different process conditions. The result revealed that removal of CV increased with contact time, adsorbent dose, initial dye concentration and decreased with increased particle size and ionic strength. pH 7 was the optimum pH for CV dye removal. The adsorption equilibrium for CV dye by Rhizophora mucronata stem-bark was attained within 60 min with removal efficacy of up to 99.8%. Pseudo-second-order kinetic model was best used to describe sorption kinetics while Freundlich isotherm model was appropriate for describing adsorption isotherm. The results demonstrated …

Kamugisha M, Mutembei HM TT. "Assessing the value of agroforestry and food security among households in Isingiro District, South-Western Uganda." International Journal of Sustainable Development and World Ecology. In Press:1-16.
2022
Mary T. Simiyu, Nyongesa FW, Birech Z, Njenga L, Ilin N, Thomas F. Krauss, Pitruzzello G, Aduda BO. "Application Of Molasses In Improving Water Purification Efficiency Of Diatomaceous Earth-Waste Ceramic Membranes.". In: EAI International Conference on Innovations and Interdisciplinary Solutions for Underserved Areas (INTERSOL 2022) . Nile University Of Nigeria Abuja ; 2022. Abstract

The World Health Organization predicts that 90.0% of the 2.3 million people who die annually due to water-borne diseases come from developing countries. At the same time fluorosis occurrence in the world’s geological fluoride belts has left many people maimed due to drinking highly fluoridated water. This work reports on the use of molasses in making carbon-activated diatomaceous earth waste (DE-waste) ceramic membranes with improved mechanical strength and water purification efficiency. The fabricated diatomaceous membranes were soaked in molasses for 24.0 hours and fired at 600.0 for 3.0 hours. The carbon-activated membranes were used to filter water contaminated with Escherichia coli, Rotavirus, and sodium fluoride. The activated carbon obtained in this work had a bulk density of 450.0 kg/m3 and it reduced the porosity of the DE-waste membranes by 18.0%. The activated carbon improved the modulus of rupture (MOR) of the DE-waste membrane by 47.8% and the average pore size of the active DE-waste membrane was 18.4 nm. The filtration process was found to be dependent on the contaminant’s size, concentration, and the external pressure applied to the water during the filtration process. The filtration efficiency of >99.9 in E. coli was concentration and pressure. Membranes reported efficiency of 97.1% and 98.9% in deflouridation and Rotavirus filtration. Thus, molasses is potential material in fabrication of water membranes

Vannevel V, Vogel JP, Pattinson RC, Adanu R, Charantimath U, Goudar SS, Gwako G, Kavi A, Maya E, Osoti A, Pujar Y, Qureshi ZP, Rulisa S, Botha T, Oladapo OT. "Antenatal Doppler screening for fetuses at risk of adverse outcomes: a multicountry cohort study of the prevalence of abnormal resistance index in low-risk pregnant women." BMJ Open. 2022;12(3):e053622. Abstract

Few interventions exist to address the high burden of stillbirths in apparently healthy pregnant women in low- and middle-income countries (LMICs). To establish whether a trial on the impact of routine Doppler screening in a low-risk obstetric population is warranted, we determined the prevalence of abnormal fetal umbilical artery resistance indices among low-risk pregnant women using a low-cost Doppler device in five LMICs.

Mwikamba JN, Otieno DJ, Oluoch-Kosura W. "Adoption of climate-smart horticulture practices and use of mobile phones in Taita-Taveta County, Kenya." East African Agricultural and Forestry Journal. 2022;85(1-4):312-324.
J O’o, J M, I O, T A. "Anatomical Variations of the Fifth Lumbar Artery in a sample Kenyan population." Ann Afr surg. 2022;19(2):100-107. AbstractWebsite

bstract
Background: Anatomical variations of lumbar arteries predispose them to iatrogenic injury during endovascular intervention or surgery. Due to limited morphological data on lumbar arteries in our setting, we aimed to determine their variant anatomy among Kenyans.

Methods: We performed the study on 90 cadaveric specimens and 120 computed tomography (CT) scans. Cadavers were dissected to expose the aorta and the lumbar arteries emerging from them. The number, origins, location relative to the vertebral bodies, and relations to aortic bifurcation were determined in cadavers and CT scans. Data were analyzed using SPSS (version 21.0).

Results: On average, 3 (3/90 [3.3%]), 4 (63/90 [70%]) or 5 (24/90 [26.7%]) pairs of lumbar arteries were observed among the cadaveric specimens, whereas 4 (100/120 [83.3%]) or 5 (20/120 [16.7%]) pairs were observed in CTs. Differences in the number of pairs observed in the cadaveric versus CT study were not statistically significant (P = .542). There were no sex differences in the number of lumbar artery pairs observed in CT scans (P = .178). The first 3 lumbar artery pairs had a single-origin, whereas the fourth lumbar artery had a common-stem origin. The first, second, and third lumbar arteries mostly originated at the upper third of their respective vertebral bodies. The fourth lumbar artery predominantly originated at the lower third.

Conclusion: Our study's findings show unique variation in the lumbar arteries' relation to the vertebral bodies and the distances between artery pairs.

Level of evidence: IV (cross-sectional study).

Clinical relevance: Variations in the anatomy of the lumbar arteries should be taken into consideration, especially in surgical or interventional procedures to avoid inadvertent injury of the vessels.

Mbindyo SN, Abuom TO, KITAA JAFREDMA. "Antibiotic Resistance and Stewardship in Small Animal Practice-A Review." Journal of Veterinary Medicine and Animal Sciences. 2022;5(1):1102.
Muchiri J. "The Art of Narrating Pain in Margaret Ogola’s Place of Destiny." The Journal of Language, Technology & Entrepreneurship in Africa. 2022;13(1):221-250.the_art_of_narrating_pain_in_place_of_destiny_2022.pdf
Nguli M, Gatari MJ, Keith Shepherd, Njenga L, Boman J. "Assessment of Essential Micronutrient Levels in Common Beans (Phaseolus vulgaris) in Kenya by Total reflection X-ray Fluorescence (TXRF)." X-Ray Spectrometry. 2022;2022. Abstract

This study reports concentrations of Mn, Fe, Cu and Zn analysed from Kenyan bean grains and leaves using Total Reflection X-ray Fluorescence (TXRF) and Inductively Coupled Plasma – Optical Emission Spectrometry (ICP-OES) methods. Samples of fresh bean leaves and 7 species of dry grains were collected from small scale farmers in Machakos and Kiambu counties. They were delivered to the laboratory where bean grain samples for TXRF analysis were prepared and leaves for both TXRF and ICP-OES. Standard methods of sample preparation successfully tested and used by other authors were used, Average elemental concentrations of the samples were then compared with established sufficiency values mainly given in ranges. Bean leaves from Muguga had sufficient Mn, Ni and Cu concentrations while 6% of the samples had Zn concentrations higher than the sufficiency range. Fe concentrations were consistently high with 97% of the samples having concentrations that were higher than the sufficiency range. No deficiencies were observed from bean leaves from Kyevaluki. For dry bean grains, deficiencies were observed in which four species were found to be deficient in Mn while Zn deficiency was observed in all the species. Fe concentrations were above the sufficiency ranges for all the species but not to toxic levels and 29% of the samples had Cu concentrations that were within the sufficiency range. The obtained data will be essential information for both farmers and policy makers on the nutritional quality of beans in the sampled areas. However, further studies are recommended including soil analysis and elemental bioavailability for full nutritional assessment. Keywords: ICP-OES, hidden hunger, mortality rate, cognitive development, bioavailable

PN R, GO O, O AE, L A, J K. "Assessment of Guideline Concordant Antibiotic Prescribing for Patients with Community Acquired Pneumonia at The Kenyatta National Hospital Medical Wards." Journal of Kenya Association of Physicians. 2022;5(1):34-42. Abstractassessment_of_guideline_concordant_antibiotic_prescribing.pdf

Background: Pneumonia is a major cause of morbidity
and mortality globally. Despite the proven benefits of
guideline concordant antibiotic prescribing, research
has shown that adherence to clinical guideline
recommendations is dismal.
Objectives: The study aims to determine utilization of
Kenyatta National Hospital antibiotic guideline titled
‘The KNH guide to empiric antimicrobial therapy
2018’ in the management of community acquired
pneumonia in the Kenyatta National Hospital medical
wards and the perceived barriers towards the utilization
of this guideline.
Materials and methods: A check list derived from the
Kenyatta National Hospital (KNH) guide to empiric
antimicrobial therapy 2018 was used to assess guideline
concordance based on seven quality indicators:
empiric antibiotic, dose and route of administration,
switch to oral antibiotics, duration of antibiotics (at
least 5 days), collection of microbiological samples
before initiating antibiotics, review of antibiotics at 48
hours and once the culture results are out. Online selfadministered questionnaires were used to determine
attitude and perceived barriers towards utilization
of the KNH guideline among the Internal Medicine
registrars and medical officers.
Analysis: Descriptive statistics were applied in
the representation of each of the seven quality
indicators. These were then compared with the
guideline recommendations and adherence to the
guideline for each parameter was expressed as a
percentage of the total number of patients admitted
with community acquired pneumonia. These were
then graded into the following categories based on the
level of concordance: Good >90%, Intermediate 60-
90%, poor <60%. Questions on the attitude and the
perceived barriers towards KNH guideline utilization
were answered using a 5 point Likert scale. Perceived
barrier statements that were positively formulated
were then recorded so that a lower score meant a
lower level of the perceived barriers and vice versa.
Percentages were then calculated for the total number
of doctors that agreed or strongly agreed that the
barrier was applicable. An open ended question on the
top three barriers to the KNH guideline utilization was
also included in the questionnaire.
Results: For each of the other quality indicators,
adherence to the KNH guideline for patients with
community acquired pneumonia was as follows:
empiric antibiotic choice 48%, collection of samples
for culture prior to antibiotic administration 0%, review
of antibiotics at 48 hours 26.4%, review of antibiotics
with culture results 45.8%, total duration of antibiotics
28.8% and time to switch to oral antibiotics 3.6%. The
top three barriers towards guideline utilization among
the doctors were: unavailability of drugs (52.7%),
inaccessibility of the KNH guideline (45.1%) and lack
of or delay of investigations (34.1%).
Conclusion: This study has demonstrated that the level
of adherence to the seven quality indicators from the
KNH guide is poor with the overall adherence being
35.5%. The recommendation least adhered to was
collection of microbiological samples before initiation
of empiric antibiotics. The most commonly identified
barriers to utilization of the guideline were external
and guideline related barriers.
Key words: Guide to empiric antimicrobial therapy
2018, Guideline Concordance antibiotic prescribing,
Community acquired pneumonia

Abdirahman FA, Wahome RG. "Assessment of the effects of Newcastle disease vaccination on chicken mortality and egg production rates in Machakos town sub-county, Kenya." International Journal of Livestock Production. 2022;12(4):168-175.
Wachira SN, Ndwigah SN, Ongarora DSB, Okaru AO. "Assessment of the Quality of Sodium Hypochlorite and Hydrogen Peroxide product samples in Nairobi County." International Journal of Novel Research and Development. 2022;7(3):503-514.
2021
Chikwana N, Maina EN, Gavamukulya Y, Bulimo W, Wamunyokoli F. "Antiproliferative Activity, c-Myc and {FGFR}1 Genes Expression Profiles and Safety of Annona muricata Fruit Extract on Rhabdomyosarcoma and {BALB}/c Mice." Journal of Complementary and Alternative Medical Research. 2021:30-46. AbstractWebsite
n/a
Geno KPO, Ralwala AO. "Assessment of Heat Stress Exposure on Construction Workers in Hot and Humid Environments during the Covid-19 Pandemic Period.". In: (Re)Setting Built Environment Theory and Practice in a Post-pandemic World: Disrupted Buildings or Design for Disruption. School of Architecture and Building Sciences (SABS) online (virtual) conference, JKUAT; 2021.
Koteng POG, Ralwala AO. "Assessment of Heat Stress Exposure on Construction Workers in Hot and Humid Environments during the Covid-19 Pandemic Period. .". In: (Re)Setting Built Environment Theory and Practice in a Post-pandemic World: Disrupted Buildings or Design for Disruption. School of Architecture and Building Sciences (SABS) online (virtual) conference, JKUAT; 2021.
Nyumba TO, Sang CC, Olago DO, Marchant R, Waruingi L, Githiora Y, Kago F, Mwangi M, Owira G, Barasa R, Omangi S. "Assessing the ecological impacts of transportation infrastructure development: A reconnaissance study of the Standard Gauge Railway in Kenya." PLOS ONE. 2021;16(1):e0246248-. AbstractWebsite

Transportation infrastructure, such as railways, roads and power lines, contribute to national and regional economic, social and cultural growth and integration. Kenya, with support from the Chinese government, is currently constructing a standard gauge railway (SGR) to support the country’s Vision 2030 development agenda. Although the actual land area affected by the SGR covers only a small proportion along the SGR corridor, a significant proportion of the area supports a wide range of ecologically fragile and important ecosystems in the country, with potential wider impacts. This study used a qualitative content analysis approach to gain an understanding and perceptions of stakeholders on the potential ecological impacts of the interactions between the SGR and the traversed ecological systems in Kenya. Three dominant themes emerged: 1) ecosystem degradation; 2) ecosystem fragmentation; and 3) ecosystem destruction. Ecosystem degradation was the most commonly cited impact at while ecosystem destruction was of the least concern and largely restricted to the physical SGR construction whereas the degradation and fragmentation have a much wider footprint. The construction and operation of the SGR degraded, fragmented and destroyed key ecosystems in the country including water towers, protected areas, community conservancies and wildlife dispersal areas. Therefore, we recommend that project proponents develop sustainable and ecologically sensitive measures to mitigate the key ecosystem impacts.

Zheng Y, Yang X-W, Schols D, Mori M, Botta B, Chevigné A, Mulinge M, Steinmetz A, Schmit J-C, Seguin-Devaux C. "Active Components from Prevent HIV-1 Entry by Distinct Mechanisms of Action." Int J Mol Sci. 2021;22(9). Abstract

is widely used in Sub-Saharan Africa for treating many diseases, including HIV-1 infection. We have recently described the chemical structures of 28 compounds isolated from an alcoholic crude extract of barks and roots of , and showed that six bioactive compounds inhibit HIV-1 infection. In the present study, we demonstrate that the six compounds block HIV-1 entry into cells: oleanolic acid, palmitic acid, taxifolin, piceatannol, guibourtinidol-(4α→8)-epiafzelechin, and a novel compound named as cassiabrevone. We report, for the first time, that guibourtinidol-(4α→8)-epiafzelechin and cassiabrevone inhibit HIV-1 entry (IC of 42.47 µM and 30.96 µM, respectively), as well as that piceatannol interacts with cellular membranes. Piceatannol inhibits HIV-1 infection in a dual-chamber assay mimicking the female genital tract, as well as HSV infection, emphasizing its potential as a microbicide. Structure-activity relationships (SAR) showed that pharmacophoric groups of piceatannol are strictly required to inhibit HIV-1 entry. By a ligand-based in silico study, we speculated that piceatannol and norartocarpetin may have a very similar mechanism of action and efficacy because of the highly comparable pharmacophoric and 3D space, while guibourtinidol-(4α→8)-epiafzelechin and cassiabrevone may display a different mechanism. We finally show that cassiabrevone plays a major role of the crude extract of by blocking the binding activity of HIV-1 gp120 and CD4.

Gwako GN, Obimbo MM, Gichangi PB, John Kinuthia, James N Kiarie, Gachuno OW, Were F. "Association between obstetric and medical risk factors and stillbirths in a low-income urban setting." Int J Gynaecol Obstet. 2021;154(2):331-336. Abstract

To evaluate the association between obstetric and medical risk factors and stillbirths in a Kenyan set-up.

Brizuela V, Cuesta C, Bartolelli G, Abdosh AA, Abou Malham S, Assarag B, Castro Banegas R, Díaz V, El-Kak F, El Sheikh M, Pérez AM, Souza JP, Bonet M, Abalos E. "Availability of facility resources and services and infection-related maternal outcomes in the WHO Global Maternal Sepsis Study: a cross-sectional study." Lancet Glob Health. 2021;9(9):e1252-e1261. Abstract

Infections are among the leading causes of maternal mortality and morbidity. The Global Maternal Sepsis and Neonatal Initiative, launched in 2016 by WHO and partners, sought to reduce the burden of maternal infections and sepsis and was the basis upon which the Global Maternal Sepsis Study (GLOSS) was implemented in 2017. In this Article, we aimed to describe the availability of facility resources and services and to analyse their association with maternal outcomes.

Gwako GN, Were F, Obimbo MM, John Kinuthia, James N Kiarie, Gachuno OW, Gichangi PB. "Association between utilization and quality of antenatal care with stillbirths in four tertiary hospitals in a low-income urban setting." Acta Obstet Gynecol Scand. 2021;100(4):676-683. Abstract

About 2.6 million stillbirths per year occur globally with 98% occurring in low- and middle-income countries including Kenya, where an estimated 35 000 stillbirths occur annually. Most studies have focused on the direct causes of stillbirth. The aim of this study was to determine the association between antenatal care utilization and quality with stillbirth in a Kenyan set up. This information is key when planning strategies to reduce the stillbirth burden.

Golden L, Chaya S, Reichmuth K, Visagie A, Ayuk A, Kwarteng Owusu S, Marangu D, Affendi N, Lakhan A, Gray D, Vanker A, Zar H, Zampoli M. "Aetiology and presentation of childhood pleural infections in the post-pneumococcal conjugate vaccine era in South Africa." Afr J Thorac Crit Care Med. 2021;27(4). Abstract

Complications of respiratory infections including pleural effusion (PE) are associated with a high morbidity. Differentiating between PE caused by (Mtb) infection and other bacterial infections in endemic areas is difficult in children, thus, impacting treatment.

Garelick S, Russell JM, Dee S, Verschuren D, Olago DO. "Atmospheric controls on precipitation isotopes and hydroclimate in high-elevation regions in Eastern Africa since the Last Glacial Maximum.". 2021;567:116984. AbstractWebsite

Tropical Africa experienced large changes in hydroclimatic conditions since the Last Glacial Maximum (LGM), ∼26.5 to 19 thousand years (ka or kyr) ago. The hydrogen isotopic composition of fossil leaf waxes (δDwax), assumed to record past variations in the hydrogen isotopic composition of precipitation (δDprecip), is increasingly being used to study past hydroclimatic change in Africa, and are commonly interpreted to reflect variation in the amount of precipitation through time (i.e., the amount effect). Although there are now many such δDprecip records from tropical Africa, there are few robust δDprecip records from easternmost equatorial Africa of sufficient length and resolution to evaluate the mechanisms governing hydroclimate variation during and since the LGM. We produced a new δDprecip record based on analyses of δDwax in sediment cores collected from Lake Rutundu, situated at an elevation of 3,078 meters above sea level (m asl) on Mt. Kenya. This record displays large variations in δDprecip corresponding with known climate events over the past 25 kyr, including D-enrichment during the Heinrich 1 stadial (H1) and the Younger Dryas (YD), and D-depletion during the Holocene portion of the African Humid Period (AHP). We also observe D-depletion during the LGM relative to the late Holocene, which, considering the amount effect, could be interpreted to imply that LGM climate conditions were wetter than today. However, because other hydroclimate proxies at this site indicate a drier LGM climate at Lake Rutundu, and since precipitation isotopes at this high-elevation site are likely influenced by different processes than at low elevations, we used a single-column Rayleigh distillation model to evaluate temperature and altitude-related effects on high-elevation δDprecip. This revealed that a change in the temperature lapse rate exerts strong control on δDprecip in this high-elevation setting, and that a steeper lapse rate could explain the observed D-depletion during the LGM at our site. Comparison of the Lake Rutundu δDprecip record with other leaf-wax based δDprecip records from East Africa indicates that changes in the meridional precipitation gradient associated with the mean annual position and intensity of the tropical rain belt, in turn driven by precessional insolation forcing, were likely a primary control on East African hydroclimate over the past 25 kyr, thereby contributing to overall regional drying during the LGM.

Garelick S, Russell JM, Dee S, Verschuren D, Olago DO. "Atmospheric controls on precipitation isotopes and hydroclimate in high-elevation regions in Eastern Africa since the Last Glacial Maximum.". 2021;567:116984. AbstractWebsite

Tropical Africa experienced large changes in hydroclimatic conditions since the Last Glacial Maximum (LGM), ∼26.5 to 19 thousand years (ka or kyr) ago. The hydrogen isotopic composition of fossil leaf waxes (δDwax), assumed to record past variations in the hydrogen isotopic composition of precipitation (δDprecip), is increasingly being used to study past hydroclimatic change in Africa, and are commonly interpreted to reflect variation in the amount of precipitation through time (i.e., the amount effect). Although there are now many such δDprecip records from tropical Africa, there are few robust δDprecip records from easternmost equatorial Africa of sufficient length and resolution to evaluate the mechanisms governing hydroclimate variation during and since the LGM. We produced a new δDprecip record based on analyses of δDwax in sediment cores collected from Lake Rutundu, situated at an elevation of 3,078 meters above sea level (m asl) on Mt. Kenya. This record displays large variations in δDprecip corresponding with known climate events over the past 25 kyr, including D-enrichment during the Heinrich 1 stadial (H1) and the Younger Dryas (YD), and D-depletion during the Holocene portion of the African Humid Period (AHP). We also observe D-depletion during the LGM relative to the late Holocene, which, considering the amount effect, could be interpreted to imply that LGM climate conditions were wetter than today. However, because other hydroclimate proxies at this site indicate a drier LGM climate at Lake Rutundu, and since precipitation isotopes at this high-elevation site are likely influenced by different processes than at low elevations, we used a single-column Rayleigh distillation model to evaluate temperature and altitude-related effects on high-elevation δDprecip. This revealed that a change in the temperature lapse rate exerts strong control on δDprecip in this high-elevation setting, and that a steeper lapse rate could explain the observed D-depletion during the LGM at our site. Comparison of the Lake Rutundu δDprecip record with other leaf-wax based δDprecip records from East Africa indicates that changes in the meridional precipitation gradient associated with the mean annual position and intensity of the tropical rain belt, in turn driven by precessional insolation forcing, were likely a primary control on East African hydroclimate over the past 25 kyr, thereby contributing to overall regional drying during the LGM.

Musiny RI, Mbari JM, Ole-Mapenay IM. "Acute and Sub-acute toxicity of the aqueous leaf extract of Lantana trifolia (Verbenaceae) in experimental rodents." The Journal of Phytopharmacolog. 2021;10(5):350-356.
Wangusi BMUYUKANI, Kanja LW, Ole-Mapenay IM, Onyancha JM. "Acute Toxicity, Phytochemical Screening, Analgesic, and Anti-Inflammatory Activities of Aqueous and Methanol Root Extracts of Maerua triphylla A. Rich. (Capparaceae)." Evidence-Based Complementary and Alternative Medicine. 2021;Volume 2021, Article ID 3121785, :9 pages.
Wangusi BMUYUKANI, Kanja LW, Ole-Mapenay IM, Onyancha JM. "Acute Toxicity, Phytochemical Screening, Analgesic, and Anti-Inflammatory Activities of Aqueous and Methanol Root Extracts of Maerua triphylla A. Rich. (Capparaceae)." Evidence-Based Complementary and Alternative Medicin. 2021;2021:11.
Josephine Wangechi Kirui, Muthama NJ, Gachuiri CK, Ngaina JN. "Adaptation and mitigation strategies to climate change by smallholder dairy farmers: A case of Nandi county in Kenya." Journal of Sustainability, Environment and Peace. 2021;4(1):39-47.
Missiame A, Irungu P, Nyikal RA, Appiah-Kubi GD. ""Adoption of rural bank credit programs among smallholder farmers in Ghana: an average treatment effect estimation of rates of exposure and adoption and their determinants"." gricultural Finance Review. 2021. AbstractWebsite

Purpose
The study aims to estimate the rates of exposure to, and adoption of, rural bank credit programs by smallholder farmers in rural Ghana and the factors responsible for those rates.

Design/methodology/approach
The study used a random sample of 300 smallholder farmers in the Fanteakwa District of Ghana, obtained through the multistage sampling technique. The study also employed the average treatment effects approach to estimate the average treatment effect of farmers’ exposure to rural bank credit programs, on their adoption of such programs.

Findings
The actual adoption rate is approximately 41%, and the potential, conditional on the whole population being aware of rural bank credit programs, is approximately 61%. Accordingly, there is a gap of about 20% in the adoption of rural bank credit programs, and is due to the incomplete exposure of smallholder farmers to the rural bank credit programs. Age of the household head, access to extension services, membership in farmer-based organizations and active savings accounts with a rural bank are the major contributors to smallholder farmer exposure to and the adoption of rural bank credit programs.

Originality/value
The current study is the first of its kind to be conducted in Ghana on rural bank credit programs. It takes into account the extent to which smallholder farmers are exposed to such credit programs and how it influences their decisions to access or adopt.

Shagwira H, Mwema FM, MBUYA TO. "Advances in animal/plant–plastic composites: preparation, characterization and applications.". In: Plant and Animal Based Composites. Berlin: De Gruyter; 2021. Abstract

This book chapter aims at exploring the preparation, characterization and applications of plant/animal fiber-reinforced polymer composites. The book addresses several key research work that have been happening as well as some of the drawbacks that affect the application of these composites in real-life applications. Each chapter begins with an overview of the various forms of plant/animal fiber-reinforced polymer composites, followed by examples of composites made up of plant/animal fibers and their promising future in terms of research and development and application in domestic and engineering products. Today, man has realized that if the environment is not preserved, the over-consumption of naturally existing resources and a drastic reduction in the amount of fresh air generated in the world would endanger him. Forest conservation and the efficient use of agricultural as well as other renewable resources such as solar, wind and tidal energy have already become critical issues globally.With this kind of concern, the utilization of renewable materials such as plant/animal fiber-reinforced polymeric composites is slowly becoming a key design requirement for the design and development of parts for a wide range of industrial products. An extensive research into such composites can, to an extent, lead to an even greener and healthier environment

Amecha SC, Njue PN. "Agile Risk Management as a Solution to the Failure of Kenyan Public Projects." American Journal of Engineering and Technology Management. 2021;6(3):35-40.
Muchiri J, Osaaji M, Odari M. "The Agile Thinking and Subversion in Chinua Achebe’s The Education of a British-Protected Child." Nairobi Journal of Literature. 2021;9:124-143.
Abuga K, Nyamweya N. "Alcohol-Based Hand Sanitizers in COVID-19 Prevention: A Multidimensional Perspective." Pharmacy. 2021;9(1):64. Abstract

The global use of alcohol-based hand sanitizers (ABHS) as an important means of controlling the transmission of infectious disease has increased significantly as governments and public health agencies across the world advocated hand hygiene as a preventative measure during the COVID-19 pandemic. Although the performance of these products is most commonly defined as a function of their alcohol concentration, they are multifaceted products in which an interplay of several factors is important in determining efficacy. This paper discusses the interplay between ABHS input (formulation) factors and output (product performance) factors in the context of a multidimen-sional perspective using a novel representative paradigm. In the model, represented in the form of a three-dimensional tetrahedron, each of the faces represents inputs in the manufacturing of the ABHS product, which are the type and amount of alcohol, the inactive ingredients, the formulation and the manufacturing practices. The four corners of the tetrahedron represent the product per-formance factors which include product efficacy, sensory characteristics, usage and compliance and product safety. The multidimensional approach to the formulation and evaluation of ABHS shows that several factors contribute to the effectiveness and utility of these products. The paradigm provides a useful framework for manufacturers of ABHS and related healthcare products.

Babiaka SB, Simoben CV, Abuga KO, Mbah JA, Karpoormath R, Ongarora D, Mugo H, Monya E, Cho-Ngwa F, Sippl W, Loveridge JE, Ntie-Kang F. "Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling." Molecules. 2021;26(1):70. Abstract

A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine A (1), along with eight known compounds—voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), ibox-ygaine (6), voacamine (7), voacorine (8) and conoduramine (9)—were isolated from the stem bark of Voacanga africana. The structures of the compounds were determined by comprehensive spec-troscopic analyses. Compounds 1, 2, 3, 4, 6, 7 and 8 were found to inhibit the motility of both the microfilariae (Mf) and adult male worms of Onchocerca ochengi, in a dose-dependent manner, but were only moderately active on the adult female worms upon biochemical assessment at 30 μM drug concentrations. The IC50 values of the isolates are 2.49–5.49 µM for microfilariae and 3.45–17.87 µM for adult males. Homology modeling was used to generate a 3D model of the O. ochengi thioredoxin reductase target and docking simulation, followed by molecular dynamics and binding free energy calculations attempted to offer an explanation of the anti-onchocercal struc-ture–activity relationship (SAR) of the isolated compounds. These alkaloids are new potential leads for the development of antifilarial drugs. The results of this study validate the traditional use of V. africana in the treatment of human onchocerciasis.

Okeyo MP, Rambo CM, NYONJE RO. "Alternative Dispute Resolution mechanism and Resolution of Contractual Disputes in Construction Industry: the case of Road Construction Projects in Kenya. ." American Journal of Engineering Research (AJER) . 2021;10(2):61-70 .
Gichure M, Onono J, Wahome R, Gathura P. "Analysis of the benefits and production challenges of working donkeys in smallholder farming systems in Kenya." Veterinary World. 2021;13(11):2346.
Onyambu CK, Angeline Anyona Aywak, Osiemo SK, Mutala TM. "Anaphylactic Reactions in Radiology Procedures.". In: Asthma. London: IntechOpen; 2021.
Onyambu CK, Tharamba NM. "Antenatal Diagnosis of Congenital Anomalies on Ultrasound Screening.". In: Midwifery. London: IntechOpen; 2021.
"Antibacterial Activities and Phytochemical Screening of Crude Extracts from Kenyan Macaranga Species Towards MDR Phenotypes Expressing Efflux Pumps." Pharmacognosy Communications. 2021;11(2). AbstractPharmacognosy Communications

Description
Introduction:
Macaranga species are traditionally used for the treatment and management of coughing, fungal infection, and wounds. In this study, the phytochemical screening and antibacterial activities of nine crude extracts from Macaranga conglomerata, Macaranga kilimandscharica and Macaranga capensis were determined against 13 bacterial strains expressing multi-drug resistance (MDR) phenotypes.
Methods:
Phytochemical screening of the extracts were carried out according to the standard methods, while the iodonitrotetrazolium chloride (INT) colorimetric assay was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the plants extracts.
Results:
Flavonoids, terpenoids, saponins and coumarins were the major secondary metabolites found in all the plant extracts. The results of antibacterial studies revealed that all the plant extracts displayed good activities with MIC values ranging from 4–128 µg/mL against the tested micro-organisms. Most of the extracts exhibited a bactericidal effect against E. coli, E. aerogenes, K. pneumoniae, P. stuartii, P. aeruginosa, and

Hashim I, Omosa LK, Nchiozem-Ngnitedem V-A, Onyari JM, Maru SM, Guefack M-GF, Mbaveng AT, Kuete V. "Antibacterial Activities and Phytochemical Screening of Crude Extracts from Kenyan Macaranga Species Towards MDR Phenotypes Expressing Effux Pumps." Pharmacognosy Communications. 2021;11(2):119-126.hashim_et_al_2021_pharmacognosy_communications.pdf
Jepkoech C, Omosa LK, Nchiozem-Ngnitedem V-A, Kenanda EO, Guefack M-GF, Mbaveng AT, Kuete V, Heydenreich M. "Antibacterial secondary metabolites from Vernonia auriculifera Hiern (Asteraceae) against MDR phenotypes." Natural Products Research. 2021:https://doi.org/10.1080/14786419.2021.1953024.jepkoech_et_al_2021_natural_products_research.pdf
Armah FA, Henneh IT, Amponsah IK, Biney RP, F M, J A, W A, Ahmed MA, Adokoh CK, Adukpo G, O AD, Gathumbi PK. "Antidepressant and Anxiolytic Effects and Subchronic Toxicity of the Aerial Parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in Murine Models." Hindawi Veterinary Medicine International. 2021;Volume 2021, Article ID 5543320, 18 pages.armah_et_al_2021.pdf
Andima M, Ndakala A, Derese S, Biswajyoti S, Hussain A, Yang LJ, Akoth OE, Coghi P, Pal C, Heydenreich M, Wong VK-W, Yenesew A. "Antileishmanial and cytotoxic activity of secondary metabolites from Taberneamontana ventricosa and two aloe species." Natural Product Research. 2021:1-5. AbstractNatural Product Research

Description
In this study, the antileishmanial and cytotoxic activities of secondary metabolites isolated from Tabernaemontana ventricosa Hochst. ex A. DC., Aloe tororoana Reynolds, and Aloe schweinfurthii var. labworana Reynolds were investigated. Overall, nineteen known compounds were isolated from the three plant species. The compounds were characterized based on their spectroscopic data. Voacristine and aloenin were the most active compounds against promastigotes of antimony-sensitive Leishmania donovani (IC50 11 ± 5.2 μM and 26 ± 6.5 µM, respectively) with low toxicity against RAW264.7, murine monocyte/macrophage-like cells. The in silico docking evaluation and in vitro NO generation assay also substantially support the antileishmanial effects of these compounds. In a cytotoxicity assay against cancer and normal cell lines, ursolic acid highly inhibited proliferation of lung cancer cells, A549 …

Andima M, Ndakala A, Derese S, Biswajyoti S, Hussain A, Yang LJ, Akoth E, Coghi P, Pal C, Heydenreich M, Wong VK-W, Yenesew A. "Antileishmanial and Cytotoxic Activity of Secondary Metabolites from Taberneamontana ventricosa and Two Aloe Species." Natural Product Research. 2021.
Mbindyo CM, Gitao CG, Plummer PJ, Kulohoma BW, Mulei CM, Bett R. "Antimicrobial Resistance Profiles and Genes of Staphylococci Isolated from Mastitic Cow’s Milk in Kenya." Antibiotics. 2021;10(772):https://doi.org/10.3390/antibiotics10070772.antibiotics-10-00772_1.pdf
Juma M, Sankaradoss A, Ndomb R, Mwaura P, Damodar T, Nazir J, Pandit A, Khurana R, Masika M, Chirchir R, Gachie J, Krishna S, Sowdhamin R, Anzala O, Iyer MS. "Antimicrobial resistance profiling and phylogenetic analysis of Neisseria gonorrhoeae clinical isolates from Kenya in resource limited setting." Frontiers in Microbiology. 2021. AbstractWebsite

Background: Africa has one of the highest incidences of gonorrhea. Neisseria gonorrhoeae is gaining resistance to most of the available antibiotics, compromising treatment across the world. Whole-genome sequencing (WGS) is an efficient way of predicting AMR determinants and their spread in the population. Recent advances in next-generation sequencing technologies like Oxford Nanopore Technology (ONT) have helped in the generation of longer reads of DNA in a shorter duration with lower cost. Increasing accuracy of base-calling algorithms, high throughput, error-correction strategies, and ease of using the mobile sequencer MinION in remote areas lead to its adoption for routine microbial genome sequencing. To investigate whether MinION-only sequencing is sufficient for WGS and downstream analysis in resource-limited settings, we sequenced the genomes of 14 suspected N. gonorrhoeae isolates from Nairobi, Kenya.

Methods: Using WGS, the isolates were confirmed to be cases of N. gonorrhoeae (n = 9), and there were three co-occurrences of N. gonorrhoeae with Moraxella osloensis and N. meningitidis (n = 2). N. meningitidis has been implicated in sexually transmitted infections in recent years. The near-complete N. gonorrhoeae genomes (n = 10) were analyzed further for mutations/factors causing AMR using an in-house database of mutations curated from the literature.

Results: We observe that ciprofloxacin resistance is associated with multiple mutations in both gyrA and parC. Mutations conferring tetracycline (rpsJ) and sulfonamide (folP) resistance and plasmids encoding beta-lactamase were seen in all the strains, and tet(M)-containing plasmids were identified in nine strains. Phylogenetic analysis clustered the 10 isolates into clades containing previously sequenced genomes from Kenya and countries across the world. Based on homology modeling of AMR targets, we see that the mutations in GyrA and ParC disrupt the hydrogen bonding with quinolone drugs and mutations in FolP may affect interaction with the antibiotic.

Conclusion: Here, we demonstrate the utility of mobile DNA sequencing technology in producing a consensus genome for sequence typing and detection of genetic determinants of AMR. The workflow followed in the study, including AMR mutation dataset creation and the genome identification, assembly, and analysis, can be used for any clinical isolate. Further studies are required to determine the utility of real-time sequencing in outbreak investigations, diagnosis, and management of infections, especially in resource-limited settings.

Chepkirui C, Ochieng PJ, Sarkar B, Hussain A, Pal C, Yang LJ, Coghi P, Akala HM, Derese S, Ndakala A, Heydenreich M, Wong VKW, Erdélyi Máté, Yenesew A. "Antiplasmodial and antileishmanial flavonoids from Mundulea sericea." Fitoterapia. 2021;149:104796. AbstractView Website

Description
Five known compounds (1–5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6–8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 μM against chloroquine-resistant W2, and 6.6 μM against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 μM, respectively. In a cytotoxicity assay, lupinifolin (3) showed significant activity on BEAS-2B (IC50 4.9 μM) and HePG2 (IC50 10.8 μM …

Derese S. "Antiplasmodial and antileishmanial flavonoids from Mundulea sericea." Fitoterapia . 2021;149:104796.
Chikwana N, Maina EN, Gavamukulya Y, Bulimo W, Wamunyokoli F. "Antiproliferative Activity, c-Myc and FGFR1 Genes Expression Profiles and Safety of Annona muricata Fruit Extract on Rhabdomyosarcoma and BALB/c Mice." Journal of Complementary and Alternative Medical Research. 2021;14(4):30-46.
Mamadou Alieu Jallow, Weke Patrick, Lukman Abiodun Nafiu, Ogutu C. "Application of a Discrete time Semi–Markov Model to the Stochastic Forecasting of Capital Assets as Stock." Far East Journal of Theoretical Statistics, . 2021;63(1):1-18.
kariuki J, DiasTibihika P, ManuelCurto, EsayasAlemayehu, GeroldWinkler, HaraldMeimberg. "Application of microsatellite genotyping by amplicon sequencing for delimitation of African tilapiine species relevant for aquaculture.". 2021.
V. O, U. Y. "Application of Polymer Based Nanocomposites for Water Shutoff-A Review." Fuels. 2021;2:304-322. AbstractWebsite

One highly undesirable characteristic of mature assets that inhibits oil recovery is high
water production. Polymer gel treatment is a popular conformance improvement technique applied
in this regard due to its cost effectiveness and proved efficiency. Despite this popularity, optimum
performance of polymer hydrogels in water shut off is inhibited by excessive aggregation, difficulty
in controlling gelation, and their instability at high temperature and high salinity reservoir conditions.
To address these shortcomings, research on the application of nanoparticles (NPs) in polymer
hydrogels to manage thermal stability and salinity sensitivity has significantly increased in the recent
past. By incorporating metal-based NPs, silica or graphene at nanoscale; the gel strength, storage
modulus, salinity tolerance and thermal stability of commonly used polymers have been greatly
enhanced. In this paper, the advances in experimental studies on polymer-based nanocomposites are
discussed and field experiences from adoption of polymer composites reviewed.

Okumu MO, Mbuthia… PG, Mbaria JM, Gikunju JK. "Artemia salina as an animal model for the preliminary evaluation of snake venom-induced toxicity." Toxicon: X, 2021. 2021;X, 2021(X, 2021).
Okumu MO, Mbaria JM, Gikunju JK, Mbuthia PG, Madadi VO, Ochola FO, Jepkorir MS. "Artemia salina as an animal model for the preliminary evaluation of snake venominduced toxicity." Toxicon. DOI: https://doi.org/10.1016/j.toxcx.2021.100082. 2021.
Cherotich S, Abong’o DA, Onyatta JO. "Assessing the Seasonal Changes on Physicochemical Parameters and Major Nutrient Levels in Water and Sediments from Sulal River, Bureti Sub County, Kericho County, Kenya." Chemical Science International Journal. 2021;30(1):46-58. AbstractChemical Science International Journal

Abstract
Sulal River is a victim of nutrient pollution as it crosses different small-scale tea farms in Bureti Sub County, Kericho County. A study was conducted to evaluate different physicochemical parameters and major chemical fertilizer’s nutrients levels in water and sediments from Sulal River. In order to understand the degree of pollution in the river due to inflow of agricultural chemical fertilizer residue levels from its catchment, the samples were collected in the dry (February 2019) and wet seasons (November 2019). The ten chosen sampling sites stretched a length of 12 Km. Samples were analyzed for pH, dissolved oxygen (DO), total dissolved solids (TDS), electrical conductivity (EC), sediment and water content (WC), nitrate-nitrogen (NO3-N), phosphorous (PO3-P) and potassium (K) using standard methods. Results were analyzed using IBM SPSS 20. The average results during dry and wet seasons in water samples for pH were 6.72±0.05 and 6.38±0.21, DO 6.78±0.59 and 9.58±0.64 mg/L, EC 174±5.02 and 205±20.14 µS /cm, TDS 92±4.59 and 120.70±19.57 mg/L, NO3-N 0.58±0.21 and 1.19±0.22 mg/L, PO3-P 0.00±0.00 and 0.13±0.84 mg/L and K 0.26±0.08 and 0.84±0.19 mg/L respectively. The average results during dry and wet seasons in sediment samples for pH were 6.62±0.20 and 6.75±0.17, EC, 67±6.66 and 52±10.19 µS /cm, WC 16.96±3.95 and 129.84±5.00%, NO3-N 0.70±0.35 and 0.42±0.23 mg/kg, PO3-P 0.49±0.25 and 1.14±0.40 mg/kg and K 1.53±0.45 and 2.86±0.31 mg/kg respectively. The levels of P in water during wet season and in sediments samples in both seasons were however, above the WHO (0.025 mg/L) and KEBS (0.030 mg/L) recommended limit for drinking and domestic use and WASREB (0.005 mg/L) level for the likelihood of eutrophication. Availability of excess phosphorus can accelerate eutrophication. The diversity of cancers has also been associated with drinking water containing phosphorous levels. The water from Sulal River may be used for irrigation purposes but not for drinking and domestic purposes. Significant seasonal variations were observed in all parameters analyzed except NO3-N in sediments. This indicates that rainfall had a great effect on some soil physicochemical properties.

Mary Waceke Thongoh1*, Henry Mikiugu Mutembei2 JM3 BEK1. "An Assessment of Barriers to MSMEs’ Adoption of CSA in Livestock Red Meat Value Chain, Kajiado County, Kenya." American journal of Climate Change. 2021;(10):237-262.ajcc_2021073014503959.pdf
and Mary W. Thongoh1*, H. M. Mutembei2 M3 K1JBE. "An Assessment of Integration of MSMEs and CSA into Livestock Red Meat Value Chain: A Case Study of Kajiado County, Kenya." International Journal of Climate Change. 2021;11(4):1-17.30387-article_text-56879-2-10-20210607.pdf
Luvai AK, Obiero JPO, Omuto CT. "Assessment of Soil Loss in a Typical Ungauged Dam Catchment using RUSLE Model (Maruba Dam, Kenya)." Journal of Environment and Earth Science. 2021;Vol 11(No. 16):56-68.
Williams F, Constantine KL, Ali AA, Karanja TW, Kibet S. "An assessment of the capacity and responsiveness of a national system to address the threat of invasive species: a systems approach." CABI Agriculture and Bioscience. 2021;2(42):1-17.
Ochiba, N. K, Abong’o DA, Onyatta JO. "The Assessment of The Effect of Proximity of Septic Tanks on The Levels of Selected Heavy Metals in Borehole Water from Ongata Rongai, Kajiado County, Kenya." International Journal of Scientific Research in Science, Engineering and Technology. 2021;8(4):64-76.
Ochiba NK, Abong’o DA, Onyatta JO. "The Assessment of The Effect of Proximity of Septic Tanks on The Levels of Selected Heavy Metals in Borehole Water from Ongata Rongai, Kajiado County, Kenya." International Journal of Scientific Research in Science, Engineering and Technology. 2021;8(4):64-76. AbstractInternational Journal of Scientific Research in Science, Engineering and Technology

Description
The study was carried out to evaluate the levels of heavy metals in groundwater samples from ten selected boreholes in Ongata Rongai town, Kajiado County. The selected heavy metals analyzed were: Zn, Pb, Hg, Mn, Cd and Cr in the dry and wet seasons. The effect of the proximity of septic tanks distance to borehole was also determined. The statistical analyses of the data using a 2-way ANOVA showed 95% confidence level (p< 0.05) interdependence of the distance from the boreholes and contaminant levels. The study showed that heavy metals were below the maximum recommended level and the guideline values of World Health Organization and Kenya Bureau of Standards. The analyses of the selected heavy metals, by Flame Atomic Absorption Spectroscopy, revealed that the detected levels of Mn (0.03±0.01-0.26±0.01 mgl-1) were higher than those recommended by WHO and KEBS of 0.01 mgl-1, while Zn (0.11±0.02-0.73±0.01 mgl-1) are within acceptable levels of WHO (3.0 mgl-1) and KEBS (5.0 mgl-1). There was no strong correlation between the distance of borehole from septic tanks and heavy metal levels in water samples. The low detected values should not be overlooked as the heavy metals are capable of bio-accumulating in body tissues.

Gitau AK, Oyieke FA, W.R. Mukabana. "Assessment of the role played by domestic animals in jigger infection in Kandara sub-county, Kenya (case control study)." The Pan African Medical Journal. 2021;39:231.
Gitau AK2021, Oyieke FA, Wolfgang Richard Mukabana. "Assessment of the role played by domestic animals in jigger infection in Kandara sub-county, Kenya (case control study)." Pan African Medical Journal. 2021;39:231.2021-1.pdf
Gitau 2. AK, Oyieke FA, Wolfgang Richard Mukabana. "Assessment of tungiasis management knowledge in Kandara sub county Mukabana, ." Journal of Entomology and Zoology studies. 2021;9(4):127-136.2021-2.pdf
Gitau AK, Oyieke FO, Mukabana WR. "Assessment of tungiasis management knowledge in Kandara sub county, Kenya." Journal of Entomology and Zoology Studies. 2021;9(4):127-136.
Mwachaka P, Amayo A, Mwang’ombe N, Kitunguu P. "Association Between Serum Sodium Abnormalities and Clinicoradiologic Parameters in Se." Ann Afr Surg. 2021;18(3):155-162.
Maina SW, Dimba E, Oyugi JO, Mwangi JW. "Antimicrobial efficacy of Hibiscus Fuscus garcke aqueous and ethanol extracts on tooth root canal microorganisms." East African Medical Journal. 2021;98. Abstract
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Mbindyo CM, Gitao GC, Plummer PJ, Kulohoma BW, Mulei CM, Bett R. "Antimicrobial Resistance Profiles and Genes of Staphylococci Isolated from Mastitic Cow’s Milk in Kenya." Antibiotics. 2021;10. AbstractWebsite

Increasing numbers of potentially zoonotic multidrug-resistant (MDR) staphylococci strains, associated with mastitis in dairy cows, are being reported globally and threaten disease management in both animal and human health. However, the prevalence and antimicrobial resistance profiles of these strains, including methicillin-resistant staphylococci (MRS), in Kenya is not well known. This study investigated the drug resistance profiles and genes carried by 183 staphylococci isolates from 142 dairy cows representing 93 farms recovered from mastitis milk of dairy cows in two selected counties in Kenya. Staphylococci isolates were characterized by phenotypic characteristics, polymerase chain reaction (PCR) amplification, partial sequencing and susceptibility testing for 10 antimicrobial drugs. Detection of seven resistance genes to the various antimicrobial drugs was conducted using PCR. Overall, phenotypic resistance among the staphylococci ranged between 66.1% for ampicillin and 3.5% for fluoroquinolones. Twenty-five percent (25%) of S. aureus and 10.8% of the coagulase-negative staphylococci (CoNS) isolates, were methicillin-resistant staphylococci phenotypically (defined as resistance to cefoxitin disk diffusion). The most common genes found in S. aureus and CoNS were blaZ and strB at 44.3% and 26%, and 78% and 50%, respectively. MDR was observed in 29.67% and 16.3% of S. aureus and CoNS, respectively. These findings pose a threat to bovine mastitis treatment and management as well as human health.

Nyumba TO, Sang CC, Olago DO, Marchant R, Waruingi L, Githiora Y, Kago F, Mwangi M, Owira G, Barasa R, others. "Assessing the ecological impacts of transportation infrastructure development: A reconnaissance study of the Standard Gauge Railway in Kenya." PLoS one. 2021;16:e0246248. Abstract
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2020
Muthomi M, Mumenya S, Mwero J, Mwea S, Kyalo G. "Academia & Practice: A Case Study of Retrofitting Reinforced Concrete Columns with Carbon Fibre Reinforced Polymer Wrap.". In: Institution of Engineers Conference. Mombasa, Kenya; 2020.
Simiyu MT, Nyongesa FW, Aduda BO, Birech Z, Mwebaze G. "Application of An Organic Plant-Derived Binder in the Fabrication of Diatomaceous Earth Waste- Based Membranes for Water Purification Systems.". In: Materials Research Society Advances. Cambridge; 2020. Abstract

This work reports on the use of diatomaceous earth (DE) waste and organic binder derived from Corchorus olitorius, locally known as “Mrenda” in the design of an efficient water filtration membranes. Charcoal powder was incorporated to enhance the porosity of the membrane. The firing was done at temperatures varying from 700.0 °C to 1150.0 °C. The DE waste samples comprised 79.0% silica (by mass) and 11.0% total flux content compared to porter's clay that had 50.0% silica, 28.8% AL2O3 and 7.0% total flux content. On the other hand, the “Mrenda” binder contained 6.5% total organic matter. The use of the plant- derived binder enhanced the mechanical strength of the greenware by 52.7% and the fired membranes by 152.2%. The fabricated DE waste-based membranes were 15.0% stronger than clay-based ceramic membranes prepared under similar conditions. A sintering temperature of 900.0 °C was optimal in producing porous membranes for filtering of 4.1 liters of water per hour. The pore diameter of the membranes fabricated from DE waste only ranged between 2.0 nm – 99.0 nm. On micro-organisms filtering efficacy, the DE waste-based membranes and those fabricated with 5.0% charcoal were 99.9% and 88.4% effective in the removal of E. coli and Rotavirus respectively.

Munyua M M, W MS, N MJ, SK M, Kyalo G. "Academia & Practise: A Case Study of Retrofitting reinforced Concrete Columns with Carbon Fiber reinforced Polymer Wrap.". In: 27th IEK Conference. Pride Inn Paradise Beach Resort Mombasa, Kenya; 2020.
Omwenga I, Aboge GO, Mitema ES, Obiero G, Ngaywa C, Ngwili N, Wamwere G, Wainaina M, Bett B. "Antimicrobial Usage and Detection of Multidrug-Resistant , Including Methicillin-Resistant Strains in Raw Milk of Livestock from Northern Kenya." Microb Drug Resist. 2020. Abstract

The association of antimicrobial usage (AMU) with prevalence of antimicrobial-resistant (AMR) , including methicillin-resistant (MRSA) in livestock raw milk consumed by pastoralists in Kenya remains unclear. We investigated the relationship between AMU and emergence of multidrug-resistant (MDR) , including MRSA in raw milk of livestock. AMU data were obtained using sales records from veterinary pharmacies. was isolated from 603 milk samples from various livestock species, including sheep, goat, cow, and camel reared in Isiolo and Marsabit counties in Kenya. Resistant phenotypes and genotypes were determined by disc diffusion and molecular methods, respectively. Correlation between AMU and occurrence of resistance was determined by Pearson's correlation coefficient () method. The consumption of various antimicrobial classes were as follows; 4,168 kg of oxytetracycline, 70 kg of sulfonamides, 49.7 kg of aminoglycosides, 46 kg of beta-lactams, 39.4 kg of macrolides, and 0.52 kg for trimethoprim. The isolates were mainly resistant to tetracycline (79%), ampicillin (58%), and oxacillin (33%), respectively. A few isolates (5-18%) were resistant to clindamycin, cephalexin, erythromycin, kanamycin, and ciprofloxacin. Most of the MDR- isolates were MRSA (94%). The genetic determinants found in the AMR isolates included K/M (96.5%/19%) for tetracycline, (79%) for penicillin, (53%) for aminoglycosides, A (41%) for oxacillin, and A/A (24%/7%) for macrolides. Oxytetracycline usage was correlated to K/M ( = 0.62/1) detection, penicillins to A/ ( = 0.86/0.98), aminoglycoside to ( 0.76/-13), and macrolide usages for detection of A/A ( = 0.94/0.77). AMU appeared to be associated with occurrence of MDR-SA and the M detection. Consumption of raw milk contaminated with MRSA could pose a serious public health risk in pastoral communities in northern Kenya.

Nanteza A, Obara I, Kasaija P, Mwega E, Kabi F, Salih DA, Njahira M, Joyce Njuguna, Odongo D, Bishop RP, Skilton RA, Ahmed J, Clausen P-H, Lubega GW. "Antigen gene and variable number tandem repeat (VNTR) diversity in Theileria parva parasites from Ankole cattle in south-western Uganda: Evidence for conservation in antigen gene sequences combined with extensive polymorphism at VNTR loci." Transbound Emerg Dis. 2020;67 Suppl 1:99-107. Abstract

Theileria parva is a tick-transmitted apicomplexan protozoan parasite that infects lymphocytes of cattle and African Cape buffalo (Syncerus caffer), causing a frequently fatal disease of cattle in eastern, central and southern Africa. A live vaccination procedure, known as infection and treatment method (ITM), the most frequently used version of which comprises the Muguga, Serengeti-transformed and Kiambu 5 stocks of T. parva, delivered as a trivalent cocktail, is generally effective. However, it does not always induce 100% protection against heterologous parasite challenge. Knowledge of the genetic diversity of T. parva in target cattle populations is therefore important prior to extensive vaccine deployment. This study investigated the extent of genetic diversity within T. parva field isolates derived from Ankole (Bos taurus) cattle in south-western Uganda using 14 variable number tandem repeat (VNTR) satellite loci and the sequences of two antigen-encoding genes that are targets of CD8+T-cell responses induced by ITM, designated Tp1 and Tp2. The findings revealed a T. parva prevalence of 51% confirming endemicity of the parasite in south-western Uganda. Cattle-derived T. parva VNTR genotypes revealed a high degree of polymorphism. However, all of the T. parva Tp1 and Tp2 alleles identified in this study have been reported previously, indicating that they are widespread geographically in East Africa and highly conserved.

Oladapo OT, Vogel JP, Piaggio G, et al. "Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries." N Engl J Med. 2020;383(26):2514-2525. Abstract

The safety and efficacy of antenatal glucocorticoids in women in low-resource countries who are at risk for preterm birth are uncertain.

Oladapo OT, Vogel JP, Piaggio G, et al. "Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries." N Engl J Med. 2020;383(26):2514-2525. Abstract

The safety and efficacy of antenatal glucocorticoids in women in low-resource countries who are at risk for preterm birth are uncertain.

Mukolwe LD, Odongo DO, Byaruhanga C, Snyman LP, Sibeko-Matjila KP. "Analysis of p67 allelic sequences reveals a subtype of allele type 1 unique to buffalo-derived Theileria parva parasites from southern Africa." PLoS One. 2020;15(6):e0231434. Abstract

East Coast fever (ECF) and Corridor disease (CD) caused by cattle- and buffalo-derived T. parva respectively are the most economically important tick-borne diseases of cattle in the affected African countries. The p67 gene has been evaluated as a recombinant subunit vaccine against ECF, and for discrimination of T. parva parasites causing ECF and Corridor disease. The p67 allele type 1 was first identified in cattle-derived T. parva parasites from East Africa, where parasites possessing this allele type have been associated with ECF. Subsequent characterization of buffalo-derived T. parva parasites from South Africa where ECF was eradicated, revealed the presence of a similar allele type, raising concerns as to whether or not allele type 1 from parasites from the two regions is identical. A 900 bp central fragment of the gene encoding p67 was PCR amplified from T. parva DNA extracted from blood collected from cattle and buffalo in South Africa, Mozambique, Kenya, Tanzania and Uganda, followed by DNA sequence analysis. Four p67 allele types previously described were identified. A subtype of p67 allele type 1 was identified in parasites from clinical cases of CD and buffalo from southern Africa. Notably, p67 allele type 1 sequences from parasites associated with ECF in East Africa and CD in Kenya were identical. Analysis of two p67 B-cell epitopes (TpM12 and AR22.7) revealed amino acid substitutions in allele type 1 from buffalo-derived T. parva parasites from southern Africa. However, both epitopes were conserved in allele type 1 from cattle- and buffalo-derived T. parva parasites from East Africa. These findings reveal detection of a subtype of p67 allele type 1 associated with T. parva parasites transmissible from buffalo to cattle in southern Africa.

Birech Z, Mwangi PW, Sehmi PK, Nyaga NM. "Application of Raman spectroscopy in comparative study of antiobesity influence of oxytocin and freeze-dried extracts of Uvariodendron anisatum Verdeck (Annonaceae) in Sprague Dawley rats." Journal of Raman SpectroscopyJournal of Raman Spectroscopy. 2020;51(3):398-405. AbstractWebsite

Abstract Obesity is a condition affecting a substantial number of people in the world. Obese people have increased risks of developing chronic metabolic diseases such as type II diabetes, hypertension, and cancer, among others. Predicting potential development together with rapid diagnosis of the condition followed by early interventions is therefore necessary. This work investigated, first, utility of Raman spectroscopy in performing comparative antiobesity influence studies of oxytocin and a freeze-dried extract of a local herbal plant exhibiting oxytocin-like properties called Uvariodendron anisatum Verdeck (Annonaceae) (UAV) on diet induced obesity in Sprague Dawley rat models. Second, we looked for obesity biomarker Raman spectral bands. The blood extracted from the rats were applied onto conductive silver paste smeared glass slides and excited using a 785-nm laser. Raman spectra of blood from oxytocin- and UAV-treated rats displayed similar profiles with low doses of UAV (100 mg/kg of body weight) being more similar to oxytocin than high doses (200 mg/kg of body weight) as revealed by cosine similarity value of 0.997. Their profiles were also different from blood of obese and nonobese (normal controls) animals. A prominent peak in spectra of treated rats centred at 401 cm?1 can be oxytocin's biomarker band in blood. Comparison of average intensity trend of fructose bands at around 638 and 812 cm?1 between prepared fructose solution and blood of treated rats revealed elevated levels of fructose in blood of rats intraperitoneally injected oxytocin and UAV extracts. The result implied upregulation of fructose in oxytocin- and UAV-treated animals. Principal component analysis confirmed that Raman spectral profiles from blood of obese rats were different from those of nonobese rats with bands ascribed to fructose (638, 812, and 1,217 cm?1) and branched chain amino acids (BCAAs; 478, 1,318, and 1,443 cm?1), being utilized in the segregation of the spectral data sets. It also showed that spectra from oxytocin-treated and UAV-treated rat's blood were similar implying identical influence of the drugs on the animals. The study showed potential of Raman spectroscopy as tool for quick obesity (or metabolic syndrome) screening with intensity of Raman bands associated with fructose and BCAAs as biomarkers. Besides, the same bands may be used in comparative efficacy studies of antiobesity drugs. The results reported here are rare in literature.

Kagunya EW, Mbaria JM, Kaingu CK. "Acute and sub-acute oral toxicity and phytochemical profile of Croton menyhartthii plant fromTana River County Kenya. ." Discovery Phytomedicine . 2020;7(3)(DOI: 10.15562/phytomedicine.2020.135):118-127.
Muia BM, Mbaria JM, Kanja LW, Gitahi N, Okumu PO, Okumu MO. "Acute and sub-acute toxicity study of the root extracts of Fagaropsis hildebrandtii in mice and evaluation of their antimicrobial effects." F1000Research,. 2020;8(1444).
Muia BM, Mbaria JM, Kanja LW, Gitahi N, Okumu PO, Okumu MO. "Acute and sub-acute toxicity study of the root extracts of Fagaropsis hildebrandtii in mice and evaluation of their antimicrobial effects." F1000Research . 2020;8:1444 .
Muia BM, Okumu MO, Okumu PO, Gitahi N, Kanja LW, Mbaria JM. "Acute and sub-acute toxicity study of the root extracts of Fagaropsis hildebrandtii in mice and evaluation of their antimicrobial effects." F1000Research 2020. 2020;(8:1444).
Mudimba TN, Mbaria J, Maitho T, Taderera T. "Acute and subacute toxicity evaluation of aqueous extracts of Carpobrotus edulis in Sprague Dawley rats." The Journal of Pharmacology. 2020;9(4):265-269 .
B O, T.M W. "Acute oral toxicity and anti-inflammatory and analgesic effect of aqueous and methanolic stem bark extracts of Piliostigma thonningii (Schumach). Hindawi." Evidence-based Complementary Alternative Medicine. 2020;2020:https:/doi.org/10.1155/2020/5651390.
Olela B, Mbaria J, Wachira T, Moriasi G. "Acute Oral Toxicity and Anti-inflammatory and Analgesic Effects of Methanolic Stem Bark Extracts of Piliostigma thonningii (Schumach.)." Evidence-Based Complementary and Alternative Medicine. 2020;Volume 2020 (Article ID 5651390 http:/doi.org/10.1155/2020/5651390).
Yala JA, Onono JO, Ogara WO, Ouma GO, Okuthe SO. "Adaptation Measures to Mitigate the Impacts of Climate Variability among Pastoralists in Kajiado, Kenya." Asian Journal of Agricultural Extension, Economics & Sociology. 2020;38(10):156-166.
Muinde VM, Onyari JM, Wamalwa B, Wabomba JN. "Adsorption of malachite green dye from aqueous solutions using mesoporous chitosan–zinc oxide composite material." Environmental Chemistry and Ecotoxicology. 2020;2:115-125. AbstractAbstract

Description
Chitosan–zinc oxide composite with an average size of 33 nm was synthesized by facile chemical precipitation technique for application in the removal of water contaminants such as dyes. Malachite green (MG) was the model colorant for the sorption process. Material characterization was achieved using selected spectroscopic techniques. Elemental analysis results revealed that the material had high concentration levels of Zn (965,000 ± 53.2 mg/kg) compared to Fe (756.5 ± 45.3 mg/kg) and P (166 ± 26.6 mg/kg). Batch adsorption experiments of the dye onto chitosan–ZnO (CS–ZnO) composite was investigated with a UV–Visible photometer. The rate of dye removal was greatly influenced by pH, dye strength, amount of adsorbent and contact time. High removal capacity of 98.5% was achieved with reducing dye strength of 2.3 mg/L, dosage of 0.6 g and pH 8 within 180 min equilibration time. Langmuir model …

Oloo CM, Onyari JM, Wanyonyi WC, Wabomba JN, Muinde VM. "Adsorptive removal of hazardous crystal violet dye form aqueous solution using Rhizophora mucronata stem-barks: Equilibrium and kinetics studies." Environmental Chemistry and Ecotoxicology. 2020. AbstractEnvironmental Chemistry and Ecotoxicology

Description
Adsorption of crystal violet (CV) dye from aqueous solution using dried bark powder of mangrove species Rhizophora mucronata was studied. Characterization of adsorbent was done using FTIR and SEM. Batch experiment was carried out to examine the viability of using mangrove bark for adsorption of CV dye from aqueous solutions under different process conditions. The result revealed that removal of CV increased with contact time, adsorbent dose, initial dye concentration and decreased with increased particle size and ionic strength. pH 7 was the optimum pH for CV dye removal. The adsorption equilibrium for CV dye by Rhizophora mucronata stem-bark was attained within 60 min with removal efficacy of up to 99.8%. Pseudo-second-order kinetic model was best used to describe sorption kinetics while Freundlich isotherm model was appropriate for describing adsorption isotherm. The results demonstrated …

Musebe E. A, Bolo, Z.A., K’ Obonyo P., R. K. "Advanced Manufacturing Technology, Competitive Advantage, and Performance of Large Manufacturing Companies In Kenya." DBA Management Review Journal. 2020;10(3):90-114.
Musebe E. A, Bolo, Z.A., K’ Obonyo P., R. K. "Advanced Manufacturing Technology, Organizational Resources and Performance of Large Manufacturing Companies In Kenya." DBA Management Review Journal. 2020;10(2):1-33.
Obiero K, Lawrence T, Ives J, Smith S, Njaya F, Kayanda R, Waidbacher H, Olago D, Miriti E, Hecky RE. "Advancing Africa’s great lakes research and academic potential: Answering the call for harmonized, long-term, collaborative networks and partnerships." Journal of Great Lakes Research. 2020. Abstractdio.org

Abstract
The African Great Lakes (AGL) have rich fisheries and are renowned “biodiversity hotspots”. Consequently the AGLand the ecosystem services they provide, underpin the welfare and livelihoods of over 50 million people across 10 countries. Despite the recognized importance of the AGL, these vital ecosystems and their livelihood support systems are threatened by numerous anthropogenic stressors at local, regional, and global scales. Past and continued efforts to address critical challenges on these lakes are often short-term, parochial, disparate, and uncoordinated resulting in a lack of comprehensive and comparable scientific data and inadequate resources to influence evidence-based policy. Over the past two decades, several international workshops, conferences and scientific publications have identified the need for collaboration, knowledge sharing, and harmonization of research and management as key elements to enhance conservation efforts in the AGL. In this commentary, we introduce the African Center for Aquatic Research and Education (ACARE), which aims to strengthen research and provide the scientific evidence needed to make informed decisions related to sustainable fisheries and aquatic resource management in the AGL. To do this, ACARE will administer a highly collaborative network of experts with three long-term goals: (1) strengthen global and regional research partnerships; (2) establish transboundary and inter-jurisdictional lake advisory groups; and (3) build capacity of freshwater scientists through experiential education and public engagement.

Keywords
African Great Lakes Collaborative networks Transboundary lake advisory groups, educationResearch partnerships

Kieti RM, Rukwaro RW, Olima WA. "Affordable Housing in Kenya: Status, Opportunities and Challenges." Africa Habitat Review Journal. 2020;14(1).
S.O O, J.N M, R. T, M K. "African Images in Kithaka wa Mberia's Poetry." Asian Journal of African Studies, Institute of African Studies,Hankuk University of Foreign Studies. 2020;49(August 2020):3-28.
Yala AJ, Okello OW, Ongisa OG, Orungo OJ, Oyieke OS. "Analysis of Climate Trends and Livestock Disease Occurrence in Kajiado County." Asian Journal of Research in Animal and Veterinary Sciences. 2020;6(1):1-15.
Nunow A, Nzioka JM, Kinama JM. "Analysis of gender parity in climate change adaptation actions within Kajiado and Kiambu counties, Kenya." East African Journal of Science, Technology and Innovation. 2020;1(2).
Kaua, CG., Thenya, Mutune JM. "Analysis of Informal Microfinance Institutions Structures in Relation to Performance in Tharaka South Subcounty, Kenya. ." European Journal of Sustainable Development . 2020;9(3):457-475.
Gichure M, Onono J, Wahome R, Gathura P. "Analysis of the benefits and production challenges of working donkeys in smallholder farming systems in Kenya, Veterinary World." Veterinary World. 2020;13(1):2346-2352.
Gichure M, Onono J, Wahome R, Gathura P. "Analysis of the benefits and production challenges of working donkeys in smallholder farming systems in Kenya." Veterinary World. 2020;13(11).
Indiatsy C, K' Obonyo P, Muindi F, M M. "An Analysis of the Effect of Employees Age on Employee Performance in Kenya State Corportations. ." Journal of Business and Social Science Review . 2020;1(11).
JessicaOsanya, I.Adam R, Otieno DJ, Nyikal R, Jaleta M. "An analysis of the respective contributions of husband and wife in farming households in Kenya to decisions regarding the use of income: A multinomial logit approach." Women's Studies International Forum. 2020;83. AbstractWebsite

This paper analyzes the socio-economic characteristics of households that affect husbands and wives' contributions to decisions regarding the use of income from crop and livestock sales in Kenya. Using a sample of 276 households, we apply a multinomial logit model to assess factors affecting decision-making. Results show that husbands make most decisions concerning agriculture, while wives mainly decide on daily household expenditure. Higher education levels were found to increase women's involvement in decision-making on income use. Group membership had a positive effect on joint decision-making on income use. The study recommends improving women's access to education, which will improve their access to productive resources, hence their decision-making power. Providing incentives for members of agricultural groups can provide avenues for learning. Gender-transformative approaches that empower women and sensitize men to allow space for women to engage in decision-making, can have an impact in improving the decision-making capacity of women in households.

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