Publications


Submitted

DR. MUKABANA, WOLFANGRICHARD.  Submitted.  Knols, B.G.J., Hood-Nowotny, R.C., Bossin, H., Franz, G., Robinson, A., Mukabana, W.R., & Kemboi, S.K. GM sterile mosquitoes: a cautionary note. Nature Biotechnology, 24(9): 1067-1068.. Nature Biotechnology, 24(9): 1067-1068.. : Journal of School of Continuous and Distance Education Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Integrated vector management (IVM) for malaria control requires ecological skills that are very scarce and rarely applied in Africa today. Partnerships between communities and academic ecologists can address this capacity deficit, modernize the evidence base for such approaches and enable future scale up. Community-based IVM programmes were initiated in two contrasting settings. On Rusinga Island, Western Kenya, community outreach to a marginalized rural community was achieved by University of Nairobi through a community-based organization. In Dar es Salaam, Tanzania, Ilala Municipality established an IVM programme at grassroots level, which was subsequently upgraded and expanded into a pilot scale Urban Malaria Control Programme with support from national academic institutes. Both programmes now access relevant expertise, funding and policy makers while the academic partners benefit from direct experience of community-based implementation and operational research opportunities. The communities now access up-to-date malaria-related knowledge and skills for translation into local action. Similarly, the academic partners have acquired better understanding of community needs and how to address them. Until sufficient evidence is provided, community-based IVM remains an operational research activity. Researchers can never directly support every community in Africa so community based IVM strategies and tactics will need to be incorporated into undergraduate teaching programmes to generate sufficient numbers of practitioners for national scale programmes. Academic ecologists at African institutions are uniquely positioned to enable the application of practical environmental and entomological skills for malaria control by communities at grassroots level and should be supported to fulfil this neglected role.
DR. MUKABANA, WOLFANGRICHARD, DR. MUKABANA WOLFANGRICHARD.  Submitted.  Ecologists can enable communities to implement malaria vector control in Africa.. Malaria Journal, 5 (1): 9.. : Journal of School of Continuous and Distance Education Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Integrated vector management (IVM) for malaria control requires ecological skills that are very scarce and rarely applied in Africa today. Partnerships between communities and academic ecologists can address this capacity deficit, modernize the evidence base for such approaches and enable future scale up. Community-based IVM programmes were initiated in two contrasting settings. On Rusinga Island, Western Kenya, community outreach to a marginalized rural community was achieved by University of Nairobi through a community-based organization. In Dar es Salaam, Tanzania, Ilala Municipality established an IVM programme at grassroots level, which was subsequently upgraded and expanded into a pilot scale Urban Malaria Control Programme with support from national academic institutes. Both programmes now access relevant expertise, funding and policy makers while the academic partners benefit from direct experience of community-based implementation and operational research opportunities. The communities now access up-to-date malaria-related knowledge and skills for translation into local action. Similarly, the academic partners have acquired better understanding of community needs and how to address them. Until sufficient evidence is provided, community-based IVM remains an operational research activity. Researchers can never directly support every community in Africa so community based IVM strategies and tactics will need to be incorporated into undergraduate teaching programmes to generate sufficient numbers of practitioners for national scale programmes. Academic ecologists at African institutions are uniquely positioned to enable the application of practical environmental and entomological skills for malaria control by communities at grassroots level and should be supported to fulfil this neglected role.
DR. MUKABANA, WOLFANGRICHARD, DR. MUKABANA WOLFANGRICHARD.  Submitted.  Malaria Infection Increases Attractiveness of Humans to Mosquitoes.. PlosBiology, 3 (9), (e298).. : Journal of School of Continuous and Distance Education Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Integrated vector management (IVM) for malaria control requires ecological skills that are very scarce and rarely applied in Africa today. Partnerships between communities and academic ecologists can address this capacity deficit, modernize the evidence base for such approaches and enable future scale up. Community-based IVM programmes were initiated in two contrasting settings. On Rusinga Island, Western Kenya, community outreach to a marginalized rural community was achieved by University of Nairobi through a community-based organization. In Dar es Salaam, Tanzania, Ilala Municipality established an IVM programme at grassroots level, which was subsequently upgraded and expanded into a pilot scale Urban Malaria Control Programme with support from national academic institutes. Both programmes now access relevant expertise, funding and policy makers while the academic partners benefit from direct experience of community-based implementation and operational research opportunities. The communities now access up-to-date malaria-related knowledge and skills for translation into local action. Similarly, the academic partners have acquired better understanding of community needs and how to address them. Until sufficient evidence is provided, community-based IVM remains an operational research activity. Researchers can never directly support every community in Africa so community based IVM strategies and tactics will need to be incorporated into undergraduate teaching programmes to generate sufficient numbers of practitioners for national scale programmes. Academic ecologists at African institutions are uniquely positioned to enable the application of practical environmental and entomological skills for malaria control by communities at grassroots level and should be supported to fulfil this neglected role.

2013

Dugassa, S, Lindh JM, Oyieke F, Mukabana WR, Lindsay SW, Fillinger U.  2013.  Development of a Gravid Trap for Collecting Live Malaria Vectors Anopheles gambiae s.l.. Website
Lorenz LM, Keane A, Moore JD, Munk CJ, Seeholzer L, Mseka A, Simfukwe E, Ligamba J, Turner EL, Biswaro LR, Okumu FO, GF K, WR M, SJ. M.  2013.  Taxis assays measure directional movement of mosquitoes to olfactory cues. Parasites & Vectors.. Parasites & Vectors. 3(6):131.

2012

Alexandra Hiscox, Nicolas Maire, Ibrahim Kiche, Mariabeth Silkey, Tobias Homan, Prisca Oria, Collins Mweresa, Bruno Otieno, Margaret Ayugi, Teun Bousema, Patrick Sawa, Jane Alaii, Thomas Smith, Cees Leeuwis, Wolfgang R Mukabana, Takken W.  2012.  The SolarMal Project: innovative mosquito trapping technology for malaria control. Malaria Journal. 11(1):O45doi:10.1186/1475-2875-11-S1-O45.
Nyasembe VO, Teal PEA, WR M, Tumlinson JH, Torto B.  2012.  Behavioural response of the malaria vector Anopheles gambiae to host plant volatiles and synthetic blends.. Parasites & Vectors. 5:234.
WR, M, Collins K. Mweresa, Philemon Omusula, Benedict O. Orindi, Renate C. Smallegange, Joop JA van Loon, Takken W.  2012.  Evaluation of low density polyethylene and nylon for delivery of synthetic mosquito attractants. Parasites & Vectors. 5:202.
Imbahale SS, WR M, Orindi B, Githeko AK, Takken W..  2012.  Variation in malaria transmission dynamics in three different sites in Western kenya.. Journal of Tropical Medicine. 912408
Imbahale SS, Githeko A, WR M, Takken W..  2012.  Integrated mosquito larval source management reduces larval numbers in two highland villages in western Kenya.. BMC Public Health. 2:362.
Wolfgang R. Mukabana, Collins K. Mweresa, Bruno Otieno, Philemon Omusula, Renate C. Smallegange, Joop JA van Loon, Takken W.  2012.  A novel synthetic odorant blend for trapping of malaria and other african mosquito species. Journal of Chemical Ecology. 38:235–244.
Wanzala W, Takken W, WR M, Pala AO, Hassanali A..  2012.  Ethnoknowledge of Bukusu community on livestock tick prevention and control in Bungoma district, western Kenya.. Journal of Ethnopharmacoly. 140(2):298-324.
Smallegange RC, GK Bukovinszkin´e, B Otieno, PA Mbadi, Takken W, Mukabana WR, vanLoon JA.  2012.  Identification of candidate volatiles that affect the behavioural response of the malaria mosquito Anopheles gambiae sensu stricto to an active kairomone blend: laboratory and semi-field assays. Physiological Entomology. 37:60–71.
Nyasembe VO, Teal PEA, MWRTJHTB.  2012.  Behavioural response of the malaria vector Anopheles gambiae to host plant volatiles and synthetic blends. Parasites & Vectors. 5(234):doi:10.1186/1756-3305-5-234.
Alexandra Hiscox, Nicolas Maire, IKMSTHPOCMBOM.  2012.  The SolarMal Project: innovative mosquito trapping technology for malaria control. Malaria Journal 2012. 11(1):O45doi:10.1186/1475-2875-11-S1-O45.

2011

Susan S Imbahale, Collins K Mweresa, Takken W, Wolfgang R Mukabana.  2011.  Development of environmental tools for Anopheline larval control. Parasites & Vectors. 4:130.
Albert O. Mala, Lucy W. Irungu, Josephat I.Shililu, Ephantus J. Muturi, Charles C. Mbogo, Joseph K. Njagi, Wolfgang R Mukabana, Githure JI.  2011.  Plasmodium falciparum transmission and aridity: a Kenyan experience from the dry lands of Baringo and its implications for Anopheles arabiensis control.. Malaria Journal. 10:121.
Verhulst N., Mukabana W.R., Takken W, R.mallegange.  2011.  Skin microbiota volatiles as odour baits for the malaria mosquito Anopheles gambiae. Entomologia Experimentalis et applicata. 139:170–179.
Susan S Imbahale, Krijn P Paaijmans, Wolfgang R Mukabana, Ron van Lammeren, Githeko AK, Takken W.  2011.  A longitudinal study on Anopheles mosquito larval abundance in distinct geographical and environmental settings in western Kenya. . Malaria Journal. 10:81.
Niels O Verhulst, Phoebe A Mbadi, Gabriella Bukovinszkine Kiss, Wolfgang R Mukabana, Joop JA van Loon, Takken W, Renate C Smallegange.  2011.  Improvement of a synthetic lure for Anopheles gambiae using compounds produced by human skin microbiota. Malaria Journal. 10:28.

2010

Renate C Smallegange, Wolfgang H Schmied, Karel J van Roey, Niels O Verhulst, Jeroen Spitzen, Wolfgang R Mukabana, Takken W.  2010.  Sugar-fermenting yeast as an organic source of carbon dioxide to attract the malaria mosquito Anopheles gambiae. . Malaria Journal. 9:292.
Ogoma SB, Lweitoijera DW, Ngonyani H, Furer B, Russell TL, WR M, GF K, SJ. M.  2010.  Screening mosquito house entry points as a potential method for integrated control of endophagic filariasis, arbovirus and malaria vectors.. PLoS Neglected Tropical Diseases. 4(8):e773.
Okumu, F., Biswaro, L., Mbeleyela, E, Killeen, G.F., Mukabana, W.R., Moore SJ.  2010.  Using Nylon Strips to Dispense Mosquito Attractants for Sampling the Malaria Vector Anopheles gambiae s.s. Journal of Medical Entomology . 47(2):274–282.
Okumu F.O., Killeen G.F., Ogoma.S, Biswaro L., Smallegange R.C., Mbeyela E., Titus E., Munk C., Ngonyani H., Takken W., Mshinda H., Mukabana W.R., Moore S.J..  2010.  Development and field evaluation of a synthetic mosquito lure that is more attractive than humans. . PLoS One. 5(1):e8951.
Olanga, EA., Okal, M., Mbadi, PA., Kokwaro, ED, Mukabana WR.  2010.  Attraction of Anopheles gambiae to odour baits augmented with heat and moisture. Malaria Journal. 9:6.

2009

Sikulu M, Govella NJ, Ogoma SB, Mpangile J, Kambi SH, Kannady K, Chaki PC, Mukabana W.R., GF K.  2009.  Comparative evaluation of the Ifakara tent trap-B, the standardized resting boxes and the human landing catch for sampling malaria vectors and other mosquitoes in urban Dar es Salaam, Tanzania.. Malaria Journal. 8:197.
Ogoma SB, Kannady K, Sikulu M, Chaki PP, Govella NJ, Mukabana W.R., GF K.  2009.  Window screening, ceilings and closed eaves as sustainable ways to control malaria in Dar es Salaam, Tanzania.. Malaria Journal. 8:221.

2008

Muriu, S.M, Muturi, E.J., Shililu, J.I., Mbogo, C.M., Mwangangi, J.M., Jacob, B.G., Irungu, L.W., Mukabana, W.R., Githure J, R.J. N.  2008.  Host choice and multiple blood feeding behaviour of malaria vectors and other anophelines in Mwea rice scheme, Kenya. Malaria Journal. 7:43.
PROF. IRUNGU, LUCYW, DR. MUKABANA WOLFANGRICHARD.  2008.  Muriu S.M., Shilulu J.I., Muturi E.J., Irungu l.W., Mwangangi J.M., Mukabana R.W., Jacob B.G., Githure J.I., and Novak R.J., (2008). Host choice and multiple blood feeding behaviour of malaria vectors and other anophelines in Mwea rice irrigation scheme, . Malaria Journal 7:43.. : Journal of School of Continuous and Distance Education Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Studies were conducted between April 2004 and February 2006 to determine the blood-feeding pattern of anopheles mosquitoes in Mwea Kenya. Samples were collected indoors by pyrethrum spay catch and outdoors by Centers for Disease Control light traps and processed for blood meal analysis by an Enzyme-linked Immunosorbent Assay. A total of 3.333 blood-fed Anopheles mosquitoes representing four Anopheles species were collected and 2.796 of the samples were assayed, with Anopheles arabiensis comprising 76.2% (n=2.542) followed in decreasing order by Anopheles coustani 8.9% (n=297), Anopheles pharoensis 8.2 % (n=272) and anopheles funestus 6.7% (n=222).  All mosquito species had a high preference for bovine (range 56.3-71.4%) over human (range 1.1-23.9%) or goat (0.1-2.2%) blood meals.  Some individuals from all the four species were found to contain mixed blood meals.  The bovine blood index (BBI) for An. arabiensis was significantly higher for populations collected indoors (71.8%), than populations collected outdoors (41.3%), but the human blood index (HBI) did not differ significantly between the two populations.  In contrast, BBI for indoor collected An. funestus (51.4%) was significantly lower than for outdoor collected populations (78.8%) and the HBI was significantly higher indoors (28.7%) than outdoors (2.4%).  Anthropophily of An. funestus was lowest within the rice scheme, moderate in unplanned rice agro-ecosystem, and highest within the non-irrigated agro-ecosystem.  Anthropophily of An. Arabiensis was significantly higher in the non-irrigated agro-ecosystem than in the other agro-ecosystems. These findings suggest that rice cultivation has an effect on host choice by Anopheles mosquitoes.  The study further indicate that zooprophylaxis may be a potential strategy for malaria control, but there is need to assess how domestic animals may influence arboviruses epidemiology before adapting the strategy.

2007

Knols, B.G.J., Bossin, H.C., Mukabana, W.R., Robinson AS.  2007.  Transgenic mosquitoes and the fight against malaria: managing technology push in a turbulent GMO world.. American Journal of Tropical Medicine and Hygiene. 77(6):232-242.
Opiyo, P., Mukabana, W.R., Kiche, I.O., Mathenge, E.M., Killeen, G.F., Fillinger, U..  2007.  An exploratory study of community factors relevant for participatory malaria control on Rusinga Island, western Kenya. . Malaria Journal. 6:48.
Mukabana, W.R., Takken, W., Killeen GF, Knols, B.G.J..  2007.  Clinical malaria reduces human attractiveness to mosquitoes.. Proceedings of the Netherlands Entomological Society. 18:125-129.
DR. MUKABANA, WOLFANGRICHARD.  2007.  Opiyo, P., Mukabana, W.R., Kiche, I.O., Mathenge, E.M., Killeen, G.F., Fillinger, U., 2007, An exploratory study of community factors relevant for participatory malaria control on Rusinga Island, western Kenya. Malaria Journal, 6: 48.. Malaria Journal, 6: 48.. : Journal of School of Continuous and Distance Education Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Capacity strengthening of rural communities, and the various actors that support them, is needed to enable them to lead their own malaria control programmes. Here the existing capacity of a rural community in western Kenya was evaluated in preparation for a larger intervention. Focus group discussions and semi-structured individual interviews were carried out in 1,451 households to determine (1) demographics of respondent and household; (2) socio-economic status of the household; (3) knowledge and beliefs about malaria (symptoms, prevention methods, mosquito life cycle); (4) typical practices used for malaria prevention; (5) the treatment-seeking behaviour and household expenditure for malaria treatment; and (6) the willingness to prepare and implement community-based vector control. Malaria was considered a major threat to life but relevant knowledge was a chimera of scientific knowledge and traditional beliefs, which combined with socio-economic circumstances, leads to ineffective malaria prevention. The actual malaria prevention behaviour practiced by community members differed significantly from methods known to the respondents. Beside bednet use, the major interventions implemented were bush clearing and various hygienic measures, even though these are ineffective for malaria prevention. Encouragingly, most respondents believed malaria could be controlled and were willing to contribute to a community-based malaria control program but felt they needed outside assistance. Culturally sensitive but evidence-based education interventions, utilizing participatory tools, are urgently required which consider traditional beliefs and enable understanding of causal connections between mosquito ecology, parasite transmission and the diagnosis, treatment and prevention of disease. Community-based organizations and schools need to be equipped with knowledge through partnerships with national and international research and tertiary education institutions so that evidence-based research can be applied at the grassroots level.
DR. MUKABANA, WOLFANGRICHARD.  2007.  Knols, B.G.J., Bossin, H.C., Mukabana, W.R., A.S. Robinson, 2007, Transgenic mosquitoes and the fight against malaria: managing technology push in a turbulent GMO world. American Journal of Tropical Medicine and Hygiene, 77 (Supplement 6), 232-242.. American Journal of Tropical Medicine and Hygiene, 77 (Supplement 6), 232-242.. : Journal of School of Continuous and Distance Education Abstract
Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}   Genetic modification (GM) of mosquitoes (which renders them genetically modified organisms, GMOs) offers opportunities for controlling malaria. Transgenic strains of mosquitoes have been developed and evaluation of these to 1) replace or suppress wild vector populations and 2) reduce transmission and deliver public health gains are an imminent prospect. The transition of this approach from confined laboratory settings to open field trials in diseaseendemic countries (DECs) is a staged process that aims to maximize the likelihood of epidemiologic benefits while minimizing potential pitfalls during implementation. Unlike conventional approaches to vector control, application of GM mosquitoes will face contrasting expectations of multiple stakeholders, the management of which will prove critical to safeguard support and avoid antagonism, so that potential public health benefits can be fully evaluated. Inclusion of key stakeholders in decision-making processes, transfer of problem-ownership to DECs, and increased support from the wider malaria research community are important prerequisites for this. It is argued that the many developments in this field require coordination by an international entity to serve as a guiding coalition to stimulate collaborative research and facilitate stakeholder involvement. Contemporary developments in the field of modern biotechnology, and in particular GM, requires competencies beyond the field of biology, and the future of transgenic mosquitoes will hinge on the ability to govern the process of their introduction in societies in which perceived risks may outweigh rational and responsible involvement.

2006

Knols, B.G.J., Hood-Nowotny, R.C., Bossin, H. FG, Robinson, A., Mukabana, W.R., Kemboi, D.C..  2006.  GM sterile mosquitoes: a cautionary note. Nature Biotechnology. 24(9):1067-1068.
Njiru, B.N., Mukabana, W.R., Takken, W., Knols, B.G.J..  2006.  Trapping of the malaria vector Anopheles gambiae with odour-baited MM-X traps in semi-field conditions in western Kenya. Malaria Journal. 5(1):39.
Harbison, J.E., Mathenge, E.M., Misiani, G.O, Mukabana, W.R., Day JF.  2006.  A simple method for sampling indoor-resting malaria mosquitoes, Anopheles gambiae and Anopheles funestus (Diptera: Culicidae) in Africa. Journal of Medical Entomology. 43(3):473-479.
Killeen, G.F., Mukabana, W.R., Kalongolela, M.S., Kannady, K., Lindsay, S.W., Tanner, M., Castro, M.C., Fillinger U.  2006.  Habitat targeting for controlling aquatic stages of malaria vectors in Africa. American Journal of Tropical Medicine and Hygiene. 74(4):517–518.

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