Bio

Publications


2013

Kahn, TR; Desmond, RMGE; GBL; CRY; KJN; FM; D;.  2013.  Delayed initiation of antiretroviral therapy among HIV-discordant couples in Kenya.. Website

2012

Bosire R, Payne BL, Choi, RY; Levinson GBL; L-PBLAY; HKOJ-SP; B; R.  2012.  Cervicovaginal HIV-1-neutralizing immunoglobulin A detected among HIV-1-exposed seronegative female partners in HIV-1-discordant couples.. AbstractWebsite

Cervicovaginal HIV-1-neutralizing immunoglobulin A (IgA) was associated with reduced HIV-1 acquisition in a cohort of commercial sex workers. We aimed to define the prevalence and correlates of HIV-1-neutralizing IgA from HIV-1-exposed seronegative (HESN) women in HIV-1-serodiscordant relationships. METHODS: HIV-1-serodiscordant couples in Nairobi were enrolled and followed quarterly up to 2 years, and women in concordant HIV-1-negative relationships were enrolled as controls. Cervicovaginal, seminal, and blood samples were collected at enrollment and follow-up. Cervicovaginal IgA was assessed for HIV-1-neutralizing activity by a peripheral blood mononuclear cell-based assay using an HIV-1 clade A primary isolate. RESULTS: HESN women in discordant relationships had significantly more HIV-1-neutralizing IgA detected in genital secretions compared with control women [36 of 155 (23%) vs. four of 70 (6%), respectively; odds ratio (OR) 5.0; 95% confidence interval (CI) 1.70-14.64; P = 0.003]. These responses persisted over time in all available follow-up cervicovaginal samples from women with detectable HIV-1-neutralizing IgA at baseline. Partner median HIV-1 plasma viral load was lower among women who had HIV-1-neutralizing IgA compared with women without detectable activity (4.3 vs. 4.8 log(10) copies/ml, respectively; OR 0.70; 95% CI 0.51-0.94; P = 0.02). A similar trend was found with partner seminal viral load (OR 0.57; 95% CI 0.32-1.02; P = 0.06). CONCLUSION: HESN women were five times more likely to have neutralizing IgA in cervicovaginal secretions than low-risk control women, and these responses were inversely associated with partner viral load. These observations support the existence of antiviral activity in the mucosal IgA fraction following sexual HIV-1 exposure.

2011

Bosire, RM.  2011.  Political Parties Index: Measuring Performance of Political Parties in Kenya. , Nairobi: Fredrich Ebert Stiftung Foundation
Bosire, RM, and(eds) KANACG.  2011.  Tanzania: Multilateralism and National Interests in the Nile River Basin Question. Cooperative Diplomacy, Regional Stability and National Interests: The Nile River and the Riparian States. , Pretoria: Africa Institute of South Africa

2010

Bosire, RM.  2010.  Institutionalization of Political Parties in Kenya 1991 to 2007. , Nairobi: Fredrich Ebert Stiftung Foundation

2009

Bosire, RM.  2009.  Constitution Making and Institution Building. Root Causes and Implications of the Post Election Violence of 2007. , Kijabe: Kijabe Printing Press

2008

Bosire, RM.  2008.  Kenya: Handle Internal Refugees with Care, February 2. Daily Nation.
Bosire, RM.  2008.  Peace Agreement will Chart the Way Forward, February 17. Sunday Nation.

2006

2004

Bosire, RM.  2004.  Migration and Refugee Settlement in Britain . International Migration Review.

2002

Bosire, RM, and(eds.) MLSW.  2002.  The Constitution and Citizenship. When the Constitution Begins to Flower. , Nairobi: Claripress Limited

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