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2019
M.W. G, Mwaura F, Wamalwa J. "Pollution along the Altitudinal Gradient of the Likii River, Laikipia County, ." Journal of Environment Pollution and Human Health, . 2019;7(1) :39-52.
Kairu-Wanyoike S, Nyamwaya D, Wainaina M, Johanna Lindahl, Ontiri E, Bukachi S, Njeru I, Johanna Lindahl, Bett B. "Positive association between Brucella spp seroprevalences in livestock and humans from a cross-sectional study in Garissa and Tana River Counties, Kenya. cross-sectional study in Garissa and Tana River Counties, Kenya." PLoS Negl Trop Dis . 2019;13(10):e0007506.
Mnyika GM, Olago DO. "The Potential for CO2 Geosequestration in Kenya: A Suitability Assessment of the Lamu Basin." Africa Journal of Physical Sciences. 2019;3:28-38. Abstract1798-6305-1-pb.pdfWebsite

There is a consensus that current trends in climate change may be due to increasing concentrations of greenhouse gases (predominantly methane and carbon dioxide) from anthropogenic emissions. Among measures proposed for curbing this increase is Carbon Capture and Sequestration (CCS) in geological media. CCS incorporates three technologies comprising; (a) carbon capture, (b) compression and transportation, and (c) injection into geological media. This paper focuses on CO2 injection into geological media and its applicability to the Lamu basin. Sedimentary basins, which host the geological formations suitable for subsurface CO2 storage, are ideal to varied extents determined by such factors as their tectonic settings. A (coarse) basin scale suitability assessment of the Lamu basin was undertaken using the following parameters; size and depth, tectonic and structural settings, seismicity, geothermal-hydrodynamic regimes, basin maturity (based on hydrocarbon well density) and economic resources. The assessed attributes are used to constrain GIS data, delineating possible CCS trap areas with the production of a preliminary map of potential trap areas. Also, a suitability matrix table is generated in comparison with analogous basins such as the Alberta basin in Canada. Following this assessment, the Lamu basin can be considered geologically suitable for geosequestration given its stable tectonic settings, good depth and size. However, the western flanks of the basin and the coastal strip are unsuitable due to shallowness, population and protected zones respectively.

Chemweno V, Gitao C, Gachohi J, Soi R, Ndungu E, Khalif A. "PPR in Camels: Sero-Prevalence and Socio-Economics." International Journal of Veterinary Science. 2019;8(2):84-88.vivian_paper.pdf
Justus O. Inyega DBM. "Pre-service graduate teachers' perceptions on instructional supervision in relation to preparation and planning for teaching and learning in Kenya." International Journal of Innovative Research and Knowledge. 2019;4(1):26-31.
Inyega JO, Bulinda DM. "Pre-service graduate teachers' perceptions on instructional supervision in relation to preparation and planning for teaching and learning in Kenya." International Journal of Innovative Research and Knowledge. 2019;4(1):26-31.
Bulinda DM, Inyega JO. "Pre-service graduate teachers' perceptions on instructional supervision in relation to students' classroom involvement and assessment in Kenya." International Journal of Creative Research and Studies. 2019;3(1):9-14.
XuEmail Y, Seward P, Gaye C, Lin L, Olago DO. "Preface: Groundwater in Sub-Saharan Africa." Hydrogeology Journal. 2019;27(3):815-822. Abstractxu2019_article_prefacegroundwaterinsub-sahara1.pdfWebsite

Introduction
Sub-Saharan Africa (SSA; Fig. 1) refers to an area encompassing the countries in Africa that are fully, or partially, located south of the Sahara. The remaining African countries are generally referred to as belonging in North Africa. Although the socio-economic and hydrogeological conditions in SSA are diverse, they are sufficiently distinct (in general) from the conditions in North Africa to warrant being assessed separately—for example, high-yielding, high-storage, sedimentary aquifers are more common in North Africa than in SSA, while low-yielding, low-storage, basement aquifers are more widespread in SSA than in North Africa. The use of fossil groundwater is more typical in North Africa, while the use or renewable groundwater is more typical in SSA. Other hydrological characteristics associated with SSA include: groundwater resources that are generally under-utilized; lack of research and development that often prevents the optimal use of groundwater rather than over-development; and a heavy reliance by the rural and urban poor on shallow unconfined or semi-confined groundwater for potable water supplies, other domestic uses, and subsistence agriculture. Because of distinguishing characteristics such as these, there are good reasons for treating the hydrogeology of SSA as a whole, and separate from North Africa.

Mutende RA, Imonje RK. "Preservice teacher preparation for application of Discussion teaching method in secondary school science Lessons." International Journal of Scientific Research and Innovative Technology . 2019;6(5).
Vekaria-Hirani 1. V, R K, R.N M, E.M W, N CI. "Prevalence and Management of Septic Shock among Children Admitted at the Kenyatta National Hospital, Logitudinal Survey." It J Pediatri. 2019:2019:1502963. 2019:1-27.
K; M, Beniamino T, Cenci-Goga, Prosperi A, Eric Etter, El-Ashram S, McCrindle C, N OJ, Karake A. "Prevalence and risk factors associated with Campylobacter spp. occurrence in healthy dogs visiting four rural community veterinary clinics in South Africa." Ondersport Journal of Veterinary Research, . 2019.
Caroline T, Elijah O, Nicholas A, Emma K, Benard G, Andrew O. "Prevalence of Anthracycline Induced Cardiomyopathy amongstCancer Patients Treated at Tertiary Teaching and Refferal Hospital in Nairobi Kenya." International Journal of Scientific Research and Management (IJSRM) . 2019;7(12):2321-3418.
Aguttu, J.M KNJM & LM. "Principals’ Support of Peer Education and Prevalence of Drug and Substance Abuse in Public Secondary Schools in Busia County, Kenya. ." Journal of African Interdisciplinary Studies . 2019;2(11):79-95.
Judith Aguttu JKLN&. "Principals’ support of peer education and prevalence of Drugs and Substance abuse in public secondary schools in Busia County, Kenya." The International Journal of Innovative Research and Development. 2019;8(11):64-72.
Jeremiah Kalai LNJA&. "Principals’ use of mentoring programmes on prevalence of Drugs and Substance abuse in public secondary schools in Busia County, Kenya." The International Journal of Innovative Research and Development . 2019;8(10):180-188.
Olaka LA, Joseph O Ogutu, Said MY, Oludhe C. "Projected climatic and hydrologic changes to lake victoria basin rivers under three rcp emission scenarios for 2015–2100 and impacts on the water sector." Water. 2019;11(7):1449. AbstractWebsite

Abstract
Rivers in the Lake Victoria Basin support a multitude of ecosystem services, and the economies of the riparian countries (Kenya, Tanzania, Uganda, Rwanda, and Burundi) rely on their discharge, but projections of their future discharges under various climate change scenarios are not available. Here, we apply Vector Autoregressive Moving Average models with eXogenous variables (VARMAX) statistical models to project hydrological discharge for 23 river catchments for the 2015–2100 period, under three representative concentration pathways (RCPs), namely RCPs 2.6, 4.5, and 8.5. We show an intensification of future annual rainfall by 25% in the eastern and 5–10% in the western part of the basin. At higher emission scenarios, the October to December season receives more rainfall than the March to May season. Temperature projections show a substantial increase in the mean annual minimum temperature by 1.3–4.5 °C and warming in the colder season (June to September) by 1.7–2.9 °C under RCP 4.5 and 4.9 °C under RCP 8.5 by 2085. Variability in future river discharge ranges from 5–267%, increases with emission intensity, and is the highest in rivers in the southern and south eastern parts of the basin. The flow trajectories reveal no systematic trends but suggest marked inter-annual variation, primarily in the timing and magnitude of discharge peaks and lows. The projections imply the need for coordinated transboundary river management in the future.

Machasio RM, Nyabanda R MTM. "Proportion of Variant Anatomy of the Circle of Willis and Association with Vascular Anomalies on Cerebral CT Angiography." Radiology Research and Practice. 2019;2019(1):Article ID 6380801, 7 pages.
Irene M, swaleh. Pure non-gestational ovarian carcinoma.; 2019.
Angeyo KH, Bhatt B, Dehayem-Kamadjeu A. "Rapid nuclear forensics analysis via machine-learning-enabled laser-induced breakdown spectroscopy (LIBS)." AIP Conference Proceedings 2109. 2019;2019(1). Abstract

Nuclear forensics (NF) is an analytical methodology that involves analysis of intercepted nuclear and radiological materials (NRM) so as to establish their nuclear attribution. The critical challenge in NF currently is the lack of suitable microanalytical methodologies for direct, rapid, minimally invasive detection and quantification of NF signatures. Laser-induced breakdown spectroscopy (LIBS) has the potential to overcome these limitations with the aid of machine-learning (ML) techniques. In this paper, we report the development of ML-enabled LIBS methodology for rapid NF analysis and attribution in support of nuclear security. The atomic uranium lines at 385.464 nm, 385.957 nm, and 386.592 nm were identified as NF signatures of uranium for rapid qualitative detection of trace uranium concealed in organic binders and uranium-bearing mineral ores. The limit of detection of uranium using LIBS was determined to be 34 ppm. A multivariate calibration strategy for the quantification of trace uranium in cellulose and uranium-bearing mineral ores was developed using an artificial neural network (ANN, a feed forward back-propagation algorithm) and spectral feature selection: (1) uranium lines (348 nm to 455 nm), (2) uranium lines (380 nm to 388 nm), and (3) subtle uranium peaks (UV range). The model utilizing category 2 was able to predict the 48 ppm of uranium with a relative error prediction (REP) of 10%. The calibration model utilizing subtle uranium peaks, that is, category 3, could predict uranium in the pellets prepared from certified reference material (CRM) IAEA-RGU-1, with an REP of 6%. This demonstrates the power of ANN to model noisy LIBS spectra for trace quantitative analysis. The calibration model we developed predicted uranium concentrations in the uranium-bearing mineral ores in the range of 54–677 ppm. Principal component analysis (PCA) was performed on the LIBS spectra (200–980 nm) utilizing feature selection of the uranium-bearing samples collected from different regions of Kenya clustered into groups related to their geographic origins. The PCA loading spectrum revealed that the groupings of these samples were mainly due to rare earth elements, namely, cerium, dysprosium, praseodymium, promethium, neodymium, and samarium. ML-enabled LIBS therefore has utility in field NF analysis and attribution of uranium in NRM under concealed conditions.

undefined. "Reforming the Duties of Directors under the Kenyan Company Law: A Critique." European Business Law Review. 2019;30(4):617.
Cyr JL, Gawriluk TR, Kimani JM, Rada B, Watford WT, Kiama SG, Seifert AW, Ezen VO. "Regeneration-Competent and -Incompetent Murids Differ in Neutrophil Quantity and Function.". 2019.
Cyr JL, Gawriluk TR, Kimani JM, Rada B, Watford WT, Kiama SG, Seifert AW, Ezenwa VO. "Regeneration-competent and-incompetent murids differ in neutrophil quantity and function.". 2019.
Siriba DN. "The Relationship between the Mining and Property Cadastre in Kenya." African Journal of Land Policy and Geospatial Sciences. 2019;2(2):1-9.
Ogeng’o J, Obimbo M, Munguti J, Cheruiyot I, Olabu B, Kariuki BN. "Remembering Prof. Hassan Saidi: The Pillar for Young Anatomists and Trainee Doctors." Ann Afr Surg. 2019;16(1):38-39. Abstractremembering_prof._hassan_saidi_the_pillar_for_young_anatomists.pdfThe ANNALS of AFRICAN SURGERY

The late Prof. Hassan Saidi (rest in peace) was a father, husband, an administrator and a surgeon. To many in the medical fraternity, he was a teacher and a mentor. As a mentor, many know of the impact he had on resident surgeons in training, but his contribution to shaping the minds of young anatomists and trainee doctors is often underestimated (1). Prof. Saidi taught in the Department of Human Anatomy, University of Nairobi, for 28 years (7 of which he was the chairman). He had also served previously as the coordinator for the Bachelor of Medicine and Surgery (MBChB) and Intercalated Bachelor of Science, Human Anatomy programs (BSc Anat) (2).

Ondicho TG. "Rethinking the New world order and its Implications for Africa.". In: Contemporary Africa and the Foreseeable World Order. London: Lexington Books; 2019.
Gikunju M, Nyamato-Kwenda R, Kwanya T. "A review of citizen librarianship in academic libraries in Kenya.". In: Digital Technologies for Information and Knowledge Management. Nairobi: Technical University of Kenya; 2019.
Owade JO, Abong’ G, Okoth M, Mwang’ombe AW. "A review of the contribution of cowpea leaves to food and nutrition security in East Africa." Food Science & Nutrition published by Wiley Periodicals, Inc.. 2019;(DOI: 10.1002/fsn3.1337).a_review_of_the_contribution_of_cowpea_leaves_to_food_and.pdf
Yohannis M, Agnes Wausi, Waema T, Hutchinson M. "The Role of ICT Tools in the Access of Climate Information by Rural Communities." Journal of Sustainability, Environment and Peace. 2019;1(2):32-38. AbstractWebsite

ABSTRACT
This paper, seeks to explore how rural communities especially women in Kitui county use
ICT tools to access localized climate information and how Digital Capital facilitates or
impedes the process. Our view is that the continued access to, and use of, ICT tools like
the mobile phone and radios offer diverse opportunities for rural communities to use
timely and relevant climate information to enhance their livelihood strategy. We
hypothesize that rural communities’ use ICT tools such as mobile phones and the
community radios to access localized climate information (weather, seasonal forecasts
and agro-advisories). A household survey of 419 respondents was adopted for data
collection and analysis, guided by the sustainable livelihood framework. The research
findings disclosed that the radios combined with the mobile phone are commonly
available, accessible and cost-effective ICT tools that have played a role in improving
rural women’s access to real-time, relevant climate and agro-advisory information
reducing information asymmetry in rural settings. The study is motivated by the
increasing challenges of climate variability and climate change that are global. Kitui
County has had its share of climate variability and climate change related problems such
as drought which create problems such as food insecurity.

Kinyungu TN, Muthomi JW, Subramanian S, Miano DW, Olubayo FM’mogi, Maobe MA. "Role of maize residues in transmission of maize chlorotic mottle virus and effect on yield." International Journal of Biosciences. 2019;14(4):338-349.
Karema FM, Irandu EM, Mbatia P. "Role of Walking and Cycling in Promotion of Mobility in Kenya: A Case Study of Laikipia County, Kenya." International Journal of Research and Innovation in Applied Science,. 2019;Vol. IV(Issue VIII):49-61.
Karema FM, Irandu EM, Mbatia P. "Role played by Bicycles in Rural Employment diversification in Laikipia County. Kenya." International Journal of Innovative Science and Research Technology. 2019;Vol. 4 (7):770-772.
Benignus Valentine Ngowi, Henri Edouardo-Zefack Tonnang, Fathiya Khamis, Evans Mungai Mwangi, Brigitte Nyambo PNN, Subramanian S. "Seasonal abundance of Plutella xylostella (Lepidoptera: Plutellidae) and diversity of its parasitoids along altitudinal gradients of the eastern Afromontane." Phytoparasitica. 2019:1-17.
Kyomuhimbo D, Michira IN, Mwaura FB, Derese S, Feleni U, Iwuoha EI. "Silver-Zinc Oxide nanocomposite Antiseptic Extract of Bidens Pilosa." SN Applied Sciences. 2019;1:681.
Derese S. "Silver–zinc oxide nanocomposite antiseptic from the extract of Bidens pilosa." Springer Nature Switzerland AG 2019. 2019;1(7):681. Abstractsilver-zinc_oxide_nanocomposite_antiseptic_from_the_extract_of_bidens.pdf

Silver nanoparticles (Ag-NPs), zinc oxide (ZnO-NPs) and zinc oxide–silver (ZnO–Ag-NPs) were biosynthesized based on
the rich matrix of alkaloids, flavones, tannins capping/stabilizing agents present in Bidens pilosa extract. Different plant
parts-root, leaf and seed ware used to prepare the plant extract for synthesis. Also, zinc and silver nitrate salts were
used as precursor materials. The surface plasmon peaks (SPR) based on the UV–Vis results for the Ag-NPs, ZnO-NPs were
located between 408–411 and 365–450 nm respectively. The SPR peaks for the Ag–ZnO-NPs occurred at 300–450 nm
indicating both blue and red shifts. The Ag–ZnO-NPs SPR shifts were associated with possible nanoparticle size reduction
and change in dielectric constant of the synthesis medium. Raman measurement peaks at 356, 484, 1350, 1578,
2435 cm−1 associated with OH, –C==C–, –C–O, S=O, =C–H moieties indicated successful capping. Nanoparticle yield was
temperature dependent and optimal yield could not be tied to a particular plant part as source of extract. Tunneling
electron microscope results showed Ag-NPs and ZnO-NPs were globular/spherical with a diameter range of 2–20 nm.
Interestingly, ZnO-NPs TEM displayed isolated miniaturized globular nanoparticles (< 2 nm) which then joined up to form
a large donut shaped structure indicating different formation mechanisms for the nanoparticles. XRD results showed the
Ag-NPs, ZnO-NPs and the Ag–ZnO-NPs particles were crystalline in nature. The high signal/noise in XRD originated from
possible crystalline biomaterials in the extracts. Energy dispersive spectroscopy (EDS) elemental composition results
confirmed successful formation of the nanoparticles. Anti-Microbial activity of the synthesized Ag-NPs, ZnO-NPs and
ZnO–Ag-NPs were studied against gram negative bacteria Escherichia coli (E. coli), gram positive bacteria Staphylococcus
aureus and fungus Candida albicans. Different ZnO: Ag-NPs nanocomposite ratios were used to test for antimicrobial
activity. Optimal antimicrobial activity was attained at Ag-NPs:ZnO-NPs ratio of 4:1 which also displayed the least minimum
inhibition concentration (MIC) and therefore was used as the active ingredient in formulating a hand sanitizing
antiseptic. The formulated antiseptic exhibited good antimicrobial activity.
Keywords

Kennedy O, Abiy Y, Ramni J, Andrew S, Keith S. "A simple field based method for rapid wood density estimation for selected tree species in Western Kenya." Scientific African. 2019;5:e00149.
Addisu A, Olago D, Wandiga S, Oriaso S, Amwata DA. "Smallholder Farmers Vulnerability Level to Climate Change Impacts and Implications to Agricultural Production in Tigray Regional State, Northern Ethiopia." Journal of Agriculture and Crops, Academic Research Publishing Group . 2019; 5(12): 237-250. Abstractideas.repec.org

Vulnerability to climate change impact is the most pressing issues for less developed countries whose economy mainly depends on the agricultural sector. The demand for food is growing swiftly whereas impacts of climate change on the global food production are increasing. More area specific research outputs and evidences-based policy directions are needed to tackle the ever changing climate and to reduce its impacts on the agricultural production. The aim of this study was to investigate subsistence farmer household’s vulnerability level to climate change impacts and its associations with household’s agricultural production. Then primary data was collected from 400 households from Kolla Temben District, Tigray Regional State, North Ethiopia. Multistage sampling techniques were applied to select households for interview from the district. In the first stage, 4 Kebelles (Kebelle - administration unit) were selected randomly out of 27 Kebelles and then400 households were selected for interview through systematic random sampling techniques (Figure 1). Multiple regressions were used to examine the associations between household’s vulnerability to climate change impacts and agricultural production. Grounded theory and content analysis techniques were use to analyze data from key informant interviews and focus group discussions. For every single unit increase in household vulnerability to climate change impacts, there was an average agricultural production decrease between 16.99 and 25.83 (Table 4). For single unit increase in household’s vulnerability to climate change impact, there was a decrease of total crop production, Total income, total livestock, total food consumption and food consumption per adult equivalent. Rainfall decrease, small farmland ownership, steep topography, frequent flood occurrences and large family size are among the major factors that negatively affect household’s agricultural production and total income. The more the vulnerable the households, the less in total annual crop production, total livestock size, total income from agricultural production and the more dependent on food aid). There is a negative association between household’s vulnerability level to climate change impacts and agricultural production (crop production, total livestock ownerships and total income from crop production). More access to irrigation and agricultural fertilizers, improved varieties of crops, small family size, improve farmland ownership size, more access to education and Agricultural Extension services are an effective areas of intervention to improve household’s resilient, reduce households vulnerability level to climate change impacts and increase household’s total agricultural production.

Mbugua, M., Nzuma, M.J., Muange, J. "Social networks and Ex-post risk management among smallholder farmers in Kenya." Development Studies Research. 2019;6(1):30-39.
Chimoita EL, Onyango CM, Gweyi-Onyango JP, Kimenju JW. "Socio-economic and Institutional Factors Influencing Uptake of Improved Sorghum Technologies in Embu, Kenya." East African Agricultural and Forestry Journal. 2019:1-11.
Chimoita EL, Onyango CM, Gweyi-Onyango JP, Kimenju JW. "Socioeconomic and Institutional Factors Influencing Uptake of Improved Sorghum Technologies in Embu, Kenya." East African Agricultural and Forestry Journal. 2019;2(1):DOI: 10.1080/00128325.2019.1597568.
IRIBEMWANGI PI, Karani R, Olali T. "Software Localization: An Exploration of the Problems Encountered by Localizers in Transfering Messages from English into Kiswahili." Mwanga wa Lugha, Kiswahili Journal of Moi University. . 2019;3(1):125-146.
Dorcas K, Koech OK, Kinama J, Chemining’wa G, Ojulong HF. "Sorghum Production Practices In An Integrated Crop-Livestock Production System In Makueni County, Eastern Kenya." Tropical and Subtropical Agroecosystems. 2019;22:13-23.2019-_sorghum_production_practices-_dorcas.pdf
"Spatial and Political Factors in Forest Resource Conflicts: The Eastern Mau Forest Case 1992–2014. ." Journal Society & Natural Resources An International Journal . 2019;32(11):1276-1292.
Nyangacha RM, Oyieke F, Erastus Muniu, Stanley Chasia MO. "Spatial distribution, prevalence and potential risk factors of Tungiasis in Vihiga County, Kenya." PLoS neglected tropical diseases. 2019;13(3):e0007244.
Nyangacha RM, Odongo D, Oyieke F, Bii C, Muniu E, Chasia S, Ochwoto M. "Spatial distribution, prevalence and potential risk factors of Tungiasis in Vihiga County,Kenya." PLoS Negl Trop Dis. 2019;13:e0007244.nyangacha_et_al._2019.pdf
Lumumba, B. O, Nzuma MJ. "Spatial Integration and Price Relationships in Kenyan Sorghum Markets." Journal of Agricultural Economics, Extension and Rural Development. 2019;7(7):944-949.
Wanjala G, Baariu IM. "Staffing Practices of the Teachers’ Service Commission and Academic Performance in Public Primary Schools in Merti Sub-County, Kenya." East African Scholars Journal of Education, Humanities and Literature . 2019;2(11):683-691.abstract--.pdf
Baariu S, Mulaku G, Siriba D. "State of Cartographic Services among the East African Community Member States." Journal of Geographic Information System. 2019;11:56-65.
and Werikhe, G. KORCNMW. "Status and process analysis of koche, a traditional pastoral meat product in Kenya." Pastoralism: Research, Policy and Practice. 2019;9(6).
G. W, N KC, MW O, H.G. R. "Status and process analysis of Koche, a traditional pastoral meat product in Kenya." Pastoralism: Research, Policy and Practice. 2019;9(6):1-7.
O.Akinyemi R, O.Owolabi M, MasafumiIhara, AlbertinoDamasceno, AdesolaOgunniyi, CatherineDotchin, Stella-MariaPaddick, Ogeng’o J, RichardWalker, N.Kalaria R. "Stroke, Cerebrovascular Diseases and Vascular Cognitive impairement in Africa." Brain res Bull. 2019;145:97-108. Abstract

With increased numbers of older people a higher burden of neurological disorders worldwide is predicted. Stroke and other cerebrovascular diseases do not necessarily present with different phenotypes in Africa but their incidence is rising in tandem with the demographic change in the population. Age remains the strongest irreversible risk factor for stroke and cognitive impairment. Modifiable factors relating to vascular disease risk, diet, lifestyle, physical activity and psychosocial status play a key role in shaping the current spate of stroke related diseases in Africa. Hypertension is the strongest modifiable risk factor for stroke but is also likely associated with co-inheritance of genetic traits among Africans. Somewhat different from high-income countries, strokes attributed to cerebral small vessel disease (SVD) are higher >30% among sub-Saharan Africans. Raised blood pressure may explain most of the incidence of SVD-related strokes but there are likely other contributing factors including dyslipidaemia and diabetes in some sectors of Africa. However, atherosclerotic and cardioembolic diseases combined also appear to be common subtypes as causes of strokes. Significant proportions of cerebrovascular diseases are ascribed to various forms of infectious disease including complications of human immunodeficiency virus. Cerebral SVD leads to several clinical manifestations including gait disturbance, autonomic dysfunction and depression. Pathological processes are characterized by arteriolosclerosis, lacunar infarcts, perivascular spaces, microinfarcts and diffuse white matter changes, which can now all be detected on neuroimaging. Except for isolated cases of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy or CADASIL, hereditary arteriopathies have so far not been reported in Africa. Prevalence estimates of vascular dementia (2–3%), delayed dementia after stroke (10–20%) and vascular cognitive impairment (30–40%) do not appear to be vastly different from those in other parts of the world. However, given the current demographic transition in both urban and rural settings these figures will likely rise. Wider application of neuroimaging modalities and implementation of stroke care in Africa will enable better estimates of SVD and other subtypes of stroke. Stroke survivors with SVD type pathology are likely to have low mortality and therefore portend increased incidence of dementia.

Abuga K, Ongarora D, Karumbi J, Olulo M, Minnaard W, Kibwage I. "Sub-Standard Pharmaceutical Services in Private Healthcare Facilities Serving Low-Income Settlements in Nairobi County, Kenya." Pharmacy. 2019;7(4):167. Abstract

Background: Quality pharmaceutical services are an integral part of primary healthcare and a key determinant of patient outcomes. The study focuses on pharmaceutical service delivery among private healthcare facilities serving informal settlements within Nairobi County, Kenya and aims at understanding the drug procurement practices, task-shifting and ethical issues associated with drug brand preference, competition and disposal of expired drugs. Methods: Forty-five private facilities comprising of hospitals, nursing homes, health centres, medical centres, clinics and pharmacies were recruited through purposive sampling. Structured electronic questionnaires were administered to 45 respondents working within the study facilities over an 8-week period.
Results: About 50% of personnel carrying out drug procurement belonged to non-pharmaceutical cadres namely; doctors, clinical officers, nurses and pharmacy assistants. Drug brand preferences among healthcare facilities and patients were mainly pegged on perceived quality and price. Unethical business competition practices were recorded, including poor professional demeanour and waiver of consultation fees veiled to undercut colleagues. Government subsidized drugs were sold at 100% profit in fifty percent of the facilities stocking them. In 44% of the facilities, the disposal of expired drugs was not in conformity to existing government regulatory guidelines. Conclusions: There is extensive task-shifting and delegation of pharmaceutical services to non-pharmaceutical cadres and poor observance of ethical guidelines in private facilities. Strict enforcement of regulations is required for optimal practices.

Wanjala G, L.P O. "Teacher Perception of Performance Appraisal and Development Tool in Public Primary Schools in Mumias East Sub-County, Kenya." International Journal of Innovative Research and Knowledge . 2019;4(6):69-78.abstract_.pdf
Bishop RP, Thomas T Dolan, Rosemary B Dolan RSPSAD. "THEILERIOSIS IN MOUNTAIN BONGO REPATRIATED TO KENYA: A CLINCAL AND MOLECULAR INVESTIGATION." Journal of Zoo and Wildlife Medicine. 2019;50(2):342-349.
HM M. "Tips on timely completion of postgraduate studies." Kenya Climate Smart Agriculture postgraduate induction workshop, Nakuru; 2019.
Kenana JK, Mbaria JM, Kaingu CK, Okumu PO. "Toxicological and Phytochemical Evaluation of Uvariodendron kirkii.". 2019;130:1487-1504.
Kalambuka Angeyo H, KokonyaSichangi E, AlixDehayem-Massop. "Trace metal biomarker based Cancer diagnostics in body tissue by energy dispersive X-ray fluorescence and scattering (EDXRFS) spectrometry." Spectrochimica Acta Part B: Atomic Spectroscopy. 2019;(Available online 10 June 2019). Abstract

Direct diagnosis and characterization of cancer in tissue via trace biometals analyzed by energy dispersive X-ray fluorescence (EDXRF) spectrometry is challenging, as it requires sensitive detection and accurate quantitative analysis of the appropriate cancer biomarkers. The EDXRF spectrometry technique is not directly applicable due to the complexity of the tissue biopsy samples that are of limited size and irregular geometry, enhanced scatter from the sample dark matrix and extreme matrix effects as well as spectral overlaps and prominent Bremsstrahlung that masks the subtle biomarker analyte peaks. We report on the direct determination of biometals namely Cu, Mn, Fe, Zn; Mg, Co and Na and associated speciation (for Cu, Mn, Fe) in soft body tissue in the context of disease diagnostics utilizing a robust chemometrics enabled energy dispersive X-ray fluorescence and scattering (EDXRFS) spectrometric method. The EDXRFS method exploits, in addition to multiple fluorescence spectral signatures, scatter profiles associated with the trace metals and dark matrix to determine through hybridized multivariate chemometrics calibration models, the biometals in thin (10 μm) tissue sections. Wavelet transform (WT), principal component analysis (PCA) and independent component analysis (ICA) were used for spectral preprocessing towards model optimization using con-jointly artificial neural network (ANN) and partial least squares (PLS) based on paraffin wax ‘standards’ spiked with the cancer biomarker trace metals. Results obtained from applying oyster tissue standard validated models (to ≤6% accuracy) to dog tissues (used here as human body tissue analogues) show that both prostate and mammary malignant tissues have significantly high concentration of Zn i.e. 301 ± 4 μg/g and 301 ± 4 μg/g respectively when compared to benign tissues i.e. 160 ± 3 μg/g and 171 ± 10 μg/g. The same is the case for Fe and Cu. The concentrations of Fe, Zn, Cu and Mg in malignant (mammary) as compared to benign tissues occur in the ratios 3:1, 2:1, 3:1 and 2:1. On the other hand, for prostate malignant compared to benign tumor the corresponding ratios are 5:2, 2:1, 2:1 and 2:1 respectively. Prostate cancer was found to be characterized by strong positive correlation between Cu and Mg (0.999) and Mn and Fe (0.999) while mammary cancer is characterized by strong negative correlations between Cu and Mg (−0.994), Mn and Fe (−0.974). ICA and PCA were further used to successfully discriminate the dog tissue to 97% accuracy as either cancerous or non-cancerous based on validated pattern recognition PCA-ICA models for the determination of speciation of Cu, Fe and Mn in soft body tissue. For both mammary and prostate cancer malignancy was characterized by higher speciation of Cu, Fe and Mn (i.e. Cu2+, Fe3+, and Mn7+) compared to the benign. The results of this study demonstrate that robust chemometrics enabled EDXRFS spectrometry not only determine directly and rapidly but also accurately in a diagnostics manner cancer biomarker trace metals in soft body tissue. The technique has an additional advantage in that it has inbuilt multivariate capability to model the determined levels, their ratios and correlations as well as alterations in the speciation of the biometals to detect and characterize cancer (according to severity) as well discriminate among different types of cancer in the same tissue in a simple methodology that has potential for clinical applications.

Ateto OP, Chepkonga DS. "Trade Union Officials' Perception of their Effectiveness in Industrial Dispute Resolution." International Journal of Research Publications. 2019;29(2):15.
T.N. Mudimba. "Traditional uses, phytochemistry and pharmacological activity of Carpobrotus edulis: A global perspective. ." The Journal of Phytopharmacology. 2019;Volume 8 Issue 3, 2019 (pp. 33-40):pp. 33-40.
Juma T, Mwango GN, Mulama B. "Transperineal ultrasound for anorectal malformation assessment at a tertiary hospital in Nairobi, Kenya." East and Central Africa Journal of Surgery. 2019;24(3).
Omole RA, Moshi MJ, Heydenreich M, Malebo HM, Gathirwa JW, Ochieng SA, Omosa LK, Midiwo JO. "Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (LF) Sol. Ex roem. & schult." Phytochemistry Letters. 2019;30:194-200. Abstract

Bioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2:MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydroheliobuphthalmin (2); and two fusicoccane diterpenoids: 11(12)-epoxyhypoestenone (3) and 3(11)-epoxyhypoestenone (4). The chemical structures were determined using various spectroscopic techniques: UV–vis, IR, CD, 1D, 2D and MS. Two fractions (RAO-43B and RAO-43D) and the isolated compounds were tested for activity against CQ susceptible (D6) and resistant (W2) Plasmodium falciparum parasite strains, in vitro and the IC50 values determined. While the whole extract and some resultant fractions displayed moderate activity, the isolated compounds exhibited mild anti-plasmodial activity against the both strains ranging from IC50 value of 328 μM in 1 to 93 μM in 3 against W2 strain.

Omole RA, Moshi MJ, Heydenreich M, Malebo HM, Ochieng’ SA, Omosa LK, Midiwo JO. "Two novel lignans derivatives and two fusicoccane diterpenoids from whole plant of Hypoestes verticillaris (L.f.) Sol. ex Roem. & Schult." Phytochemistry Letters. 2019;30:194-200.omole_et_al_2019.pdf
Michira JN, Indindi H. "Uchanganuzi wa Tafsiri za Kiwavuti katika Ujifunzaji wa Kiswahili kama Lugha ya Kigeni: Mfano wa Google Translate." Jarida la Kimataifa la Isimu ya Kibantu (JAKIIKI). 2019;Toleo Maalum:62-79.
Makunda CS, Edeholt H. "The Unsustainability of Urban Habitat Transformation: A Case Study of Kileleshwa in Nairobi, Kenya." Africa Habitat Review Journal. 2019;13(1):1547-1560.
Ru BL, Capdevielle-Dulac C, Njaku M, Assefa Y, Chipabika G, George Ong’Amo, Jérôme Barbut GKJ. "Updated phylogenetic and systematics of the Acrapex albivena Hampson, 1910 and A. stygiata (Hampson, 1910) species groups (Lepidoptera, Noctuidae, Noctuinae, Apameini, Sesamiina), with the description of nine new species from the Afrotropics." Annales de la Société entomologique de France (NS). 2019;55(3):219-248.
Mutembei HM NG. "Urban and Peri-urban Agriculture in Nairobi; status of governance instruments in food security and Livelihoods.". In: Drivers, challenges and Sustainability issues in food security in Africa. Nairobi: Kenya Literature BureauUnversity press; 2019.
Omweri EA, Manyasi BN, Migosi J. "Use of Athletics and Debate in Developing Competencies Among Learners: Perception of Teachers." Journal of Education and Practice. 2019;10(35):54-62.
TIMAMMY RAYYA. "Ushairi katika Siasa Lamu.". In: Kiswahili, Utangamano na Maendeleo Endelevu Afrika Mashariki. Zanzibar: Kamisheni ya Kiswahili ya Afrika Mashariki; 2019.
Esther Githumbi, Marchant R, Olago D. "Using the Past to Inform a Sustainable Future: Palaeoecological Insights from East Africa.". In: Using the Past to Inform a Sustainable Future. Springer, Cham; 2019. Abstractusing_past.pdf

Abstract

An important aspect of the UN Framework Convention on Climate Change (UNFCCC), which aims to limit the increase in global temperature to 1.5 °C by 2050, has been the development of monitoring and evaluation plans that integrate climate change perspectives into new policies and programs for the protection and functioning of ecological systems. These include measures that enhance adaptive capacity, strengthen resilience and reduce vulnerability to climate change. Ecosystem change and the interaction of the different drivers of change in ecosystems have been studied at different temporal and spatial scales across different disciplines. However, the use of long temporal records documenting environmental and climatic change in understanding the impacts of the interacting drivers of change and planning sustainable use of resources is relatively new. We present examples of the use of palaeoecological data from East Africa in planning for the long-term sustainable use of natural resources by providing long-term historical perspectives on human–environment–societal–wildlife interactions and engagement with the biocultural heritage and societal evaluations of these spaces to achieve an increasingly diverse set of conservation, social and economic objectives. We link the Earth system processes whose associated boundaries can be directly related to sustainable development goals in our attempt to prevent unacceptable environmental change. The realisation that humans are having a significant impact on climate and landscapes means we now need to showcase the societal relevance of palaeoecological research and utilise its output especially in our efforts to remain within a safe operating space for humanity and ecosystems.

Awori MN, khan Mohamed MN, Mohamed AA. "Utility of the Bidirectional Glenn Shunt." Annals of African Surgery. 2019. AbstractWebsite

Background: Congenital heart disease (CHD) is a significant cause of childhood morbidity and mortality worldwide. Bi-directional Glenn Shunts (BDGS) form part of the surgical strategy used to treat CHD; no data exists on BDGS usage in the study locality. Methods: A 7-year retrospective, descriptive study was carried out at the Kenyatta National Hospital in Nairobi, Kenya, between 1 January 2006 and 31 December 2012. Results: Eleven BDGS were performed on 11 patients; 63.6% had tricuspid atresia, 27.3% had double outlet right ventricle and 9.1% had pulmonary atresia with intact ventricular septum.

Conclusion: Further studies are warranted to identify factors contributing to the late performance of BDGS, poor post-operative follow-up and failure to perform FC.

Wamwea C, Ngare P, Bidima MLDM, Mwelu S. "Valuation of Quanto Caps and Floors in a Calibrated Multi-Curve Cross-Currency LIBOR Market Model." Journal of Mathematical Finance. 2019;9(4):698-725. AbstractWebsite

Interest rate derivatives form part of the largest portion of traded financial instruments. Hence, it is important to have models that describe their dynamics accurately. This study aims at pricing Quanto caps and floors using the multi-curve cross-currency LIBOR market model (MCCCLMM) dynamics. A Black Scholes MCCCLMM Quanto caplet and floorlet formula is first derived. The MCCCLMM parameters are then calibrated to exactly match the USD and GBP cap market prices. The estimated model parameters are then used to price the Quanto options in the Black MCCCLMM Quanto caplet and floorlet formula. These prices are then compared to the Quanto cap and floor prices estimated via Monte Carlo simulations so as to ascertain its pricing accuracy

Ogeng’o JA, Mpekethu N, Gichangi P, Olabu B, Odula P, Munguti J, Misiani M. "VARIANT ANATOMY OF THE TESTICULAR ARTERY AMONG BLACK KENYANS." Anatomy Journal of Africa . 2019;8(1):1358-1367. Abstractvariant_anatomy_of_the_testicular_artery_among.pdf

Variant anatomy of the testicular artery is important for safe surgery in the retroperioneal area, and
accurate diagnosis of testicular and renal disease. The pattern of origin, number, course and branching
display ethnic and geographical variations. Data from black African populations and especially Eastern
Africa is scarce. The objective of this study was, therefore, to describe the topography of the intraabdominal
part of testicular artery in a sample of the Kenyan population. This was a descriptive crosssectional
study on one hundred (100) testicular arteries at the Department of Human Anatomy, University
of Nairobi. The samples were obtained from autopsy cases and cadaveric specimens. Standard midline
abdominal incisions were made, flaps of the anterior abdominal wall reflected and the intestines,
mesentery and pariental peritoneum retracted systematically to expose the testicular arteries. Their site
and level of origin, number, course and branching were examined. Macrographs of representative
variations were taken using a high resolution digital camera. The results were analysed using SPSS
version 21, and are presented using macrographs and frequency tables. Thirty three (33%) of the arteries
displayed a variant anatomy, with regard to their site of origin (8%), number (4%), course (14%) and
branching pattern (7%). Among the 14 cases of aberrant course, five (5%) arched over the left renal
vein, eight (8%) were retrocaval and one (1%) had a retroureteric course. Seven (7%) bifurcated within
the abdomen. The level of origin along the aorta varied from 1 centimetre above the renal arteries to 5.5
centimetres below them while the vertebral level of origin ranged from T12 to L4. This shows that the
testicular artery among Kenyans displays a high prevalence of variant anatomy characterized by origin
from the accessory renal artery, high level of aortic origin, duplication, retrocaval course and
intraabdominal; division. Preopertaive evaluation of renal and gonadal vasculature is recommended to
minimize misdiagnosis and inadvertent injury retroperitoneal surgery.

Muthini DN, Nzuma JN, Nyikal AR. "Variety Awareness, Nutrition Knowledge and Adoption of Nutritionally Enhanced Crop Varieties: Evidence from Kenya." African Journal of Agricultural and Resource Economics. 2019;14(4):225-237.
JK Omari, Mworia JK, Gichuki N, Mligo C. "Woody Species Composition in Upper Tana River Floodplain of Kenya: Potential Effects of Change in Flood Regimes." Journal of sustainability, environment and peace . 2019;1:91-97.
ONYANGO M A, OLUOCH M F. "Workforce Diversity and Performance of Kisumu Law Courts, Kenya." International Journal of Business and Social Science. 2019;10(12):doi:10.30845/ijbss.v10n12p3.
Isaac MM, Muya SM, Kiiru W, Muchai M, others. "Avian Abundance, Diversity and Conservation Status in Etago Sub-County Kisii County Kenya." Open Journal of Ecology. 2019;9:157. Abstract
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Ndithia HK, Versteegh MA, Muchai M, Tieleman IB. "AVIAN BIOLOGY.". 2019. Abstract
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Kanoti JR, Olago D, Opiyo N, Nyamai C, Dindi E, Kuria Z. "Characterization of Major Ion Chemistry and Hydro-Geochemical Processes in Mt. Elgon Trans-Boundary Aquifer and Their Impacts on Public Health." Journal of Environment and Earth Science. 2019;9(4):38-45. AbstractWebsite

There is a gradual paradox shift from the utilization of surface water to groundwater in both urban and rural Kenya. This is because surface water is both diminishing in quantity due to climate variability and deteriorating in quality due to high levels of anthropogenic contamination. In the quest to attain the Sustainable Development Goal number 6 that aim at ensuring access to safe water by all by 2030, the Government of Kenya is encouraging the development of groundwater resources whose potential is enormous though it has not been quantified. The Inter-governmental Authority on Development (IGAD) supported this research on the shared Mt. Elgon trans-boundary aquifer between Kenya and Uganda aimed at understanding its dynamics. Mt. Elgon is a Tertiary age mountain that straddles the Kenya-Uganda border and has a trans-boundary aquifer. This study investigated the groundwater chemistry and its implication on water management and human health. Physico-chemical parameters of water that included electrical conductivity, pH, and temperature were measured in the field and the major cations and anions were measured at the Central Laboratories of the State Department for Water. Geological mapping and identification of sanitary risks were undertaken during the field work. The study revealed that the concentration of cations and anions in the groundwater varied spatially and temporally. Abundance of these ions were in the order Ca²⁺ > Na⁺ > Mg²⁺ > K⁺ for most samples and HCO₃⁻ > Cl⁻ > SO₄²⁻ >NO₃⁻. Interpretation of hydro-chemical data suggests that calcium carbonate dissolution, halite dissolution, Ca/Na ion exchange and Mg/Na ion exchange are the major processes that control the ground-water chemistry. Chemical results indicate further that the groundwater is suitable for domestic use but is threatened by both anthropogenic and geological factors. Extensive use of fertilizer and the destruction of the catchment area coupled with low permeability and rock-water interactions in the metamorphic rock terrains are the main threats to groundwater quality in the region. A few water points had water with some ionic composition exceeding WHO and the local KEBS maximum limits for drinking water. Such water pose a risk to human health.

Kanoti JR, Olago D, Opiyo N, Nyamai C, Dindi E, Kuria Z. "Characterization of Major Ion Chemistry and Hydro-Geochemical Processes in Mt. Elgon Trans-Boundary Aquifer and Their Impacts on Public Health." Journal of Environment and Earth Science. 2019;9(4):38-45. AbstractWebsite

There is a gradual paradox shift from the utilization of surface water to groundwater in both urban and rural Kenya. This is because surface water is both diminishing in quantity due to climate variability and deteriorating in quality due to high levels of anthropogenic contamination. In the quest to attain the Sustainable Development Goal number 6 that aim at ensuring access to safe water by all by 2030, the Government of Kenya is encouraging the development of groundwater resources whose potential is enormous though it has not been quantified. The Inter-governmental Authority on Development (IGAD) supported this research on the shared Mt. Elgon trans-boundary aquifer between Kenya and Uganda aimed at understanding its dynamics. Mt. Elgon is a Tertiary age mountain that straddles the Kenya-Uganda border and has a trans-boundary aquifer. This study investigated the groundwater chemistry and its implication on water management and human health. Physico-chemical parameters of water that included electrical conductivity, pH, and temperature were measured in the field and the major cations and anions were measured at the Central Laboratories of the State Department for Water. Geological mapping and identification of sanitary risks were undertaken during the field work. The study revealed that the concentration of cations and anions in the groundwater varied spatially and temporally. Abundance of these ions were in the order Ca²⁺ > Na⁺ > Mg²⁺ > K⁺ for most samples and HCO₃⁻ > Cl⁻ > SO₄²⁻ >NO₃⁻. Interpretation of hydro-chemical data suggests that calcium carbonate dissolution, halite dissolution, Ca/Na ion exchange and Mg/Na ion exchange are the major processes that control the ground-water chemistry. Chemical results indicate further that the groundwater is suitable for domestic use but is threatened by both anthropogenic and geological factors. Extensive use of fertilizer and the destruction of the catchment area coupled with low permeability and rock-water interactions in the metamorphic rock terrains are the main threats to groundwater quality in the region. A few water points had water with some ionic composition exceeding WHO and the local KEBS maximum limits for drinking water. Such water pose a risk to human health.

Mwangi WE, Mogoa EM, Mwangi JN, Mbuthia PG, Mbugua SW, others. "Effects of butorphanol, meloxicam and butorphanol-meloxicam combination on wound healing after ovariohysterectomy in dogs." International Journal of Veterinary Science. 2019;8:300-307. Abstract
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Otange B, Birech Z, Rop R, Julius Oyugi. "Estimation of HIV-1 viral load in plasma of HIV-1-infected people based on the associated Raman spectroscopic peaks." Journal of Raman Spectroscopy. 2019. Abstract
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Adwet WM, Pant HJ, MANGALA MJ,... "Evaluation of hydraulic performance of an anaerobic pond using radiotracer technique." Applied Radiation and …. 2019. AbstractWebsite

A radiotracer investigation was carried out in a wastewater stabilization pond using radiotracer technique. Residence time distribution (RTD) of wastewater was measured using Iodine-131 as a radiotracer. The measured RTD was treated and mean residence time …

GATARI MJ. "First WHO Global Conference on Air Pollution and Health: A Brief Report." Clean Air Journal. 2019. AbstractWebsite

The subject conference (documented in www. who. int) was organized by WHO in collaboration with WMO, CCAC, UNFCC, UNECE, The World Bank, UN-DESA and EU-DEVCO in Geneva, Switzerland from 30 October to 01 November 2018. The conference …

GATARI MJ, Kinney PL, Yan B, Sclar E,... "High airborne black carbon concentrations measured near roadways in Nairobi, Kenya." … Research Part D …. 2019. AbstractWebsite

Airborne black carbon (BC) particles have serious implications for human health and climate change and thus represent a prime target for mitigation policies. The sources of BC include vehicles burning diesel fuel, which are common in urban areas in low-income countries. The …

Gitau J, GATARI MJ, Pant HJ. "Investigation of flow dynamics of porous clinkers in a ball mill using technitium-99m as a radiotracer." Applied Radiation and Isotopes. 2019. AbstractWebsite

A radiotracer investigation was carried out in a ball mill of a cement plant in Kenya. Residence time distribution (RTD) of raw feed to the mill was measured using Technetium-99m adsorbed on the clinkers as a radiotracer. From the measured RTDs, solid holdup and …

KANOTI JR, Olago D, Opiyo N, Nyamai C, Dulo S, Ayah R. "Microbial and Physical Chemical Indicators of Groundwater Contamination in Kenya: A Case Study of Kisumu Aquifer System, Kenya." Journal of Water Resource & Protection. 2019;11:404-418. AbstractWebsite

Safe water of adequate quantity, and dignified sanitation, is vital for the sustenance of a healthy and productive human population. In the recognition of this, the United Nations formulated the Sustainable Development Goal No. 6 to ensure access to safe water and sanitation by all by 2030. Actualization of this Goal requires information on the existing status of water resources and sanitation levels. Knowledge on contamination of groundwater is essential to prevent risks to human health. The objective of this study was to determine groundwater contamination in Kisumu, Kenya. A total of 275 water samples were collected from 22 sites within the informal settlements between December 2016 and December 2017. The samples were analysed for bacterial contamination and physical chemical quality. Thermal tolerant coliform bacteria enumeration was used as a proxy to bacteria contamination, and the pH, turbidity, dissolved oxygen, conductivity, salinity and temperature were used as physical chemical indicators of contamination. The results indicate that groundwater in Kisumu hosed coliform bacteria and therefore didn’t comply with contamination limits for domestic water proposed by WHO and local KEBS standards. The results further indicated that the levels of bacteriological contamination vary with water type, shallow well having the highest bacterial loads. The study concluded that there were potential risks to human health due to high content of coliform bacteria. The study attributed the contribution to pit latrines that were present in virtually all compounds. The pit latrines are located close to the water points. The study recommended the definition of minimum distance between the pit latrines and shallow wells to minimize contamination. The low income dwellers should be educated on simple ways of treating drinking water contaminated by microbial to minimize enteric infections.

KANOTI JR, Olago D, Opiyo N, Nyamai C, Dulo S, Ayah R. "Microbial and Physical Chemical Indicators of Groundwater Contamination in Kenya: A Case Study of Kisumu Aquifer System, Kenya." Journal of Water Resource & Protection. 2019;11:404-418. AbstractWebsite

Safe water of adequate quantity, and dignified sanitation, is vital for the sustenance of a healthy and productive human population. In the recognition of this, the United Nations formulated the Sustainable Development Goal No. 6 to ensure access to safe water and sanitation by all by 2030. Actualization of this Goal requires information on the existing status of water resources and sanitation levels. Knowledge on contamination of groundwater is essential to prevent risks to human health. The objective of this study was to determine groundwater contamination in Kisumu, Kenya. A total of 275 water samples were collected from 22 sites within the informal settlements between December 2016 and December 2017. The samples were analysed for bacterial contamination and physical chemical quality. Thermal tolerant coliform bacteria enumeration was used as a proxy to bacteria contamination, and the pH, turbidity, dissolved oxygen, conductivity, salinity and temperature were used as physical chemical indicators of contamination. The results indicate that groundwater in Kisumu hosed coliform bacteria and therefore didn’t comply with contamination limits for domestic water proposed by WHO and local KEBS standards. The results further indicated that the levels of bacteriological contamination vary with water type, shallow well having the highest bacterial loads. The study concluded that there were potential risks to human health due to high content of coliform bacteria. The study attributed the contribution to pit latrines that were present in virtually all compounds. The pit latrines are located close to the water points. The study recommended the definition of minimum distance between the pit latrines and shallow wells to minimize contamination. The low income dwellers should be educated on simple ways of treating drinking water contaminated by microbial to minimize enteric infections.

Kanoti JR, Olago D, Opiyo N, Nyamai C. "An overview of groundwater and sanitation challenges in Kisumu City, Kenya." International Journal of Innovative Research & Development. 2019;8(4). AbstractWebsite

The sub-surface is used in most parts of Africa as a repository of human waste and as a source of groundwater through pit latrines and shallow wells respectively. The wells provide freshwater to millions of people in Africa who are either not connected to the piped water or have intermittent supplies. These shallow wells are hand dug and therefore are mostly less than 20 meters in depth. This same sub-surface environment is also used as a repository of human waste through pit latrines. The water points and the sanitation facilities are mostly located close to each other. This study aimed at appraising the groundwater and sanitation challenges based on a rapid survey, sampling, interviews, existing literature review and historical borehole data in Kisumu city, Kenya. Previous studies in the area have shown that the number of shallow wells, city buildings, density of unimproved pit latrines and sanitary risks have increased tremendously between 1999 and 2019. Most of the wells are shallow and therefore prone to contamination by pollutants. Fluoride and chloride content in most boreholes are above the recommended WHO maximum values and the local KEBS standards. The study confirmed that the main water and sanitation challenges in Kisumu are poor and deteriorating water quality, poor waste disposal management systems and poor sanitation services. There is need for the introduction of new and sustainable groundwater approaches supported by scientific models and involving all stakeholders. Current deficiencies in the provision of adequate water and dignified sanitation to the poor in Kisumu can be remedied through improved knowledge on shallow aquifer dynamics and innovative research. It was noted that apart from the donor agencies and multi-national NGOs, the private investors are unwilling to invest in water projects in Kisumu due in part to government legislation that constrains the cost that may be levied on water

Kanoti JR, Olago D, Opiyo N, Nyamai C. "An overview of groundwater and sanitation challenges in Kisumu City, Kenya." International Journal of Innovative Research & Development. 2019;8(4). Abstract

The sub-surface is used in most parts of Africa as a repository of human waste and as a source of groundwater through pit latrines and shallow wells respectively. The wells provide freshwater to millions of people in Africa who are either not connected to the piped water or have intermittent supplies. These shallow wells are hand dug and therefore are mostly less than 20 meters in depth. This same sub-surface environment is also used as a repository of human waste through pit latrines. The water points and the sanitation facilities are mostly located close to each other. This study aimed at appraising the groundwater and sanitation challenges based on a rapid survey, sampling, interviews, existing literature review and historical borehole data in Kisumu city, Kenya. Previous studies in the area have shown that the number of shallow wells, city buildings, density of unimproved pit latrines and sanitary risks have increased tremendously between 1999 and 2019. Most of the wells are shallow and therefore prone to contamination by pollutants. Fluoride and chloride content in most boreholes are above the recommended WHO maximum values and the local KEBS standards. The study confirmed that the main water and sanitation challenges in Kisumu are poor and deteriorating water quality, poor waste disposal management systems and poor sanitation services. There is need for the introduction of new and sustainable groundwater approaches supported by scientific models and involving all stakeholders. Current deficiencies in the provision of adequate water and dignified sanitation to the poor in Kisumu can be remedied through improved knowledge on shallow aquifer dynamics and innovative research. It was noted that apart from the donor agencies and multi-national NGOs, the private investors are unwilling to invest in water projects in Kisumu due in part to government legislation that constrains the cost that may be levied on water

KokonyaSichangi E, Kalambuka Angeyo H, AlixDehayem-Massop. "Trace metal biomarker based Cancer diagnostics in body tissue by energy dispersive X-ray fluorescence and scattering (EDXRFS) spectrometry." Spectrochimica Acta Part B: Atomic Spectroscopy. 2019:105635. Abstract
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KokonyaSichangi E, Kalambuka Angeyo H, AlixDehayem-Massop. "Trace metal biomarker based Cancer diagnostics in body tissue by energy dispersive X-ray fluorescence and scattering (EDXRFS) spectrometry." Spectrochimica Acta Part B: Atomic Spectroscopy. 2019:105635. Abstract
n/a
KokonyaSichangi E, Kalambuka Angeyo H, AlixDehayem-Massop. "Trace metal biomarker based Cancer diagnostics in body tissue by energy dispersive X-ray fluorescence and scattering (EDXRFS) spectrometry." Spectrochimica Acta Part B: Atomic Spectroscopy. 2019:105635. Abstract
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2018
Kamweru K. "Housing as Process: An Approach Based of a Multiple Client Approach.". In: 8th Annual East Africa Workshop and Exhibition,. ADD Building, University of Nairobi; 2018.
Kanoti JR, Olago D, Taylor R, Opiyo N, Nyamai C. "Situational analysis of threats to groundwater in the Lake Victoria Basin: A case study of Kisumu City, Kenya.". In: IAH Congress. Daejeon, South Korea; 2018. Abstract

Based on a five-town case-study cohort in Kenya, a conceptual framework has been developed to enable the formulation of holistic and effective strategies that encompass the national aspirations and regional to global sustainability agendas, and which can be used to monitor progress in achieving set objectives. The approach is flexible, scalable and transferrable, so that it can be applied in different contexts and using different indicators, based upon the same construct. Insufficient technical knowledge of urban aquifers and their interplay with the wider social-ecological system constrains the development of holistic, effective and robust management systems to ensure their sustainability for intended uses. The objective was to consider governance and management solutions that could promote water security for urban towns in Kenya through the sustainable use of groundwater in the context of its complex hydrogeology, water access disparities, competing uses and future risks. The in force national and county water policies, strategies, and plans for the case study areas were critically reviewed. The status of aquifer knowledge, water access disparities, competing uses, and risks was evaluated from critical literature reviews and data compilation, fieldwork, and analysis of indicator datasets from the Kenya 2009 census. Key aquifers need urgent characterisation to reverse the current situation whereby development proceeds with insufficient aquifer knowledge. Private sector and public participation in management should be enhanced through decentralised management approaches. Water infrastructure and technologies should be fit-for-purpose in application and scale, and the pro-poor focus should be underpinned by appropriately focused management regimes.

Kanoti JR, Olago D, Taylor R, Opiyo N, Nyamai C. "Situational analysis of threats to groundwater in the Lake Victoria Basin: A case study of Kisumu City, Kenya.". In: IAH Congress. Daejeon, South Korea; 2018. Abstract

Based on a five-town case-study cohort in Kenya, a conceptual framework has been developed to enable the formulation of holistic and effective strategies that encompass the national aspirations and regional to global sustainability agendas, and which can be used to monitor progress in achieving set objectives. The approach is flexible, scalable and transferrable, so that it can be applied in different contexts and using different indicators, based upon the same construct. Insufficient technical knowledge of urban aquifers and their interplay with the wider social-ecological system constrains the development of holistic, effective and robust management systems to ensure their sustainability for intended uses. The objective was to consider governance and management solutions that could promote water security for urban towns in Kenya through the sustainable use of groundwater in the context of its complex hydrogeology, water access disparities, competing uses and future risks. The in force national and county water policies, strategies, and plans for the case study areas were critically reviewed. The status of aquifer knowledge, water access disparities, competing uses, and risks was evaluated from critical literature reviews and data compilation, fieldwork, and analysis of indicator datasets from the Kenya 2009 census. Key aquifers need urgent characterisation to reverse the current situation whereby development proceeds with insufficient aquifer knowledge. Private sector and public participation in management should be enhanced through decentralised management approaches. Water infrastructure and technologies should be fit-for-purpose in application and scale, and the pro-poor focus should be underpinned by appropriately focused management regimes.

Kanoti JR, Olago D, Taylor R, Opiyo N, Nyamai C. "Situational analysis of threats to groundwater in the Lake Victoria Basin: A case study of Kisumu City, Kenya.". In: IAH Congress. Daejeon, South Korea; 2018. Abstract

Based on a five-town case-study cohort in Kenya, a conceptual framework has been developed to enable the formulation of holistic and effective strategies that encompass the national aspirations and regional to global sustainability agendas, and which can be used to monitor progress in achieving set objectives. The approach is flexible, scalable and transferrable, so that it can be applied in different contexts and using different indicators, based upon the same construct. Insufficient technical knowledge of urban aquifers and their interplay with the wider social-ecological system constrains the development of holistic, effective and robust management systems to ensure their sustainability for intended uses. The objective was to consider governance and management solutions that could promote water security for urban towns in Kenya through the sustainable use of groundwater in the context of its complex hydrogeology, water access disparities, competing uses and future risks. The in force national and county water policies, strategies, and plans for the case study areas were critically reviewed. The status of aquifer knowledge, water access disparities, competing uses, and risks was evaluated from critical literature reviews and data compilation, fieldwork, and analysis of indicator datasets from the Kenya 2009 census. Key aquifers need urgent characterisation to reverse the current situation whereby development proceeds with insufficient aquifer knowledge. Private sector and public participation in management should be enhanced through decentralised management approaches. Water infrastructure and technologies should be fit-for-purpose in application and scale, and the pro-poor focus should be underpinned by appropriately focused management regimes.

Gitao, C.G. "PhD supervision at University of Nairobi.". In: Carta Supervision workshop. Johannesburg, South Africa; 2018.
"The entitled family relations." People Daily, May 29, 2018.
Kiragu H, Mwangi E, Kamucha G. "A rapid MRI reconstruction method based on compressive sampling and concomitant artifacts suppression.". In: 19th IEEE Mediterranean Electrotechnical Conference (MELECON). Marrakesh, Morocco ; 2018.
Kanyinga K. "Amusing game of corruption in Africa as the rule of law fails." Sunday Nation, March 24, 2018.
Kanyinga K. "Expected break with past is still elusive." Sunday Nation, March 10, 2018.
Mitema A, Okoth S, Rafudeen SM. "Molecular biomarkers and phenotypic characterization as a means of determining genetic diversity in Aspergillus flavus isolates.". In: 40th Mycotoxin Workshop Munich 2018. Munich; 2018.
Kanyinga K. "What it takes to unify the country goes beyond mega development projects." Sunday Nation, January 28, 2018.
Nambati EA, Kiarie WC, Kimani F, Kimotho JH, Otinga MS, Too E, Kaniaru S, Limson J, Bulimo W. "Unclear association between levels of Plasmodium falciparum lactate dehydrogenase (PfLDH) in saliva of malaria patients and blood parasitaemia: diagnostic implications?" Malaria Journal. 2018;17:9. Abstractnambati_et_al_2018.pdfnambati_et_al_2018.pdfWebsite

The use of saliva in diagnosis of infectious diseases is an attractive alternative to procedures that involve blood drawing. It promises to reduce risks associated with accidental needle pricks and improve patient compliance particularly in malaria survey and drug efficacy studies. Quantification of parasitaemia is useful in establishing severity of disease and in assessing individual patient response to treatment. In current practice, microscopy is the recommended technique, despite its limitations. This study measured the levels of Plasmodium falciparum lactate dehydrogenase (PfLDH) in saliva of malaria patients and investigated the relationship with blood parasitaemia.

Kanyinga K. "How to boost citizens’ participation in decision-making." Sunday Nation, February 24, 2018.
Mumbi M. "limate Responsive Architecture: Learning from the History of the Origin, Spread and Development of Tropical Modern Architecture.". In: annual Eastern African Regional Workshop, Nairobi. ADD Building, University of Nairobi; 2018.
Kanyinga K. "You needed to get close to the man to understand diplomacy." Sunday Nation, August 19, 2018.
"Nafasi ya Kiswahili katika Maswala ya Afya: mtazamo wa kiekolojia.". In: CHAKAMA. Maasai Mara University; 2018.
Muigua K. "Towards an Overarching Policy: Understanding Kenya’s Alternative Dispute Resolution Mechanisms Landscape and Culture.". In: 1st Nairobi Centre for International Arbitration (NCIA) Alternative Dispute Resolution (ADR) National Conference. Intercontinental Hotel, ; 2018.towards_an_overarching_policy-ncia_conference_paper-ncia_conference_conference_paper_6th_june_2018_kariuki_muigua_ph.d.pdf
"Decolonising Language in Kenya by use of Kiswahili and Local Languages.". In: 1st International Conference on Decolonising Education. Embu University; 2018.
Muigua K. "Utilising Alternative Dispute Resolution Mechanisms to Manage Commercial Disputes.". In: 1st Nairobi Centre for International Arbitration (NCIA) Alternative Dispute Resolution (ADR) National Conference. InterContinental Hotel, Nairobi; 2018.
Muthomi J. "Technologies and innovations in Phytosanitary Systems.". In: The 2nd Phytosanitary Conference. KEPHIS Headquarter, Nairobi, Kenya; 2018.
Mwangi N, Minnies D, Parsley S, Patel D, Gichuhi S, Muthami L, Moorman C, Macleod D, Bascaran C, Foster A. "Developing open online learning resources: Lessons from a short course on the control of blindness from diabetic retinopathy.". In: College of Ophthalmologists in Eastern Central & Southern Africa (COECSA). Addis Ababa; 2018. Abstract

Background: A need identified during another study prompted the development of the open online course on control of blindness from diabetic retinopathy. In our technological age, potential for learning online can provide a unique opportunity to develop context-specific content for local relevance. We report on the lessons learnt in the development of this short online course for an international audience of diverse eye care practitioners.

Methods: We developed this online short course through a formal planning process facilitated by UNESCO. The participants included eye health educators, learning designers, and content experts. The course curriculum was informed by learning from an ongoing doctorate program, as well as by clinical, public health and educational experience.

Results: Lessons learnt include:
1. Identifying the need and content – Learning and research from a doctorate research program can inform content development.
2. Identifying the relevance – the content needs to be customized for the target audience and local context.
3. Developing the learning design – promoting digital teaching skills and co-creation of content are valuable entry points.
4. Accommodating appropriate peer review and mentorship may enhance learning and quality assurance.
5. Resource planning activities need to be documented as a learning point.
6. There are significant costs in course development, such as time spent in content development, and ongoing maintenance eg maintaining the online platform.
7. Sources of quality open access resources in eye care are limited.

Conclusion: Content development is a unique learning experience, and it is essential to develop and support context specific learning resources. Open educational practice supports a collaborative process that enhances relevance and quality of training. The online format emphasizes the importance of learning design requirements to bridge the transactional distance between the participant and the educator.

Osiro OA, Kariuki DK, Gathece LW. "Composition, Particle Size, Setting Time of Clinker and Geopolymer Cements.". In: IADR. London, UK; 2018.
Mwadime JM, Waruiru RM, Mbuthia PG, Wanja DW, Maina JG, Maina SK, Nzalawahe J, Mdegela RH. "Heavy Neascus species infestation of farmed Oreochromis niloticus in Kirinyaga county, Kenya.". In: KVA Annual Scientific Conference. Greenhill Hotel, Nyeri, Kenya; 2018.
Wanja DW, Mbuthia PG, Waruiru RM, Mwadime JM, Bebora LC, Nyaga PN, Ngowi HA, Mdegela RH. "Preliminary findings of common bacterial pathogens affecting farmed fish in Kirinyaga County, Kenya.". In: KVA Annual Scientific Conference. Greenhill Hotel, Nyeri, Kenya; 2018.
Olali T. "Ecology as thematic foci: The identity of Swahili Poetry and Ecocriticism experiment.". In: Environments of African Literature. Marriott Wardman Park, Washington, D.C, USA ; 2018.
Otieno CA, Wairimu S, Madadi VO, Kimani E, Jama HH, Ayah R. "TO DETERMINE THE USE OF LOCAL RAW MATERIALS IN MANUFACTURE OF MEDICAL DEVICES: CASE STUDY OF ZEOLITE FOR OXYGEN CONCENTRATOR .". In: 1st Annual Conference on Science for Development: Supporting Manufacturing, Affordable Housing, Universal Healthcare and Food Security . Nairobi, Kenya; 2018.
Inyega HN, Inyega JO. "Implementing a school-based teacher support system for sustainable education development in Kenya.". In: International Conference on Research and innovation in Education. Nairobi: University of Nairobi; 2018.
Mwihia EW, Lyche JL, Mbuthia PG, Gathumbi JK, Maina J, Ivanova L, Uhlig S, Mulei IR, Eriksen GS. "Co-occurrence of multiple mycotoxins in fish feed in Kenya.". In: ASM 2018 Scientific Programme. Leisure Lodge Resort, Mombasa, Kenya; 2018.
Ayah R, Gitau S, Rogge M, Mugasia D, Hoyle W, Ogot M. "Creating High Value, High Impact Products from Recycled Plastic: Case Study, Building Digital Microscopes for Malaria Diagnosis. .". In: 1st Annual Architecture & Engineering Conference. Nairobi, Kenya; 2018.
Njenga L, Nguli1 M, M. J. Gatari1, Shepherd2 K. "Assessment of Selected Micronutrients in Common Beans in Kenya.". In: INTERNATIONAL INORGANIC CHEMISTRY CONFERENCE. Best western Meridian Hotel, Nairobi, Kenya; 2018.
Njenga LW, Mbugua, M., Onani, M.O., Odhiambo RA, Wandiga SO. "New Bis(Pyrrolylimine) Platinum (II) and Palladium (II) Complexes: Synthesis, X-Ray Structure Determination, Spectroscopic Characterization, and in vitro Anticancer Activity on Various Human Carcinoma Cell Lines.". In: INTERNATIONAL INORGANIC CHEMISTRY CONFERENCE. Best western Meridian Hotel, Nairobi, Kenya; 2018.
Njenga1 LW, Njogu1 REN, Kariuki1 DK, AY1O, Wendt OF. "Tris-Cyclometalated Iridium (III) Complexes: Synthesis, Characterization and Selected Applications.". In: INTERNATIONAL INORGANIC CHEMISTRY CONFERENCE. Best western Meridian Hotel, Nairobi, Kenya; 2018.
Lolgisoi LB, Kimani EK, Ayah R, Jama HH. "Improving the Prototyping Manufacturing Processes: The Development of an Assembly Manual for Suction Machine.". In: 1 st Annual Architecture and Engineering Conference 2018. Nairobi, Kenya; 2018.
Kimani EK, Ayah R, Jama HH. "Prototyping Process at the University of Nairobi Maker-Space: A Case Study of Medical Devices for Maternal Newborn Health.". In: 1 st Annual Architecture and Engineering Conference 2018. Nairobi, Kenya; 2018.
BIRIR J, Gatari MJ, RAJAGOPAL P, Mwea SK, MUIA ML. "Interaction of ultrasonic waves with defects.". In: NDE2018. Mumbai, India; 2018.
"Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women." J. Infect. Dis.. 2018;218(8):1210-1218. Abstract

Attenuated varicella zoster virus (VZV) is a promising vector for recombinant vaccines. Because human immunodeficiencyvirus (HIV) vaccines are believed to require mucosal immunogenicity, we characterized mucosal VZV-specific humoral immunity following VZVOka vaccination.

Marangu D, Pillay K, Banderker E, Gray D, Vanker A, Zampoli M. "Exogenous lipoid pneumonia: an important cause of interstitial lung disease in infants." Respirol Case Rep. 2018;6(7):e00356. Abstract

Exogenous lipoid pneumonia (ELP), an important cause of interstitial lung disease, often goes unrecognized. We conducted a retrospective study of children with histologically confirmed ELP at Red Cross Children's Hospital, South Africa. Twelve children of Zimbabwean heritage aged 2.1-10.8 months were identified between 2012 and 2017. Repeated oral administration of plant-based oil for cultural reasons was reported by 10 of 11 caregivers. Cough (12/12), tachypnoea (11/12), hypoxia (9/12), and diffuse alveolar infiltrates on chest radiography (12/12) were common at presentation. Chest computed tomography revealed ground-glass opacification with lower zone predominance (9/9) and interlobular septal thickening (8/9). Bronchoalveolar lavage specimens appeared cloudy/milky, with abundant lipid-laden macrophages and extracellular lipid on Oil-Red-O staining (12/12), with polymicrobial (6/12) and Mycobacterium abscessus (2/12) co-infection. Antibiotics, systemic corticosteroids, and therapeutic lavage were interventions in all eight and five patients, respectively. Clinicians should consider ELP in children with non-resolving pneumonia in settings with similar practices.

Nangia V, Jonas JB, George R, Lingam V, Ellwein L, Cicinelli MV, Das A, Flaxman SR, Keeffe JE, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Resnikoff S, Silvester AJ, Tahhan N, Taylor HR, Wong TY, Bourne RRA. "Prevalence and causes of blindness and vision impairment: magnitude, temporal trends and projections in South and Central Asia." Br J Ophthalmol. 2018. AbstractWebsite

BACKGROUND:To assess prevalence and causes of vision loss in Central and South Asia.

METHODS: A systematic review of medical literature assessed the prevalence of blindness (presenting visual acuity<3/60 in the better eye), moderate and severe vision impairment (MSVI; presenting visual acuity <6/18 but ≥3/60) and mild vision impairment (MVI; presenting visual acuity <6/12 and ≥6/18) in Central and South Asia for 1990, 2010, 2015 and 2020.

RESULTS: In Central and South Asia combined, age-standardised prevalences of blindness, MSVI and MVI in 2015 were for men and women aged 50+years, 3.72% (80% uncertainty interval (UI): 1.39-6.75) and 4.00% (80% UI: 1.41-7.39), 16.33% (80% UI: 8.55-25.47) and 17.65% (80% UI: 9.00-27.62), 11.70% (80% UI: 4.70-20.32) and 12.25% (80% UI:4.86-21.30), respectively, with a significant decrease in the study period for both gender. In South Asia in 2015, 11.76 million individuals (32.65% of the global blindness figure) were blind and 61.19 million individuals (28.3% of the global total) had MSVI. From 1990 to 2015, cataract (accounting for 36.58% of all cases with blindness in 2015) was the most common cause of blindness, followed by undercorrected refractive error (36.43%), glaucoma (5.81%), age-related macular degeneration (2.44%), corneal diseases (2.43%), diabetic retinopathy (0.16%) and trachoma (0.04%). For MSVI in South Asia 2015, most common causes were undercorrected refractive error (accounting for 66.39% of all cases with MSVI), followed by cataract (23.62%), age-related macular degeneration (1.31%) and glaucoma (1.09%).

CONCLUSIONS: One-third of the global blind resided in South Asia in 2015, although the age-standardised prevalence of blindness and MSVI decreased significantly between 1990 and 2015.

Andreieva IO, Konstantynovska O, Midulla F, Marangu D, Mchedlishvili N. "Summer schools of adult and paediatric respiratory medicine: course report." Breathe (Sheff). 2018;14(1):9-12. Abstract
Mwangi N, Gachago M, Gichangi M, Gichuhi S, Githeko K, Jalango A, Karimurio J, Kibachio J, Muthami L, Ngugi N, Nduri C, Nyaga P, Nyamori J, Zindamoyen ANM, Bascaran C, Foster A. "Adapting clinical practice guidelines for diabetic retinopathy in Kenya: process and outputs." Implement Sci. 2018;13(1):81. Abstract

The use of clinical practice guidelines envisages augmenting quality and best practice in clinical outcomes. Generic guidelines that are not adapted for local use often fail to produce these outcomes. Adaptation is a systematic and rigorous process that should maintain the quality and validity of the guideline, while making it more usable by the targeted users. Diverse skills are required for the task of adaptation. Although adapting a guideline is not a guarantee that it will be implemented, adaptation may improve acceptance and adherence to its recommendations.

Mwangi N, Ng'ang'a M, Gakuo E, Gichuhi S, Macleod D, Moorman C, Muthami L, Tum P, Jalango A, Githeko K, Gichangi M, Kibachio J, Bascaran C, Foster A. "Effectiveness of peer support to increase uptake of retinal examination for diabetic retinopathy: study protocol for the DURE pragmatic cluster randomized clinical trial in Kirinyaga, Kenya." BMC Public Health. 2018;18(1):871. Abstract

All patients with diabetes are at risk of developing diabetic retinopathy (DR), a progressive and potentially blinding condition. Early treatment of DR prevents visual impairment and blindness. The natural history of DR is that it is asymptomatic until the advanced stages, thus annual retinal examination is recommended for early detection. Previous studies show that the uptake of regular retinal examination among people living with diabetes (PLWD) is low. In the Uptake of Retinal Examination in Diabetes (DURE) study, we will investigate the effectiveness of a complex intervention delivered within diabetes support groups to increase uptake of retinal examination.

Wilson KS, Wanje G, Masese L, Simoni JM, Shafi J, Adala L, Overbaugh J, Jaoko W, Richardson BA, McClelland RS. "A Prospective Cohort Study of Fertility Desire, Unprotected Sex, and Detectable Viral Load in HIV-Positive Female Sex Workers in Mombasa, Kenya." J. Acquir. Immune Defic. Syndr.. 2018;78(3):276-282. Abstract

Little is known about fertility desire in HIV-positive female sex workers. Fertility desire could increase HIV transmission risk if it was associated with condomless sex or lower adherence to antiretroviral therapy.

Pankau MD, Dalton Wamalwa, Benki-Nugent S, Tapia K, Ngugi E, Langat A, Otieno V, Moraa H, Maleche-Obimbo E, Overbaugh J, John-Stewart GC, Lehman DA. "Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants." Open Forum Infect Dis. 2018;5(1):ofx268. Abstract

We compared change in HIV reservoir DNA following continued antiretroviral therapy (ART) vs short treatment interruption (TI) in early ART-treated Kenyan infants. While HIV DNA in the reservoir decayed with continued ART, HIV DNA levels were similar to pre-TI HIV DNA reservoir levels in most children after short TI.

Pertet AM, Kaseje D, Otieno-Odawa CF, Kirika L, Wanjala C, Ochieng J, Jaoko M, Otieno W, Odindo D. "Under vaccination of children among Maasai nomadic pastoralists in Kenya: is the issue geographic mobility, social demographics or missed opportunities?" BMC Public Health. 2018;18(1):1389. Abstract

Nomadic lifestyle has been shown to be a significant factor in low immunization coverage. However, other factors which might aggravate vaccination uptake in nomadic pastoralists are poorly understood. Our study aimed at establishing the relative influence of social demographics, missed opportunities, and geographical mobility on severe under vaccination in children aged less than two years living in a nomadic pastoralist community of Kenya.

Pertet AM, Kaseje D, Otieno-Odawa CF, Kirika L, Wanjala C, Ochieng J, Jaoko M, Otieno W, Odindo D. "Under vaccination of children among Maasai nomadic pastoralists in Kenya: is the issue geographic mobility, social demographics or missed opportunities?" BMC Public Health. 2018;18(1):1389. Abstract

Nomadic lifestyle has been shown to be a significant factor in low immunization coverage. However, other factors which might aggravate vaccination uptake in nomadic pastoralists are poorly understood. Our study aimed at establishing the relative influence of social demographics, missed opportunities, and geographical mobility on severe under vaccination in children aged less than two years living in a nomadic pastoralist community of Kenya.

Davis SM, Pals S, Yang C, Odoyo-June E, Chang J, Walters MS, Jaoko W, Bock N, Westerman L, Toledo C, Bailey RC. "Circumcision status at HIV infection is not associated with plasma viral load in men: analysis of specimens from a randomized controlled trial." BMC Infect. Dis.. 2018;18(1):350. Abstract

Male circumcision provides men with approximately 60% protection from acquiring HIV infection via heterosexual sex, and has become a key component of HIV prevention efforts in sub-Saharan Africa. Possible mechanisms for this protection include removal of the inflammatory anaerobic sub-preputial environment and the high concentration of Langerhans cells on the inside of the foreskin, both believed to promote local vulnerability to HIV infection. In people who do acquire HIV, viral load is partially determined by infecting partner viral load, potentially mediated by size of infecting inoculum. By removing a portal for virion entry, prior male circumcision could decrease infecting inoculum and thus viral load in men who become HIV-infected, conferring the known associated benefits of slower progression to disease and decreased infectiousness.

Karthik S, Djukic T, Kim J-D, Zuber B, Makanya A, Odriozola A, Hlushchuk R, Filipovic N, Jin SW, Djonov V. "Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development." Sci Rep. 2018;8(1):9840. Abstract

Intussusceptive angiogenesis (IA) is a complementary method to sprouting angiogenesis (SA). The hallmark of IA is formation of trans-capillary tissue pillars, their fusion and remodeling of the vascular plexus. In this study, we investigate the formation of the zebrafish caudal vein plexus (CVP) in Tg(fli1a:eGFP) and the synergistic interaction of IA and SA in crafting the archetypical angio-architecture of the CVP. Dynamic in vivo observations and quantitative analyses revealed that the primitive CVP during development was initiated through SA. Further vascular growth and remodeling occurred by IA. Intussusception contributed to the expansion of the CVP by formation of new pillars. Those pillars arose in front of the already existing ones; and in a subsequent step the serried pillars elongated and fused together. This resulted in segregation of larger vascular segments and remodelling of the disorganized vascular meshwork into hierarchical tree-like arrangement. Blood flow was the main driving force for IA, particularly shear stress geometry at the site of pillar formation and fusion. Computational simulations based on hemodynamics showed drop in shear stress levels at locations of new pillar formation, pillar elongation and fusion. Correlative 3D serial block face scanning electron microscopy confirmed the morphological substrate of the phenomena of the pillar formation observed in vivo. The data obtained demonstrates that after the sprouting phase and formation of the primitive capillary meshwork, the hemodynamic conditions enhance intussusceptive segregation of hierarchical vascular tree i.e. intussusceptive arborization resulting in complex vascular structures with specific angio-architecture.

Gitobu CM, Gichangi PB, Mwanda WO. "The effect of Kenya's free maternal health care policy on the utilization of health facility delivery services and maternal and neonatal mortality in public health facilities." BMC Pregnancy Childbirth. 2018;18(1):77. Abstract

Kenya abolished delivery fees in all public health facilities through a presidential directive effective on June 1, 2013 with an aim of promoting health facility delivery service utilization and reducing pregnancy-related mortality in the country. This paper aims to provide a brief overview of this policy's effect on health facility delivery service utilization and maternal mortality ratio and neonatal mortality rate in Kenyan public health facilities.

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