Effect of visual deprivation on the optic centers of growing and adult mice

Citation:
Gyllensten, Lars, Torbjörn Malmfors, and Marie-Louise Norrlin. "Effect of visual deprivation on the optic centers of growing and adult mice." The Journal of Comparative Neurology. 124 (1965): 149-160.

Abstract:

The thickness of the visual cortex, the diameter of cell nuclei and the mean volume of internuclear material per nucleus in the visual cortex, geniculate bodies and superior colliculi were determined in growing and adult mice. The influence of prolonged stay in complete darkness was investigated.In the visual cortex of normal mice, a peak in nuclear size occurred 20–30 days after birth, followed by a peak in relative volume of internuclear material.In growing mice, reared in darkness from birth, a highly significant decrease in relative volume of internuclear material occurred in all visual centers. The decrease was greatest in the geniculate bodies and greater in the granular and supragranular layers of the cortex than in the infragranular. In the cortex, the decrease was most pronounced after two months and became less pronounced during prolonged stay in darkness. No similar normalization was observed in subcortical visual centers. In the same mice, visual deprivation caused a highly significant decrease in the thickness of the visual cortex and in the diameter of its cell nuclei. The decrease in nuclear diameter was greater in the granular and supragranular than in the infragranular layers of the cortex and exhibited a similar normalization during prolonged stay in darkness as the decrease in relative volume of internuclear material.In adult mice, visual deprivation caused decrease in internuclear material.

Notes:

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