DR. PAUL MUNGAI MBUGUA

Citation:

MUNGAI DRMBUGUAPAUL. "Mbugua P M and Karlsson (1985): Fasciculins from Dendroaspis angusticeps venom and their effects on cholinesterases. Toxicon 23 : 595.". In: Federation of Analytical Chemistry and Spectroscopy Society (FACSS) XV, Boston, November 1988. AWC and FES; 1985.

Abstract:

Anderson AJ, Harvey AL, Mbugua PM.
Fasciculin 2, a polypeptide from green mamba (Dendroaspis angusticeps) venom, causes an increase in the twitch response of mouse phrenic nerve-hemidiaphragm preparations to indirect stimulation. Intracellular recording reveals that fasciculin 2 augments neuromuscular transmission by increasing the amplitude and duration of endplate potentials. Its action is not reversed by washing. Interactions with neostigmine confirm that fasciculin 2 acts as an anticholinesterase. It has no presynaptic actions on transmitter release or postsynaptic receptor blocking actions. On chicken muscle preparations, fasciculin 2 has no anticholinesterase actions. Because of this selectivity and its apparent irreversibility, fasciculin 2 should be useful in characterizing different forms of acetylcholinesterase.
PMID: 2986055 [PubMed - indexed for MEDLINE]

Notes:

n/a

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