Ernest Njoroge, Peter Mbithi, Timothy Wachira, Joseph Gathuma, Peter Gathura, T E Maitho, Japhet Magambo, Eberhard Zeyhle (2005) Comparative Study of Albendazole and Oxfendazole in the Treatment of Cystic Echinococcosis in Sheep and Goats. International J

Citation:
PROF. MBITHI PMF. "Ernest Njoroge, Peter Mbithi, Timothy Wachira, Joseph Gathuma, Peter Gathura, T E Maitho, Japhet Magambo, Eberhard Zeyhle (2005) Comparative Study of Albendazole and Oxfendazole in the Treatment of Cystic Echinococcosis in Sheep and Goats. International J.". In: 4th TICH Annual Scientific Conference Kisumu, Kenya. AWC and FES; 2005.

Abstract:

The objective of this study was to compare the efficacy of teo drugs, albendazole and oxfendazole in treatment of cystic echinococcosis using naturally infected sheep and goats. Fifteen (15) animals were randomly selected into 3 groups of 5 animals each, with each group having 2 sheep and 3 goats respectively. Two groups were treated orally with either albendazole of oxfendaole at 30 mg/kg body weight twice a week for 4 weeks while the third group served as controls. Ultrasound and post mortem examination of the animals , and microscopic examination of protoscolices for eosin dye exclusion and flame cell motility were used to determine the efficacy of the two drugs. Ultrasound examination revealed that 4 animals in the albendazole group and 3 in oxfendazole group had decreased cyst viability (p<0.05). There were no changes in idendifiable cysts of control animals. Microscopic ecaminaiton showed that 60.9% (14/23) of the cysts from albendazole group had dead protoscolices compared to 93.3% (14/15) and 27.3% (3/11) for oxfendazole and control groups respectively. There were no significant differences between the effect of either albendazole or oxfendazole between sheep and goats. In the present study , oxfendazole has a higher efficacy (93.3%) than albendazole (60.7%) when administered at the same dosage rate (30mg/kg-body weight) and for the same period 9twice weekly for 4 weeks). Based on the findings in this study, exfendazole seems promising as an alternative drug for treatment of cystic echinococcosis.

Notes:

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