Evaluation of the efficacy of aqueous extracts of albizia anthelmintica and maerua edulis against the nematode heligmosomoides polygyrus infections in mice. Kenya Veterinaria

Citation:
Gakuya DW, Mbithi PMF, Mugambi JM, Maitho TE, Musimba NKR. "Evaluation of the efficacy of aqueous extracts of albizia anthelmintica and maerua edulis against the nematode heligmosomoides polygyrus infections in mice. Kenya Veterinaria.". In: 4th TICH Annual Scientific Conference Kisumu, Kenya. AWC and FES; 2005.

Abstract:

Anthelmintic activity of the water extracts of Albizia anthemintica bark and Maerua_edulis root was evaluated in mice that had been experimentally infected with the instestinal nematode heligmosmoides polygyrus. The mice were randomly allocated into six treatment grops and once control group. Groups 1,2 and 3 were given and one dose of water extratss of a. anthelmintica at 5gm/kg, 10gm/kg and 20 gm/kg bodyweight respectively in a divided dose on day 17 post-infection. Groups 4, 5 and 6 were given water extracts of M. edulis at a dosage of 5 gm/kg, 10gm aand 20 gm bodyweight respectively in a divided dose. Group 7 was the control and was concurrently gien a double oral dose of 0.2ml pf physiological saline each. Mortality of some mice was observed in four groups after treatment. Five days after treatment, faecal worm egg count reduction was determined. The results showed a percentage faecal H. polygyrus egg count reduction of 72%, 69%, 50%, 42% in groups 2,6,3 and I respectively. Seven days after treatment there was a reduction I worm counts at postmortem of 68%, 36%, 20%, 19%, 16% and 14% in groups 1,5,2,3, 6 and 4 respectively compared to untreated controls. These results indicate that the plant extracts had anthelmintic activity and support the use f these plants as anthelmintics.

Notes:

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