Bio

Njogu, P.M.

Dr. Njogu P. Mbugua attended Mau-Summit Primary School from 1985 to 1992 and Njoro High School from 1993 to 1996. He proceeded to the University of Nairobi in 1998 from where he graduated with a Bachelor of Pharmacy degree in 2002. He worked with the Ministry of Health, Republic of Kenya, from 2002 to 2005. He then joined the University of Nairobi to pursue Masters of Pharmacy (Pharmaceutical Analysis) and graduated in 2007. In 2008, he commenced his doctoral studies at the University of Cape Town, graduating with a PhD in Chemistry in 2012. Dr.

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Publications


2016

Njogu, PM, Chibale K.  2016.  Current and Future Strategies for Improving Drug Discovery Efficiency. Attrition in the Pharmaceutical Industry: Reasons, Implications and Pathways Forward. , Hoboken: John Wiley & Sons, Inc

2015

Kimondo, J, Miaron J, Mutai P, Njogu P.  2015.  Ethnobotanical survey of food and medicinal plants of the Ilkisonko Maasai community in Kenya. Journal of Ethnopharmacology. 175 :463–469.

2013

Njogu, PM, Gut J, Rosenthal PJ, Chibale K.  2013.  Design, synthesis and antiplasmodial activity of hybrid compounds based on (2R,3S)-N-benzoyl-3-phenylisoserine. ACS Med. Chem. Lett.. 4(7):637-641. Abstract

A series of hybrid compounds based on (2R,3S)-N-benzoyl-3-phenylisoserine, artemisinin and quinoline moieties was synthesized and tested for in vitro antiplasmodial activity against erythrocytic stages of K1 and W2 strains of Plasmodium falciparum. Two hybrid compounds incorporating (2R,3S)-N-benzoyl-3-phenylisoserine and artemisinin scaffolds were three- to four-fold more active than dihydroartemisinin, with nanomolar IC50 values against Plasmodium falciparum K1 strain.

Njogu, PM, Chibale K.  2013.  Recent Developments in Rationally Designed Multitarget Antiprotozoan Agents. Curr. Med. Chem. 20(13):1715-1742. Abstract

Protozoan infections are the leading causes of morbidity and mortality among parasitic infections of humans, accounting for approximately 800 thousand mortalities and a loss of more than 30 million disability-adjusted life years annually. The major protozoan infections of humans, namely malaria, Chagas disease, human African trypanosomiasis, and leishmaniasis, are primarily centered in the tropics, with a reach into some subtropical regions of the world. Though globally massive in their impact, these diseases mostly afflict the least economically endowed and geographically marginalized populations in low-income countries. As such, there is no sufficient market incentive for industrial business-driven antiprotozoal drug discovery due to poor marketing prospects and low returns on investment. Consequently, the pharmacopoeia for majority of these diseases, composed mainly of agents with poor efficacy and unsatisfactory safety profiles, has essentially remained unchanged for decades, creating a compelling need for more efficacious and better tolerated medicines. The policy makers and the scientific community are seeking effective ways to meet this need. So far, two approaches have emerged promising in this regard: combination chemotherapy and drug repositioning. Molecular hybridization has been cited as a potential third approach that could be used to deliver new antiprotozoal chemical entities. In this review article, recent applications of this novel strategy in antimalarial, antichagasic, antitrypanosomal, and antileishmanial drug discovery research and development over the last five years will be presented and discussed.

2012

Njogu, PM, Hendricks DT, Chibale K.  2012.  Hybrids of (2R,3S)-N-benzoyl-3-phenylisoserine and anticancer pharmacophores: Design, synthesis and biological evaluation, 15-18 April. 12th Frank Warren Conference 2012. , Bloemfontein, South Africa

2011

Njogu, PM, Thoithi GN, Mwangi JW, Kamau FN, Kibwage IO, Kariuki ST, Yenesew A, Mugo HN, Mwalukumbi JM.  2011.  Phytochemical and Antimicrobial Investigation of Girardinia diversifolia (Link) Friis (Urticaceae). East Cent. Afr. J. Pharm. Sci. 14(3):89-94. AbstractPhytochemical and Antimicrobial Investigation of Girardinia diversifolia (Link) Friis (Urticaceae)

Root and stem extracts of Girardinia diversifolia exhibited varying degrees of activity against Bacillus pumilus, Staphylococcus aureus, Escherichia coli, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae. Three compounds namely β-sitosterol, 7-hydroxysitosterol and 3-hydroxystigmast-5-en-7-one, were isolated from the petroleum ether root extract. The present study gives scientific credence to the traditional use of Girardinia diversifolia in the management of microbial infections.

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