F.A. Okalebo, B.A. Rababha, A.N. Guantai, C.K. Maitai, I.O. Kibwage .W. Mwangi and W. Masengo. The Antimalarial and Antimicrobial Activity and Brine Shrimp Toxicity of Clematis Brachiata Extracts

Citation:
"F.A. Okalebo, B.A. Rababha, A.N. Guantai, C.K. Maitai, I.O. Kibwage .W. Mwangi and W. Masengo. The Antimalarial and Antimicrobial Activity and Brine Shrimp Toxicity of Clematis Brachiata Extracts." East and Central African Journato(Phannaceutical Sciences. 2002;5:15-18.

Abstract:

The ill vitro antimalarial activity of the root extract in partly supports the
ethnobotanical use of the plant to manage malaria. Clematis brachiata Thunberg
(Ranunculaceae) is used in Kenya for the management of headaches, malaria and
other febrile illnesses, abdominal disorders, yaws and for skin disorders. Old stems
and leaves are chewed for the management of toothaches and sore throats. Extracts
of the plant were subjected to tests for antimalarial, antibacterial and antifungal
activity. The toxicity of the extracts was assessed using the brine shrimp lethality
bioassay. The root extract gave the highest ill vitro antimalarial activity against the
mulitidrug resistant strain, Plasmodium Jalciparum VIIS (ICso=39.24 ug/ml). The
stem and leaf extracts had insignificant antiplasmodial activity. The leaf, stem and
root extracts had no bacterial 01' fungal inhibitory effects even at very high
concentrations of 10 mg/ml. The LDso values of the stem and leaf methanol extracts
against the brine shrimp larvae was 365.60 and 66.5 Ilg/ml, respectively.

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