M.O. Oluka, E.S. Mi1ema, I.0. Kibwage, T.O. Kwasa , G. O. Kokwaro. A Comparative Bioavailability of four carbamazepine tablet formulations available in the kenyan market.

Citation:
"M.O. Oluka, E.S. Mi1ema, I.0. Kibwage, T.O. Kwasa , G. O. Kokwaro. A Comparative Bioavailability of four carbamazepine tablet formulations available in the kenyan market. .". 1996.

Abstract:

The relative bloavailabilities of three carbamazepine tablet formulations available in the
Kenyan market (Temporal", Taver" and Carbamazepine Lincoln) compared with the
innovator formulation (Tegretol") were evaluated in seven healthy African volunteers (5
males, two females; aged 22-36 years), according to a randomlsed fourway crossover study
design, following oral administration of single 200mg doses with a three week washout
period. I" vitro dissolution profiles of the tablets were also evaluated. Relative bioavailabilities
(Frel) of Temporal", TaverR and Carbamazepine Linocoln were 101.2%, 82.2% and 71.6%
respectively, compared with Tegretols, Percent drug content dissolved ill vitro after I hour
were 91.3%, 75.9% and 39.3% for Temporal's, Taverb and Carbamazepine Lincoln,
respectively. It was concluded that Temporal+ was bioequivalent to TegretolR while TaverR
and Carbamazepin Lincoln were bioinequivalent to Tegre~IR. Administration ofTaverR or
Carbamazepine Lincoln might lead to poor control of epileptic seizures.

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