Bio

Prof. Oduor Okelo Dominic

SHORT  BIOGRAPHY

POSITION:  Professor  of  Veterinary  Anatomy.

EDUCATION.

Secondary:

  1. Strathmore  College  of  Arts & Science, Nairobi. London GCE(“A” Level)—January, 1967.
  1. St. Mary’s  School, Yala.  Cambridge School  Certificate (“O” Level)--- December, 1964.

University:

Publications


2010

2009

LETURA, DRKISIPANMOSIANY, NDEGWA DRMAKANYAANDREW,. DRONYANGODANIELW, ODUOR PROFOKELLODOMINIC.  2009.  The morphology and morphometry of the male reproductive system of the rufous sengi (Elephantulus rufescens).. MSc. Thesis, University of Nairobi. : Kisipan, M.L.

2006

2005

2004

2002

2001

2000

Otiang'a-owiti, GE, Oduor-Okelo D, Onyango DW, Werner G.  2000.  Morphological characterization of the seminiferous cycle in the goat (Capra hircus): a histological and ultrastructural study.. Abstract

The cycle of spermatogenesis/seminiferous cycle was investigated in the goat testis using both light and electron microscopy techniques. Using the various cell associations and the accompanying changes in spermatid shape and location, the cycle was divided into eight (8) successive stages. The cycle began with the accomplishment of spermiation (stage 1) and ended with apical migration and close attachment of late maturation phase spermatids at the Sertoli cell apex accompanied by adluminal retention of residual bodies with dense staining inclusions (stage 8). The early stages of the cycle (stages 1-4) were therefore characterized by the presence of only one generation of spermatids, the second one appearing only after the division of secondary spermatocytes in stage 4. Consequently, stages 5-8 had two generations of spermatids; Golgi or cap phase as well as maturation phase spermatids. Although stages 5 to 7 appeared as distinct entities, stages 6 and 7 were rather short-lived and considered as continuations of stage 5. Therefore, the 8 stages of the cycle in the goat were further condensed into 6 main divisions. The duration of each stage was estimated by the frequency of occurrence in sections. Among these, stage 1 had the highest frequency (34%) followed by stages 5-7 (27%). Stages 8 and 4 had the shortest frequency (up to 9%) while stages 2 and 3 had 13% and 12% respectively. These results indicate that, like most domestic species, goats have a cycle of 8 stages with 6 main divisions, the longest being stage 1.

ODUOR, PROFOKELLODOMINIC.  2000.  ODUOR-OKELO, D., (2000). The veterinarians and their role in leadership. Kenya Vet. 19:5-6.. MSc. Thesis, University of Nairobi. : Kisipan, M.L.

1998

1997

ODUOR, PROFOKELLODOMINIC.  1997.  OTIANG. MSc. Thesis, University of Nairobi. : Kisipan, M.L.

1995

ODUOR, PROFOKELLODOMINIC, W. PROFMAKAWITIDOMINIC.  1995.  ODUMA, J. A., WANGO, E. O., ODUOR-OKELO, D., MAKAWITI, D. W. & ODONGO, H. O. (1995). In vivo and in vitro effects of graded doses of the pesticide Hepatchlor on female sec steroid production in rats. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1994

ODUOR, PROFOKELLODOMINIC.  1994.  MAKORI,N. ODUOR- OKELO,D. WARUI C. N. & OWITI, G.E.O. (1994), , An ultrastructural and morphometric study of the late-term placenta of the root rats(Tachyoryctes splendors). In advanced in Reproductive Research in man and animals.Proc. 2nd Int. Conf. In R. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.
ODUOR, PROFOKELLODOMINIC.  1994.  OJOO, R.O., OWITI, G. E. O., ODUOR-OKELO, D. & WANGO, E.O. (1994).Daytime variations of serum testosterone and luteinizing hormone in captive thick tailed Bush Babies. J. Primat. 35(2): 211-217.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1993

ODUOR, PROFOKELLODOMINIC.  1993.  ONYANGO, D. W., ODUOR-OKELO, D. & OWITI, G E.O.(1993).Ultrastructural study of the testis of non-breeding naked mole rat (Heterocephalus glaber, Ruppell).Annals of Anatomy 175: 447-452.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1992

ODUOR, PROFOKELLODOMINIC.  1992.  OWITI, G. E. O., ODUOR-OKELO, D. & GOMBE, S. (1992). Foetal membranes and placenta of the E. African spring hare (Pedeses capensis larvalis Hollister). Afri.J. Ecol. Vol. 30: 74-86.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.
ODUOR, PROFOKELLODOMINIC.  1992.  GOMBE, S. & ODUOR-OKELO, D. (1992). Impairment of gonadal function and epididymal sperm passage following Cremaster muscle transection in the goat. J.Obst. & Gyn, E. and Central Afric. 10(2): 56-61.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1991

ODUOR, PROFOKELLODOMINIC.  1991.  MAKORI, N., ODUOR-OKELO, D. & OWITI, G. E. O., (1991). Morphogenesis of the foetal membranes and placenta of the root rat (Tachyorocytes spendens). Afric. J.Ecol. 29: 248-260.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.
ODUOR, PROFOKELLODOMINIC.  1991.  ONYANGO, D. W., OWITI, G.E.O., ODUOR-OKELO, D. & MAKAWITI, D. W.(1991). In vitro testicular interstitial (Leydig) cell response to LH and concentration of plasma testosterone and LH in the naked mole rat (Heterocephalus glaber, Ruppel). Afr. J. Ecol. Vol.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.
ODUOR, PROFOKELLODOMINIC.  1991.  ODUOR-OKELO, D. & AJIBOLA-TAYLOR,T.(1991) Universities in Kenya. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.
ODUOR, PROFOKELLODOMINIC.  1991.  ODUOR-OKELO, D. & GOMBE, S. (1991). Development of the fetal membrane in the cane rat, (Thryonomys swinderianus): A re-interpretation. Afric. J. Ecol. 29: 157-167.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1990

ODUOR, PROFOKELLODOMINIC.  1990.  WYNN, R.M., HOSCHNER, J.A. & ODUOR-OKELO, D. (1990). The interhaemal membrane of the spotted hyena: An immunohystochemical appraisal. Placenta, 11:215-221.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1986

ODUOR, PROFOKELLODOMINIC.  1986.  WAINDI, E. N., GOMBE, S. & ODUOR-OKELO, D. (1986). D. Plasma testosterone in Trypanosoma conglense infected Togernburg goats. Archives Androl. 17: 9-17.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.
ODUOR, PROFOKELLODOMINIC.  1986.  GOMBE, S. & ODUOR-OKELO, D. & O. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1985

ODUOR, PROFOKELLODOMINIC.  1985.  OWITI, G.E.O., ODUOR-OKELO, D. & GOMBE, S. (1985). Ultrastructure of the choriallantoic placenta of the spring hare (Pedetes capensis larvallis Hollister). Afic.J. Ecol. 23: 145-152.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.
ODUOR, PROFOKELLODOMINIC.  1985.  ODUOR-OKELO, D. (1985). Ultrastructural observations on the choriallantoic placenta of the golden-rumped elephant shrew, (Rhynchocyon chrysopygus). Afric. J.Ecol. 23: 155-166.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1984

ODUOR, PROFOKELLODOMINIC.  1984.  ODUOR-OKELO, D. (1984). Histology of choriallantoic placenta of the golden rumped elephant shrew (Rhynchocyon chrysophygus, Gunther 1881). Anat. Anz. Jena 157: 395-407.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.
ODUOR, PROFOKELLODOMINIC.  1984.  ODUOR-OKELO, D. (1984). An electron microscopic study of the choriallantoic placenta and subplacenta of the cane rat. (Thryonomys swinderianus Temmick).Placenta 5: 433-442.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

1983

ODUOR, PROFOKELLODOMINIC.  1983.  OGAA, J.S. & ODUOR-OKELO, D. (1983) Wildlife obstetrics. A challenge to veterinarians. Kenya Vet. 7: 14-16.. J. Comp. Biochem. Physiol. 111 C (2): 191-196.. : Kisipan, M.L. Abstract
Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental period, and blood samples were assayed for progesterone and oestrogen by radioimmunoassay. Ovarian cells from the rats were isolated and incubated either on their own, or in the presence of LH or FSH, and production of progesterone and oestrogen determined. Control incubations consisted of cells from corn oil-treated rats. The latter were also incubated on their own or in the presence of LH or FSH. Heptachlor significantly suppressed blood progesterone and oestradiol levels (P < 0.05 to P < 0.001), the degree of suppression depending on the dose and the stage of the oestrous cycle in which samples were obtained. Production of oestradiol by ovarian cells from heptachlor-treated rats was lower than for corn oil-treated controls. Cells from rats treated with low doses of heptachlor (5 mg per kg body weight) showed an increased production of progesterone, while high doses (> 20 mg per kg body weight) suppressed production.

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