Using plasma viral load to guide antiretroviral therapy initiation to prevent HIV-1 transmission.

Citation:
Murnane PM, Hughes JP, Celum C, Lingappa JR, Mugo N, Farquhar C, Kiarie J, Wald A, Baeten JM. "Using plasma viral load to guide antiretroviral therapy initiation to prevent HIV-1 transmission." PLoS ONE. 2012;7(11):e51192.

Abstract:

Current WHO guidelines recommend antiretroviral therapy (ART) initiation at CD4 counts ≤350 cells/µL. Increasing this threshold has been proposed, with a primary goal of reducing HIV-1 infectiousness. Because the quantity of HIV-1 in plasma is the primary predictor of HIV-1 transmission, consideration of plasma viral load in ART initiation guidelines is warranted.

Notes:

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