Bio

DR. ESTHER NJOKI MWANGI MAINA

Senior Lecturer in the Department of Biochemistry with interests in the Molecular Genetics of Cancer(Oncogenomics)

I am a Biochemist with a PhD in Cancer Genetics . My research interests are in the unraveling and understanding of the African Genome in matters Cancer. I am currently involved in research work on Prostate cancer and involving the multiomic approach.

I am also a Departmental Representative in various academic committees at the College of Agriculture and Veterinary Science (2009- present)

Publications


Submitted

{Capdevielle-Dulac, MZ, Balliau T, Ru BL, Kaiser-Arnauld L, Juma G, Maina E, Calatayud P-A.  Submitted.  The use of salivary $\alpha$-amylase as an evolutionary solution to host selection in parasitoids 2. Abstract
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2022

Mwakumanya, M, Ng’ong’a FA, Mutinda C K, Maina EN.  2022.  Phytochemical analysis and safety evaluation of ethanol roots extract of Erythrina sacleuxii hua in Wistar albino rats. Journal of Medicinal Plants Research. 16:126–140., Number 4 Abstract
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2021

Bor, H, Maina EN, Nyambega B, Patel KT, Ochieng’Olwal C, Nalyanya W, Gavamukulya Y.  2021.  The Potential of Differentiation-Related Gene-1 (DRG1) as a Biomarker for Metastasis of Estrogen Receptor-Positive Breast Cancer. : Journal of Advances in Medicine and Medical Research (JAMMR) Abstract
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Abdille, AA, Kimani J, Wamunyokoli F, Bulimo W, Gavamukulya Y, Maina EN.  2021.  Dermaseptin B2’s Anti-Proliferative Activity and down Regulation of Anti-Proliferative, Angiogenic and Metastatic Genes in Rhabdomyosarcoma RD Cells in Vitro. Advances in Bioscience and Biotechnology. 12:337–359., Number 10: Scientific Research Publishing Abstract
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Scriven, YA, Mulinge MM, Saleri N, Luvai EA, Nyachieo A, Maina EN, Mwau M.  2021.  Prevalence and factors associated with HIV-1 drug resistance mutations in treatment-experienced patients in Nairobi, Kenya: A cross-sectional study. Medicine. 100, Number 40: Wolters Kluwer Health Abstract
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Gavamukulya, Y, Maina EN, El-Shemy HA, Meroka AM, Kangogo GK, Magoma G, Wamunyokoli F.  2021.  Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis. Tumor Biology. 43:37–55., Number 1: IOS Press Abstract
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2020

Gavamukulya, Y, Maina EN, El-Shemy HA, Wamunyokoli F, Magoma G.  2020.  Synthesis and Characterization of Nanoparticles from Extracts of Fruits of Annona Muricata: A Green Nanobiotechnology Approach. AFRICAN JOURNAL OF SCIENCE, TECHNOLOGY AND ENGINEERING (AJSTE). 1:153–171., Number 1 Abstract
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Maina, ENM, Njau VN, Gavamukulya Y.  2020.  Phytochemical analysis and antileishmanial activity of Clerodendrum myricoides and Salvadora persica plant extracts against leishmania major. Journal of Complementary and Alternative Medical Research. 9:29–44., Number 1 Abstract
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{Kaiser, L, Juma G, Maina EN, Calatayud P-A.  2020.  Salivary $\alpha$-Amylase of Stem Borer Hosts Determines Host Recognition and Acceptance for Oviposition by Cotesia spp.(Hymenoptera, Braconidae). Parasitoids’ Ecology and Evolution. : Frontiers Media SA Abstract
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Gavamukulya, Y, Maina EN, Meroka AM, Madivoli ES, El-Shemy HA, Wamunyokoli F, Magoma G.  2020.  Green synthesis and characterization of highly stable silver nanoparticles from ethanolic extracts of fruits of Annona muricata. Journal of Inorganic and Organometallic Polymers and Materials. 30:1231–1242., Number 4: Springer US Abstract
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2019

Gavamukulya, Y, Maina EN, Wamunyokoli F, Meroka AM, Madivoli ES, El-Shemy HA, Magoma G.  2019.  Synthesis and Characterization of Silver Nanoparticles from Ethanolic Extracts of Leaves of Annona muricata: A Green Nanobiotechnology Approach. Biotechnol. J. Int. 4:1–18. Abstract
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Cheruiyot, GK, Wanyonyi WC, Kiplimo JJ, Maina EN.  2019.  Adsorption of toxic crystal violet dye using coffee husks: equilibrium, kinetics and thermodynamics study. Scientific African. 5:e00116.: Elsevier Abstract
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Gavamukulya, Y, El-Shemy HA, Meroka AM, Madivoli ES, Maina EN, Wamunyokoli F, Magoma G.  2019.  Advances in green nanobiotechnology: Data for synthesis and characterization of silver nanoparticles from ethanolic extracts of fruits and leaves of Annona muricata. Data in brief. 25:104194.: Elsevier Abstract
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Gavamukulya, Y, Maina EN, Meroka AM, Madivoli ES, El-Shemy HA, Magoma G, Wamunyokoli F.  2019.  Liquid chromatography single quadrupole mass spectrometry (LC/SQ MS) analysis reveals presence of novel antineoplastic metabolites in ethanolic extracts of fruits and leaves of Annona muricata. Pharmacognosy Journal. 11, Number 4 Abstract
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2018

Bichang’a, G, Lage J-LD, Capdevielle-Dulac C, Zivy M, Balliau T, Sambai K, Ru BL, Kaiser L, Juma G, Maina ENM, others.  2018.  $\alpha$-Amylase mediates host acceptance in the braconid parasitoid Cotesia flavipes. Journal of chemical ecology. 44:1030–1039., Number 11: Springer US Abstract
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{Bichang'a, GB, Lage J-LD, Sambai K, Mule S, Ru BL, Kaiser L, Juma G, Maina EN, Calatayud P-A.  2018.  Salivary $\alpha$-Amylase of Stem Borer Hosts Determines Host Recognition and Acceptance for Oviposition by Cotesia spp.(Hymenoptera, Braconidae). Frontiers in Ecology and Evolution. 6:228.: Frontiers Media SA Abstract
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Abdelrahman, MT, Maina EN, Elshemy HA.  2018.  Clove (Syzygium aromaticum) and honey extracts significantly reduce inflammatory cytokines and liver function enzymes in experimental rats fed on carbon tetrachloride (CCl4). Journal of radiation research and applied sciences. 11:416–422., Number 4: Taylor & Francis Abstract
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2017

Bichang’a, G, Lage J-LD, Mailhan C-M, Marion-Poll F, Capdevielle-Dulac C, Zivy M, Balliau T, Ru BL, Kaiser-Arnauld L, Juma G, others.  2017.  The use of salivary $\alpha$-amylase as an evolutionary solution to host selection in parasitoids. bioRxiv. :227173.: Cold Spring Harbor Laboratory Abstract
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Njau, VN, Maina ENM, Anjili CO, Ingonga JM, Koech JC, Kariuki HW, Ngure PK.  2017.  In vitro antileishmanial activity and phytochemical analysis of Carissa edulis against Leishmania major. African Journal of Pharmacology and Therapeutics. 5, Number 4 Abstract
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2014

Maina, EN, Kinyi HW, Ochwang’i DO, Meroka AM, Wanyonyi WC.  2014.  Liver toxicity of Crude extract of Ficus natalensis traditionally used in South Western Uganda. African Journal of Pharmacology and Therapeutics. 3, Number 4 Abstract
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Maina, EN, Kinyi HW, Ochwang’i DO, Meroka AM, Wanyonyi WC.  2014.  Liver toxicity of Crude extract of Ficus natalensis traditionally used in South Western Uganda. African Journal of Pharmacology and Therapeutics. 3(4):116-121.

2013

Maina, EN, Webb TT, Arrand JR, Whittington J, Soni S, Boer H, Clarke D, Holland AJ.  2013.  Investigation of Prader-Willi-like Phenotype using a Whole Genome Array. African Journal of Pharmacology and Therapeutics. 1, Number 3 Abstract
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Maina, E.  2013.  Lifestyle diseases pose a definite threat to the developing world. Your Doctor Magazine.

2012

Maina, E.  2012.  Looking to the study of genes for cancer diagnoses and Treatment. Your Doctor Magazine. 4, Number 1 Abstract
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Holland, AJ, Clarke D, Boer H, Soni S, Whittington J, Arrand JR, Webb TT, Maina EN.  2012.  Investigation Of Prader-Willi-like Phenotype Using A Whole Genome Array. Abstract
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Maina, EN, Webb T, Arrand JR, Whittington J, Soni S, Boer H, Clarke D, Holland AJ.  2012.  Investigation of Prader-Willi-like Phenotype using a Whole Genome Array. African Journal of Pharmacology and Therapeutics. 1(3):84-91.

2010

2009

Murray, PG, Woodman CB, Stankovic T, Teo SH, Young LS, Lim PV, Arrand J, Wei W, Buettner M, Maina E, others.  2009.  The ATM Tumour Suppressor Gene Is Down-regulated In EBV-associated Nasopharyngeal Carcinoma.. Abstract
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Stankovic, T, Taylor M, Falciani F, Kearns P, Lawson S, Powell JE, Sameith K, Mapp K, Skowronska A, Agathanggelou A, others.  2009.  Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response.. Abstract
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Marston, E, Weston V, Jesson J, Maina E, McConville C, Agathanggelou A, Skowronska A, Mapp K, Sameith K, Powell JE, Lawson S, Kearns P, Falciani F, Taylor M, Stankovic T.  2009.  Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response., 2009 Jan 1. Blood. 113(1):117-26. Abstract

The molecular basis of different outcomes in pediatric acute lymphoblastic leukemia (ALL) remains poorly understood. We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionizing radiation (IR)-induced DNA double-strand breaks in 74 pediatric patients with ALL. We found an apoptosis-resistant response in 36% of patients characterized by failure to cleave caspase-3, -7, -9, and PARP1 by 24 hours after IR and an apoptosis-sensitive response with the cleavage of the same substrates in the remaining 64% of leukemias. Resistance to IR in vitro was associated with poor early blast clearance at day 7 or 15 and persistent minimal residual disease (MRD) at day 28 of induction treatment. Global gene expression profiling revealed abnormal up-regulation of multiple prosurvival pathways in response to IR in apoptosis-resistant leukemias and differential posttranscriptional activation of the PI3-Akt pathway was observed in representative resistant cases. Importantly, pharmacologic inhibition of selected prosurvival pathways sensitized apoptosis-resistant ALL cells to IR in vitro. We suggest that abnormal prosurvival responses to DNA damage provide one of the mechanisms of primary resistance in ALL, and that they should be considered as therapeutic targets in children with aggressive disease.

Bose, S, Yap L-F, Fung M, Starzcynski J, Saleh A, Morgan S, Dawson C, Chukwuma MB, Maina E, Buettner M, Wei W, Arrand J, Lim PVH, Young LS, Teo SH, Stankovic T, Woodman CBJ, Murray PG.  2009.  The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma., 2009 Feb. The Journal of pathology. 217(3):345-52. Abstract

A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in the EBV-positive line, C666.1, and in none of five EBV-negative lines. In vitro infection of EBV-negative NPC cell lines with a recombinant EBV was followed by the down-regulation of ATM mRNA and protein, and only EBV-positive cells showed a defective DNA damage response following gamma-irradiation. Our data suggest that loss of ATM function could be an important step in the pathogenesis of NPC, and may have implications for the treatment of this disease.

2008

Clarke, D, Boer H, Maina EN, Webb T, Holland AJ, Whittington J, Soni S.  2008.  The Phenomenology And Diagnosis Of Psychiatric Illness In People With Prader-Willi Syndrome.. Abstract
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Webb, T, Maina EN, Soni S, Whittington J, Boer H, Clarke D, Holland A.  2008.  In search of the psychosis gene in people with Prader-Willi syndrome. American Journal of Medical Genetics Part A. 146:843–853., Number 7: Wiley Online Library Abstract
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Soni, S, Whittington J, Holland AJ, Webb T, Maina EN, Boer H, Clarke D.  2008.  The phenomenology and diagnosis of psychiatric illness in people with Prader–Willi syndrome. Psychological Medicine. 38:1505–1514., Number 10: Cambridge University Press Abstract
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Webb, T, Maina EN, Soni S, Whittington J, Boer H, Clarke D, Holland A.  2008.  In search of the psychosis gene in people with Prader-Willi syndrome., 2008 Apr 1. American journal of medical genetics. Part A. 146(7):843-53. Abstract

The two main causes of Prader-Willi syndrome (PWS) are a paternally derived deletion in the maternally imprinted 15q11-q13 region or UPD(15)mat. Both mechanisms result in a loss of the active paternal contribution to the region. The affective psychosis associated with PWS has been found to be mainly confined to the propositi with UPD(15)mat rather than to those with a deletion. This suggests that the psychosis may be related to the presence of two copies rather than a single copy of a gene or genes located in the distal half of the region which is paternally imprinted, but maternally active, and whose loss results in Angelman syndrome (AS). A large population-based study of PWS allowed the identification of 12 people with a 15q11-q13 deletion who had suffered psychotic episodes and four adults with UPD(15)mat who so far had not. When these people were investigated using microsatellite markers, the 12 with a deletion were found to have two maternally derived copies of a narrow region between D15S975 and D15S661 making them effectively disomic for these loci. Thus all of the people with psychosis had two active copies of any imprinted genes in the region while all non-psychotic people (including controls) had only one. Quantitative RT-PCR studies suggest that a lack of expression of FLJ33332, either as a result of or resulting in gene dysregulation, may be associated with psychosis in PWS.

2007

Maher, ER, Latif F, Johnson CM, Richards FM, Wiesener MS, Banks RE, Raval RR, Zatyka M, Morris MR, Maina EN, others.  2007.  Identification Of Novel VHL Targets That Are Associated With The Development Of Renal Cell Carcinoma.. Abstract
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