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Publications


2012

Ong, KKH, Nyamweya NN, Nyamweya NN.  2012.  Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2. AbstractWebsite

Pharmaceutical dosage forms useful for improving the cardiovascular and/or metabolic health of patients, particularly those suffering from type 2 diabetes, are disclosed, as well as methods of their manufacture

2008

N, N, SW H.  2008.  Influence of Coloring Agents on the Properties of Polymeric Coating Systems. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd edition. , New York: Informa Healthcare

2001

Nair, R; Nyamweya, GM-MHN; S; L.  2001.  Influence of various drugs on the glass transition temperature of poly (vinylpyrrolidone): a thermodynamic and spectroscopic investigation. Abstract

Purpose: To determine the influence of hydrogen bonding and solubility parameter on the glass transition temperature (Tg) of various drug–poly(vinylpyrrolidone) blends. Methods: The Tg of PVP films containing either acetaminophen, naproxen, salicylamide, carbamazepine, griseofulvin or propranolol hydrochloride were measured using differential scanning calorimetry. Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction was used to characterize the specific interactions between the drug–PVP blends and the physical state of the films, respectively. The total solubility parameter and its individual components were calculated using the method of Van Krevelen. Results: Salicylamide displayed the greatest plasticizing effect, depressing the Tg to the minimum. This was consistent with the FTIR data, which indicated the presence of hydrogen bonding with PVP. Griseofulvin showed the least plasticizing effect due to lack of interaction with PVP. All the drugs except griseofulvin were amorphous within the film up to 30% (w/w) drug composition. The correlation between the various components of the solubility parameters and the plasticizing effect of drugs was very poor. Conclusions: Spectroscopic investigation for the presence of interaction between the drugs and PVP proved to be extremely predictive of the plasticizing effect of various drugs. In contrast, solubility parameters appeared to be far less sensitive indicators of drug–PVP miscibility.

1998

Nyamweya, NN, Gurley BJ, Breen P, Light KE.  1998.  Pharmacokinetics of cocaine and metabolites following intragastric administration to ten-day-old rat pups. Abstract

Fetal cocaine exposure is a major problem resulting from the illicit use of cocaine by pregnant women. Studies examining the prevalence of cocaine use during pregnancy estimate usage ranges from 5-17% (I). Although no definitive syndrome has been defined, prenatal cocaine exposure is associated with decreased birth weight and size, brain injury and congenital anomalies (2).

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