Othieno-Abinya NA, Abwao HO, Maina JM, Nyabola LO, Opiyo A, Njuguna E, Ndege P, Musibi A. Non-Hodgkin's lymphomas at Kenyatta the National Hospital Nairobi in the 1990's

Citation:
"Othieno-Abinya NA, Abwao HO, Maina JM, Nyabola LO, Opiyo A, Njuguna E, Ndege P, Musibi A. Non-Hodgkin's lymphomas at Kenyatta the National Hospital Nairobi in the 1990's." East Afr Med J. . 2004;81(9):450-8.

Abstract:

OBJECTIVES: To determine the clinico-pathologic and prognostic factors, treatment
and outcome of non-Hodgkin's lymphomas as seen at the Kenyatta National Hospital
in the 1990s.
DESIGN: Retrospective study of patients with non-Hodgkin's Iymphoma.
SETTING: Kenyatta National Hospital, Nairobi, Kenya, between January 1990 and
January 2000 inclusive.
SUBJECTS: Patients aged 13 years and above, with non-Hodgkin's Iymphomas.
RESULTS: Case records were available for 207 patients, 146 males and 60 females,
with one having had gender not clarified. Fifty two per cent of the patients were
aged less than 40 years and 18.4% over 60 years. Forty one per cent were not
properly classified histologically, seventy patients out of 190 evaluable (36.8%)
had stages IVA and IVB disease at diagnosis. Twenty five out of 77(32.5%) tested
positive for HIV infection, none of them being of the indolent variety. Up to
57.1% of cases of Burkitt's lymphoma tested positive for HIV infection.
Cyclophosphamide, doxorubicin, vincristine and prednisone, (CHOP) chemotherapy
was given to 68.7% of the patients with complete remission rates of 55.6% for
those who got a minimum of six courses of chemotherapy. Only 15.3% of 105
patients evaluable were followed up for 36 months and above, the majority of
patients having been lost to follow-up. Poor performance status at diagnosis
correlated with shorter follow-up durations (p<0.05).
CONCLUSION: A good percentage of the patients were not comprehensively
characterized pathologically. Standard treatment was offered to the majority of
patients, and those who could afford to purchase the medicines stood good chance
of achieving complete remission. Poor performance status at diagnosis correlated
with shorter follow-up durations and early stage disease correlated with longer
follow-up durations. Overall, the outlook for NHLs treated at KNH in the 1990s
appears to have improved tremendously.

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