Noguchi, A., Mukuria, J.C., Suzuki, E. and Naiki, M. (1996). Failure of human immunoresponse to N-Glycolylneuraminic acid epitope contained in recombinant human erythropoietin. Nephron 72: 599

Citation:
C PROFMUKURIAJOSEPH. "Noguchi, A., Mukuria, J.C., Suzuki, E. and Naiki, M. (1996). Failure of human immunoresponse to N-Glycolylneuraminic acid epitope contained in recombinant human erythropoietin. Nephron 72: 599 .". In: Nephron 72: 599 . Plant Molecular Biology Reporter Vol. 27, pp. 79-85.; 1996.

Abstract:

A preliminary short follow-up study of Hanganutziu and Deicher (HD) antibody titre and sialic acid levels in sera from 7 patients with hepatoma was carried out. Weekly HD antibody titres were abnormal in 6 patients with titres of 4 of the 6 falling to normal in some weeks. Sialic acids levels, however were abnormal (3.830-6.82mmol/ l) compared to those of 33 normal sera (1.08-2.73 mmol/1) throughout the 8 week screening period. There was a poor correlation between the antibody tires and the sialic acid levels (r<0.50) suggesting that at some stage of malignancy, the tumour was expressing N-glycolylneuraminic acid (Neu5Gc), the epitope of HD antigens as well as shedding into circulation, excess N-acetylneuraminic acid (Neu5Gc). Neu5Gc is a tumor-associated antigen. Measurement of antibodies to this epitope have shown that the antibodies have a potential of offering an alternative method of determining tumor growth and/or metastases. A major follow-up study incorporating information on cancer type, disease stage, therapy and the immnunological status of the patient is called for.

Notes:

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