Publications


2011

Charles N. Chunge, Ruth N. Chunge, MJAMS.  2011.  An outbreak of schistosomiasis following a church retreat to Mwanza, Tanzania. Journal of Travel Medicine. 189(6):408-410.

2009

M, DRWANYOIKEMILICENT, S PROFMASINDEMICHAEL.  2009.  Njambi L, Kariuki M.M, Masinde S. Ocular findings in children attending occupational therapy clinic at Kenyatta National Hospital, Nairobi, Kenya. East Afr. j. ophthalmol. 2009 Jul; 15(1): 21-26.. East African Journal of Ophthalmology. Abstract
Objectives: To describe the pattern of ocular abnormalities, their correlation with the physical disorders and describe associated risk factors in children attending the Occupational therapy clinic at Kenyatta National Hospital.   Design: Cross sectional hospital based.   Subjects: A hundred and eighty seven children, aged between three months and 13 years with cerebral palsy and sensory integration deficits.   Results: Majority of the patients had cerebral palsy(CP), 160(85.6%), while in those with sensory integration deficit(SID), attention- deficit / hyperactive disorder and autism had almost equal proportions, 20(10.7%) and 18(9.6%) respectively. Among all the children, 62% had ocular anomalies. Children with CP had a much higher prevalence (58.3%) compared to SID group (3.7%). The common ocular abnormalities included cortical visual impairment (48.7%), refractive errors (39%) and squints (34.2%). Association between physical disability and ocular anomalies was noted more in patients with CP compared with SID. Strabismus, cortical visual impairment and myopia were more likely to occur in patients with CP. Significant hyperopia was noted only in CP patients. Strabismus and cortical visual impairment were more likely to occur in patient with neonatal jaundice, while refractive errors in patients with congenital causes and optic atrophy in patients with meningitis.   Conclusion: Visual disabilities in children with physical disabilities were common. Cortical visual impairment, refractive errors and squints were more common. Children with CP had a much higher prevalence compared to the SID group.   Recommendation: All Children with CP and SID should be referred to ophthalmologist and low vision specialist for assessment.

2008

Mundia, DG, ILAKO DR, Masinde MS.  2008.  Risk Of Newborns Developing Neonatal Conjunctivitis From Mothers With Prolonged Labour. Abstractrisk_of_developing_neonatal_conjunctivitis_in_newborns_of_mothers_with...pdf

To determine whether prolonged labour increased the rate of exposure of the newborn eyes to maternal vaginal fl ora, and whether this exposure led to higher risk of developing neonatal conjunctivitis. Study design: cohort study Settings: Kenyatta National hospital and Pumwani Maternity Hospital in Kenya between August 2000 and March 2001. Subjects: Fifty four cases of prolonged labour (PL) and 55 cases of controls were studied. Conjunctival swabs were taken from all the newborns and high vaginal swabs taken from every second mother. A case pair consisted of such a pair where samples were taken from both the mother and her baby. 23 case pairs of PL and 19 of controls were studied. This was done on average 24hrs after delivery. Results: Conjunctival swabs were positive in 63% of the prolonged labour (PL) group compared to 51% of the control group (odds ratio 1.9; p-value 0.09). The rate of transmission of vaginal fl ora to the eyes of the newborns was 57% in the PL group compared to 40% in the controls (odds ratio 1.95; p value 0.27). The longer, from birth, it took before taking the conjunctival swabs from the baby, the higher was the likelihood of obtaining a positive culture (p-value 0.017 MW test). The longer the duration of labour in the PL group, the higher the rate of development of conjunctivitis (p-value 0.029 MW test). Staphylococcal aureus, Staphylococcal epidermidis and E.coli were the three most common organisms isolated in both groups. Conclusion: Prolonged labour increased the rate of transmission of maternal vaginal flora to the eyes of the newborns and to subsequent development of neonatal conjunctivitis.

2005

S, PROFMASINDEMICHAEL.  2005.  New trends in ocular Aids in children submitted to E.A.J.O. 2005.. E.A.J.O. 2005.. Abstract
Objectives: To describe the pattern of ocular abnormalities, their correlation with the physical disorders and describe associated risk factors in children attending the Occupational therapy clinic at Kenyatta National Hospital.   Design: Cross sectional hospital based.   Subjects: A hundred and eighty seven children, aged between three months and 13 years with cerebral palsy and sensory integration deficits.   Results: Majority of the patients had cerebral palsy(CP), 160(85.6%), while in those with sensory integration deficit(SID), attention- deficit / hyperactive disorder and autism had almost equal proportions, 20(10.7%) and 18(9.6%) respectively. Among all the children, 62% had ocular anomalies. Children with CP had a much higher prevalence (58.3%) compared to SID group (3.7%). The common ocular abnormalities included cortical visual impairment (48.7%), refractive errors (39%) and squints (34.2%). Association between physical disability and ocular anomalies was noted more in patients with CP compared with SID. Strabismus, cortical visual impairment and myopia were more likely to occur in patients with CP. Significant hyperopia was noted only in CP patients. Strabismus and cortical visual impairment were more likely to occur in patient with neonatal jaundice, while refractive errors in patients with congenital causes and optic atrophy in patients with meningitis.   Conclusion: Visual disabilities in children with physical disabilities were common. Cortical visual impairment, refractive errors and squints were more common. Children with CP had a much higher prevalence compared to the SID group.   Recommendation: All Children with CP and SID should be referred to ophthalmologist and low vision specialist for assessment.

2003

S, PROFMASINDEMICHAEL.  2003.  Munene, R. M., Adala, H. S., Masinde, M. S., Rana, F. S. Vitamin A deficiency among Kenya children as detected by conjunctival impression cytology. E. African Medical Journal. 80: 476, 2003.. E. African Medical Journal. 80: 476, 2003.. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.

2002

S, PROFMASINDEMICHAEL.  2002.  Paschke, C., Masinde, S., Gaeckle, H. Provoked preference test . E. African Journal of Ophthalmology 11: 48 , 2002. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.

1994

S, PROFMASINDEMICHAEL.  1994.  Datta, P., Frost E., Peeling, R., Masinde, M. S., Deslandes, S., Echelu, C., Wamola, I., Brunham, R.C. Ophthalmia neonatorum in a trachoma Endemic area. Sex Transm Dis. 21 (1): 1 . Sex Transm Dis. 21 (1): 1 . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.

1992

JEFITHA, DRKARIMURIO, S PROFMASINDEMICHAEL.  1992.  Masinde, M. S., Karimurio, J. Epidemiology of concomitant esotropia at Kenyatta National Hospital. E. African Journal of Ophthalmology 8: 42 . E. African Journal of Ophthalmology 8: 13 . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S, PROFMASINDEMICHAEL.  1992.  Masinde, M. S., Duku, A. W. Appraisal of Xerophthalmia in selected centres in Kenya E. African Journal of Ophthalmology 8: 7 . E. African Journal of Ophthalmology 8: 7 . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S, PROFMASINDEMICHAEL.  1992.  Masinde, M. S., Othero, F. A Comparison of drop of intraocular pressure between pilocarpine 2% and levobunolol 0.5%. E. African Journal of Ophthalmology 8: 13 . E. African Journal of Ophthalmology 8: 13 . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.

1991

S, PROFMASINDEMICHAEL, R. DRILAKODUNERA.  1991.  D.R. Ilako, M. Bhaiji, M.S. Masinde Immunoglobulin Levels in Tears M.Med Thesis 1991. M.Med Thesis 1991. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.

1988

S, PROFMASINDEMICHAEL.  1988.  Masinde, M. S., Adala, H. S., Kabuleeta, H. Corneal Ulcers at Kenyatta National Hospital. E. African Journal of Ophthalmology 8: 65. E. African Journal of Ophthalmology 8: 65. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S, PROFMASINDEMICHAEL.  1988.  Masinde, M. S. et al. Observer variation in estimation of Cup Disc Ratio as a screening test for chronic simple glaucoma. East African Journal of Ophthalmology 8: 1 . East African Journal of Ophthalmology 8: 1 . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S, PROFMASINDEMICHAEL.  1988.  Masinde, M. S. Epidemiology of ocular injuries at Kenyatta National Hospital. East African Journal of Ophthalmology 8: 19 . East African Journal of Ophthalmology 8: 19 . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.

1983

S, PROFMASINDEMICHAEL.  1983.  Traumatic and Surgical hyphema at Kenyatta National Hospital, Nairobi. Thesis for M.Med (Ophthalmology) . Thesis for M.Med (Ophthalmology) . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.

1982

S, PROFMASINDEMICHAEL.  1982.  Masinde, M. S. Hyphema study at Kenyatta National Hospital East. African Journal of Ophthalmology 6: 32 . African Journal of Ophthalmology 6: 32 . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S, PROFMASINDEMICHAEL.  1982.  Mnjalla, N., Masinde M. S. Trachoma survey in primary schools in Machakos District, Kenya E. African of Ophthalmology 5: 25 . Kenya E. African of Ophthalmology 5: 25 . Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.

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