Antiplasmodial Quinones from Pentas longiflora and Pentas lanceolata

Citation:
Mbogua M. "Antiplasmodial Quinones from Pentas longiflora and Pentas lanceolata.". 2011.

Abstract:

The dichloromethane/methanol (1 : 1) extracts of
the roots of Pentas longiflora and Pentas lanceolata
showed low micromolar (IC50 = 0.9–3 µg/mL) in
vitro antiplasmodial activity against chloroquineresistant
(W2) and chloroquine-sensitive (D6)
strains of Plasmodium falciparum. Chromatographic
separation of the extract of Pentas longiflora
led to the isolation of the pyranonaphthoquinones
pentalongin (1) and psychorubrin (2)
with IC50 values below 1 µg/mL and the naphthalene
derivative mollugin (3), which showed marginal
activity. Similar treatment of Pentas lanceolata
led to the isolation of eight anthraquinones
(4–11, IC50 = 5–31 µg/mL) of which one is new
(5,6-dihydroxydamnacanthol, 11), while three –
nordamnacanthal (7), lucidin-ω-methyl ether (9),
and damnacanthol (10) – are reported here for
the first time from the genus Pentas. The compounds
were identified by NMR and mass spectroscopic
techniques.

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