Found 46 results

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In Press
Owino I, Omosa LK, Onyari JM, Mulaa F. "Improvement of Fastness of Tagetes minuta L (Tami) dye onto cotton fabric through functionalization." Journal of Natural Sciences Research Journal of Natural Sciences Research . In Press.
Omole RA, Moshi MJ, Ilias M, Larry W, Malebo HM, Omosa LK, Midiwo JO. "In vitro Antiplasmodial and Cytotoxic activity of Three Medicinal Plants used Traditionally for Treatment of Malaria." Investigational Medicinal Chemistry & Pharmacology. 2020;10(1):2-6.omole_et_al_2020.pdf
Nchiozem-Ngnitedema V-A, Omosa LK, Derese S, Tane P, Heydenreich M, Spiteller M, Ean-JeongSeo, Efferth T. "Two new flavonoids from Dracaena usambarensis Engl." Phytochemistry Letter. 2020;36:80-85.alex_et_al_2020.pdf
Kenanda EO, Omosa LK. "Anti-leishmanial activity of some surface compounds of Tarchonanthus camphoratus." Investigational Medicinal Chemistry & Pharmacology. 2019;2 (2):30.kenanda_et_al_05082019.pdf
Omole RA, Moshi MJ, Heydenreich M, Malebo HM, Gathirwa JW, Oriko RO, Omosa LK, Midiwo JO. "Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl." Pharmacognosy Communications. 2019;9(3):96-99.
Omosa LK, Mbogo GM, Korir E, Omole R, Ean-JeongSeo, Yenesew A, Midiwo MHJO, Efferth T. "Cytotoxicity of Fagaramide Derivative and Canthin-6-one from Zanthoxylum (Rutaceae) Species against Multidrug Resistant Leukemia Cells." Natural Products Research. 2019; pdf
Kamau RW, Midiwo JO, Mgani QA, Masila VM, Omosa LK, Bwire RN, Jacob MR, Frank T. Wiggers IM. "Oleanolic Acid and other Compounds Isolated from Cordia Africana Lam which Inhibit Vancomycin Resistant Enterococcus." Pharmacognosy Communications. 2019;9(3):91-95.rahab_et_al_2019_pharmacognosy.pdf
Omole RA, Moshi MJ, Heydenreich M, Malebo HM, Ochieng’ SA, Omosa LK, Midiwo JO. "Two novel lignans derivatives and two fusicoccane diterpenoids from whole plant of Hypoestes verticillaris (L.f.) Sol. ex Roem. & Schult." Phytochemistry Letters. 2019;30:194-200.omole_et_al_2019.pdf
Kuete V, Omosa LK, Karaosmanoğlu O, Sivas H. "Cytotoxicity of 11 Naturally occurring Phenolics and Terpenoids from Kenyan Flora towards Human Carcinoma Cells." Journal of Ayurveda and Integrative Medicine. 2018; pdfkuete_et_al_2018 pdf
Nyaboke HO, Moraa M, Omosa LK, Mbaveng AT, Vaderament-Alexe N-N, Masila V, Okemwa E, Heydenreich M, Efferth T, Kuete V. "Cytotoxicity of Lupeol from the Stem Bark of Zanthoxylum gilletii against Multi-factorial Drug Resistant Cancer Cell Lines ." Investigational Medicinal Chemistry & Pharmacology . 2018;1(1):10.
Mwangi HN, Onyango, Omosa LK, Mulaa F. "Virtual Screening and Validation of Potential Lead Compound from the Malaria Box against Plasmodium Falciparum S7 and S19 Proteins." Journal of Pharmaceutical Research. 2018;2(2).
Milugo T, Masila VM, Owuor B, Bulimo W, Julius Oyugi, Ochanda J, Wamunyokoli F, Omosa LK. "Anti-cancer activities of crude extracts from medicinal plants Moringa oleifera Lam and Rauwolfia caffra against selected cancer cell lines." IOSR Journal of Pharmacy and Biological Sciences. 2016;11(3):59-64.milugo_et_al._2016.pdf
Omosa LK, Midiwo JO, Mbaveng AT, Tankeo SB, Seukep JA, Voukeng IK, Dzotam JK, Isemeki J, Omolle RA, Efferth T, Kuete V. "Antibacterial Activity and Structure-Activity Relationships of a Panel of 48 Compounds from Kenyan Plants against Multidrug Resistant Phenotypes." SpringerPlus. 2016;5:901.omosa_et_al._springerplus_paper.pdf
LK O, O MJ, VM M, R M, V K, T E. "Cytotoxicity of 91 Kenyan indigenous medicinal plants towards human CCRF-CEM leukemia cells." Journal of Ethnopharmacology. 2016;179:177-196.omosa_et_al_ethnopharmacology.pdf
Victor, L.K O, V.R.S T, J.O M, A.T M, O K, H S, S S. "Cytotoxicity of Plumbagin, Rapanone and 12 other Naturally occurring Quinones towards Human Carcinoma Cells." BMC Pharmacology and Toxicology. 2016;17:60.kuete_and_omosa_et_al._2016.pdf
T E, M B, N.W P, S A, J A, G E, S H, C H, R H, O K, J N, D O, E O, N O, M.E.M S, M S, E.-J S, C.-F W, G Y, M Z, Q Z, M.S A-D, K A, G A, D B, D B-G, V B, L.K O,, J.N Kiiru, et al. "Drug discovery and biopiracy of natural products" ." Phytomedicine. 2016;Elsevier(23(2)):166-173.efferth_et_al._2016.pdf
B N, M.K L, D.A M, H E, M.R J, S.I K, I M, L.K O, J.O M. "New ent-clerodane and abietane diterpenoids from the roots of Kenyan Croton megalocarpoides Friis & M.G. Gilbert." Planta Medica. 2016;doi,
VM M, O MJ, J Z, BM G, R M, LK O, FT W, MR J, LA W, I M. "Anti-Vancomycin-resistant Enterococcus faecium and E. faecalis activities of (-)-gossypol and derivatives from Thespesia garckeana." Natural Product Communications (NPC). 2015;10(4):613-616.masila_et_al.pdf
Djeussi DE, Sandjo LP,.Noumedem JAK, Omosa LK, Ngadjui BT, Kuete V. "Antibacterial Activities of the Methanol Extracts and Compounds from Erythrina sigmoidea against Gram-negative Multi-drug Resistant Phenotypes." BMC Complementary and Alternative Medicine. 2015;15:453.bmc_2015_djeussi_et_al._erythrina1.pdf
Ndunda B, Langat MK, Midiwo JO, Omosa LK. "Diterpenoid Derivatives of Kenyan Croton sylvaticus Hochst." Natural Product Communications (NPC). 2015;10(4):557-558.ndunda_et_al.pdf
Akimanya A, Midiwo JO, Matasyoh J, Okanga F, Masila VM, Walker L, Tekwani BL, Muhammad I, Omosa LK. "Two polymethoxylated flavonoids with antioxidant activities and a rearranged clerodane diterpenoid from the leaf exudates of Microglossa pyrifolia." Phytochemistry Letters. 2015;11:183-187.akimanya_et_al.pdf
Kariuki DK, Miaron JO, Mugweru J, Kerubo LO. "Antibacterial Activity of Five Medicinal Plant Extracts Used by the Maasai People of Kenya." BEST: International Journal of Humanities, Arts, Medicine and Sciences (BEST: IJHAMS) . 2014;2(7):1-6.kariuki_et_al__2014.pdf
Omosa LK, Amugune B, Ndunda B, Milugo TK, Heydenreich M, Yenesew A, Midiwo JO. "Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia." South African Journal of Botany. 2014;91:58-62.omosa_eet_al._sajb.pdf
Amugune BK, Thoithi GN, Mwangi JW, L.K.Omosa, Kibwage IO. "Antimicrobial Activity and Bioactive Constituents of Alectras sessiliflora (Vahl) Kuntze Methanol Extract." East and Central African Journal of Pharmaceutical Sciences . 2013;16 :61-68.amugune_et_al.pdf
Kerubo L, Midiwo JO, Derese S, Langat MK, Akala HM, Waters NC, Peter M, Heydenreich M. "Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus." Natural Products Communications. 2013;7:1-2.kerubo_et_al_3_npc.pdf
Derese S, Kerubo L, Yenesew A, Machumi F, Midiwo JO. "Natural Products from Plant Diversity and their Potential in Management of Neglected Diseases.". 2011. Abstractmidiwo_et_al._napreca_abstracct.pdfNatural Products from Plant Diversity and their Potential in Management of Neglected Diseases

Conventionally, neglected diseases are considered as a group of 13 infectious diseases that are . endemic in the low income populations in the tropical developing world. They can be classified as those caused by trypanosomal parasites, helminthes, bacteria and viruses. They cause death to an estimated 0.5- 1m people annually. Trypanosomal diseases are represented by Kala-azar or visceral leshmaniasis, African sleeping sickness (African trypanosomiasis) and Chaga's disease (American trypanosomiasis); the current drugs for these diseases are relatively toxic even though the disease is not that lethal. Helminth infections include schistosomiasis treated with the inexpensive praziquantel but which cannot stop re-infection; onchocerciasis (river blindness), on which anthelmintic treatment is being tried; dracunculiasis (guinea worm), which should have been eradicated in 2009; lymphatic filiriasis (elephantiasis), managed by anthelmintic treatments. The others are soil transmitted worms such as ascariasis (round worms), trichuriasis (whipworms) and hookworms which are really best controlled by good hygienic practices. Leprosy, trachoma, Buruli ulcer and cholera represent the prevalent bacterial problems. Viral infections are yellow and dengue fevers caused by flavivirus transmitted by Aedes aegyptii and Japanese encephilitis caused by a flavivirus transmitted by Culex tritaeniorhynchus; the viral infections can be controlled through vaccination (WHO, 2008).

Omosa LK, Midiwo JO, Derese S, Yenesew A, Peter MG, Heydenreich M. "neo-Clerodane diterpenoids from the leaf exudate of Dodonaea angustifolia." Phytochemistry Letters. 2010;3:217-220.omosa_et_al._phytochemistry_letters.pdf
Echeverry C, F A, A A-CJ, O MJ, C O, L K, F D. "Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study." Journal of Agriculture and Food Chemistry. 2010;54(4):2111-2115.

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