Bio

Publications


Forthcoming

M, G, L.K O, D M, M.O O, O.G O.  Forthcoming.  Cytotoxicity of compounds from some Zanthoxylum species. African Journal of Biotechnology.
R, M, L.K O, J.O M, V M.  Forthcoming.  Cytotoxicity of principles from Bridelia micrantha.

Submitted

2017

Omosa, LK, Masinde RW, Midiwo JO, Okemwa EK, Munayi R, Ndunda B, Bwire R, Heydenreich M, Akala H, Kamau E, Okemwa EK, Omole RA, Yenesew A, Omosa LK.  2017.  Antiplasmodial activities of the stem bark extract and compounds of Zanthoxylum gilletii (De wild) P.G. Waterman. Pharmacognosy Communications. 7(1):41-46.

2016

  2016.  Standardization of Commiphora Abyssinica Engl. Gum Resin From Kajiado, Kenya. IOSR Journal of Applied Chemistry (IOSR-JAC) . 9(8):69-74.waweru_et_al_2016_iosr-jac.pdf
Victor, L.K O, V.R.S T, J.O M, A.T M, O K, H S, S S.  2016.  Cytotoxicity of Plumbagin, Rapanone and 12 other Naturally occurring Quinones towards Human Carcinoma Cells. BMC Pharmacology and Toxicology. 17:60.kuete_and_omosa_et_al._2016.pdf
B, N, M.K L, D.A M, H E, M.R J, S.I K, I M, L.K O, J.O M.  2016.  New ent-clerodane and abietane diterpenoids from the roots of Kenyan Croton megalocarpoides Friis & M.G. Gilbert. Planta Medica. doi, http://dx.doi.org/10.1055/s-0042-108857ndunda_et_al._planta_medica_2.pdf
E, A, L.K O, J.O M, A N, J M.  2016.  Antioxidant Activities of Flavonoid Aglycones from Kenyan Gardenia ternifolia Schum and Thonn. IOSR Journal of Pharmacy and Biological Sciences . 11(3):136-141.awas_et_al._iosr-jpbs.final_.pdfawas_et_al._iosr-jpbs.final_.pdf
Milugo, T, Masila VM, Owuor B, Bulimo W, Julius Oyugi, Ochanda J, Wamunyokoli F, Omosa LK.  2016.  Anti-cancer activities of crude extracts from medicinal plants Moringa oleifera Lam and Rauwolfia caffra against selected cancer cell lines. IOSR Journal of Pharmacy and Biological Sciences. 11(3):59-64.milugo_et_al._2016.pdf
Omosa, LK, Midiwo JO, Mbaveng AT, Tankeo SB, Seukep JA, Voukeng IK, Dzotam JK, Isemeki J, Omolle RA, Efferth T, Kuete V.  2016.  Antibacterial Activity and Structure-Activity Relationships of a Panel of 48 Compounds from Kenyan Plants against Multidrug Resistant Phenotypes. SpringerPlus. 5:901.omosa_et_al._springerplus_paper.pdf
T, E, M B, N.W P, S A, J A, G E, S H, C H, R H, O K, J N, D O, E O, N O, M.E.M S, M S, E.-J S, C.-F W, G Y, M Z, Q Z, M.S A-D, K A, G A, D B, D B-G, V B, L.K O,, J.N Kiiru, et al.  2016.  Drug discovery and biopiracy of natural products" . Phytomedicine. Elsevier(23(2)):166-173.efferth_et_al._2016.pdf
LK, O, O MJ, VM M, R M, V K, T E.  2016.  Cytotoxicity of 91 Kenyan indigenous medicinal plants towards human CCRF-CEM leukemia cells. Journal of Ethnopharmacology. 179:177–196.omosa_et_al_ethnopharmacology.pdf

2015

Djeussi, DE, Sandjo LP,.Noumedem JAK, Omosa LK, Ngadjui BT, Kuete V.  2015.  Antibacterial Activities of the Methanol Extracts and Compounds from Erythrina sigmoidea against Gram-negative Multi-drug Resistant Phenotypes. BMC Complementary and Alternative Medicine. 15:453.bmc_2015_djeussi_et_al._erythrina1.pdf
VM, M, O MJ, J Z, BM G, R M, LK O, FT W, MR J, LA W, I M.  2015.  Anti-Vancomycin-resistant Enterococcus faecium and E. faecalis activities of (-)-gossypol and derivatives from Thespesia garckeana. Natural Product Communications (NPC). 10(4):613-616.masila_et_al.pdf
Ndunda, B, Langat MK, Midiwo JO, Omosa LK.  2015.  Diterpenoid Derivatives of Kenyan Croton sylvaticus Hochst. Natural Product Communications (NPC). 10(4):557-558.ndunda_et_al.pdf
Akimanya, A, Midiwo JO, Matasyoh J, Okanga F, Masila VM, Walker L, Tekwani BL, Muhammad I, Omosa LK.  2015.  Two polymethoxylated flavonoids with antioxidant activities and a rearranged clerodane diterpenoid from the leaf exudates of Microglossa pyrifolia. Phytochemistry Letters. 11:183-187.akimanya_et_al.pdf

2014

Kariuki, DK, Miaron JO, Mugweru J, Kerubo LO.  2014.  Antibacterial Activity of Five Medicinal Plant Extracts Used by the Maasai People of Kenya. BEST: International Journal of Humanities, Arts, Medicine and Sciences (BEST: IJHAMS) . 2(7):1-6.kariuki_et_al__2014.pdf
Omosa, LK, Amugune B, Ndunda B, Milugo TK, Heydenreich M, Yenesew A, Midiwo JO.  2014.  Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia. South African Journal of Botany. 91:58-62.omosa_eet_al._sajb.pdf

2013

Amugune, BK, Thoithi GN, Mwangi JW, L.K.Omosa, Kibwage IO.  2013.  Antimicrobial Activity and Bioactive Constituents of Alectras sessiliflora (Vahl) Kuntze Methanol Extract. East and Central African Journal of Pharmaceutical Sciences . 16 :61-68.amugune_et_al.pdf
Kerubo, L, Midiwo JO, Derese S, Langat MK, Akala HM, Waters NC, Peter M, Heydenreich M.  2013.  Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus. Natural Products Communications. 7:1-2.kerubo_et_al_3_npc.pdf

2011

Derese, S, Kerubo L, Yenesew A, Machumi F, Midiwo JO.  2011.  Natural Products from Plant Diversity and their Potential in Management of Neglected Diseases. Abstractmidiwo_et_al._napreca_abstracct.pdfNatural Products from Plant Diversity and their Potential in Management of Neglected Diseases

Conventionally, neglected diseases are considered as a group of 13 infectious diseases that are . endemic in the low income populations in the tropical developing world. They can be classified as those caused by trypanosomal parasites, helminthes, bacteria and viruses. They cause death to an estimated 0.5- 1m people annually. Trypanosomal diseases are represented by Kala-azar or visceral leshmaniasis, African sleeping sickness (African trypanosomiasis) and Chaga's disease (American trypanosomiasis); the current drugs for these diseases are relatively toxic even though the disease is not that lethal. Helminth infections include schistosomiasis treated with the inexpensive praziquantel but which cannot stop re-infection; onchocerciasis (river blindness), on which anthelmintic treatment is being tried; dracunculiasis (guinea worm), which should have been eradicated in 2009; lymphatic filiriasis (elephantiasis), managed by anthelmintic treatments. The others are soil transmitted worms such as ascariasis (round worms), trichuriasis (whipworms) and hookworms which are really best controlled by good hygienic practices. Leprosy, trachoma, Buruli ulcer and cholera represent the prevalent bacterial problems. Viral infections are yellow and dengue fevers caused by flavivirus transmitted by Aedes aegyptii and Japanese encephilitis caused by a flavivirus transmitted by Culex tritaeniorhynchus; the viral infections can be controlled through vaccination (WHO, 2008).

2010

Echeverry, C, F A, A A-CJ, O MJ, C O, L K, F D.  2010.  Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. Journal of Agriculture and Food Chemistry. 54(4):2111-2115.
Omosa, LK, Midiwo JO, Derese S, Yenesew A, Peter MG, Heydenreich M.  2010.  neo-Clerodane diterpenoids from the leaf exudate of Dodonaea angustifolia. Phytochemistry Letters. 3:217-220.omosa_et_al._phytochemistry_letters.pdf

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