Isolation and structural elucidation of compounds from the non-alkaloidal extract of Nicandra physaloides and the antimicrobial activity of withanicandrin

Citation:
Mukungu NA, Abuga KO, Mungai NN, Karumi EW. "Isolation and structural elucidation of compounds from the non-alkaloidal extract of Nicandra physaloides and the antimicrobial activity of withanicandrin." East Cent. Afr. J. Pharm. . 2013;16(2):49-53.

Abstract:

The aerial parts of Nicandra physaloides plant collected from Kenyatta National Hospital grounds were dried and subjected to acid-base extraction and partitioned to obtain alkaloidal and non-alkaloidal extracts. The non-alkaloidal extract yielded three compounds; withanicandrin, β-sitosterol and stigmasterol after column chromatography. Withanicandrin exhibited antifungal activity against Saccharomyces cerevisiae and Candida albicans but lacked antibacterial activity.

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