Abuga K.O., Kokwaro G.O., Bosire K.O. Concomitant administration of theophylline and oxamniquine in rats: Effect on theophylline clearance

Citation:
"Abuga K.O., Kokwaro G.O., Bosire K.O. Concomitant administration of theophylline and oxamniquine in rats: Effect on theophylline clearance." East Cent. Afr. J. Pharm. Sci. . 1998;1(1):22-23.

Abstract:

This report describes an investigation into the effect of oxamniquine on systemic clearance of theophylline in rat. Male Wister rats (N=12, 5 weeks old) were divide into 3 groups (N=4 per group) and administered buffer plus theophylline (10 mg/kg), controls, oxamniquine( 5 mg/kg), and theophylline (10 mg/kg) oxamniquine (20 mg/kg) intravenously. Theophylline clearance was estimated from a single plasma sample obtained 6 hours post drug administration. Oxamniquine had no effect on theophylline clearance compared to controls. It was concluded that clinically important interaction between oxamniquine and theophylline is unlikely to occur.

Notes:

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