Dreher, D., Kok M., C. Obregon, Kiama S. G., Gehr P., and L. P Nicod(2002). Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells. Journal of Leukocyte Biology 72:743-751.

Citation:
GITAHI DRKIAMASTEPHEN. "Dreher, D., Kok M., C. Obregon, Kiama S. G., Gehr P., and L. P Nicod(2002). Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells. Journal of Leukocyte Biology 72:743-751.". In: Faculty of Veterinary Medicine Biennial Scientific Conference, 3rd to 5th November 2004. Elsevier; 2002.

Abstract:

Interleukin-18 (IL-18) plays an important role in innate and acquired immunity, in particular against intracellular pathogens. However, little is known about the microbial factors that trigger IL-18 secretion by dendritic cells (DCs). To determine the influence of bacterial virulence factors on the activation and release of IL-18, we infected human monocyte-derived DCs with virulence mutants of the facultative intracellular pathogen Salmonella typhimurium. Our results show that infection by S. typhimurium causes caspase-1-dependent activation of IL-18 and triggers the release of IL-18 in human DCs. The secretion of IL-18 by the DCs was closely correlated with the ability of the S. typhimurium strains to induce apoptosis. We demonstrate that activation and release of IL-18 are blocked by mutations in the Salmonella sipB gene, which encodes a virulence factor that activates caspase-1 to induce apoptosis. These findings indicate that the activation and release of IL-18 induced by bacterial virulence factors may represent one component of innate immunity against the intracellular bacteria.

Notes:

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