Bio

DR. JOSEPH MWANZIA NGUTA

A Veterinary surgeon by training and Pharmacologist and Toxicologist by specialization, i am a Senior Lecturer at the Department of Public Health, Pharmacology and Toxicology (PHPT), University of Nairobi with nine (9) years’ experience in undergraduate and postgraduate teaching and supervision. I hold MSc and PhD qualifications in natural product Pharmacology and toxicology from the University of Nairobi.

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(Last updated: June 12, 2019)

Publications

Submitted

NGUTA, DRJOSEPHMWANZIA.  Submitted.  Ethnodiagnostic Skill of the Digo Community for Malaria: A lead to traditional bioprospecting. J.M.Nguta*, J.M.Mbaria; D.W.Gakuya;P.K.Gathumbi; J.D.Kabasa; S.G.Kiama. Frontiers in Pharmacology. : Frontiers, 2011 Abstract
Malaria is a major public health problem that is presently complicated by the development of resistance by Plasmodium falciparum to the mainstay drugs. Thus, new drugs with unique structures and mechanism of action are required to treat drug-resistant strains of malaria. Historically, compounds containing a novel structure from natural origin represent a major source for the discovery and development of new drugs for several diseases. This paper presents ethnophytotherapeutic remedies, ethnodiagnostic skills, and related traditional knowledge utilized by the Digo community of the Kenyan Coast to diagnose malaria as a lead to traditional bioprospecting. The current study was carried out in three Digo villages of Diani sub-location between May 2009 and December 2009. Data was collected using semi-structured interviews, and open and close-ended questionnaires. A total of 60 respondents (34 men and 26 women) provided the targeted information. The results show that the indigenous knowledge of Digo community on malaria encompasses not only the symptoms of malaria but also the factors that are responsible for causing malaria, attributes favoring the breeding of mosquitoes and practices employed to guard against mosquito bites or to protect households against malaria. This knowledge is closely in harmony with scientific approaches to the treatment and control of the disease. The Digo community uses 60 medicinal plants distributed in 52 genera and 27 families to treat malaria. The most frequently mentioned symptoms were fever, joint pains, and vomiting while the most frequently mentioned practices employed to guard against mosquito bites and/or to protect households against malaria was burning of herbal plants such as Ocimum suave and ingestion of herbal decoctions and concoctions. The Digo community has abundant ethnodiagnostic skills for malaria which forms the basis of their traditional bioprospecting techniques. Keywords: malaria, antimalarials, ethnopharmacology, ethnodiagnostic skills, Digo community, bioprospecting
NGUTA, DRJOSEPHMWANZIA.  Submitted.  Antimalarial herbal remedies of Msambweni, Kenya J.M. Nguta, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama. Journal of Ethnopharmacology 128 (2010) 424. : ELSEVIER
NGUTA, DRJOSEPHMWANZIA.  Submitted.  Traditional antimalarial phytotherapy remedies used by the South Coast community, Kenya J.M. Nguta, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama. Journal of Ethnopharmacology.
NGUTA, DRJOSEPHMWANZIA.  Submitted.  BIOLOGICAL SCREENING OF KENYAN MEDICINAL PLANTS USING ARTEMIA SALIA L. (ARTEMIIDAE). J.M.Nguta *, J.M.Mbaria; D.W.Gakuya; P.K.Gathumbi; J.D.Kabasa; , S.G.Kiama. Pharmacologyonline 2: 458-478 (2011). : University of Salerno, Italy
NGUTA, DRJOSEPHMWANZIA.  Submitted.  Bioavailability of cobalt, Zinc and Selenium and Anthelmintic effects of fortified and non fortified Albendazole in Sheep. J.M.Nguta; J.M.Mbaria. The Kenya Veterinarian, Volume 35, Issue 1, 2011. : The Kenya Veterinary Association Abstract
Abstract: The present study was carried out to compare the use of liver and plasma analysis as methods of assessing the status of cobalt, zinc and selenium in sheep, and also to assess the anthelmintic efficacy of fortified and non-fortified albendazole preparations. plasma and liver samples were collected in duplicate from fourteen sheep aged nine to twelve months. Plasma samples were collected on days 0, 7, 14, 21 and 28 and liver samples  on days 0, 14 and 28 post treatment, upon sacrifice of the study animals. Various trace elements were isolated from the organic matrix by wet oxidation for mineral analysis using atomic absorption spectrophotometry. data was statistically analysed using repeated measurement test. Significance was noted at p < 0.05. Both the fortified albendazole and non fortified albendazole cleared all the worms in the treated sheep by day 14 post treatment. All the trace elements were shown to be more bioavailable in the liver and plasma of fortified albendazole (Group B) treated sheep compared to the non-fortified albendazole (Group A) treated sheep. The current study has shown that the liver is a better indicator of cobalt, zinc and selenium status in sheep compared to plasma. Key words: Plasma; Liver; Cobalt; Zinc and Selenium

2019

Micheni, NK.  2019.  In vitro Antimicrobial Activity of Aqueous Extracts of Ocimum suave Willd. Plectranthus barbatus Andrews and Zanthoxylum chalybeum Engl. Against Selected Pathogenic Bacteria.. Biomed Biotechnol Res J, . (3)::30-34..
T.N. Mudimba..  2019.  Traditional uses, phytochemistry and pharmacological activity of Carpobrotus edulis: A global perspective. . The Journal of Phytopharmacology. Volume 8 Issue 3, 2019 (pp. 33-40):pp.33-40.
  2019.  In vivo Antimalarial Activity, Toxicity and Phytochemical Composition of Total Extracts from Securidaca longepedunculata Fresen. (Polygalaceae)..

2017

Chalo, DM, Lukhoba CW, Dossaji, S. F..  2017.  Antimicrobial activity, toxicity and phytochemical screening of selected medicinal plants of Losho, Narok County, Kenya. . Journal of Natural Product Biochemistry. Vol 15((1)):pp.29-43.
Musila, FM, Lukhoba CW, Dossaji SF.  2017.  Antibacterial and antifungal activities of 10 Kenyan Plectranthus species in the Coleus clade.. Journal of Pharmacy Research. Vol. 11,(Issue 8):pp1003-1014.
Musila, F.M., Lukhoba CW, Dossaji SF.  2017.  Phylogeny of ten Kenyan Plectranthus species in the coleus clade inferred from leaf micromorphology, Rbcl and MatK genes.. Journal of Botany, . (Vol. 2017),:pp.1-16..

2016

Kiraithe, MN, Nguta JM, Mbaria JM, Kiama SG.  2016.  Evaluation of the use of Ocimum suave Willd. (Lamiaceae), Plectranthus barbatus Andrews (Lamiaceae) and Zanthoxylum chalybeum Engl. (Rutaceae) as antimalarial remedies in Kenyan folk medicine. . Journal of Ethnopharmacology. . 178, .:266–271.
Omwenga, I, Kanja L, Nguta JM, Mbaria JM, Irungu P.  2016.  Organochlorine pesticide residues in farmed fish in Machakos and Kiambu counties, Kenya.. Cogent Environmental Science. . 2(1153215.)
Njenga, D, Irungu B, Mbaria J, Mutai C, Nguta J.  2016.  Antiplasmodial activity, cytotoxicity and acute toxicity of Zanthoxylum Chalybeum Engl. World Journal of Pharmacy and Pharmaceutical Sciences,. World Journal of Pharmacy and Pharmaceutical Sciences,. 5(11), :208-217..
Nguta, JM, Appiah-Opong R, Nyarko AK, Yeboah-Manu, D., Addo GA, Otchere, I., Kissi-Twum A.  2016.  Antimycobacterial and cytotoxic activity of selected medicinal plant extracts.. Journal of Ethnopharmacology. 182, :10–15..
Nguta, JM, Appiah-Opong R, Nyarko AK, Yeboah-Manu D, Addo, G.A., Otchere ID, Kissi-Twum, A..  2016.  In vitro antimycobacterial and cytotoxic data on medicinal plants used to treat tuberculosis.. Data in Brief. 7 (2016) (7 (2016) ):1124-1130.
Appiah-Opong R., NyarkoA.K., Yeboah-Manu D, Addo GA, Otchere ID, Kissi-Twum A.  2016.  In vitro antimycobacterial activity and toxicity of eight medicinal plants against pathogenic and non-pathogenic mycobacterial strains.. . International Journal of Mycobacteriology,. 5(5 (2016) ):S106-S107.

2013

M.F. Musila, S.F. Dossaji, NLMJMCW.  2013.  In vivo antimalarial activity, toxicity and phytochemical screening of selected antimalarial plants. Journal of Ethnopharmacology. 146:557-561.

2012

Mbaria, JM;, Nguta JM.  2012.  Natural products: An exciting source of new pharmacophores against malaria. Presented as an oral presentation In: The 8th Biennial Scientific Conference and the 46th Kenya Veterinary Association Annual Scientific Conference held at Safari Park Hotel, Nair.
Nguta, JM.  2012.  Heavy Metal Residues In Camel Milk From Kenya: Health Implications. Abstract

Arsenic and Lead are naturally occurring elements whose toxicity in humans has been documented throughout history. These metals are widely present in our environment due to their natural occurrence and human activities that have introduced them into the general environment such as the use of borehole water and leaded gasoline. Because arsenic and lead may be present in environments where food crops are grown and animals used for food are raised, various foods such as milk may contain unavoidable but small amounts of arsenic and lead that do not pose a significant risk to human health. However, in certain circumstances they may contain high levels that may lead to contamination of milk with levels that may pose a risk to human health. Camel milk samples (n=15) were collected from Nanyuki, Kenya for arsenic and lead analysis. The heavy metals were determined using atomic absorption spectrophotometry following protein precipitation by use of trichloroacetic acid. All the samples analyzed had arsenic levels that ranged from 0.007 ppm to 0.099 ppm. These levels were found to be lower than the Food and Drug Administration (FDA) recommended maximum level of 0.1 parts per million (0.1 ppm), while 14 out of 15 samples (93%) had lead levels ranging from 0.072 ppm to 0.449 ppm and were observed to be above the codex standard (193- 1995) recommended maximum level of 0.02 ppm. The above results indicate that the sampled camel milk may not be safe for human consumption.

2010

Nguta, JM;, Mbaria JM.  2010.  Spectroscopic Determination of Cobalt and Copper in Grass Pastures in Kabete.

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