B. Syuto., K. Oguma., H. Iida and S. Kubo. Compariosn of antigenicity of toxins produced by Clostridium botulinum type C and D strains. Appl. Environ. Microbial. 47, 1319-1322.

Citation:
O. PROFOCHANDAJAMES. "B. Syuto., K. Oguma., H. Iida and S. Kubo. Compariosn of antigenicity of toxins produced by Clostridium botulinum type C and D strains. Appl. Environ. Microbial. 47, 1319-1322.". In: Infect Immun. 1985 May;48(2):312-7. East African Medical Journal; 1984.

Abstract:

The toxin produced by Clostridium botulinum type C 6813 (C-6813) was purified 1,009-fold from the culture supernatant in an overall yield of 30%. The specific toxicity was 1.1 X 10(7) mouse minimum lethal doses per mg of protein. The toxin had a molecular weight of 144,000, composed of the light and heavy chains with molecular weights of 52,000 and 92,000, respectively, linked by one or two disulfide bond(s). The purified C-6813 toxin heavy and light chains reacted strongly with anti-type D heavy chain immunoglobulin G and anti-type C1 light chain immunoglobulin G, respectively. The amino acid compositions of C-6813 toxin heavy and light chains were more similar to those of type D heavy chain and type C1 light chain than to those of type C1 heavy chain and type D light chain, respectively. These results suggest that in the toxin produced by the type C strain at least two subtypes exist.

Notes:

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