Mostad SB, Kreiss JK, Ryncarz AJ, Overbaugh J, Mandaliya K, Chohan B, Ndinya-Achola J, Bwayo JJ, Corey L.Cervical shedding of cytomegalovirus in human immunodeficiency virus type 1-infected women.J Med Virol. 1999 Dec;59(4):469-73.

Citation:
O. PROFNDINYA-ACHOLAJ. "Mostad SB, Kreiss JK, Ryncarz AJ, Overbaugh J, Mandaliya K, Chohan B, Ndinya-Achola J, Bwayo JJ, Corey L.Cervical shedding of cytomegalovirus in human immunodeficiency virus type 1-infected women.J Med Virol. 1999 Dec;59(4):469-73.". In: J Med Virol. 1999 Dec;59(4):469-73. IBIMA Publishing; 1999.

Abstract:

Cervical shedding of cytomegalovirus (CMV) is important in transmission of CMV to exposed sexual partners and neonates. We evaluated prevalence and correlates of CMV DNA shedding in cervical secretions from a large cohort of HIV-1-seropositive women. Using polymerase chain reaction (PCR) assays, CMV DNA was detected in 183 (59%) cervical swab samples from 311 women. Cervical shedding of CMV DNA was significantly associated with shedding of HIV-1 DNA (odds ratio 1.8; 95% confidence interval 1.1-2.8). CMV shedding was also more frequent in women with Neisseria gonorrhoeae and Trichomonas vaginalis infections, but these associations were not statistically significant. Cervical shedding of CMV in HIV-1-infected women is very frequent and may reflect higher risk of transmission to sexual partners and neonates than previously appreciated. Copyright 1999 Wiley-Liss, Inc.

Notes:

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