MacDonald KS, Malonza I, Chen DK, Nagelkerke NJ, Nasio JM, Ndinya-Achola J, Bwayo JJ, Sitar DS, Aoki FY, Plummer FA.Vitamin A and risk of HIV-1 seroconversion among Kenyan men with genital ulcers.AIDS. 2001 Mar 30;15(5):635-9.

Citation:
O. PROFNDINYA-ACHOLAJ. "MacDonald KS, Malonza I, Chen DK, Nagelkerke NJ, Nasio JM, Ndinya-Achola J, Bwayo JJ, Sitar DS, Aoki FY, Plummer FA.Vitamin A and risk of HIV-1 seroconversion among Kenyan men with genital ulcers.AIDS. 2001 Mar 30;15(5):635-9.". In: AIDS. 2001 Mar 30;15(5):635-9. IBIMA Publishing; 2001.

Abstract:

{ BACKGROUND: Vitamin A is involved in normal immune function and the maintenance of mucosal integrity through complex effects on cellular differentiation. OBJECTIVE: We sought to determine whether serum vitamin A levels were associated with altered susceptibility to primary infection with HIV-1 in men with high-risk sexual behaviour and genital ulcers who presented for treatment at an STD clinic in Nairobi, Kenya. METHODS: HIV-1 seronegative men were prospectively followed. Vitamin A levels at study entry were compared among 38 men who HIV-1 seroconverted versus 94 controls who remained HIV seronegative. RESULTS: Vitamin A deficiency (retinol less than 20 microg/dl) was very common and was present in 50% of HIV-1 seroconverters versus 76% of persistent seronegatives. Seroconversion was independently associated with a retinol level greater than 20 microg/dl (HR 2.43, 95% CI 1.25-4.70

Notes:

n/a

Website

UoN Websites Search