New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & MG Gilbert

Citation:
Ndunda B, Langat MK, Mulholland DA, Eastman H, Jacob MR, Khan SI, Walker LA, Muhammad I, Kerubo LO, Midiwo JO. "New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & MG Gilbert." Planta medica. 2016;82(11/12):1079-1086.

Abstract:

The roots of the endangered medicinal plant Croton megalocarpoides collected in Kenya were investigated and twenty-two compounds isolated. Among them were twelve new ent-clerodane (1–12) and a new abietane (13) diterpenoids, alongside the known crotocorylifuran (4 a), two known abietane and four known ent-trachylobane diterpenoids, and the triterpenoids, lupeol and acetyl aleurotolic acid. The structures of the compounds were determined using NMR, HRMS and ECD. The isolated compounds were evaluated against a series of microorganisms (fungal and bacteria) and also against Plasmodium falciparum, however no activity was observed.
Key words:
Croton megalocarpoides - Euphorbiaceae - abietane - ent-clerodane - ent-trachylobane - diterpenoids - electronic circular dichroism

Full text link

UoN Websites Search