Diterpenoids from the stem bark of Croton megalocarpoides Friis & MG Gilbert

Citation:
Langat MK, Ndunda BM, Salter C, Odusina BO, Isyaka SM, Mas-Claret E, Onocha PA, Midiwo JO, Nuzillard J-M, Mulholland DA. "Diterpenoids from the stem bark of Croton megalocarpoides Friis & MG Gilbert." Phytochemistry Letters. 2020;39:1-7.

Abstract:

Description
Five previously undescribed compounds, megalocarpoidolide I (1), megalocarpoidolide J (3), 12-epi-crotonzambefuran A (4), megalocarpoidolide K (5), 1-trans-p-hydroxycoumaroyl–geranylgerani-1-ol (6) were isolated from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. The known ent-trachyloban-18-ol, megalocarpoidolide B, megalocarpoidolide C (2), megalocarpoidolide H, crotocorylifuran, 7,8-dehydrocrotocorylifuran, 1,2-dehydrocrotocorylifuran-2-one, acetyl aleuritolic acid, lupeol, N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine, dodecyl trans-ferulate and lignoceryl trans-ferulate were also isolated. The structures of the compounds were determined using NMR, IR spectroscopy and HRMS. The structure of compound 1 was determined using Logic for Structural Determination (LSD). Compounds 1, 2 and 3 that were selected for screening based on their ability to add diversity to the …

Phytochemistry Letters

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