Anti-Plasmodial and Larvicidal Effects of Surface Exudates of Gardenia ternifolia Aerial Parts

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Ochieng CO, Midiwo OJ, Owuor OP. "Anti-Plasmodial and Larvicidal Effects of Surface Exudates of Gardenia ternifolia Aerial Parts.". 2010.

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Various parts of Gardenia ternifolia (leaves, roots and stem bark) have been reported by traditional healers as a remedy against malaria fever. The aerial parts are coated with shiny materials rich in flavonoid aglycones. The crude acetone wash of the aerial parts showed anti-plasmodial activity of IC50 values 1.06 and 0.94 μg mL-1 against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum, respectively. Bioassay guided chromatographic separation of the crude extracts afforded five flavonoids; (naringenin-7-O-methylether, quercetin-4, 7-O-dimethylether, kaempferol-7-O-methylether, 4, 5-Dihydroxy-6, 7-dimethoxyflavanone, naringenin-4, 7-O-dimethyl-ether) and two steroids; (stigmasterol, β-sitosterol). The same crude acetone surface extract as well as the pure isolates showed moderate larvicidal effects against 2nd instar Ae. aegypti larvae. Naringenin-7-O-methyl-ether was the most potent principle.

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