Indeterminate rapid HIV-1 test results among antenatal and postnatal mothers

Citation:
Matemo D;, Kinuthia J;, John F;, Chung M;, Farquhar C;, Stewart J;G, Kiarie J. "Indeterminate rapid HIV-1 test results among antenatal and postnatal mothers.". 2008.

Abstract:

Summary: The sensitivity and specificity of rapid HIV-1 tests may be altered during pregnancy and postpartum. We conducted a study to determine the prevalence and correlates of false-positive Abbott DetermineTM and false-negative Uni-GoldTM rapid HIV-1 test results among antenatal and postnatal mothers attending a primary care clinic in Nairobi, Kenya. Mothers were tested for HIV-1 using Abbott DetermineTM and non-reactive results were considered HIV-1 antibody negative. Reactive samples by Determine were re-tested by Uni-GoldTM. Vironostika HIV-1 and Uni-FORM II Enzyme-linked immunosorbent assays were used to confirm samples that had positive Abbott DetermineTM and negative Uni-GoldTM. Among 2311 women who accepted HIV-1 testing, 1238 (54%) were tested antenatallyand 1073 (46%) were tested postnatally. Of tested women, 274 (12%) women were reactive by Abbott DetermineTM and on retesting with Uni-GoldTM 30 (11%) had indeterminate results. The prevalence of indeterminate results was significantly higher in antenatal women than in postnatal women (2% versus 1%,P¼ 0.03). In conclusion, indeterminate rapid HIV-1 test results are more common in the antenatal period and appropriate safeguards to confirm HIV-1 infection status should be implemented in antenatal programmes.

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