In vitro production of testosterone and plasma levels of luteinising hormone, testosterone and cortisol in male rats treated with heptachlor. E O Wango, D W Onyango, H Odongo, E Okindo, J Mugweru

Citation:
MR. ODONGO HESBONO. "In vitro production of testosterone and plasma levels of luteinising hormone, testosterone and cortisol in male rats treated with heptachlor. E O Wango, D W Onyango, H Odongo, E Okindo, J Mugweru.". In: Journal of the South African Veterinary Association. 73, 201-206. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology&endocrinology.118(3):381-6; 1997.

Abstract:

Male rats were divided into six groups of five rats each. Rats were injected subcutaneously with different concentrations of heptachlor for 2 weeks. Heptachlor at all doses significantly suppressed plasma testosterone levels (P < 0.05). Plasma luteinizing hormone (LH) (P < 0.01) and cortisol (P < 0.02) levels were significantly elevated in heptachlor-treated rats as compared to corn oil-treated controls. LH and testosterone levels showed strong correlation (r = 0.69, P < 0.05). The testes in rats treated with 25 mg/kg body weight of heptachlor showed some pathological changes. We conclude that heptachlor causes adverse effects on several male reproductive parameters in rats.

Notes:

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