Khat (Catha edulis) lowers plasma luteinizing hormone (LH) and testosterone secretion, but increases cortisol levels in male rabbits.

Citation:
MR. ODONGO HESBONO. "Khat (Catha edulis) lowers plasma luteinizing hormone (LH) and testosterone secretion, but increases cortisol levels in male rabbits.". In: Journal of the South African Veterinary Association. 73, 201-206. Journal of ethnopharmacology;116(2):245-50; 2008.

Abstract:

This study investigated the effects of fresh khat extract on specific circulating hormones in male rabbits. MATERIALS AND METHODS: A total of 25 male New Zealand White rabbits were divided into five groups each comprising five animals. The first four groups were fed four doses (1.5 g/kg, 4.5 g/kg, 13.5 g/kg and 40.5 g/kg body weight) of khat extract twice a week for 5 weeks while the last group, serving as control, was fed only normal saline via intragastric tube. Blood samples were collected at 15 min interval for up to 3 h after khat extract administration and plasma assayed for luteinizing hormone (LH), testosterone and cortisol levels using radioimmunoassay technique. RESULTS: Khat extract at all doses significantly lowered (P<0.05) LH pulse frequency, area under LH curve, mean plasma LH and mean plasma testosterone levels. Plasma cortisol levels were significantly elevated (P<0.05) in khat-treated rabbits in a dose-dependent manner. CONCLUSION: This study demonstrates that khat may impair reproductive function in male rabbits by interfering with sex hormone profiles.

Notes:

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