Anti-Schistosomal activity of five plant extracts on Swiss white mice infected with Schistosoma mansoni

Citation:
Waiganjo N, Yole D, Ochanda H. Anti-Schistosomal activity of five plant extracts on Swiss white mice infected with Schistosoma mansoni.; 2016.

Abstract:

Schistosomiasis in humans is a major public health problem worldwide. Schistosomiasis occurs
in 76 tropical countries and it is estimated that 85% of the infections are in Africa. In Kenya, it is estimated that
3 million people are infected. The Conventional drugs are effective in the treatment of the disease but very little
progress has been achieved on treatment of Schistosomiasis in Kenya. Any effort towards developing alternative
drugs for the disease is worthwhile. Praziquantel is the most effective drug against all adult stages of human
Schistosomiasis, being the drug of choice for morbidity control of Schistosomiasis. However it is not a satisfying
situation to have one drug used for the treatment. Ideally other drugs should be availed in order to avoid
development of drug resistance. The use of plant extracts in treatment of diseases is universal. The results
obtained showed that Ocimum americanum and Bridelia micrantha plant extracts had antischistosomal activity
as indicated by high worm reduction and reduced gross pathology. Histopathology showed no or few
granuloma in the liver tissue. Further work should be done on the efficacious extracts, towards drug
development.
Keywords: Antischistosomal activity, Pathology, Plant extracts, Praziquantel, Schistosomiasis

Website

UoN Websites Search